EP0831880A1 - Antibody and antibody fragments for inhibiting the growth of tumors - Google Patents
Antibody and antibody fragments for inhibiting the growth of tumorsInfo
- Publication number
- EP0831880A1 EP0831880A1 EP96921457A EP96921457A EP0831880A1 EP 0831880 A1 EP0831880 A1 EP 0831880A1 EP 96921457 A EP96921457 A EP 96921457A EP 96921457 A EP96921457 A EP 96921457A EP 0831880 A1 EP0831880 A1 EP 0831880A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- amino acid
- variable region
- chain variable
- acid sequence
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48298295A | 1995-06-07 | 1995-06-07 | |
US482982 | 1995-06-07 | ||
US57328995A | 1995-12-15 | 1995-12-15 | |
US573289 | 1995-12-15 | ||
PCT/US1996/009847 WO1996040210A1 (en) | 1995-06-07 | 1996-06-07 | Antibody and antibody fragments for inhibiting the growth of tumors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0831880A1 true EP0831880A1 (en) | 1998-04-01 |
EP0831880A4 EP0831880A4 (en) | 2004-12-01 |
Family
ID=27047489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96921457A Withdrawn EP0831880A4 (en) | 1995-06-07 | 1996-06-07 | Antibody and antibody fragments for inhibiting the growth of tumors |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0831880A4 (en) |
JP (3) | JPH11507535A (en) |
AU (1) | AU6267896A (en) |
CA (1) | CA2222231A1 (en) |
WO (1) | WO1996040210A1 (en) |
Families Citing this family (427)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
NZ337413A (en) * | 1997-03-10 | 2003-02-28 | Univ California | Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer. |
US20020173629A1 (en) | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO1998051702A1 (en) * | 1997-05-14 | 1998-11-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
US6706721B1 (en) | 1998-04-29 | 2004-03-16 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate |
MXPA00011248A (en) * | 1998-05-15 | 2004-09-06 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
AU768027B2 (en) * | 1999-02-24 | 2003-11-27 | Uab Research Foundation, The | Taxane derivatives for targeted therapy of cancer |
BR0010524A (en) * | 1999-05-14 | 2002-05-28 | Imclone Systems Inc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
EP1189641B1 (en) | 1999-06-25 | 2009-07-29 | Genentech, Inc. | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
ES2330301T3 (en) | 1999-08-27 | 2009-12-09 | Genentech, Inc. | DOSAGES FOR TREATMENT WITH ANTI-ERBB2 ANTIBODIES. |
US7087613B2 (en) | 1999-11-11 | 2006-08-08 | Osi Pharmaceuticals, Inc. | Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
UA74803C2 (en) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use |
ES2528794T3 (en) | 2000-04-11 | 2015-02-12 | Genentech, Inc. | Multivalent antibodies and uses thereof |
CN102698265A (en) | 2000-05-19 | 2012-10-03 | 杰南技术公司 | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
JP2004527456A (en) * | 2000-08-09 | 2004-09-09 | イムクローン システムズ インコーポレイティド | Treatment of hyperproliferative diseases with EGF receptor antagonists |
RU2297245C2 (en) * | 2001-02-19 | 2007-04-20 | Мерк Патент Гмбх | Modified anti-egfr antibodies with reduced ammonogenicity |
JP2004528851A (en) * | 2001-05-07 | 2004-09-24 | ハイブリドン・インコーポレイテッド | Epidermal growth factor receptor antisense oligonucleotides |
ES2552281T3 (en) | 2001-05-11 | 2015-11-26 | Ludwig Institute For Cancer Research Ltd. | Specific binding proteins and uses thereof |
US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
DE10133394A1 (en) * | 2001-07-13 | 2003-01-30 | Merck Patent Gmbh | Liquid formulation containing cetuximab |
JP4606739B2 (en) * | 2002-01-18 | 2011-01-05 | ピエール、ファーブル、メディカマン | Novel anti-IGF-IR antibodies and uses thereof |
US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
AU2003210802B2 (en) | 2002-02-05 | 2009-09-10 | Genentech Inc. | Protein purification |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
JP2005535572A (en) * | 2002-04-12 | 2005-11-24 | メディミューン,インコーポレーテッド | Recombinant anti-interleukin-9 antibody |
CA2478925C (en) | 2002-04-26 | 2016-06-07 | Robert Lee Fahrner | Non-affinity purification of proteins |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
PT1585966E (en) | 2002-07-15 | 2012-02-20 | Hoffmann La Roche | Treatment of cancer with the anti-erbb2 antibody rhumab 2c4 |
BRPI0314814C1 (en) | 2002-09-27 | 2021-07-27 | Xencor Inc | antibody comprising an fc variant |
JP2006524036A (en) * | 2002-11-08 | 2006-10-26 | アブリンクス エン.ヴェー. | Single domain antibodies targeting tumor necrosis factor alpha and uses thereof |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
EP1583562B1 (en) | 2003-01-06 | 2011-06-15 | Angiochem Inc. | Angiopep-1, related compounds, and uses thereof |
ES2574993T3 (en) | 2003-01-22 | 2016-06-23 | Roche Glycart Ag | Fusion constructs and use thereof to produce antibodies with higher Fc receptor binding affinity and effector function |
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
WO2004093807A2 (en) | 2003-04-22 | 2004-11-04 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Somatostatin vectors |
ES2786568T3 (en) | 2003-07-28 | 2020-10-13 | Genentech Inc | Reduction of protein A leaching during protein A affinity chromatography |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
KR101520209B1 (en) | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | Monomethylvaline compounds capable of conjugation to ligands |
DE10355904A1 (en) * | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Solid forms of anti-EGFR antibodies |
EP1701979A2 (en) * | 2003-12-03 | 2006-09-20 | Xencor, Inc. | Optimized antibodies that target the epidermal growth factor receptor |
EP2221315A1 (en) | 2003-12-04 | 2010-08-25 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
JP4969440B2 (en) | 2004-04-08 | 2012-07-04 | デビッド, ビー. エイガス, | ErbB antagonist for the treatment of pain |
NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
EP1919950A1 (en) | 2004-07-15 | 2008-05-14 | Xencor, Inc. | Optimized fc variants |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
EP1791565B1 (en) | 2004-09-23 | 2016-04-20 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
US7939267B2 (en) | 2004-11-04 | 2011-05-10 | Laboratory Corporation Of America Holdings | Detection of activation of endothelial cells as surrogate marker for angiogenesis |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
