EP0689547A4 - Recepteur alpha1c-adrenergique humain clone - Google Patents

Recepteur alpha1c-adrenergique humain clone

Info

Publication number
EP0689547A4
EP0689547A4 EP94912209A EP94912209A EP0689547A4 EP 0689547 A4 EP0689547 A4 EP 0689547A4 EP 94912209 A EP94912209 A EP 94912209A EP 94912209 A EP94912209 A EP 94912209A EP 0689547 A4 EP0689547 A4 EP 0689547A4
Authority
EP
European Patent Office
Prior art keywords
adrenergic receptor
cloned human
alpha1c
alpha1c adrenergic
cloned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94912209A
Other languages
German (de)
English (en)
Other versions
EP0689547A1 (fr
Inventor
Marvin L Bayne
Bradley V Clineschmidt
Catherine D Strader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0689547A1 publication Critical patent/EP0689547A1/fr
Publication of EP0689547A4 publication Critical patent/EP0689547A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP94912209A 1993-03-15 1994-03-10 Recepteur alpha1c-adrenergique humain clone Withdrawn EP0689547A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3284993A 1993-03-15 1993-03-15
US32849 1993-03-15
PCT/US1994/002609 WO1994021660A1 (fr) 1993-03-15 1994-03-10 Recepteur alpha1c-adrenergique humain clone

Publications (2)

Publication Number Publication Date
EP0689547A1 EP0689547A1 (fr) 1996-01-03
EP0689547A4 true EP0689547A4 (fr) 1998-10-28

Family

ID=21867151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94912209A Withdrawn EP0689547A4 (fr) 1993-03-15 1994-03-10 Recepteur alpha1c-adrenergique humain clone

Country Status (5)

Country Link
EP (1) EP0689547A4 (fr)
JP (1) JPH08508163A (fr)
AU (1) AU685789B2 (fr)
CA (1) CA2158345A1 (fr)
WO (1) WO1994021660A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2145182C (fr) * 1992-09-25 2001-09-18 Jonathan A. Bard Sequences d'adn codant pour des recepteurs alpha 1 adrenergiques humains et leur utilisation
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
US5578611A (en) * 1992-11-13 1996-11-26 Synaptic Pharmaceutical Corporation Use of α-1C specific compounds to treat benign prostatic hyperplasia
US6015819A (en) 1992-11-13 2000-01-18 Synaptic Pharmaceutical Corporation Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
EP1775311B1 (fr) * 2004-08-04 2018-09-05 Sekisui Chemical Co., Ltd. Procédé pour produire une résine d'acétal de polyvinyle
WO2006021344A1 (fr) * 2004-08-27 2006-03-02 Bayer Healthcare Ag Diagnostic et traitement de maladies associees au recepteur adrenergique alpha-1a (adra1a)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016213A1 (fr) * 1991-03-20 1992-10-01 Merck & Co., Inc. Combinaison pharmaceutique pour le traitement de l'hyperplasie de la prostate renfermant un inhibiteur de 5 alpha-reductase et un antiandrogene
WO1993023038A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. INHIBITEURS DE 5α-REDUCTASE A BASE DE 4-AZASTEROIDES A SUBSTITUTION AMINO EN POSITION 17
WO1994008040A1 (fr) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Adn codant des recepteurs adrenergiques alpha 1 humains et leurs utilisations
WO1994010989A1 (fr) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Utilisation de composes specifiques alpha-1c dans le traitement de l'hyperplasie benigne de la prostate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016213A1 (fr) * 1991-03-20 1992-10-01 Merck & Co., Inc. Combinaison pharmaceutique pour le traitement de l'hyperplasie de la prostate renfermant un inhibiteur de 5 alpha-reductase et un antiandrogene
WO1993023038A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. INHIBITEURS DE 5α-REDUCTASE A BASE DE 4-AZASTEROIDES A SUBSTITUTION AMINO EN POSITION 17
WO1994008040A1 (fr) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Adn codant des recepteurs adrenergiques alpha 1 humains et leurs utilisations
WO1994010989A1 (fr) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Utilisation de composes specifiques alpha-1c dans le traitement de l'hyperplasie benigne de la prostate

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRUNO J.F. ET AL.: "Molecular cloning and sequencing of a cDNA encoding a human alpha1A adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 179, no. 3, 30 September 1991 (1991-09-30), pages 1485 - 1490, XP002059308 *
HARISAWA A.: "Cloning, functional expression and tissue distribution of human cDNA for the alpha1C-adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 195, no. 2, 15 September 1993 (1993-09-15), pages 902 - 909, XP002059309 *
LEPOR H ET AL: "THE ALPHA-ADRENOCEPTOR SUBTYPE MEDIATING THE TENSION OF HUMAN PROSTATIC SMOOTH MUSCLE", THE PROSTATE, vol. 22, no. 4, 16 June 1993 (1993-06-16), pages 301 - 307, XP002047748 *
MELLIN T N ET AL: "AZASTEROIDS AS INHIBITORS OF TESTOSTERONE 5ALPHA-REDUCTASE IN MAMMALIAN SKIN", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 44, no. 2, February 1993 (1993-02-01), pages 121 - 131, XP002028037 *
SCHWINN D A & LOMASNEY J W: "Pharmacological characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 227, no. 4, 1 December 1992 (1992-12-01), pages 433 - 436, XP002075428 *
See also references of WO9421660A1 *

Also Published As

Publication number Publication date
AU6445394A (en) 1994-10-11
JPH08508163A (ja) 1996-09-03
AU685789B2 (en) 1998-01-29
CA2158345A1 (fr) 1994-09-29
WO1994021660A1 (fr) 1994-09-29
EP0689547A1 (fr) 1996-01-03

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19951016

AK Designated contracting states

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RHK1 Main classification (correction)

Ipc: C12N 15/12

A4 Supplementary search report drawn up and despatched

Effective date: 19980910

AK Designated contracting states

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18D Application deemed to be withdrawn

Effective date: 20010907