EP0792135B1 - Spritzenvorrichtung befestigbar an einem fläschchen - Google Patents

Spritzenvorrichtung befestigbar an einem fläschchen Download PDF

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Publication number
EP0792135B1
EP0792135B1 EP95940304A EP95940304A EP0792135B1 EP 0792135 B1 EP0792135 B1 EP 0792135B1 EP 95940304 A EP95940304 A EP 95940304A EP 95940304 A EP95940304 A EP 95940304A EP 0792135 B1 EP0792135 B1 EP 0792135B1
Authority
EP
European Patent Office
Prior art keywords
syringe
guide part
guide
flask
face
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95940304A
Other languages
English (en)
French (fr)
Other versions
EP0792135A1 (de
Inventor
Frédéric Neftel
Bernard Bouvier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiotech SA
Original Assignee
Debiotech SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9413605A external-priority patent/FR2726767A1/fr
Application filed by Debiotech SA filed Critical Debiotech SA
Publication of EP0792135A1 publication Critical patent/EP0792135A1/de
Application granted granted Critical
Publication of EP0792135B1 publication Critical patent/EP0792135B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable

Definitions

  • the present invention relates to a syringe device fixable on a bottle, in particular a bottle containing a liquid inject or a freeze-dried product to be mixed with a liquid physiological or medication to inject the mixture.
  • the most commonly used solution is to store the powder in a separate container which is sealed with a membrane or waterproof cap that can be pierced with a needle.
  • a membrane or waterproof cap that can be pierced with a needle.
  • we just draw in a second container a certain amount of solvent and injected into the first container to through the membrane the desired amount of solvent.
  • the liquid for example the serum physiological
  • the liquid is already contained in the syringe. It then suffices to inject through the perforable membrane the liquid in the container containing the product in powder form and then re-aspirate the whole after its mixed.
  • US-A-5,247,972 describes a syringe device according to the preamble of claim 1.
  • An object of the present invention is to provide a device for syringe fixed on a bottle which ensures the perforation of the stopper perforable in its center and which, moreover, makes this operation very safe and perfectly repetitive. Furthermore, an object of the present invention is to provide such a device that is adaptable to the bottle commonly used to contain medicated powders mix with a solvent and in particular lyophilized products.
  • the syringe device fixable on a bottle having a cylindrical body, an opening surrounded by a flange having a side face and a plug perforable closing off said opening comprising a guide piece able to cooperate with said bottle and a syringe provided with a needle and of a body and sliding mount in said guide piece, said guide piece having a first open end having at its terminal part a first internal surface cylindrical guide capable of cooperating with the cylindrical body of said a sufficient length of bottle, a second internal surface of guide able to cooperate with the side wall of the flange of the bottle, and means for securing said piece to said collar separate from said guide surfaces and set back relative to said first internal guide surface, said securing means being activated during the establishment of said device on said bottle, said guide piece comprising a second end and a running part capable of receiving said syringe provided with means for guiding said translation in translation syringe in said guide piece for bringing said syringe in a
  • the presence of the fastening elements makes it possible to secure the guide piece and therefore the syringe on the vial, which makes it easier to handle the syringe compared to the bottle.
  • this allows very precise control the insertion of the syringe into the guide piece and therefore the penetration of the tip of the needle into the bottle after perforation of the plug, so that penetration is reduced as much as possible.
  • the securing means are arranged between the first and second guide surfaces.
  • the means for guiding the syringe in translation in the guide piece include sealing means for ensuring a seal between the internal face of the guide piece and the body of said syringe.
  • the means of guide the syringe in the guide piece include at at least one guide face formed in the internal face of the workpiece guide able to cooperate with a portion of the body of said syringe.
  • the guide piece has a plate member disposed substantially perpendicularly to the direction of movement of the syringe in which is formed said central orifice, the face of said plate facing the first end of the guide piece being provided with a rib projecting annular surrounding said central orifice, whereby said rib is applied against the stopper of said bottle when said securing means cooperate with said bottle.
  • a bottle 10 of standard type containing for example a medicament in the form freeze-dried.
  • the bottle 10 comprises a cylindrical body 12 and a neck 14 limiting an opening 16.