CN102746404B (en) | 2004-11-12 | 2016-01-20 | 赞科股份有限公司 | To FcRn in conjunction with reformed Fc variant |
EP1812064A4 (en) | 2004-11-19 | 2009-07-08 | Cornell Res Foundation Inc | Use of vascular endothelial growth factor receptor 1+ cells in treating and monitoring cancer and in screening for chemotherapeutics |
EP3698807A1 (en) | 2005-01-21 | 2020-08-26 | Genentech, Inc. | Fixed dosing of her antibodies |
US20080161251A1 (en) | 2005-01-21 | 2008-07-03 | Astex Therapeutics Limited | Pharmaceutical Compounds |
PT2360258E (en) | 2005-02-18 | 2015-01-13 | Angiochem Inc | Aprotinin polypeptides for transporting a compound across the blood-brain barrier |
AU2006216732C1 (en) | 2005-02-23 | 2017-07-20 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients using a HER dimerization inhibitor |
AR053272A1 (en) | 2005-05-11 | 2007-04-25 | Hoffmann La Roche | DETERMINATION OF RESPONSIVES TO CHEMOTHERAPY |
DK2433653T3 (en) | 2005-07-15 | 2019-08-19 | Angiochem Inc | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
ES2530265T3 (en) | 2005-07-21 | 2015-02-27 | Genmab A/S | Binding potency assays of an antibody drug substance to an FC receptor |
RU2515108C2 (en) | 2005-08-19 | 2014-05-10 | Эббви Инк | Immunoglobulin with double variable domains and its applications |
EP2500356A3 (en) | 2005-08-19 | 2012-10-24 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
DE602006013029D1 (en) | 2005-11-12 | 2010-04-29 | Lilly Co Eli | ANTI-EGFR ANTIBODY |
CA2641310C (en) | 2006-02-03 | 2013-08-20 | Imclone Systems Incorporated | Igf-ir antagonists as adjuvants for treatment of prostate cancer |
AR060635A1 (en) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | DERIVATIVES OF 1,2-DIHIDRO-3H-PIRAZOLO [3,4-D] PIRIMIDIN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE TREATMENT OF CANCER |
FR2902799B1 (en) | 2006-06-27 | 2012-10-26 | Millipore Corp | METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID |
JP2008081492A (en) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | New aminopyridine derivative having aurora a selective inhibitory action |
CA2662236A1 (en) | 2006-09-12 | 2008-03-20 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of cancer |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
US7820159B2 (en) * | 2006-10-31 | 2010-10-26 | Instiute of Virology of the Slovak Academy of Sciences | MN/CA IX and EGFR pathway inhibition |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
WO2008079280A1 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
EP2123676A4 (en) * | 2007-01-05 | 2011-01-05 | Univ Tokyo | Diagnosis and treatment of cancer by using anti-prg-3 antibody |
ES2426158T3 (en) | 2007-01-22 | 2013-10-21 | Genentech, Inc. | Precipitation with polyelectrolyte and antibody purification |
US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
WO2008101177A2 (en) * | 2007-02-16 | 2008-08-21 | University Of Virginia Patent Foundation | Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis |
EP2132229B1 (en) | 2007-03-01 | 2016-05-11 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
WO2008109440A2 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
MX2009009782A (en) | 2007-03-15 | 2010-09-10 | Ludwig Inst Cancer Res | Treatment method using egfr antibodies and src inhibitors and related formulations. |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
WO2008154249A2 (en) | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
SI3597659T1 (en) | 2007-07-09 | 2023-04-28 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
AU2008315048A1 (en) | 2007-10-23 | 2009-04-30 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
RS53850B2 (en) | 2007-10-30 | 2018-07-31 | Genentech Inc | Antibody purification by cation exchange chromatography |
MX2010005222A (en) | 2007-11-12 | 2010-09-28 | Bipar Sciences Inc | Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents. |
SI2808343T1 (en) | 2007-12-26 | 2019-10-30 | Xencor Inc | Fc variants with altered binding to FcRn |
US8454960B2 (en) * | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
TWI472339B (en) | 2008-01-30 | 2015-02-11 | Genentech Inc | Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof |
SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
RU2010153578A (en) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | IMMUNOGLOBULINS WITH DOUBLE VARIABLE DOMAINS AND THEIR APPLICATION |
CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
US8999702B2 (en) | 2008-06-11 | 2015-04-07 | Emd Millipore Corporation | Stirred tank bioreactor |
RU2011104348A (en) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | IMMUNOGLOBULINS WITH DOUBLE VARIABLE DOMAIN AGAINST PROSTAGLANDINE E2 AND THEIR APPLICATION |
HUE047316T2 (en) | 2008-08-14 | 2020-04-28 | Genentech Inc | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
CN102137874B (en) | 2008-08-29 | 2015-02-18 | 西福根有限公司 | Recombinant anti-epidermal growth factor receptor antibody compositions |
JP5705115B2 (en) | 2008-09-10 | 2015-04-22 | ジェネンテック, インコーポレイテッド | Compositions and methods for prevention of oxidative degradation of proteins |
KR20190025057A (en) | 2008-10-14 | 2019-03-08 | 제넨테크, 인크. | Immunoglobulin variants and uses thereof |
CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
BRPI0922689A2 (en) | 2008-12-05 | 2018-11-06 | Angiochem Inc. | neurotensin conjugates or neurotensin analogs and uses thereof |
CN105037535A (en) | 2008-12-16 | 2015-11-11 | Emd密理博公司 | Stirred tank reactor and method |
JP2012512244A (en) | 2008-12-16 | 2012-05-31 | イー・エム・デイー・ミリポア・コーポレイシヨン | Protein purification |
US8288396B2 (en) | 2009-02-25 | 2012-10-16 | Msdkk | Pyrimidopyrimidoindazole derivative |
US8435488B2 (en) | 2009-02-27 | 2013-05-07 | Genentech, Inc. | Methods and compositions for protein labelling |
EP2810652A3 (en) | 2009-03-05 | 2015-03-11 | AbbVie Inc. | IL-17 binding proteins |
EP2403339B1 (en) | 2009-03-06 | 2017-01-18 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an akt inhibitor and other anticancer agents |
ES2572728T3 (en) | 2009-03-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Bispecific anti-HER antibodies |
MX2011010169A (en) * | 2009-04-07 | 2011-10-11 | Roche Glycart Ag | Bispecific anti-erbb-1/anti-c-met antibodies. |
