EP0858285A4 - Mikroporation der menschlichen haut zur arzneimittelabgabe und überwachungsanwendungen - Google Patents

Mikroporation der menschlichen haut zur arzneimittelabgabe und überwachungsanwendungen

Info

Publication number
EP0858285A4
EP0858285A4 EP96929098A EP96929098A EP0858285A4 EP 0858285 A4 EP0858285 A4 EP 0858285A4 EP 96929098 A EP96929098 A EP 96929098A EP 96929098 A EP96929098 A EP 96929098A EP 0858285 A4 EP0858285 A4 EP 0858285A4
Authority
EP
European Patent Office
Prior art keywords
stratum comeum
selected area
skin
stratum
wire
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96929098A
Other languages
English (en)
French (fr)
Other versions
EP0858285A1 (de
Inventor
Jonathan A Eppstein
Michael R Hatch
Difei Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Altea Therapeutics Corp
Spectrx Inc
Original Assignee
Spectrx Inc
Altea Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Technologies Inc filed Critical Spectrx Inc
Priority to EP15151012.0A priority Critical patent/EP2921111A1/de
Priority to EP05011002.2A priority patent/EP1563788B8/de
Priority to DK05011002.2T priority patent/DK1563788T3/da
Publication of EP0858285A1 publication Critical patent/EP0858285A1/de
Publication of EP0858285A4 publication Critical patent/EP0858285A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Laser Surgery Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP96929098A 1995-08-29 1996-08-29 Mikroporation der menschlichen haut zur arzneimittelabgabe und überwachungsanwendungen Withdrawn EP0858285A4 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP15151012.0A EP2921111A1 (de) 1995-08-29 1996-08-29 Mikroporation der menschlichen Haut zur Arzneimittelabgabe und Überwachungsanwendungen
EP05011002.2A EP1563788B8 (de) 1995-08-29 1996-08-29 Mikroperforation von menschlicher Haut zur Medikamentenverabreichung und Überwachungsanwendungen
DK05011002.2T DK1563788T3 (da) 1995-08-29 1996-08-29 Mikroperforering af human hud til stofindgift og overvågningsformål

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US520547 1995-08-29
US804395P 1995-10-30 1995-10-30
US8043 1995-10-30
PCT/US1996/013865 WO1997007734A1 (en) 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP05011002.2A Division EP1563788B8 (de) 1995-08-29 1996-08-29 Mikroperforation von menschlicher Haut zur Medikamentenverabreichung und Überwachungsanwendungen
EP15151012.0A Division EP2921111A1 (de) 1995-08-29 1996-08-29 Mikroporation der menschlichen Haut zur Arzneimittelabgabe und Überwachungsanwendungen

Publications (2)

Publication Number Publication Date
EP0858285A1 EP0858285A1 (de) 1998-08-19
EP0858285A4 true EP0858285A4 (de) 2000-05-17

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96929098A Withdrawn EP0858285A4 (de) 1995-08-29 1996-08-29 Mikroporation der menschlichen haut zur arzneimittelabgabe und überwachungsanwendungen

Country Status (14)