  • the neck 14 is surrounded by a collar cylindrical 18 which has a lateral face 20, an upper face 22 and a lower face 24.
  • the bottle is closed by a stopper made of a perforable material 26 which is engaged in the opening 16 of the bottle.
  • the periphery 28 of the plug is applied against the upper face 22 of the flange and a metal crimping cap 30 ensures the watertight fixing of the cap on the opening 16 of the bottle 10.
  • the diameter D constituting the perforable central part of the cap is relatively small, this diameter depending on the dimensions of the bottle which can range from 5 to 2 mm.
  • the device for syringe 40 is essentially constituted by a guide piece 42 and a conventional type syringe 44 fitted with a needle 45.
  • the part of guide 42 which preferably has a symmetry of revolution around the axis XX 'has a first end 46 intended to be secured to the bottle 10, a second end 48 intended for receiving and guiding in translation the syringe 44 and a running part intermediate 50.
  • the first end 46 includes a first guide surface 52 of internal diameter D'2 intended to cooperate with the cylindrical part 12 of the bottle, the latter having a diameter D2 slightly smaller than the diameter D'2.
  • the end 46 has a second guide revolution surface 54 intended to cooperate with the side face 20 of the flange 18 of the bottle, this guide surface having an internal diameter D'1 slightly greater than the diameter D1 of the collar 18. Between the guide surfaces 52 and 54, the end 46 of the guide piece has elastic clip elements 58 used to secure the end 46 of the guide piece 42 on the neck of the bottle 10. As best shown in Figures 2 and 4, the end 46 of the guide piece is connected to its current part by a part forming a plate 60 substantially orthogonal to the axis XX 'and making integral part of the guide piece. This plate 60 is provided with a axial sleeve 62 which defines a central orifice 64 arranged along the axis XX 'of the guide piece.
  • the central opening 64 is extended by a frusto-conical part 66 facing the second end of the part guidance.
  • the end of the needle 45 is disposed inside the central orifice 64.
  • the underside 60a of the plate 60 is preferably provided with a annular rib 70 surrounding the orifice 64 and projecting out of the face 60a. This secures the guide piece 42 on the bottle, the elastic tabs 58 cooperating with the underside 24 of the collar while the rib 70 is applied to the plug.
  • FIG. 4b shows an alternative embodiment of the surface of guide 52, and possibly the guide surface 54. It allows to achieve a very good centering of the guide piece 42 on the bottle despite the dimensional tolerances of the bottle.
  • We plan on the face internal 52a of the guide surface at least one longitudinal rib 53 and preferably three arranged at 120 degrees in cross section triangular or the like. The edges of these ribs can crush partially according to the effective diameter of the cylindrical body or the flange while maintaining centering.
  • FIG. 2 shows, in dotted lines, another alternative embodiment of the guide piece.
  • the perforable membrane 72 is replaced by a film 73 (shown in the figure in dotted line) whose periphery is tightly fixed on the workpiece guide 54.
  • This very thin waterproof film has in its center of the primers of tear.
  • the bottle cap exerts a pressure on the film 73 causing it to tear in its center.
  • the needle can freely cross it.
  • the internal face of the zone can also be fitted guide 52 of a thread. Removable hood with external filtering can then be aimed at the end of the guide piece.
  • the syringe 44 is guided in translation inside the part current of the guide piece by an annular seal 78 which has on its external face 78a, preferably, three ribs sealing 80, 82 and 84 cooperating with the guide piece.
  • the face internal 78b of the seal 78 has a shoulder 86 cooperating with the body of syringe 44. Consequently, the seal is driven by the syringe when it is inserted into the guide piece. In however, the seal is free from the syringe when moving this to extract it from the guide piece.
  • the end 48 of the guide piece comprises elastic strips 90 making protrusion inside the guide piece.
  • the ends of the elastic strips 90 are interposed between the ribs 82 and 84 ensuring a certain immobilization of the seal 78 relative to the guide piece. So, we actually obtains a mechanical connection between the syringe and the guide piece via the seal 78 which, moreover, ensures a dynamic seal between the guide piece and the body of the syringe.
  • the guide piece 42 has on its external face a flange 92 which protects the fingers of the manipulators when refitting initial place of the syringe inside the guide piece after its use.
  • FIG. 5 shows an alternative embodiment of the guidance.
  • This variant consists only of another mode of realization of the plate 60 and the sleeve 62.
  • the plate element which is then referenced 60 ′ comprises a cylindrical sleeve 96 defining an axial bore 97 of large dimensions.
  • an insert 98 In this axial bore is engaged an insert 98.
  • This part 98 includes a plate portion 100 provided with the rib 70 '.
  • the insert 98 also includes a part forming a sleeve 102 which is engaged in the cylindrical sleeve 96.