RU2011146654A (en) | 2009-04-20 | 2013-05-27 | Ангиокем Инк. | METHODS FOR TREATING OVARIAN CANCER USING CONJUGATED PRODUCT |
CA2765287C (en) | 2009-06-15 | 2018-12-11 | Bayer Bioscience N.V. | Nicotiana benthamiana plants deficient in xylosyltransferase activity |
IN2012DN00248A (en) | 2009-07-02 | 2015-05-01 | Angiochem Inc | |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
HUE048980T2 (en) | 2009-08-11 | 2020-08-28 | Hoffmann La Roche | Production of proteins in glutamine-free cell culture media |
KR20120060877A (en) | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | Dual variable domain immunoglobulins and uses thereof |
US9428548B2 (en) | 2009-09-01 | 2016-08-30 | Genentech, Inc. | Enhanced protein purification through a modified protein A elution |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
ES2354922B1 (en) | 2009-09-02 | 2012-02-07 | Fundacion Institut De Recerca De L'hospital Universitari Vall D'hebron | MARKERS FOR THE SELECTION OF PERSONALIZED THERAPIES FOR THE TREATMENT OF THE C�? NCER. |
AR078161A1 (en) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | VERY CONCENTRATED PHARMACEUTICAL FORMULATIONS OF AN ANTIBODY ANTI CD20. USE OF THE FORMULATION. TREATMENT METHOD |
US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
UY32979A (en) | 2009-10-28 | 2011-02-28 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
EP2507381A4 (en) | 2009-12-04 | 2016-07-20 | Hoffmann La Roche | Multispecific antibodies, antibody analogs, compositions, and methods |
CN102712640A (en) | 2010-01-12 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
US20120309056A1 (en) | 2010-02-04 | 2012-12-06 | Leon Arnaud | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
WO2011097527A2 (en) | 2010-02-04 | 2011-08-11 | Xencor, Inc. | Immunoprotection of therapeutic moieties using enhanced fc regions |
JP5981853B2 (en) | 2010-02-18 | 2016-08-31 | ジェネンテック, インコーポレイテッド | Neuregulin antagonists and their use in the treatment of cancer |
EP2536432B1 (en) | 2010-02-19 | 2018-08-08 | Cornell University | Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases |
AU2011222012C1 (en) | 2010-03-02 | 2015-02-26 | Kyowa Kirin Co., Ltd. | Modified antibody composition |
EP2547338A2 (en) | 2010-03-17 | 2013-01-23 | F. Hoffmann-La Roche AG | Imidazopyridine compounds, compositions and methods of use |
PL2550018T3 (en) | 2010-03-22 | 2019-08-30 | F.Hoffmann-La Roche Ag | Compositions and methods useful for stabilizing protein-containing formulations |
WO2011118739A1 (en) | 2010-03-26 | 2011-09-29 | 協和発酵キリン株式会社 | Novel antibody having modification site introduced therein, and antibody fragment |
WO2011120135A1 (en) | 2010-03-29 | 2011-10-06 | Zymeworks, Inc. | Antibodies with enhanced or suppressed effector function |
MX2012011887A (en) | 2010-04-16 | 2012-11-30 | Genentech Inc | Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy. |
EP2566510A1 (en) | 2010-05-03 | 2013-03-13 | F. Hoffmann-La Roche AG | Compositions and methods useful for reducing the viscosity of protein-containing formulations |
SI2571532T1 (en) | 2010-05-14 | 2017-10-30 | Abbvie Inc. | Il-1 binding proteins |
EP2571903B1 (en) | 2010-05-17 | 2019-09-04 | EMD Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
JP6050226B2 (en) | 2010-05-28 | 2016-12-21 | ジェネンテック, インコーポレイテッド | Lowering lactic acid levels and increasing polypeptide production by downregulating LDH and PDHK expression |
CA2802756C (en) | 2010-06-24 | 2021-05-04 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
WO2012006500A2 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
UY33492A (en) | 2010-07-09 | 2012-01-31 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
JP5953303B2 (en) | 2010-07-29 | 2016-07-20 | ゼンコア インコーポレイテッド | Antibodies with modified isoelectric points |
KR20130100118A (en) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | Dual variable domain immunoglobulins and uses therof |
US9051370B2 (en) * | 2010-08-10 | 2015-06-09 | Glycotope Gmbh | Humanized EGFR antibodies |
EP2603528B1 (en) | 2010-08-10 | 2016-10-12 | Glycotope GmbH | Fab-glycosylated antibodies |
BR112013003279A2 (en) | 2010-08-13 | 2016-06-14 | Genentech In | "Methods for treating a disease, method for neutralizing or blocking il-1ß and / or il-18 activity, antibody, uses of an antibody and uses of a monoclonal antibody" |
CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
SG10201408229WA (en) | 2010-08-31 | 2015-02-27 | Genentech Inc | Biomarkers and methods of treatment |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
BR112013006016A2 (en) | 2010-09-15 | 2016-06-07 | Hoffmann La Roche | azabenzothiazole compounds, compositions and methods of use |
WO2012048332A2 (en) * | 2010-10-08 | 2012-04-12 | John Williams | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
US8962804B2 (en) | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
US9309322B2 (en) | 2010-11-12 | 2016-04-12 | Scott & White Healthcare (Swh) | Antibodies to tumor endothelial marker 8 |
WO2012066061A1 (en) | 2010-11-19 | 2012-05-24 | F. Hoffmann-La Roche Ag | Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors |
KR20130133247A (en) | 2010-12-21 | 2013-12-06 | 애브비 인코포레이티드 | Il-1-alpha and -beta bispecific dual variable domain immunoglobulins and their use |
WO2012085176A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors |
JP5882913B2 (en) | 2010-12-27 | 2016-03-09 | 協和発酵キリン株式会社 | Method for preparing aqueous solution containing medium and chelating agent |
WO2012095514A1 (en) | 2011-01-14 | 2012-07-19 | Vivalis | Recombinant protein production system |
WO2012100346A1 (en) * | 2011-01-24 | 2012-08-02 | Ym Biosciences Inc. | Antibodies selective for cells presenting egfr at high density |
EA028804B1 (en) | 2011-03-25 | 2018-01-31 | Гленмарк Фармасьютикалс С.А. | Hetero-dimeric immunoglobulins |
EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
RU2014101492A (en) | 2011-06-20 | 2015-07-27 | Траслэшионал Кэнсэр Драгз Фарма, С.Л. | METHOD FOR PREDICTING A CLINICAL RESPONSE TO CHEMOTHERAPY IN A SUBJECT WITH CANCER |
WO2019071023A1 (en) | 2017-10-04 | 2019-04-11 | Yale University | Compositions and methods for making selenocysteine containing polypeptides |