Country Link
EP (1) EP0858285A4 (de)
JP (2) JP3899427B2 (de)
CN (1) CN1174713C (de)
AU (1) AU707065B2 (de)
BR (1) BR9610012A (de)
CA (1) CA2199002C (de)
ES (1) ES2536459T3 (de)
GB (1) GB2307414B (de)
HK (1) HK1009321A1 (de)
IL (1) IL123379A (de)
NO (1) NO334437B1 (de)
PT (1) PT1563788E (de)
TR (1) TR199800347T1 (de)
WO (1) WO1997007734A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251100B1 (en) * 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
AU3399197A (en) 1996-06-18 1998-01-07 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DK0921840T3 (da) * 1996-07-03 2003-09-22 Altea Therapeutics Corp Multipel mekanisk mikroperforering af hud eller slimhinde
EP0934093B1 (de) * 1996-09-17 2003-01-15 Deka Products Limited Partnership System zur medikamentenabgabe durch transport
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
CA2789115C (en) * 1996-12-31 2014-04-29 Altea Therapeutics Corporation Microporation of tissue for delivery of bioactive agents
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6027496A (en) * 1997-03-25 2000-02-22 Abbott Laboratories Removal of stratum corneum by means of light
WO1999020181A1 (en) 1997-10-21 1999-04-29 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6155992A (en) * 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037687B8 (de) 1997-12-11 2008-10-22 Alza Corporation Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
ATE302041T1 (de) * 1997-12-11 2005-09-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
ATE375752T1 (de) * 1998-03-06 2007-11-15 Spectrx Inc Integrierte gewebeporations-, flüssigkeitsammel- und analysevorrichtung
US6530915B1 (en) 1998-03-06 2003-03-11 Spectrx, Inc. Photothermal structure for biomedical applications, and method therefor
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6569157B1 (en) * 1998-05-18 2003-05-27 Abbott Laboratories Removal of stratum corneum by means of light
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6077660A (en) * 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
PT1124607E (pt) 1998-07-14 2008-12-31 Altea Therapeutics Corp Remoção controlada de membranas biológicas por carga pirotécnica, para transporte transmembranar
AU5004299A (en) * 1998-07-21 2000-02-14 Altea Technologies, Inc. System and method for continuous analyte monitoring
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
CA2342801A1 (en) * 1998-09-04 2000-03-16 Powderject Research Limited Monitoring methods using particle delivery methods
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
ATE324922T1 (de) * 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6355054B1 (en) * 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE19963034A1 (de) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur verbesserten Bestimmung des Glukosespiegels anhand von Messungen in interstitieller Flüssigkeit
IL136008A0 (en) 2000-05-07 2001-05-20 Elecsys Ltd Electrically-mediated transdermal drug injection
US7597692B2 (en) 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
AUPR044000A0 (en) * 2000-09-28 2000-10-26 Norwood Abbey Ltd Diagnostic device
US6537243B1 (en) 2000-10-12 2003-03-25 Abbott Laboratories Device and method for obtaining interstitial fluid from a patient for diagnostic tests
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6733493B2 (en) * 2000-11-16 2004-05-11 Innotech Usa, Inc. Laser skin perforator
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
JP4704583B2 (ja) * 2001-02-28 2011-06-15 有限会社開発顧問室 パッチテスト用シート
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
WO2003024507A2 (en) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002330083A1 (en) 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
EP1450876B1 (de) 2001-11-07 2016-08-17 Syneron Medical Ltd. Integriertes transdermales arzneimittelabgabesystem
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
ES2701884T3 (es) 2002-03-11 2019-02-26 Nitto Denko Corp Sistema de parche de administración transdérmica de fármacos
AU2003226605A1 (en) 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
WO2005042054A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20050089554A1 (en) * 2003-10-24 2005-04-28 Cormier Michel J. Apparatus and method for enhancing transdermal drug delivery
RU2007118684A (ru) 2004-10-21 2008-11-27 БАЙЕР ХЕЛТКЭА ЭлЭлСи (US) Способ и система для определения концентрации анализируемого вещества в жидкости организма
JP2006326147A (ja) * 2005-05-30 2006-12-07 Shingo Wakamatsu レーザー治療装置
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
JP5011935B2 (ja) * 2006-10-11 2012-08-29 パナソニック株式会社 血液検査装置
JP5011936B2 (ja) * 2006-10-11 2012-08-29 パナソニック株式会社 血液検査装置
WO2008059810A1 (fr) * 2006-11-14 2008-05-22 Kagoshima University Dispositif d'injection de médicament
AU2008245585B2 (en) * 2007-04-27 2011-10-06 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
EP2200666B1 (de) 2007-10-09 2014-12-03 Syneron Medical Ltd. Magnetische pflasterkopplung
EP2205967B1 (de) 2007-10-17 2013-05-01 Syneron Medical Ltd. Überprüfung der auflösungsrate
WO2009060701A1 (ja) * 2007-11-06 2009-05-14 Konica Minolta Opto, Inc. 微小開口形成装置およびそれを用いる体液収集システム
AU2008332738B2 (en) 2007-12-05 2013-08-15 Syneron Medical Ltd. A disposable electromagnetic energy applicator and method of using it
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20100256466A1 (en) * 2009-04-02 2010-10-07 Avraham Shekalim Metabolite Management System
JP5774001B2 (ja) 2009-07-27 2015-09-02 ノヴォクセル リミテッド 組織焼灼のための方法および装置
PT105635B (pt) * 2011-04-19 2014-04-11 Univ De Coimbra Dispositivo para a administração eficiente de compostos na pele ou barreiras biológicas, ou através dessas, usando filmes finos absorventes de luz
WO2016042547A1 (en) * 2014-09-15 2016-03-24 Novoxel Ltd. Methods and devices for thermal surgical vaporization and incision of tissue
KR102329660B1 (ko) 2013-12-18 2021-11-23 노보셀 리미티드 조직 기화를 위한 장치 및 방법
EP3193761B1 (de) 2014-09-15 2021-03-24 Novoxel Ltd. Verfahren zur herstellung von vorrichtungen für thermale gewebevaporisation und -kompression
EP3265168A1 (de) * 2015-03-03 2018-01-10 Guided Therapy Systems, L.L.C. Verfahren und systeme zur ultraschallunterstützten abgabe eines arzneimittels an gewebe
WO2017102867A1 (en) * 2015-12-15 2017-06-22 Koninklijke Philips N.V. Surface treatment device and method
CN108780085A (zh) * 2016-01-15 2018-11-09 辛辛那提大学 先进的电穿孔装置和用于获得生物流体中的分析物的方法
US10729497B2 (en) * 2016-06-20 2020-08-04 University Of North Texas Laser-assisted machining (LAM) of non-monolithic composite bone material
FI127811B (en) * 2016-11-21 2019-03-15 Helsingin Yliopisto APPARATUS FOR SAMPLING ONE OR MORE ANALYTICAL SAMPLES
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US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
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WO2020264034A1 (en) * 2019-06-28 2020-12-30 Passport Technologies, Inc. Methods and systems for controlling energy delivery to filament devices
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
WO1992000106A2 (en) * 1990-06-27 1992-01-09 Diomed Limited Method of treatment and compositions therefore
US5165418A (en) * 1992-03-02 1992-11-24 Tankovich Nikola I Blood sampling device and method using a laser
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2798459B2 (ja) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー エレクトロポレーションを利用した診断装置及び分子の組織内移動装置
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
JP3189337B2 (ja) * 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
US5582184A (en) * 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
JPH10509632A (ja) * 1995-07-25 1998-09-22 マサチューセッツ インスティチュート オブ テクノロジー 超音波を使用する増強された経皮送達