  • the sleeve 102 has a frustoconical end 104 and the central orifice 105, as well as the sleeve 62 included a frustoconical end 66. It is understood that, when the insert 98 is placed in the sleeve 96, a structure is reconstructed which is identical to that shown in Figure 2.
  • the advantage of this solution consists in the fact that in the preliminary operations of the syringe device, we first put the syringe 44 in place in the guide piece 42 without the latter is still equipped with part 98, then we set up part 98 by the first end of the guide piece.
  • Figures 6a to 6b illustrate the use of the syringe.
  • Figure 6a there is shown on the one hand the device for syringe 40 and on the other hand the vial 10 with its perforable cap 26.
  • FIG 6b there is shown the establishment of the device syringe 40 on the bottle 10.
  • the guide piece 42 is perfectly positioned relative to the bottle and therefore relative to the cap thanks to the guide surfaces 52 and 54.
  • the clip tabs 58 by cooperating with the flange 18 of the bottle ensure the joining of these two pieces.
  • Figure 6c shows the insertion of the syringe into the guide 42. This depression is controlled by the presence of the seal 78.
  • the needle 45 perforates the plug 26 in its center. It is then possible by actuating the plunger of the syringe to penetrate the liquid which it contains in bottle 10. After mixing the two products, draw up the mixture thus prepared using the syringe. Just extract the syringe 44 outside the guide piece 42, the seal 78 remaining trapped in the guide piece thanks to the presence of the tabs elastic 90.
  • the guidance in translation of the syringe in the guide piece is produced by the gasket 78 which also provides sealing and therefore maintenance sterility of volume 76 containing the needle.
  • This dual function could be obtained by providing that the syringe body 44 has itself annular ribs, for example three, offset axially which cooperate with the internal face of the current part of the guide piece.
  • Translation guidance is provided by the cooperation of guide surfaces internal to the guide part with certain body portions 47 of the syringe.
  • the end of the body 47 on which the needle 45 is mounted has a nozzle 120, a cylindrical portion of reduced diameter 122 and a cylindrical portion 124 of diameter greater than that of the portion current from the syringe body.
  • the internal face 50a of the current part 50 of the piece of guide has a diameter slightly greater than the outer diameter of the portion 124 of the syringe body, thus forming a first guide surface.
  • Inside the guide piece are provided four radiating guide fins 126 whose edges 126a are arranged on a cylindrical surface of revolution whose diameter is slightly higher than that of the portion 122 of the syringe body. This defines a second guide surface. The distance between these two guide surfaces is sufficient to ensure very good guidance in translation of the syringe in the guide piece and therefore a perfect centering of the needle 45 relative to the plug 26.
  • the upper end 126b of the fins 126 constitutes a stop for driving the syringe by cooperation with the large diameter portion 124 of the syringe body.
  • This stop ensures that, after having inserted the syringe into the guide part, the tip of the needle 45 has passed through the stopper 26 of the bottle but that it penetrates very little in the bottle.
  • These legs 130 are intended to ensure the effective fastening in translation of the syringe and the piece of guidance when the syringe is fully inserted into the workpiece guidance. This makes handling of the rod more comfortable.
  • syringe plunger control to inject the contained liquid into the syringe and to draw the mixture out of the vial.
  • FIG. 7 another improvement has been shown which could also be implemented in the two previous modes of achievement.
  • This improvement concerns the recovery of gases harmful which can possibly leave the bottle after the mixture of compounds. Indeed, due to the overpressure which can result from the mixing in the bottle and temporary deformation and local stopper when the tip of the needle comes out of the stopper, harmful gases or a residual fraction of liquid can enter the guide piece and escapes into the surrounding air.
  • a piece 140 of a porous material such as porous foam.
  • the gases possibly leaving the bottle are absorbed, trapped or blocked by part 140.
  • part 140 is crossed by the needle.
  • This filter is also used to compensate for pressures inside and the outside of the guide piece during movements of the syringe in the guide piece.
  • the syringe device according to the invention not only ensures rigorous coaxiality of the needle the syringe and the vial, but also to rigorously position the guide piece relative to the bottle in the direction of the axis XX '.
  • To control the insertion of the needle into the bottle it suffices to check the insertion of the syringe into the guide piece. This result can be obtained automatically by providing a stop limiting the insertion of the syringe into the guide part.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (20)

