EP0707085B1 - Körperverträgliche Legierung auf Titan-Basis mit niedrigen Modul für medezinische Geräte - Google Patents

Körperverträgliche Legierung auf Titan-Basis mit niedrigen Modul für medezinische Geräte Download PDF

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Publication number
EP0707085B1
EP0707085B1 EP95307277A EP95307277A EP0707085B1 EP 0707085 B1 EP0707085 B1 EP 0707085B1 EP 95307277 A EP95307277 A EP 95307277A EP 95307277 A EP95307277 A EP 95307277A EP 0707085 B1 EP0707085 B1 EP 0707085B1
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Prior art keywords
medical device
alloys
weight
atomic percent
elasticity
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Expired - Lifetime
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EP95307277A
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English (en)
French (fr)
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EP0707085A1 (de
Inventor
Toseef Ahmed
Henry J. Rack
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Osteonics Corp
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Osteonics Corp
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    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Definitions

  • the present invention relates to biocompatible titanium base alloys which exhibit a low modulus of elasticity.
  • the invention relates to biocompatible titanium base alloys with niobium, tantalum, and zirconium in such relative proportions that the resulting alloys are ductile and exhibit a stable beta (BCC) morphology, a modulus of elasticity below 70 GPa, and a tensile strength of at least 550 MPa (80,000 psi).
  • This invention relates to a family of quaternary titanium base alloys, which are composed of biocompatible elements and are free from toxic metallic elements such as Al, Fe, Ni, Co, Cr, Mo, or W, and are therefore useful in medical devices which are intended to reside on or in the human body for an extended period of time.
  • One such device is a surgical implant, and for the purpose of illustration, the invention will be described for such a use, although it is to be understood that the alloys may have other utility, both medical and non-medical, by virtue of their chemical and physical properties.
  • the alloys be free of elements which are toxic to human beings, and be composed entirely of elements which are biocompatible with human tissues. It is also desirable that the alloys are ductile and possess a low modulus of elasticity comparable to that of bones in the human body.
  • Biocompatible titanium base alloys are described in a number of United States Patents including the following:
  • the present invention is an improvement over the alloys described in the above noted patents insofar as it provides novel fully biocompatible alloys with a low modulus of elasticity.
  • the toxicity of various elements are discussed and alloys of titanium and/or zirconium containing 3 to 30% by weight of at least one member selected from the group consisting of Nb, Ta, Cr, Mo, and Al are described.
  • Several ⁇ - ⁇ alloys are described along with a number of alloys containing Al, Mo, and Cr. No quaternary alloys of Ti, Nb, Ta, and Zr are described.
  • the presence of Al, Cr, or Mo is undesirable because of their toxicity when the alloys are utilized in medical devices, such as surgical implants.
  • the alloys of the present invention do not contain any Al, Cr, or Mo.
  • the alloys described in the two Wang et al patents contain an amount up to 3% of at least one eutectoid beta stabilizer selected from the group consisting of Fe, Mn, Cr, Co, and Ni, each of which is orders of magnitude more toxic than Ti, Zr, Nb, or Ta.
  • the alloys described in these patents possess a modulus of elasticity (E) of 66.9 to 100 GPa with most of the alloys exhibiting a modulus of elasticity between 75 and 100 GPa.
  • the alloys of the present invention do not contain any of the toxic eutectoid stabilizers required by Wang et al.
  • One object of the present invention is to provide new and improved alloys for medical devices intended to remain on or in a living human body for an extended period of time.
  • a further object is to provide new and improved biocompatible titanium base alloys which possess moduli of elasticity below 70 GPa, preferably 65 GPa, and most preferably between 50 and 60 GPa.
  • Another object is to produce biocompatible titanium base alloys of Ti, Nb, Ta, and Zr exhibiting a modulus of elasticity below 70 GPa.
  • a further object of the invention is to provide surgical implants composed of the novel alloys of this invention.
  • Still a further object of the invention is to provide titanium base alloys consisting essentially of between about 2 and about 9 atomic percent Zr and between about 22 and 30 atomic percent of Nb plus Ta and the balance Ti, with the atomic ratio of Nb to Ta between 2 and 16. Stated in weight percent, the alloys of this invention comprise between about 2.5 up to 13% Zr, 20 to 40% Nb, 5 to 25% Ta, the total of Nb and Ta being between about 36.5 and 47%, the balance being Ti.
  • a further object is to provide biocompatible ⁇ stable titanium base alloys of Ta, Nb, and Zr which are isotropic when solution annealed.
  • a medical device for use in the human body having been fabricated from an isotropic, biocompatible titanium alloy consisting of between 2.5% and 13% by weight Zr, between 20% and 40% by weight Nb, between 4.5% and 25% Ta, and the balance Ti;
  • the Nb plus Ta content of the alloy is preferably between 38% and 46% by weight.
  • the Ti content of the alloy is preferably between 46% and 58% by weight.
  • Tables 1 and 2 describe alloys of the present invention prepared from pure elemental metals which were melted in either an arc or plasma furnace to form the desired composition.
  • the resulting ingot may be forged or machined to the shape of the device in which the alloy is to be used.
  • Solution heat treatment to ensure an all ⁇ structure, or a combination of heat treatment and/or working may be employed to produce an ⁇ - ⁇ alloy if such is desired.
  • the biocompatible titanium-zirconium-niobium-tantalum alloys of this invention may also include one or more non-toxic interstitial elements (C,N, and O) for the beneficial effects these elements have on the physical properties of the alloys.
  • the total amounts of these elements which may be added to the alloys of this invention should not exceed 0.5% by weight.
  • the drawing is a plot of moduli of elasticity for the titanium based alloys of Tables 1 and 2 with 2 to 9 atomic percent Zr, 22 to 27 atomic percent Ta plus Nb, and various atomic ratios of Nb/Ta between 1.9 and 16.
  • the quaternary alloys of the present invention contain between 2 and 9 atomic percent Zr, Nb/Ta ratios from 1.9 to 16, and exhibit moduli of elasticity between 47.1 and 66.6 GPa.
  • Particularly preferred alloys are those with the lowest moduli of elasticity, as shown on the graph.
  • Three such preferred alloys described in the tables are TA5, TA7, and TA22 with the following compositions, in weight percent: 23.8 Nb 21.6 Ta 4.6 Zr balance Ti 29.2 Nb 12.4 Ta 7.1 Zr balance Ti 35.3 Nb 5.7 Ta 7.3 Zr balance Ti
  • Implants fabricated from the alloys of this invention may be coated or given other surface treatments such as passivation to enhance their utility.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Claims (14)

