EP0763202A4 - Encoded combinatorial libraries - Google Patents

Encoded combinatorial libraries

Info

Publication number
EP0763202A4
EP0763202A4 EP95920576A EP95920576A EP0763202A4 EP 0763202 A4 EP0763202 A4 EP 0763202A4 EP 95920576 A EP95920576 A EP 95920576A EP 95920576 A EP95920576 A EP 95920576A EP 0763202 A4 EP0763202 A4 EP 0763202A4
Authority
EP
European Patent Office
Prior art keywords
combinatorial libraries
encoded combinatorial
encoded
libraries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95920576A
Other languages
German (de)
French (fr)
Other versions
EP0763202A1 (en
Inventor
Dennis Shinji Yamashita
Joseph Weinstock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US24779394A priority Critical
Priority to US247793 priority
Priority to US26733394A priority
Priority to US267333 priority
Priority to US382542 priority
Priority to US38254295A priority
Priority to US410436 priority
Priority to US41043695A priority
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to PCT/US1995/006392 priority patent/WO1995032425A1/en
Publication of EP0763202A1 publication Critical patent/EP0763202A1/en
Publication of EP0763202A4 publication Critical patent/EP0763202A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00592Split-and-pool, mix-and-divide processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
EP95920576A 1994-05-23 1995-05-23 Encoded combinatorial libraries Withdrawn EP0763202A4 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US24779394A true 1994-05-23 1994-05-23
US247793 1994-05-23
US26733394A true 1994-06-28 1994-06-28
US267333 1994-06-28
US38254295A true 1995-02-01 1995-02-01
US382542 1995-02-01
US41043695A true 1995-03-23 1995-03-23
US410436 1995-03-23
PCT/US1995/006392 WO1995032425A1 (en) 1994-05-23 1995-05-23 Encoded combinatorial libraries

Publications (2)

Publication Number Publication Date
EP0763202A1 EP0763202A1 (en) 1997-03-19
EP0763202A4 true EP0763202A4 (en) 1998-12-09

Family

ID=27500266

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95920576A Withdrawn EP0763202A4 (en) 1994-05-23 1995-05-23 Encoded combinatorial libraries

Country Status (3)

Country Link
EP (1) EP0763202A4 (en)
JP (1) JPH10500951A (en)
WO (1) WO1995032425A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
US6096496A (en) * 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
CA2298629A1 (en) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Method of identifying and developing drug leads
CA2313047A1 (en) * 1997-12-04 1999-12-16 Nicholas Thomas Multiple assay method
US6455263B2 (en) 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
US6054047A (en) 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6720190B1 (en) 1998-03-27 2004-04-13 Ole Hindsgaul Methods for screening compound libraries
CA2240325A1 (en) 1998-03-27 1998-11-14 Synsorb Biotech, Inc. Methods for screening compound libraries
US6613575B1 (en) 1998-03-27 2003-09-02 Ole Hindsgaul Methods for screening compound libraries
DE69941193D1 (en) 1998-08-17 2009-09-10 Bristol Myers Squibb Co Identification of compound protein interactions with libraries of coupled protein nucleic acid molecules
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
AUPP737298A0 (en) * 1998-11-30 1998-12-24 University Of Queensland, The Combinatorial libraries
EP1169123A1 (en) * 1999-04-09 2002-01-09 Glaxo Group Limited Encoding scheme for solid phase chemical libraries
CA2366093A1 (en) * 1999-04-15 2000-10-26 Ilya Ravkin Combinatorial chemical library supports having indicia at coding positions and methods of use
AT322558T (en) 2000-01-24 2006-04-15 Compound Therapeutics Inc Sensitive and multiplexed diagnostic tests for protein analysis
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
CA2398700A1 (en) * 2000-02-07 2001-08-16 Kyowa Medex Co., Ltd. Method for detecting substance
AU5917201A (en) * 2000-04-26 2001-11-07 Streamline Proteomics Apparatus and methods for assays of one or more analytes
ES2284832T3 (en) * 2001-02-13 2007-11-16 Pronostics Limited Biochemical procedure and apparatus for the detection of protein characteristics.
AT359376T (en) * 2001-02-13 2007-05-15 Pronostics Ltd Biochemical method and apparatus for detecting genetic characteristics
WO2005061094A1 (en) 2003-12-22 2005-07-07 Versamatrix A/S Identification of encoded beads
EP1699553A2 (en) 2003-12-22 2006-09-13 VersaMatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
JP4842400B2 (en) 2007-03-22 2011-12-21 ヘプテアズ・セラピューティクス・リミテッド G protein-coupled receptor mutant and selection method thereof
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
GB0904904D0 (en) 2009-03-23 2009-05-06 Univ Leiden Medical Ct Angiogenesis methods, medicaments and agents
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
GB201002082D0 (en) 2010-02-09 2010-03-24 Univ Leiden Medical Ct Biological material
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (en) 2010-03-01 2015-09-02 Quanterix Corporation Methods to extend the dynamic range in assays for the detection of molecules or particles
US20140030218A1 (en) 2011-01-05 2014-01-30 Imperial Innovations Limited Treatment And Screening
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
GB201501004D0 (en) 2015-01-21 2015-03-04 Cancer Rec Tech Ltd Inhibitors
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9532425A1 *

Also Published As

Publication number Publication date
WO1995032425A1 (en) 1995-11-30
EP0763202A1 (en) 1997-03-19
JPH10500951A (en) 1998-01-27

Similar Documents

Publication Publication Date Title
DE69617429D1 (en) Cdma-modem
DE69618179D1 (en) Arylsulfonylaminohydroxamsäurederivate
DE69626513D1 (en) Imidazolverbindungen
DE69635135D1 (en) Benzimidazolderivate
DE69632779D1 (en) Intrauterines ablationssystem
DE69626006D1 (en) Tibiale prothese
DE69513693D1 (en) Positions-servo-system
DE69634771D1 (en) Rotationslasersystem
DE69626660D1 (en) 2-alkylpyrrolidine
DE69627491D1 (en) Translaterale wirbelsäulenimplantatie
DE59611481D1 (en) Chromatin-regulatorgene
ZA9602759B (en) Catalysts
HK1029694A1 (en) Transcoding
HU9602322D0 (en) Knee-prothesis
PL182223B1 (en) Usg contrast medium
IL131549D0 (en) Molding processes
DE69608292D1 (en) Audio-synthesizer
DE69619704D1 (en) Heteroacylcarbonsäureamiderivate
HU9600648D0 (en) Palette-container
HU9800299A3 (en) Gnrh-leukotoxin chimeras
AU2586995A (en) Combinatorial dihydrobenzopyran library
DE59607964D1 (en) Oxymethoxy-3-aryl-pyron-derivate
DE69606427D1 (en) Hydroformylierungsverfahren
IL135227D0 (en) Moving microdroplets
AU2292695A (en) Complex combinatorial chemical libraries encoded with tags

Legal Events

Date Code Title Description
17P Request for examination filed

Effective date: 19961206

AK Designated contracting states:

Kind code of ref document: A1

Designated state(s): BE CH DE FR GB IT LI NL

A4 Despatch of supplementary search report

Effective date: 19981027

AK Designated contracting states:

Kind code of ref document: A4

Designated state(s): BE CH DE FR GB IT LI NL

RHK1 Main classification (correction)

Ipc: C07K 1/04

17Q First examination report

Effective date: 20001219

18D Deemed to be withdrawn

Effective date: 20030211