EP0763202A4 - Bibliotheques combinatoires codees - Google Patents

Bibliotheques combinatoires codees

Info

Publication number
EP0763202A4
EP0763202A4 EP95920576A EP95920576A EP0763202A4 EP 0763202 A4 EP0763202 A4 EP 0763202A4 EP 95920576 A EP95920576 A EP 95920576A EP 95920576 A EP95920576 A EP 95920576A EP 0763202 A4 EP0763202 A4 EP 0763202A4
Authority
EP
European Patent Office
Prior art keywords
combinatorial libraries
encoded combinatorial
encoded
libraries
combinatorial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95920576A
Other languages
German (de)
English (en)
Other versions
EP0763202A1 (fr
Inventor
Dennis Shinji Yamashita
Joseph Weinstock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0763202A1 publication Critical patent/EP0763202A1/fr
Publication of EP0763202A4 publication Critical patent/EP0763202A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP95920576A 1994-05-23 1995-05-23 Bibliotheques combinatoires codees Withdrawn EP0763202A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US24779394A 1994-05-23 1994-05-23
US247793 1994-05-23
US26733394A 1994-06-28 1994-06-28
US267333 1994-06-28
US38254295A 1995-02-01 1995-02-01
US382542 1995-02-01
US41043695A 1995-03-23 1995-03-23
US410436 1995-03-23
PCT/US1995/006392 WO1995032425A1 (fr) 1994-05-23 1995-05-23 Bibliotheques combinatoires codees

Publications (2)

Publication Number Publication Date
EP0763202A1 EP0763202A1 (fr) 1997-03-19
EP0763202A4 true EP0763202A4 (fr) 1998-12-09

Family

ID=27500266

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95920576A Withdrawn EP0763202A4 (fr) 1994-05-23 1995-05-23 Bibliotheques combinatoires codees

Country Status (3)

Country Link
EP (1) EP0763202A4 (fr)
JP (1) JPH10500951A (fr)
WO (1) WO1995032425A1 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
US6096496A (en) * 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
AU8678198A (en) * 1997-08-01 1999-02-22 Novalon Pharmaceutical Corporation Method of identifying and developing drug leads
JP4318859B2 (ja) * 1997-12-04 2009-08-26 ジーイー・ヘルスケア・ユーケイ・リミテッド 複合アッセイ方法
US6455263B2 (en) * 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
US6720190B1 (en) 1998-03-27 2004-04-13 Ole Hindsgaul Methods for screening compound libraries
US6054047A (en) 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6613575B1 (en) 1998-03-27 2003-09-02 Ole Hindsgaul Methods for screening compound libraries
CA2240325A1 (fr) 1998-03-27 1998-11-14 Synsorb Biotech, Inc. Methodes de criblage de banques de constituants
US6602685B1 (en) 1998-08-17 2003-08-05 Phylos, Inc. Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
AUPP737298A0 (en) * 1998-11-30 1998-12-24 University Of Queensland, The Combinatorial libraries
EP1169123A1 (fr) * 1999-04-09 2002-01-09 Glaxo Group Limited Systeme de codage pour banques de produits chimiques en phase solide
EP1175505A4 (fr) * 1999-04-15 2005-04-20 Vitra Bioscience Inc Supports de banque chimique combinatoire possedant des marques au niveau de positions de codage, et procedes d'utilisation
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
EP1250463B1 (fr) 2000-01-24 2006-04-05 Compound Therapeutics, Inc. Methodes de diagnostique multiplexees et sensibles destinees a l'analyse de proteines
EP1258730A4 (fr) * 2000-02-07 2004-12-29 Kyowa Medex Co Ltd Procede de detection d'une substance
AU2001259172A1 (en) * 2000-04-26 2001-11-07 Streamline Proteomics Apparatus and methods for assays of one or more analytes
DK1360491T3 (da) * 2001-02-13 2007-08-20 Pronostics Ltd Biokemisk fremgangsmåde og apparat til detektion af proteinegenskaber
AU2002229977A1 (en) * 2001-02-13 2002-08-28 Smartbead Technologies Limited Biochemical method and apparatus for detecting genetic characteristics
EP1699553A2 (fr) 2003-12-22 2006-09-13 VersaMatrix A/S Appareil et procedes permettant d'analyser et de trier des particules telles que des billes de polymere
WO2005061094A1 (fr) 2003-12-22 2005-07-07 Versamatrix A/S Identification de billes codees
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
PT2121919E (pt) 2007-03-22 2012-05-17 Heptares Therapeutics Ltd Receptores acoplados à proteína-g e métodos para a sua selecção
EP2201374B1 (fr) 2007-08-30 2015-10-07 Trustees Of Tufts College Procédés pour déterminer la concentration d'un analyte dans une solution
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
GB0904904D0 (en) 2009-03-23 2009-05-06 Univ Leiden Medical Ct Angiogenesis methods, medicaments and agents
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
GB201002082D0 (en) 2010-02-09 2010-03-24 Univ Leiden Medical Ct Biological material
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
JP5363663B2 (ja) 2010-03-01 2013-12-11 クワンテリクス コーポレーション 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム
WO2012093258A2 (fr) 2011-01-05 2012-07-12 Imperial Innovations Limited Traitement et criblage
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
GB201501004D0 (en) 2015-01-21 2015-03-04 Cancer Rec Tech Ltd Inhibitors
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins
GB201814451D0 (en) 2018-09-05 2018-10-17 Valerie Nicholas Carl Kristoffer Methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9532425A1 *

Also Published As

Publication number Publication date
JPH10500951A (ja) 1998-01-27
EP0763202A1 (fr) 1997-03-19
WO1995032425A1 (fr) 1995-11-30

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