  1. Medizinische Einrichtung zur Verwendung im menschlichen Körper, hergestellt aus einer isotropen, biokompatiblen Titanlegierung, bestehend aus zwischen 2,5 und 13 Gew.% Zr, zwischen 20 und 40 Gew.% Nb, zwischen 4,5 und 25 Gew.% Ta, wahlweise bis zu insgesamt 0,5 Gew.% mindestens eines Zwischengitterelements, ausgewählt aus der Gruppe C, N und 0, und einem Ausgleich Ti,
       wobei das Gewicht von Nb und Ta zwischen 35 und 52% ist, das Atomverhältnis von Nb zu Ta zwischen 1,9 und 16 ist, und die relativen Anteile Ti, Zr, Ta und Nb so sind, dass der Elastizitätsmodul unter 70 GPa ist.
  2. Medizinische Einrichtung nach Anspruch 1, wobei die Legierung besteht aus 29,2% Nb, 12,4% Ta, 7,1% Zr, bezogen auf das Gewicht, und einem Ausgleich Ti.
  3. Medizinische Einrichtung nach Anspruch 1, wobei die Legierung besteht aus 23,8% Nb, 21,6% Ta, 4,6% Zr, bezogen auf das Gewicht, und einem Ausgleich Ti.
  4. Medizinische Einrichtung nach Anspruch 1, wobei die Legierung besteht aus 35,3% Nb, 5,7% Ta, 7,3% Zr, bezogen auf das Gewicht, und einem Ausgleich Titan.
  5. Medizinische Einrichtung nach Anspruch 1, wobei der Gehalt an Nb und Ta zwischen 38 und 46 Gew.% ist.
  6. Medizinische Einrichtung nach Anspruch 1, wobei der Titangehalt zwischen 46 und 58 Gew.% ist.
  7. Medizinische Einrichtung nach irgendeinem Anspruch 1 bis 6, wobei die medizinische Einrichtung ein chirurgisches Implantat ist.
  8. Medizinische Einrichtung nach irgendeinem Anspruch 1 bis 6, wobei die medizinische Einrichtung ein Prothetik-Implantat ist.
  9. Medizinische Einrichtung nach Anspruch 1, wobei die Legierung besteht aus zwischen 2 und 9 Atomprozent Zr, zwischen 24 und 30 Atomprozent Nb und Ta und einem Ausgleich Titan.
  10. Medizinische Einrichtung nach irgendeinem Anspruch 1 bis 9, wobei die Legierung lösungsgetempert ist.
  11. Medizinische Einrichtung nach Anspruch 1, wobei der Zirkongehalt zwischen 4 und 7 Atomprozent ist, der Gehalt an Ta und Nb zwischen 22 und 28 Atomprozent ist und der Elastizitätsmodul unter 58 GPa ist.
  12. Medizinische Einrichtung nach Anspruch 1, wobei das Atomverhältnis von Nb zu Ta zwischen 4 und 6 ist.
  13. Medizinische Einrichtung nach Anspruch 1, wobei das Atomverhältnis von Nb zu Ta zwischen 10 und 14 ist.
  14. Medizinische Einrichtung nach irgendeinem Anspruch 1 bis 13, wobei der Elastizitätsmodul unter 57 GPa ist.
EP95307277A 1994-10-14 1995-10-13 Körperverträgliche Legierung auf Titan-Basis mit niedrigen Modul für medezinische Geräte Expired - Lifetime EP0707085B1 (de)