US9464288B2 (en) | 2011-07-11 | 2016-10-11 | Yale University | Compositions and methods for making selenocysteine containing polypeptides |
WO2013007768A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors |
WO2013007765A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
EP2551348B1 (en) | 2011-07-29 | 2014-09-24 | Icon Genetics GmbH | Production of galactosylated N-glycans in plants |
WO2013022855A1 (en) | 2011-08-05 | 2013-02-14 | Xencor, Inc. | Antibodies with modified isoelectric points and immunofiltering |
CN103889976A (en) | 2011-08-12 | 2014-06-25 | 弗·哈夫曼-拉罗切有限公司 | Indazole compounds, compositions and methods of use |
MX2014001766A (en) | 2011-08-17 | 2014-05-01 | Genentech Inc | Neuregulin antibodies and uses thereof. |
KR101870555B1 (en) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
CA2845409A1 (en) | 2011-09-20 | 2013-03-28 | Yingjie Lai | Imidazopyridine compounds, compositions and methods of use |
US10196664B2 (en) | 2011-10-04 | 2019-02-05 | Icon Genetics Gmbh | Nicotiana benthamiana plants deficient in fucosyltransferase activity |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
JP6310394B2 (en) | 2011-10-10 | 2018-04-11 | ゼンコア インコーポレイテッド | Methods for purifying antibodies |
MX2014004977A (en) | 2011-10-24 | 2014-09-11 | Abbvie Inc | Immunobinders directed against sclerostin. |
CA2857114A1 (en) | 2011-11-30 | 2013-06-06 | Genentech, Inc. | Erbb3 mutations in cancer |
TR201815709T4 (en) | 2011-12-22 | 2018-11-21 | Hoffmann La Roche | Ion exchange membrane chromatography. |
TW201333035A (en) | 2011-12-30 | 2013-08-16 | Abbvie Inc | Dual specific binding proteins directed against IL-13 and/or IL-17 |
US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
EP3296320A1 (en) | 2012-03-08 | 2018-03-21 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
JP2015514710A (en) | 2012-03-27 | 2015-05-21 | ジェネンテック, インコーポレイテッド | Diagnosis and treatment of HER3 inhibitors |
CN109880867A (en) | 2012-03-27 | 2019-06-14 | 弗·哈夫曼-拉罗切有限公司 | Improved harvest for recombinant protein operates |
BR112014028600B1 (en) | 2012-05-18 | 2022-11-22 | Genentech, Inc | SUSPENSION FORMULATIONS COMPRISING HIGH CONCENTRATION MONOCLONAL ANTIBODY, ITS METHOD OF PREPARATION, ITS USE AND DEVICE FOR SUBCUTANEOUS ADMINISTRATION, AND METHOD FOR PRODUCING AN ARTICLE OF MANUFACTURING |
MX2014014356A (en) | 2012-05-24 | 2015-07-06 | Fundació Inst D Investigació Biomédica De Bellvitge Idibell | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis. |
AU2013270684B2 (en) | 2012-06-08 | 2018-04-19 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
JP6103832B2 (en) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | EGFR binding peptide |
WO2014011955A2 (en) | 2012-07-12 | 2014-01-16 | Abbvie, Inc. | Il-1 binding proteins |
ES2907763T3 (en) | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Modified amino acids comprising an azido group |
WO2014056783A1 (en) | 2012-10-08 | 2014-04-17 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
AU2013334493B2 (en) | 2012-10-26 | 2018-11-29 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
CA2890263C (en) | 2012-11-01 | 2020-03-10 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
SG10201802044RA (en) | 2012-11-01 | 2018-05-30 | Abbvie Inc | Stable dual variable domain immunoglobulin protein formulations |
CN104994885B (en) | 2012-12-19 | 2017-09-29 | 基因泰克公司 | Method and composition for radiohalogen protein labeling |
AU2014205086B2 (en) | 2013-01-14 | 2019-04-18 | Xencor, Inc. | Novel heterodimeric proteins |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
EP2945969A1 (en) | 2013-01-15 | 2015-11-25 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
EP2954068B8 (en) | 2013-02-05 | 2018-10-31 | Pierian Holdings, Inc. | Drug selection for non-small cell lung cancer therapy |
JP2016509045A (en) | 2013-02-22 | 2016-03-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | How to treat cancer and prevent drug resistance |
MY192312A (en) | 2013-02-26 | 2022-08-17 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
RU2015140915A (en) | 2013-02-26 | 2017-04-03 | Роше Гликарт Аг | BSPECIFIC ANTI-BINDING MOLECULES ACTIVATING T-CELLS |
US9925240B2 (en) | 2013-03-06 | 2018-03-27 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
CN105980386B (en) | 2013-03-13 | 2021-08-13 | 基因泰克公司 | Pyrazolo compounds and uses thereof |
EP2968540A2 (en) | 2013-03-14 | 2016-01-20 | Genentech, Inc. | Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use |
CA2905070A1 (en) | 2013-03-14 | 2014-09-25 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
EP3421495A3 (en) | 2013-03-15 | 2019-05-15 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
MX2015011899A (en) | 2013-03-15 | 2016-05-05 | Genentech Inc | Methods of treating cancer and preventing cancer drug resistance. |
WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
CN105143257B (en) | 2013-03-15 | 2020-10-27 | 艾伯维生物医疗股份有限公司 | FC variants |
ES2658039T3 (en) | 2013-07-10 | 2018-03-08 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods for their preparation and methods of use |
WO2015035044A2 (en) | 2013-09-04 | 2015-03-12 | Abbvie Biotherapeutics Inc. | Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
WO2015035062A1 (en) | 2013-09-05 | 2015-03-12 | Genentech, Inc. | Antiproliferative compounds |
TW201605857A (en) | 2013-10-03 | 2016-02-16 | 赫孚孟拉羅股份公司 | Therapeutic inhibitors of CDK8 and uses thereof |
WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
MX2016004802A (en) | 2013-10-18 | 2016-07-18 | Genentech Inc | Anti-rsp02 and/or anti-rsp03 antibodies and their uses. |
PE20160724A1 (en) | 2013-11-04 | 2016-08-04 | Glenmark Pharmaceuticals Sa | PRODUCTION OF T-CELL REDIRECTING HETERODIMERIC IMMUNOGLOBULINS |
EP3083692B1 (en) | 2013-12-17 | 2020-02-19 | F.Hoffmann-La Roche Ag | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
CA2934028A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
BR112016021383A2 (en) | 2014-03-24 | 2017-10-03 | Genentech Inc | METHOD TO IDENTIFY A PATIENT WITH CANCER WHO IS LIKE OR LESS LIKELY TO RESPOND TO TREATMENT WITH A CMET ANTAGONIST, METHOD TO IDENTIFY A PATIENT WITH PREVIOUSLY TREATED CANCER, METHOD TO DETERMINE THE EXPRESSION OF THE HGF BIOMARKER, ANTI-C-MET ANTAGONIST AND ITS USE, DIAGNOSTIC KIT AND ITS PREPARATION METHOD |