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
WO1992000106A2 (en) * 1990-06-27 1992-01-09 Diomed Limited Method of treatment and compositions therefore
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5165418A (en) * 1992-03-02 1992-11-24 Tankovich Nikola I Blood sampling device and method using a laser
US5165418B1 (en) * 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9707734A1 *

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JPH11511360A (ja) 1999-10-05
CN1174713C (zh) 2004-11-10
GB9702766D0 (en) 1997-04-02
ES2536459T3 (es) 2015-05-25
GB2307414A (en) 1997-05-28
EP0858285A1 (de) 1998-08-19
AU6863196A (en) 1997-03-19
TR199800347T1 (xx) 1998-05-21
PT1563788E (pt) 2015-06-02
JP3899427B2 (ja) 2007-03-28
BR9610012A (pt) 1999-12-21
CA2199002C (en) 1999-02-23
WO1997007734A1 (en) 1997-03-06
HK1009321A1 (en) 1999-05-28
GB2307414B (en) 1998-03-11
JP2006192285A (ja) 2006-07-27
NO334437B1 (no) 2014-03-03
NO980878L (no) 1998-04-27
AU707065B2 (en) 1999-07-01
IL123379A (en) 2002-04-21
CA2199002A1 (en) 1997-03-01
NO980878D0 (no) 1998-02-27
CN1195276A (zh) 1998-10-07
IL123379A0 (en) 1998-09-24

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