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US32345394A 1994-10-14 1994-10-14
US323453 1994-10-14

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EP0707085A1 EP0707085A1 (de) 1996-04-17
EP0707085B1 true EP0707085B1 (de) 1999-01-07

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US (1) US5871595A (de)
EP (1) EP0707085B1 (de)
JP (1) JPH08299428A (de)
AU (1) AU705336B2 (de)
CA (1) CA2159974A1 (de)
DE (1) DE69507104T2 (de)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611592B2 (en) 2006-02-23 2009-11-03 Ati Properties, Inc. Methods of beta processing titanium alloys
US7837812B2 (en) 2004-05-21 2010-11-23 Ati Properties, Inc. Metastable beta-titanium alloys and methods of processing the same by direct aging
US8048240B2 (en) 2003-05-09 2011-11-01 Ati Properties, Inc. Processing of titanium-aluminum-vanadium alloys and products made thereby
US8337750B2 (en) 2005-09-13 2012-12-25 Ati Properties, Inc. Titanium alloys including increased oxygen content and exhibiting improved mechanical properties
US8499605B2 (en) 2010-07-28 2013-08-06 Ati Properties, Inc. Hot stretch straightening of high strength α/β processed titanium
US8652400B2 (en) 2011-06-01 2014-02-18 Ati Properties, Inc. Thermo-mechanical processing of nickel-base alloys
US9050647B2 (en) 2013-03-15 2015-06-09 Ati Properties, Inc. Split-pass open-die forging for hard-to-forge, strain-path sensitive titanium-base and nickel-base alloys
US9192981B2 (en) 2013-03-11 2015-11-24 Ati Properties, Inc. Thermomechanical processing of high strength non-magnetic corrosion resistant material
US9206497B2 (en) 2010-09-15 2015-12-08 Ati Properties, Inc. Methods for processing titanium alloys
US9255316B2 (en) 2010-07-19 2016-02-09 Ati Properties, Inc. Processing of α+β titanium alloys
US9777361B2 (en) 2013-03-15 2017-10-03 Ati Properties Llc Thermomechanical processing of alpha-beta titanium alloys
US9869003B2 (en) 2013-02-26 2018-01-16 Ati Properties Llc Methods for processing alloys
US10053758B2 (en) 2010-01-22 2018-08-21 Ati Properties Llc Production of high strength titanium
US10094003B2 (en) 2015-01-12 2018-10-09 Ati Properties Llc Titanium alloy
US10502252B2 (en) 2015-11-23 2019-12-10 Ati Properties Llc Processing of alpha-beta titanium alloys
US10513755B2 (en) 2010-09-23 2019-12-24 Ati Properties Llc High strength alpha/beta titanium alloy fasteners and fastener stock
US11111552B2 (en) 2013-11-12 2021-09-07 Ati Properties Llc Methods for processing metal alloys