EP3954713A3 (en) | 2014-03-28 | 2022-03-30 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
EP3632934A1 (en) | 2014-03-31 | 2020-04-08 | F. Hoffmann-La Roche AG | Anti-ox40 antibodies and methods of use |
WO2015153514A1 (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
ES2825574T3 (en) | 2014-07-09 | 2021-05-17 | Hoffmann La Roche | PH adjustment to improve thaw recovery of cell banks |
PE20170263A1 (en) | 2014-08-04 | 2017-03-30 | Hoffmann La Roche | T-CELL ACTIVATING ANTIGEN-BINDING BI-SPECIFIC MOLECULES |
WO2016036873A1 (en) | 2014-09-05 | 2016-03-10 | Genentech, Inc. | Therapeutic compounds and uses thereof |
EP3193866A1 (en) | 2014-09-19 | 2017-07-26 | Genentech, Inc. | Use of cbp/ep300 and bet inhibitors for treatment of cancer |
EP3204379B1 (en) | 2014-10-10 | 2019-03-06 | Genentech, Inc. | Pyrrolidine amide compounds as histone demethylase inhibitors |
SG10202006685XA (en) | 2014-10-23 | 2020-08-28 | Innate Pharma | Treatment of Cancers Using Anti-NKG2A Agents |
CN114381521A (en) | 2014-11-03 | 2022-04-22 | 豪夫迈·罗氏有限公司 | Methods and biomarkers for efficacy prediction and assessment of OX40 agonist treatment |
CA2966523A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Assays for detecting t cell immune subsets and methods of use thereof |
US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
RU2017119428A (en) | 2014-11-06 | 2018-12-06 | Дженентек, Инк. | COMBINED THERAPY, INCLUDING THE USE OF OX40-CONNECTING AGONISTS AND TIGIT INHIBITORS |
MA40940A (en) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS |
MA40943A (en) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS |
JP6639497B2 (en) | 2014-11-10 | 2020-02-05 | ジェネンテック, インコーポレイテッド | Bromodomain inhibitors and uses thereof |
WO2016081384A1 (en) | 2014-11-17 | 2016-05-26 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
BR112017010324A2 (en) | 2014-11-20 | 2018-05-15 | F. Hoffmann-La Roche Ag | method for treating or slowing cancer progression in an individual, molecules, methods for enhancing immune function in an individual and for selecting a patient for treatment, kits, pharmaceutical composition and uses of a combination of one molecule |
CA2967426A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and tumor antigens |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
BR112017011166A2 (en) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | heterodimeric antibodies that bind to cd3 and cd38 |
EP3224258B1 (en) | 2014-11-27 | 2019-08-14 | Genentech, Inc. | 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors |
ES2764299T3 (en) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Human monoclonal antibodies against AXL |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
RU2710735C2 (en) | 2014-12-23 | 2020-01-10 | Дженентек, Инк. | Compositions and methods of treating and diagnosing cancer-resistant cancer |
EP3240908A2 (en) | 2014-12-30 | 2017-11-08 | F. Hoffmann-La Roche AG | Methods and compositions for prognosis and treatment of cancers |
CN107406414B (en) | 2015-01-09 | 2022-04-19 | 基因泰克公司 | (piperidin-3-yl) (naphthalen-2-yl) methanone derivatives as inhibitors of histone demethylase KDM2B for the treatment of cancer |
JP6889661B2 (en) | 2015-01-09 | 2021-06-18 | ジェネンテック, インコーポレイテッド | 4,5-Dihydroimidazole derivative and its use as a histone dimethylase (KDM2B) inhibitor |
CN107406429B (en) | 2015-01-09 | 2021-07-06 | 基因泰克公司 | Pyridazinone derivatives and their use in the treatment of cancer |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
KR101776879B1 (en) | 2015-01-19 | 2017-09-08 | 주식회사 녹십자 | Pharmaceutical formulation comprising anti-egfr antibody |
WO2016123391A1 (en) | 2015-01-29 | 2016-08-04 | Genentech, Inc. | Therapeutic compounds and uses thereof |
WO2016123387A1 (en) | 2015-01-30 | 2016-08-04 | Genentech, Inc. | Therapeutic compounds and uses thereof |
MA41598A (en) | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | PYRIDAZINE THERAPEUTIC COMPOUNDS AND THEIR USES |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
CN107709364A (en) | 2015-04-07 | 2018-02-16 | 豪夫迈·罗氏有限公司 | Antigen binding complex and application method with agonist activity |
ES2835866T3 (en) | 2015-05-12 | 2021-06-23 | Hoffmann La Roche | Therapeutic and diagnostic procedures for cancer |
KR20180012753A (en) | 2015-05-29 | 2018-02-06 | 제넨테크, 인크. | Treatment and Diagnosis Methods for Cancer |
EP3303399A1 (en) | 2015-06-08 | 2018-04-11 | H. Hoffnabb-La Roche Ag | Methods of treating cancer using anti-ox40 antibodies |
CA2988420A1 (en) | 2015-06-08 | 2016-12-15 | Genentech, Inc. | Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists |
CA2989400A1 (en) | 2015-06-15 | 2016-12-22 | Angiochem Inc. | Ang1005 for the treatment of leptomeningeal carcinomatosis |
TW201710286A (en) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | Binding proteins against VEGF, PDGF, and/or their receptors |
MX2017016353A (en) | 2015-06-17 | 2018-05-02 | Genentech Inc | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes. |
DK3341376T3 (en) | 2015-08-26 | 2021-03-29 | Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio | CONDENSED TRICYCLIC COMPOUNDS AS PROTEINKINASE INHIBITORS |
MX2018002226A (en) | 2015-08-28 | 2018-03-23 | Amunix Operating Inc | Chimeric polypeptide assembly and methods of making and using the same. |
WO2017041027A1 (en) | 2015-09-04 | 2017-03-09 | Obi Pharma, Inc. | Glycan arrays and method of use |
AR106188A1 (en) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE |
CN107849137B (en) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | Bispecific anti-CEAXCD 3T cell activating antigen binding molecules |
EP3387013B1 (en) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
JP7325186B2 (en) | 2015-12-09 | 2023-08-14 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Type II anti-CD20 antibody for reducing the formation of anti-drug antibodies |
CN113999249A (en) | 2015-12-16 | 2022-02-01 | 基因泰克公司 | Methods for making tricyclic PI3K inhibitor compounds and methods of treating cancer therewith |
MX2018008347A (en) | 2016-01-08 | 2018-12-06 | Hoffmann La Roche | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies. |
CN109196121B (en) | 2016-02-29 | 2022-01-04 | 基因泰克公司 | Methods for treatment and diagnosis of cancer |