  1. Spritzenvorrichtung, die an einem Fläschchen (10) mit einem zylindrischen Hauptteil (12), einer Öffnung, die von einem Bund (18) mit einer Seitenfläche umgeben ist, und einem die genannte Öffnung verschließenden durchstechbaren Stopfen befestigbar ist, mit einem Führungsteil (42), das mit dem Fläschchen (10) zusammenzuwirken vermag, und einer Spritze (44), die mit einer Nadel und einem Hauptteil (45) versehen und im genannten Führungsteil verschiebbar angeordnet ist, wobei das Führungsteil ein erstes offenes Ende (46) aufweist, das an seinem Endabschnitt mit einer ersten zylindrischen, inneren Führungsfläche (52) versehen ist, die mit dem zylindrischen Hauptteil (12) des Fläschchens auf einer ausreichenden Länge zusammenzuwirken vermag, eine zweite innere Führungsfläche (54), die mit der Seitenwand vom Bund (18) des Fläschchens (10) zusammenzuwirken vermag, und Vorrichtungen (58) zum festen Verbinden des genannten Teils am genannten Bund, die von den genannten Führungsflächen verschieden und in bezug auf die genannte erste innere Führungsfläche zurückgesetzt sind, wobei die genannten Vorrichtungen zum festen Verbinden beim Instellungbringen der genannten Vorrichtung am Fläschchen zur Wirkung kommen, das genannte Führungsteil ein zweites Ende (48) und einen normalen Abschnitt (50) aufweist, der die genannte Spritze aufzunehmen vermag, mit Vorrichtungen (78) zum Führen der genannten Spritze beim translatorischen Verschieben im genannten Führungsteil versehen ist, um die genannte Spritze in eine Eindringstellung zu verbringen, in der die Nadel die durchstechbare Membran des Fläschchen durchsticht,
    dadurch gekennzeichnet, daß das Führungsteil einstückig ist und eine Vorrichtung aufweist, die eine Mittelöffnung von verkleinertem Durchmesser begrenzt, in deren Innern das Ende der Nadel angeordnet ist und die das Durchlassen des Endes der genannten Nadel unter der Wirkung der translatorischen Verschiebung der genannten Spritze ermöglicht.
  2. Spritzenvorrichtung nach Anspruch 1,
    dadurch gekennzeichnet, daß die Vorrichtungen (58) zum festen Verbinden zwischen der ersten (52) und der zweiten (54) Führungsfläche angeordnet sind.
  3. Spritzenvorrichtung nach einem der Ansprüche 1 und 2,
    dadurch gekennzeichnet, daß die genannten Vorrichtungen zum Führen beim Parallelverschieben Dichtvorrichtungen (78) aufweisen, um zwischen der Innenfläche des Führungsteils (42) und dem Hauptteil der Spritze (44) abzudichten.
  4. Spritzenvorrichtung nach Anspruch 3,
    dadurch gekennzeichnet, daß die genannten Dichtvorrichtungen eine ringförmige Dichtung (78) aufweisen, deren Außenfläche (78a) mit dem genannten Führungsteil und die Innenfläche (78b) mit dem Hauptteil der Spritze (44) zusammenwirken.
  5. Spritzenvorrichtung nach Anspruch 4,
    dadurch gekennzeichnet, daß die Dichtung (78) mit der Spritze (44) in der Richtung des Eindringens der Spritze in das genannte Führungsteil verschiebefest ist.
  6. Vorrichtung nach einem der Ansprüche 4 und 5,
    dadurch gekennzeichnet, daß das Führungsteil (42) in der Nähe seines zweiten Endes in einer Richtung wirksame Verriegelungsvorrichtungen (90) aufweist, die mit der Dichtung (78) zusammenwirken, um die genannte Dichtung und das genannte Führungsteil fest miteinander zu verbinden und nur das Eindringen der genannten Dichtung in das genannte Führungsteil zu ermöglichen.
  7. Vorrichtung nach einem der Ansprüche 1 und 2,
    dadurch gekennzeichnet, daß die genannten Vorrichtungen zum Führen beim Parallelverschieben ringförmige Rippen aufweisen, die aus dem Hauptteil der Spritze (44) herausragen und mit der Innenfläche des Führungsteils (42) zusammenwirken.
  8. Vorrichtung nach einem der Ansprüche 1 und 2,
    dadurch gekennzeichnet, daß die genannten Vorrichtungen zum Führen beim Parallelverschieben wenigstens eine erste Führungsfläche aufweisen, die in der Innenfläche des genannten Führungsteils zum Zusammenwirken mit einem Abschnitt vom Hauptteil der genannten Spritze ausgebildet ist.
  9. Vorrichtung nach Anspruch 8,
    dadurch gekennzeichnet, daß die genannten Vorrichtungen zum Führen beim Parallelverschieben eine zweite Führungsfläche aufweisen, die in der Innenfläche des Führungsteils zum Zusammenwirken mit einem anderen Abschnitt vom Haupteil der genannten Spritze ausgebildet ist.