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772790B1 (fr) * 1997-12-18 2000-02-04 Snecma ALLIAGES INTERMETALLIQUES A BASE DE TITANE DU TYPE Ti2AlNb A HAUTE LIMITE D'ELASTICITE ET FORTE RESISTANCE AU FLUAGE
US6767418B1 (en) * 1999-04-23 2004-07-27 Terumo Kabushiki Kaisha Ti-Zr type alloy and medical appliance formed thereof
EP1114876B1 (de) * 1999-06-11 2006-08-23 Kabushiki Kaisha Toyota Chuo Kenkyusho Titanlegierung und verfahren zu deren herstellung
US6402859B1 (en) 1999-09-10 2002-06-11 Terumo Corporation β-titanium alloy wire, method for its production and medical instruments made by said β-titanium alloy wire
WO2001083838A1 (fr) * 2000-05-02 2001-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Alliage de titane
JP4547797B2 (ja) * 2000-12-19 2010-09-22 大同特殊鋼株式会社 生体用Ｔｉ合金およびその製造方法
DE60138731D1 (de) 2000-12-20 2009-06-25 Toyota Chuo Kenkyusho Kk Verfahren zur Herstellung einer TITANLEGIERUNG MIT HOHEM ELASTISCHEM VERFORMUNGSVERMÖGEN.
EP1375690B1 (de) * 2001-03-26 2006-03-15 Kabushiki Kaisha Toyota Chuo Kenkyusho Hochfeste titanlegierung und verfahren zu ihrer herstellung
US20030220696A1 (en) * 2002-05-23 2003-11-27 Levine David Jerome Implantable porous metal
JP4257581B2 (ja) * 2002-09-20 2009-04-22 株式会社豊田中央研究所 チタン合金およびその製造方法
US20070276488A1 (en) * 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
DE10305349A1 (de) 2003-02-10 2004-08-26 Cell Center Cologne Gmbh Innenohr-Steckverbindung
ATE343403T1 (de) * 2003-02-10 2006-11-15 Heraeus Gmbh W C Verbesserte metalllegierung für medizinische geräte und implantate
US20080038146A1 (en) * 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
US20040260331A1 (en) * 2003-06-20 2004-12-23 D'aquanni Peter Beta titanium embolic protection frame and guide wire
US7722805B2 (en) * 2003-12-25 2010-05-25 Institute Of Metal Research Chinese Academy Of Sciences Titanium alloy with extra-low modulus and superelasticity and its producing method and processing thereof
CN1323181C (zh) * 2004-04-29 2007-06-27 大连盛辉钛业有限公司 一种高强度低模量生物医用钛合金
DE102004022458B4 (de) * 2004-04-29 2006-01-19 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Kaltumformbare Formkörper aus Titanbasislegierungen und Verfahren zu deren Herstellung
DE102006025292A1 (de) * 2006-05-31 2007-12-06 Gfe Metalle Und Materialien Gmbh Biokompatible Titanlegierung, Verfahren zu deren Herstellung sowie daraus bestehendes medizinisches Knochen-Implantat
EP2297370B1 (de) * 2008-05-28 2013-12-04 Korea Institute Of Machinery & Materials Titanlegierung auf beta-basis mit niedrigem elastizitätsmodul
EP2301590B1 (de) 2008-06-03 2014-10-29 Advanced Medix Inc. Verfahren zur herstelung eines knochenreparaturmaterials
EP2364376A1 (de) 2008-09-23 2011-09-14 Sandvik Intellectual Property AB Titanlegierung
US8639352B2 (en) * 2009-04-06 2014-01-28 Medtronic, Inc. Wire configuration and method of making for an implantable medical apparatus
US8613818B2 (en) 2010-09-15 2013-12-24 Ati Properties, Inc. Processing routes for titanium and titanium alloys
US8340759B2 (en) 2011-04-22 2012-12-25 Medtronic, Inc. Large-pitch coil configurations for a medical device
US8660662B2 (en) 2011-04-22 2014-02-25 Medtronic, Inc. Low impedance, low modulus wire configurations for a medical device
US9409008B2 (en) 2011-04-22 2016-08-09 Medtronic, Inc. Cable configurations for a medical device
WO2013016523A1 (en) * 2011-07-28 2013-01-31 Synthes Usa, Llc Orthopedic implants
RU2485197C1 (ru) * 2011-10-03 2013-06-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский технологический университет "МИСиС" Металлический наноструктурный сплав на основе титана и способ его обработки
KR101234505B1 (ko) 2012-11-08 2013-02-20 한국기계연구원 선형적 탄성변형을 하며 초고강도, 초저탄성 특성을 가지는 타이타늄 합금
CN103074511B (zh) * 2012-11-13 2015-07-22 西北有色金属研究院 一种医用多孔植入合金材料及其制备方法
US20140212688A1 (en) * 2013-01-31 2014-07-31 Ametek, Inc. High grade titanium alloy sheet and method of making same
WO2017003192A1 (ko) * 2015-06-30 2017-01-05 (주)강앤박메디컬 TiNi계 의료용 합금 및 그 제조 방법
CN105400990B (zh) * 2015-07-30 2017-10-31 贵州大学 一种低模量高强度生物医用钛合金及其制备方法
FR3047489B1 (fr) * 2016-02-08 2022-09-23 Abdelmadjid Djemai Procede de fabrication d'un beta-alliage titane niobium zirconium (tnz) a tres bas module d'elasticite pour applications biomedicales et son mode de realisation par fabrication additive
PT3489375T (pt) 2017-11-22 2020-07-14 Biotech Dental Ligas ternárias de ti-zr-o, métodos para a produção das mesmas e utilizações associadas das mesmas
BR112020019365A2 (pt) 2018-04-13 2020-12-29 Taniobis Gmbh Pó de metal para impressão em 3d