UA125378C2 (en) | 2016-03-14 | 2022-03-02 | Універшітетет І Осло | Engineered immunoglobulins with altered fcrn binding |
FI3433280T3 (en) | 2016-03-22 | 2023-06-06 | Hoffmann La Roche | Protease-activated t cell bispecific molecules |
US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
KR20180121786A (en) | 2016-03-29 | 2018-11-08 | 오비아이 파머 인코퍼레이티드 | Antibodies, pharmaceutical compositions and methods |
EP3436610A1 (en) | 2016-03-29 | 2019-02-06 | Geltor, Inc. | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
WO2017180864A1 (en) | 2016-04-14 | 2017-10-19 | Genentech, Inc. | Anti-rspo3 antibodies and methods of use |
JP2019515670A (en) | 2016-04-15 | 2019-06-13 | ジェネンテック, インコーポレイテッド | Methods for monitoring and treating cancer |
CN109072311A (en) | 2016-04-15 | 2018-12-21 | 豪夫迈·罗氏有限公司 | Diagnostic and therapeutic method for cancer |
ES2850428T3 (en) | 2016-04-15 | 2021-08-30 | Hoffmann La Roche | Cancer monitoring and treatment procedures |
KR20230110820A (en) | 2016-04-22 | 2023-07-25 | 오비아이 파머 인코퍼레이티드 | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
EP3454863A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
CN109476641B (en) | 2016-05-24 | 2022-07-05 | 基因泰克公司 | Heterocyclic inhibitors of CBP/EP300 and their use in the treatment of cancer |
CN109476663B (en) | 2016-05-24 | 2021-11-09 | 基因泰克公司 | Pyrazolopyridine derivatives for the treatment of cancer |
CN109415441B (en) | 2016-05-24 | 2023-04-07 | 英斯梅德股份有限公司 | Antibodies and methods of making same |
SG11201810793XA (en) | 2016-06-03 | 2018-12-28 | Giordano Caponigro | Pharmaceutical combinations |
EP3469099A1 (en) | 2016-06-08 | 2019-04-17 | F. Hoffmann-La Roche AG | Diagnostic and therapeutic methods for cancer |
MX2018015592A (en) | 2016-06-14 | 2019-04-24 | Xencor Inc | Bispecific checkpoint inhibitor antibodies. |
US11098107B2 (en) | 2016-06-15 | 2021-08-24 | Sutro Biopharma, Inc. | Antibodies with engineered CH2 domains, compositions thereof and methods of using the same |
CA3029328A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
CN110072545A (en) | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | Immunogenicity/therapeutic glycan pool object and application thereof |
KR102528998B1 (en) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | Human Antibodies, Pharmaceutical Compositions and Methods |
EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
JP7250674B2 (en) | 2016-08-08 | 2023-04-03 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | CANCER TREATMENT AND DIAGNOSTIC METHOD |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
EP3519437B1 (en) | 2016-09-30 | 2021-09-08 | F. Hoffmann-La Roche AG | Bispecific antibodies against p95her2 |
AU2017339517B2 (en) | 2016-10-06 | 2024-03-14 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
AU2017342559B2 (en) | 2016-10-14 | 2022-03-24 | Xencor, Inc. | Bispecific heterodimeric fusion proteins containing IL-15/IL-15Ralpha Fc-fusion proteins and PD-1 antibody fragments |
EP3532091A2 (en) | 2016-10-29 | 2019-09-04 | H. Hoffnabb-La Roche Ag | Anti-mic antibidies and methods of use |
JP2019535731A (en) | 2016-11-21 | 2019-12-12 | オービーアイ ファーマ,インコーポレイテッド | Conjugated biological molecules, pharmaceutical compositions and methods |
JP2020503316A (en) | 2016-12-22 | 2020-01-30 | ジェネンテック, インコーポレイテッド | Methods and formulations for reducing the reconstitution time of lyophilized polypeptides |
TW201837467A (en) | 2017-03-01 | 2018-10-16 | 美商建南德克公司 | Diagnostic and therapeutic methods for cancer |
AU2018250875A1 (en) | 2017-04-13 | 2019-10-03 | F. Hoffmann-La Roche Ag | An interleukin-2 immunoconjugate, a CD40 agonist, and optionally a PD-1 axis binding antagonist for use in methods of treating cancer |
CN108948206B (en) * | 2017-05-23 | 2022-08-23 | 赵磊 | anti-EGFR/PD-1 double-targeting antibody, preparation method and application thereof |
JP2020529832A (en) | 2017-06-30 | 2020-10-15 | ゼンコア インコーポレイテッド | Targeted heterodimer Fc fusion protein containing IL-15 / IL-15Rα and antigen binding domain |
JP2020527351A (en) | 2017-07-21 | 2020-09-10 | ジェネンテック, インコーポレイテッド | Cancer treatment and diagnosis |
WO2019033043A2 (en) | 2017-08-11 | 2019-02-14 | Genentech, Inc. | Anti-cd8 antibodies and uses thereof |
KR102208378B1 (en) | 2017-08-17 | 2021-01-28 | 주식회사 녹십자 | Pharmaceutical formulation comprising anti-egfr antibody |
CA3073073A1 (en) | 2017-09-08 | 2019-03-14 | F. Hoffmann-La Roche Ag | Diagnostic and therapeutic methods for cancer |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
JP2021502066A (en) | 2017-11-06 | 2021-01-28 | ジェネンテック, インコーポレイテッド | Cancer diagnosis and therapy |
EP3706793A1 (en) | 2017-11-08 | 2020-09-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
WO2019125732A1 (en) | 2017-12-19 | 2019-06-27 | Xencor, Inc. | Engineered il-2 fc fusion proteins |
AU2019218959A1 (en) | 2018-02-08 | 2020-09-03 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
WO2019165434A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
AU2019247415A1 (en) | 2018-04-04 | 2020-10-22 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
CA3097593A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
AU2019256529A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and TIM-3 antigen binding domains |
EP3794041B1 (en) | 2018-05-18 | 2023-07-12 | Glycotope GmbH | Anti-muc1 antibody |
AU2019275404A1 (en) | 2018-05-21 | 2020-12-03 | Nanostring Technologies, Inc. | Molecular gene signatures and methods of using same |
WO2019246557A1 (en) | 2018-06-23 | 2019-12-26 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
BR112020025623A2 (en) | 2018-07-03 | 2021-03-23 | Bristol-Myers Squibb Company | methods of producing recombinant proteins |
CA3104147A1 (en) | 2018-07-18 | 2020-01-23 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent |
WO2020028909A1 (en) | 2018-08-03 | 2020-02-06 | Brown University | Oral formulations with increased uptake |
JP2021535169A (en) | 2018-09-03 | 2021-12-16 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Carboxamide and sulfonamide derivatives useful as TEAD modulators |
AU2019342099A1 (en) | 2018-09-19 | 2021-04-08 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
EP4249917A3 (en) | 2018-09-21 | 2023-11-08 | F. Hoffmann-La Roche AG | Diagnostic methods for triple-negative breast cancer |
