EP0853479A4 - ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b - Google Patents

ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b

Info

Publication number
EP0853479A4
EP0853479A4 EP96933093A EP96933093A EP0853479A4 EP 0853479 A4 EP0853479 A4 EP 0853479A4 EP 96933093 A EP96933093 A EP 96933093A EP 96933093 A EP96933093 A EP 96933093A EP 0853479 A4 EP0853479 A4 EP 0853479A4
Authority
EP
European Patent Office
Prior art keywords
alpha
receptor antagonists
adrenergic receptor
adrenergic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96933093A
Other languages
German (de)
English (en)
Other versions
EP0853479A1 (fr
Inventor
Mark G Bock
William C Lumma
Michael A Patane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604288.2A external-priority patent/GB9604288D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0853479A1 publication Critical patent/EP0853479A1/fr
Publication of EP0853479A4 publication Critical patent/EP0853479A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96933093A 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b Withdrawn EP0853479A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US450195P 1995-09-29 1995-09-29
US4501P 1995-09-29
GB9604288 1996-02-29
GBGB9604288.2A GB9604288D0 (en) 1996-02-29 1996-02-29 Alpha 1b adrenergic receptor antagonists
PCT/US1996/015223 WO1997011698A1 (fr) 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b

Publications (2)

Publication Number Publication Date
EP0853479A1 EP0853479A1 (fr) 1998-07-22
EP0853479A4 true EP0853479A4 (fr) 2001-04-11

Family

ID=26308827

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96933093A Withdrawn EP0853479A4 (fr) 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b

Country Status (4)

Country Link
EP (1) EP0853479A4 (fr)
JP (1) JPH11512710A (fr)
CA (1) CA2232138A1 (fr)
WO (1) WO1997011698A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312310B1 (it) 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
ES2251512T3 (es) 2000-08-31 2006-05-01 F. Hoffmann-La Roche Ag Derivados de quinazolina como antagonista adrenergicos alfa-1.
ATE469245T1 (de) 2004-09-14 2010-06-15 Univ Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
US9415047B2 (en) * 2012-11-26 2016-08-16 Liaoning Emmy Biological Pharmaceutical Co., Ltd. Use of benzo five-membered nitrogen heterocyclic piperazine or piperidine derivatives
EP3939591A1 (fr) 2016-06-27 2022-01-19 Achillion Pharmaceuticals, Inc. Composés de quinazoline et d'indole pour traiter des troubles médicaux

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
GB2171977A (en) * 1985-03-05 1986-09-10 Emi Plc Thorn Gripper

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793977A (en) * 1980-11-26 1982-06-11 Sankyo Co Ltd Acylaminoquinazoline derivative and its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
GB2171977A (en) * 1985-03-05 1986-09-10 Emi Plc Thorn Gripper

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
I.TAKAYANAGI, F.KONNO, H.ARAI, K. CHIMOTO AND T. KITADA: "Newly synthesized alpha1-adrenoceptor blockers (SM911 and SM2470) and characterization of alpha-adrenoceptors in rat aortic strips, rat vas deferens preparations and rabbit aortic strips", GEN.PHARMACOL., vol. 16, no. 6, 1985, pages 613 - 615, XP000973937 *
See also references of WO9711698A1 *
VALERIE A. ALABASTER, SIMON F.CAMPBELL, JOHN C. DANILEWICZ, COLIN W.GREENGRASS, AND RHONA M. PLEWS: "2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) Derivatives as alpha1-Adrenoceptor Antagonists and Antihypertensive Agents", J.MED.CHEM., vol. 30, 1987, pages 999 - 1003, XP002159406 *

Also Published As

Publication number Publication date
JPH11512710A (ja) 1999-11-02
CA2232138A1 (fr) 1997-04-03
EP0853479A1 (fr) 1998-07-22
WO1997011698A1 (fr) 1997-04-03

Similar Documents

Publication Publication Date Title
EP0822814A4 (fr) ANTAGONISTES DES RECEPTEURS ADRENERGIQUES ALPHA 1a
EP0998285A4 (fr) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a
IL125717A0 (en) Il-8 receptor antagonists
HU9603525D0 (en) Vironectin receptor antagonists
EP0833637A4 (fr) ANTAGONISTES DU RECEPTEUR ALPHA ADRENERGIQUE 1a
IL125030A0 (en) Vitronectin receptor antagonists
HU9601529D0 (en) Pyrimidinedion-, pyrimidinetrion-, triazinedion-, tetrahydro-quinazolinedion- derivatives as alpha-adrenerg receptor antagonists
IL125033A0 (en) Vitronectin receptor antagonists
IL125034A0 (en) Vitronectin receptor antagonists
ZA955391B (en) Vitronectin receptor antagonists
EP0831823A4 (fr) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a
EP0755392A4 (fr) Antagonistes du recepteur adrenergique alpha1c
EP1019052A4 (fr) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a
EP1023068A4 (fr) ANTAGONISTES DES ADRENORECEPTEURS ALPHA 1a
EP1014973A4 (fr) ANTAGONISTES DES ADRENORECEPTEURS ALPHA 1a
EP0831824A4 (fr) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a
EP0853479A4 (fr) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b
HU9600333D0 (en) Adhesive receptor antagonists
EP0773959A4 (fr) Recepteur adrenergique
EP0812196A4 (fr) ANTAGONISTES DU RECEPTEUR ALPHA-1a-ADRENERGIQUE
AU5234899A (en) Alpha 1a adrenergic receptor antagonists
AU7734496A (en) Alpha 1a adrenergic receptor antagonists
GB9604288D0 (en) Alpha 1b adrenergic receptor antagonists
GB9605165D0 (en) Alpha 1a adrenergic receptor antagonists
GB9719392D0 (en) Alpha la adrenergic receptor antagonists

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17P Request for examination filed

Effective date: 19980429

A4 Supplementary search report drawn up and despatched

Effective date: 20010221

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20010403