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081465A (en) * 1963-10-23 1967-08-31 Hitachi Ltd Superconducting materials
US3671226A (en) * 1966-02-28 1972-06-20 Mitsubishi Electric Corp Superconductive alloys
US3849124A (en) * 1969-12-05 1974-11-19 Norton Co Capacitor powder
US3597664A (en) * 1969-12-05 1971-08-03 Norton Co Niobium-zirconium-titanium capacitor electrode
CH526346A (de) * 1970-07-13 1972-08-15 Straumann Inst Ag Metallischer Schall-Leiter oder Schallstrahler
US4040129A (en) * 1970-07-15 1977-08-09 Institut Dr. Ing. Reinhard Straumann Ag Surgical implant and alloy for use in making an implant
CH539118A (de) * 1970-07-15 1973-07-15 Straumann Inst Ag Schmiedbare Legierung für Implantate für die Knochen- und Zahnchirurgie
JPS5428079B2 (de) * 1973-01-23 1979-09-13
JPS5538951A (en) * 1978-09-13 1980-03-18 Permelec Electrode Ltd Electrode substrate alloy for electrolysis
JPS61157652A (ja) * 1984-12-28 1986-07-17 Toshiba Corp 金属装飾品
EP0312494A3 (de) * 1987-10-16 1991-01-16 Institut Straumann Ag Alloplastisches Material für die Bildung eines künstlichen und/oder Verstärkung eines natürlichen Weichgewebeteils
US4952236A (en) * 1988-09-09 1990-08-28 Pfizer Hospital Products Group, Inc. Method of making high strength, low modulus, ductile, biocompatible titanium alloy
US4857269A (en) * 1988-09-09 1989-08-15 Pfizer Hospital Products Group Inc. High strength, low modulus, ductile, biopcompatible titanium alloy
US5169597A (en) * 1989-12-21 1992-12-08 Davidson James A Biocompatible low modulus titanium alloy for medical implants
AU644393B2 (en) * 1989-12-21 1993-12-09 Smith & Nephew, Inc. Biocompatible low modulus titanium alloy for medical implants
US5545227A (en) * 1989-12-21 1996-08-13 Smith & Nephew Richards, Inc. Biocompatible low modulus medical implants