  10. Vorrichtung nach einem der Ansprüche 8 und 9,
    dadurch gekennzeichnet, daß das genannte Führungsteil außerdem lösbare Rastvorrichtungen aufweist, um die genannte Spritze mit dem genannten Führungsteil vorübergehend fest zu verbinden, wenn die genannte Spritze in das genannte Führungsteil vollständig eingedrungen ist.
  11. Vorrichtung nach einem der Ansprüche 1 bis 10,
    dadurch gekennzeichnet, daß das erste Ende (46) des Führungsteils (42) mit einer die genannten Mittelöffnung (64) umgebenden ringförmigen Rippe (70, 70') versehen ist, wodurch die genannte Rippe an den Stopfen (26) des Fläschchens (10) angepreßt wird, wenn die Vorrichtungen (58) zum festen Verbinden mit dem Fläschchen zusammenwirken.
  12. Vorrichtung nach Anspruch 11,
    dadurch gekennzeichnet, daß die genannten Vorrichtungen zum Ausbilden der Mittelöffnung (64) ein mit dem genannten Führungsteil fest verbundenes Plattenelement (60, 100) umfassen, das im wesentlichen rechtwinklig zur Verschieberichtung der Spritze, in der die Mittelöffnung (64) ausgebildet ist, angeordnet ist, wobei die gegen das erste Ende des genannten Führungsteils weisende Fläche der genannten Platte mit der genannten herausragenden, die genannte Mittelöffnung umgebenden ringförmigen Rippe (70, 70') versehen ist.
  13. Vorrichtung nach einem der Ansprüche 11 und 12,
    dadurch gekennzeichnet, daß die Vorrichtungen zum festen Verbinden Einrastvorrichtungen (58) umfassen, die mit der Fläche (24) vom Bund (18) des Fläschchens, die der den genannten Stopfen aufnehmenden entgegengesetzt ist, zusammenzuwirken vermag.
  14. Vorrichtung nach einem der Ansprüche 1 bis 13,
    dadurch gekennzeichnet, daß die Mittelöffnung (64) von einem Einsatzstück (98) gebildet ist, das im ersten Ende (46) des Führungsteils angeordnet ist, einen Abschnitt in Form einer Hülse (102), deren eines Ende sich konisch erweitert, und einen Abschnitt umfaßt, der eine die genannte Öffnung umgebende ringförmige Rippe bildet.
  15. Vorrichtung nach einem der Ansprüche 1 bis 14,
    dadurch gekennzeichnet, daß sie außerdem eine durchstechbare Membran (72) aufweist, die die genannte Mittelöffnung verschließt.
  16. Vorrichtung nach einem der Ansprüche 1 bis 14,
    dadurch gekennzeichnet, daß sie außerdem einen dünnen Film (73) aufweist, dessen Außenumfang an der Innenwand des ersten Endes vom genannten Führungsteil (42) in dessen Abschnitt, der sich zwischen den Vorrichtungen (58) zum festen Verbinden und der Mittelöffnung (64) erstreckt, unter Abdichtung befestigt ist, wobei der genannte Film Anfangsstellen für Risse aufweist, wodurch der genannte Film unter der Wirkung des Stopfens (26) des Fläschchens aufgebrochen wird, wenn die Spritzenvorrichtung am Fläschchen angeordnet wird.
  17. Vorrichtung nach einem der Ansprüche 1 bis 14,
    dadurch gekennzeichnet, daß sie außerdem eine wegnehmbare Schutzkappe aufweist, die im ersten Ende (46) des Führungsteils befestigt ist.
  18. Vorrichtung nach einem der Ansprüche 1 bis 17,
    dadurch gekennzeichnet, daß das genannte Führungsteil anschlagbildende Vorrichtungen zum Begrenzen der Eindringbewegung der genannten Spritze in das genannte Führungsteil aufweist.
  19. Vorrichtung nach einem der Ansprüche 1 bis 18,
    dadurch gekennzeichnet, daß das genannte Führungsteil außerdem vor der genannten Öffnung ein Bauteil aus porösem Werkstoff aufweist.
  20. Vorrichtung nach einem der Ansprüche 1 bis 19,
    dadurch gekennzeichnet, daß das genannte Führungsteil in seiner Seitenwand eine von einem mikroporösen Filter verschlossene Öffnung aufweist.
EP95940304A 1994-11-14 1995-11-13 Spritzenvorrichtung befestigbar an einem fläschchen Expired - Lifetime EP0792135B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9413605A FR2726767A1 (fr) 1994-11-14 1994-11-14 Dispositif de seringue fixable sur un flacon
FR9413605 1994-11-14
FR9414973 1994-12-13
FR9414973A FR2726768A1 (fr) 1994-11-14 1994-12-13 Dispositif de seringue fixable sur un flacon
PCT/FR1995/001488 WO1996014820A1 (fr) 1994-11-14 1995-11-13 Dispositif de seringue fixable sur un flacon