JP2022503959A (en) | 2018-10-03 | 2022-01-12 | ゼンコア インコーポレイテッド | IL-12 heterodimer FC-fusion protein |
US20210380923A1 (en) | 2018-10-10 | 2021-12-09 | Boehringer Ingelheim International Gmbh | Method for membrane gas transfer in high density bioreactor culture |
WO2020076849A1 (en) | 2018-10-11 | 2020-04-16 | The Scripps Research Institute | Antibody compounds with reactive arginine and related antibody drug conjugates |
MX2021004348A (en) | 2018-10-18 | 2021-05-28 | Genentech Inc | Diagnostic and therapeutic methods for sarcomatoid kidney cancer. |
WO2020136147A1 (en) | 2018-12-26 | 2020-07-02 | Innate Pharma | Compounds and methods for treatment of head and neck cancer |
MX2021007797A (en) | 2018-12-28 | 2021-10-26 | Kyowa Kirin Co Ltd | BISPECIFIC ANTIBODY BINDING TO TfR. |
CN113396230A (en) | 2019-02-08 | 2021-09-14 | 豪夫迈·罗氏有限公司 | Methods of diagnosis and treatment of cancer |
JP2022522185A (en) | 2019-02-27 | 2022-04-14 | エピアクシス セラピューティクス プロプライエタリー リミテッド | Methods and agents for assessing T cell function and predicting response to treatment |
CN113710706A (en) | 2019-02-27 | 2021-11-26 | 豪夫迈·罗氏有限公司 | Administration for anti-TIGIT antibody and anti-CD 20 antibody or anti-CD 38 antibody treatment |
WO2020180726A1 (en) | 2019-03-01 | 2020-09-10 | Xencor, Inc. | Heterodimeric antibodies that bind enpp3 and cd3 |
SG11202109884WA (en) * | 2019-03-29 | 2021-10-28 | Green Cross Corp | Fusion protein comprising anti-mesothelin antibody, anti-cd3 antibody or anti-egfr antibody, bispecific or trispecific antibody comprising same, and uses thereof |
KR20210145152A (en) | 2019-04-01 | 2021-12-01 | 제넨테크, 인크. | Compositions and methods for stabilization of protein-containing formulations |
CN113993885A (en) | 2019-04-12 | 2022-01-28 | 格尔托公司 | Recombinant elastin and production thereof |
WO2020223233A1 (en) | 2019-04-30 | 2020-11-05 | Genentech, Inc. | Prognostic and therapeutic methods for colorectal cancer |
AU2020270376A1 (en) | 2019-05-03 | 2021-10-07 | Genentech, Inc. | Methods of treating cancer with an anti-PD-L1 antibody |
CN114269749A (en) | 2019-06-10 | 2022-04-01 | 苏特罗生物制药公司 | 5H-pyrrolo [3,2-d ] pyrimidine-2, 4-diamino compounds and antibody conjugates thereof |
JP2022536800A (en) | 2019-06-17 | 2022-08-18 | ストロ バイオファーマ インコーポレーテッド | 1-(4-(aminomethyl)benzyl)-2-butyl-2H-pyrazolo[3,4-C]quinolin-4-amine derivatives and related compounds as TOLL-like receptor (TLR) 7/8 agonists, and antibody drug conjugates thereof for use in cancer therapy and diagnosis |
CN112300279A (en) | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | Methods and compositions directed to anti-CD 73 antibodies and variants |
KR20220039777A (en) | 2019-08-01 | 2022-03-29 | 브리스톨-마이어스 스큅 컴퍼니 | Methods for improving protein productivity in fed-batch cell culture |
MX2022002738A (en) | 2019-09-04 | 2022-06-27 | Genentech Inc | Cd8 binding agents and uses thereof. |
CR20220127A (en) | 2019-09-27 | 2022-05-27 | Genentech Inc | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
US20230024096A1 (en) | 2019-10-29 | 2023-01-26 | Hoffmann-La Roche Inc. | Bifunctional compounds for the treatment of cancer |
US20220389103A1 (en) | 2019-11-06 | 2022-12-08 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
CA3155989A1 (en) | 2019-11-13 | 2021-05-20 | Jason Robert ZBIEG | Therapeutic compounds and methods of use |
WO2021100034A1 (en) | 2019-11-19 | 2021-05-27 | Protalix Ltd. | Removal of constructs from transformed cells |
PE20221511A1 (en) | 2019-12-13 | 2022-10-04 | Genentech Inc | ANTI-LY6G6D ANTIBODIES AND METHODS OF USE |
AU2020408562A1 (en) | 2019-12-20 | 2022-06-23 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
EP4114852A1 (en) | 2020-03-03 | 2023-01-11 | Sutro Biopharma, Inc. | Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use |
WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
CN115698717A (en) | 2020-04-03 | 2023-02-03 | 基因泰克公司 | Methods of treatment and diagnosis of cancer |
EP4143345A1 (en) | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
EP3915576A1 (en) | 2020-05-28 | 2021-12-01 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Chimeric antigen receptors specific for p95her2 and uses thereof |
KR20230025691A (en) | 2020-06-16 | 2023-02-22 | 제넨테크, 인크. | Methods and compositions for treating triple negative breast cancer |
EP4168118A1 (en) | 2020-06-18 | 2023-04-26 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
AU2021291011A1 (en) | 2020-06-19 | 2023-01-05 | F. Hoffmann-La Roche Ag | Antibodies binding to CD3 and CD19 |
EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
CN115843335A (en) | 2020-06-30 | 2023-03-24 | 国家医疗保健研究所 | Method for predicting the risk of relapse and/or death of a patient with solid cancer after preoperative adjuvant and radical surgery |
EP3939999A1 (en) | 2020-07-14 | 2022-01-19 | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Interleukin 11 receptor alpha subunit (il11ra) neutralizing antibodies and uses thereof |
US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
JP2023536602A (en) | 2020-08-03 | 2023-08-28 | ジェネンテック, インコーポレイテッド | Diagnostic and therapeutic methods for lymphoma |
EP4196612A1 (en) | 2020-08-12 | 2023-06-21 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
AU2021329378A1 (en) | 2020-08-19 | 2023-03-23 | Xencor, Inc. | Anti-CD28 compositions |
KR20230073270A (en) | 2020-09-22 | 2023-05-25 | 브리스톨-마이어스 스큅 컴퍼니 | Methods of producing therapeutic proteins |
IL301524A (en) | 2020-09-23 | 2023-05-01 | Erasca Inc | Tricyclic pyridones and pyrimidones |
CN116406291A (en) | 2020-10-05 | 2023-07-07 | 基因泰克公司 | Administration of treatment with anti-FCRH 5/anti-CD 3 bispecific antibodies |
US20230374447A1 (en) | 2020-10-05 | 2023-11-23 | Protalix Ltd. | Dicer-like knock-out plant cells |
WO2022103983A2 (en) | 2020-11-11 | 2022-05-19 | Sutro Biopharma, Inc. | Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use |
US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
PE20231505A1 (en) | 2021-02-12 | 2023-09-26 | Hoffmann La Roche | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER |
EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
WO2022192586A1 (en) | 2021-03-10 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