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US9796005B2 (en) 2003-05-09 2017-10-24 Ati Properties Llc Processing of titanium-aluminum-vanadium alloys and products made thereby
US8597443B2 (en) 2003-05-09 2013-12-03 Ati Properties, Inc. Processing of titanium-aluminum-vanadium alloys and products made thereby
US8597442B2 (en) 2003-05-09 2013-12-03 Ati Properties, Inc. Processing of titanium-aluminum-vanadium alloys and products of made thereby
US8623155B2 (en) 2004-05-21 2014-01-07 Ati Properties, Inc. Metastable beta-titanium alloys and methods of processing the same by direct aging
US7837812B2 (en) 2004-05-21 2010-11-23 Ati Properties, Inc. Metastable beta-titanium alloys and methods of processing the same by direct aging
US9523137B2 (en) 2004-05-21 2016-12-20 Ati Properties Llc Metastable β-titanium alloys and methods of processing the same by direct aging
US8568540B2 (en) 2004-05-21 2013-10-29 Ati Properties, Inc. Metastable beta-titanium alloys and methods of processing the same by direct aging
US9593395B2 (en) 2005-09-13 2017-03-14 Ati Properties Llc Titanium alloys including increased oxygen content and exhibiting improved mechanical properties
US8337750B2 (en) 2005-09-13 2012-12-25 Ati Properties, Inc. Titanium alloys including increased oxygen content and exhibiting improved mechanical properties
US7611592B2 (en) 2006-02-23 2009-11-03 Ati Properties, Inc. Methods of beta processing titanium alloys
US10053758B2 (en) 2010-01-22 2018-08-21 Ati Properties Llc Production of high strength titanium
US10144999B2 (en) 2010-07-19 2018-12-04 Ati Properties Llc Processing of alpha/beta titanium alloys
US9765420B2 (en) 2010-07-19 2017-09-19 Ati Properties Llc Processing of α/β titanium alloys
US9255316B2 (en) 2010-07-19 2016-02-09 Ati Properties, Inc. Processing of α+β titanium alloys
US8499605B2 (en) 2010-07-28 2013-08-06 Ati Properties, Inc. Hot stretch straightening of high strength α/β processed titanium
US8834653B2 (en) 2010-07-28 2014-09-16 Ati Properties, Inc. Hot stretch straightening of high strength age hardened metallic form and straightened age hardened metallic form
US9624567B2 (en) 2010-09-15 2017-04-18 Ati Properties Llc Methods for processing titanium alloys
US9206497B2 (en) 2010-09-15 2015-12-08 Ati Properties, Inc. Methods for processing titanium alloys
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US9192981B2 (en) 2013-03-11 2015-11-24 Ati Properties, Inc. Thermomechanical processing of high strength non-magnetic corrosion resistant material
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US9050647B2 (en) 2013-03-15 2015-06-09 Ati Properties, Inc. Split-pass open-die forging for hard-to-forge, strain-path sensitive titanium-base and nickel-base alloys
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US11851734B2 (en) 2015-01-12 2023-12-26 Ati Properties Llc Titanium alloy
US10502252B2 (en) 2015-11-23 2019-12-10 Ati Properties Llc Processing of alpha-beta titanium alloys

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EP0707085A1 (de) 1996-04-17
JPH08299428A (ja) 1996-11-19
AU3305795A (en) 1996-05-02
AU705336B2 (en) 1999-05-20
US5871595A (en) 1999-02-16
CA2159974A1 (en) 1996-04-15
DE69507104T2 (de) 1999-06-10
DE69507104D1 (de) 1999-02-18

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