Publications (2)

Publication Number Publication Date
EP0792135A1 EP0792135A1 (de) 1997-09-03
EP0792135B1 true EP0792135B1 (de) 2001-08-22

Family

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Application Number Title Priority Date Filing Date
EP95940304A Expired - Lifetime EP0792135B1 (de) 1994-11-14 1995-11-13 Spritzenvorrichtung befestigbar an einem fläschchen

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US (1) US6280430B1 (de)
EP (1) EP0792135B1 (de)
JP (1) JP3987106B2 (de)
AU (1) AU4179896A (de)
BR (1) BR9509660A (de)
DE (1) DE69522340T2 (de)
ES (1) ES2162945T3 (de)
FR (1) FR2726768A1 (de)
WO (1) WO1996014820A1 (de)

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Also Published As

Publication number Publication date
BR9509660A (pt) 1997-10-28
EP0792135A1 (de) 1997-09-03
FR2726768A1 (fr) 1996-05-15
DE69522340T2 (de) 2002-06-13
WO1996014820A1 (fr) 1996-05-23
DE69522340D1 (de) 2001-09-27
US6280430B1 (en) 2001-08-28
ES2162945T3 (es) 2002-01-16
JP3987106B2 (ja) 2007-10-03
AU4179896A (en) 1996-06-06
JPH10508525A (ja) 1998-08-25

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