AU2022280025A1 (en) | 2021-05-25 | 2023-12-07 | Erasca, Inc. | Sulfur-containing heteroaromatic tricyclic kras inhibitors |
WO2022266206A1 (en) | 2021-06-16 | 2022-12-22 | Erasca, Inc. | Kras inhibitor conjugates |
WO2023010060A2 (en) | 2021-07-27 | 2023-02-02 | Novab, Inc. | Engineered vlrb antibodies with immune effector functions |
WO2023015234A1 (en) | 2021-08-05 | 2023-02-09 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
WO2023018699A1 (en) | 2021-08-10 | 2023-02-16 | Erasca, Inc. | Selective kras inhibitors |
WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
WO2023097195A1 (en) | 2021-11-24 | 2023-06-01 | Genentech, Inc. | Therapeutic indazole compounds and methods of use in the treatment of cancer |
US20230203062A1 (en) | 2021-11-24 | 2023-06-29 | Genentech, Inc. | Therapeutic compounds and methods of use |
WO2023164487A1 (en) | 2022-02-22 | 2023-08-31 | Brown University | Compositions and methods to achieve systemic uptake of particles following oral or mucosal administration |
EP4253418A1 (en) | 2022-03-29 | 2023-10-04 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Immune cells expressing chimeric antigen receptors and bispecific antibodies and uses thereof |
WO2023191816A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023219613A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2024006272A1 (en) | 2022-06-27 | 2024-01-04 | Sutro Biopharma, Inc. | β-GLUCURONIDE LINKER-PAYLOADS, PROTEIN CONJUGATES THEREOF, AND METHODS THEREOF |
WO2024015897A1 (en) | 2022-07-13 | 2024-01-18 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024015229A1 (en) | 2022-07-15 | 2024-01-18 | Sutro Biopharma, Inc. | Protease/enzyme cleavable linker-payloads and protein conjugates |
WO2024020432A1 (en) | 2022-07-19 | 2024-01-25 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024033389A1 (en) | 2022-08-11 | 2024-02-15 | F. Hoffmann-La Roche Ag | Bicyclic tetrahydrothiazepine derivatives |
WO2024033457A1 (en) | 2022-08-11 | 2024-02-15 | F. Hoffmann-La Roche Ag | Bicyclic tetrahydrothiazepine derivatives |
WO2024033458A1 (en) | 2022-08-11 | 2024-02-15 | F. Hoffmann-La Roche Ag | Bicyclic tetrahydroazepine derivatives |
WO2024033388A1 (en) | 2022-08-11 | 2024-02-15 | F. Hoffmann-La Roche Ag | Bicyclic tetrahydrothiazepine derivatives |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
ES2206447T3 (en) * | 1991-06-14 | 2004-05-16 | Genentech, Inc. | HUMANIZED ANTIBODY FOR HEREGULINE. |
-
1996
- 1996-06-07 CA CA002222231A patent/CA2222231A1/en not_active Abandoned
- 1996-06-07 AU AU62678/96A patent/AU6267896A/en not_active Abandoned
- 1996-06-07 WO PCT/US1996/009847 patent/WO1996040210A1/en active Application Filing
- 1996-06-07 JP JP9502046A patent/JPH11507535A/en active Pending
- 1996-06-07 EP EP96921457A patent/EP0831880A4/en not_active Withdrawn
-
2006
- 2006-04-25 JP JP2006120814A patent/JP2006246896A/en active Pending
-
2008
- 2008-09-18 JP JP2008239345A patent/JP2009062375A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
Non-Patent Citations (2)
Title |
---|
FAN Z ET AL: "Blockade of Epidermal Growth Factor REceptor function by bivalent and monovalent fragments of 225 anti-EGFR monoclonal antibodies" CANCER RESEARCH, vol. 53, , pages 4322-4328, XP008014409 * |
See also references of WO9640210A1 * |
Also Published As
Publication number | Publication date |
---|---|
CA2222231A1 (en) | 1996-12-19 |
EP0831880A4 (en) | 2004-12-01 |
JP2009062375A (en) | 2009-03-26 |
AU6267896A (en) | 1996-12-30 |
JP2006246896A (en) | 2006-09-21 |
WO1996040210A1 (en) | 1996-12-19 |
JPH11507535A (en) | 1999-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7060808B1 (en) | Humanized anti-EGF receptor monoclonal antibody | |
EP0831880A1 (en) | Antibody and antibody fragments for inhibiting the growth of tumors | |
KR101676622B1 (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
KR101706255B1 (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
EP1527100B1 (en) | Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same | |
EP2516469B1 (en) | ANTI-HER3 Antibodies and uses thereof | |
EP2220121B1 (en) | Axl antibodies | |
JP5513888B2 (en) | Compositions and methods for glucagon receptor antibodies | |
CN105968206B (en) | anti-ERBB 3 antibodies | |
CN110545844A (en) | Cancer treatment using antibodies that bind cytotoxic T lymphocyte antigen-4 (CTLA-4) | |
EP2476427B1 (en) | A method of treating cancer comprising a VEGF-B antagonist | |
EP2943508B1 (en) | Combination therapy of anti-her3 and anti-her2 antibodies | |
KR20180004277A (en) | PDL-1 antibody, pharmaceutical composition thereof and uses thereof | |
JP2002514421A (en) | Antibodies to CD23, their derivatives, and their therapeutic use | |
RU2766582C2 (en) | Immunotherapy using antibodies binding programmed cell death protein ligand 1 (pd-l1) | |
EP2420514A1 (en) | Targeted binding agents directed to PDGFR-alpha and uses thereof | |
SK332792A3 (en) | Humanized and chimeric monoclonal antibodies | |
US20170002084A1 (en) | Monoclonal antibodies directed to cd20 | |
KR20230034960A (en) | Antibodies that bind to LAG3 and uses thereof | |
CA3067597C (en) | Chimeric antibodies for treatment of amyloid deposition diseases | |
US20030224001A1 (en) | Antibody and antibody fragments for inhibiting the growth of tumors | |
CA2791560A1 (en) | Monoclonal antibodies directed to cd20 | |
CN115702003A (en) | Chemokine receptor 4 (CXCR 4) antagonist antibodies | |
WO2023241656A1 (en) | Bispecific antibody containing anti-cldn18.2 antibody, and pharmaceutical composition and use thereof | |
EP4059963A1 (en) | Molecule capable of binding to human 4-1bb, and application of molecule |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19971204 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL PAYMENT 971204;LT PAYMENT 971204;LV PAYMENT 971204;SI PAYMENT 971204 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041015 |
|
17Q | First examination report despatched |
Effective date: 20050502 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SALDANHA, JOSE WILLIAM Inventor name: JONES, STEVEN TARRAN Inventor name: GIORGIO, NICHOLAS A. Inventor name: GOLDSTEIN, NEIL I. |
|
17Q | First examination report despatched |
Effective date: 20050502 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090519 |