EP0689547A4 - Cloned human alpha1c adrenergic receptor - Google Patents

Cloned human alpha1c adrenergic receptor

Info

Publication number
EP0689547A4
EP0689547A4 EP94912209A EP94912209A EP0689547A4 EP 0689547 A4 EP0689547 A4 EP 0689547A4 EP 94912209 A EP94912209 A EP 94912209A EP 94912209 A EP94912209 A EP 94912209A EP 0689547 A4 EP0689547 A4 EP 0689547A4
Authority
EP
European Patent Office
Prior art keywords
adrenergic receptor
cloned human
alpha1c
alpha1c adrenergic
cloned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94912209A
Other languages
German (de)
French (fr)
Other versions
EP0689547A1 (en
Inventor
Marvin L Bayne
Bradley V Clineschmidt
Catherine D Strader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0689547A1 publication Critical patent/EP0689547A1/en
Publication of EP0689547A4 publication Critical patent/EP0689547A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94912209A 1993-03-15 1994-03-10 Cloned human alpha1c adrenergic receptor Withdrawn EP0689547A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3284993A 1993-03-15 1993-03-15
US32849 1993-03-15
PCT/US1994/002609 WO1994021660A1 (en) 1993-03-15 1994-03-10 Cloned human alpha1c adrenergic receptor

Publications (2)

Publication Number Publication Date
EP0689547A1 EP0689547A1 (en) 1996-01-03
EP0689547A4 true EP0689547A4 (en) 1998-10-28

Family

ID=21867151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94912209A Withdrawn EP0689547A4 (en) 1993-03-15 1994-03-10 Cloned human alpha1c adrenergic receptor

Country Status (5)

Country Link
EP (1) EP0689547A4 (en)
JP (1) JPH08508163A (en)
AU (1) AU685789B2 (en)
CA (1) CA2158345A1 (en)
WO (1) WO1994021660A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861309A (en) * 1992-09-25 1999-01-19 Synaptic Pharmaceutical Corporation DNA endoding human alpha 1 adrenergic receptors
US5578611A (en) * 1992-11-13 1996-11-26 Synaptic Pharmaceutical Corporation Use of α-1C specific compounds to treat benign prostatic hyperplasia
US6015819A (en) * 1992-11-13 2000-01-18 Synaptic Pharmaceutical Corporation Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
CN100575368C (en) * 2004-08-04 2009-12-30 积水化学工业株式会社 The manufacture method of the manufacture method of polyvinyl acetal resin, polyvinyl butyral resin and esterified polyvinyl alcohol resin
WO2006021344A1 (en) * 2004-08-27 2006-03-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with alpha-1a adrenergic receptor (adra1a)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016213A1 (en) * 1991-03-20 1992-10-01 Merck & Co., Inc. Pharmaceutical combination for the treatment of prostatic hyperplasia, containing a 5 alpha-reductase inhibitor and an antiandrogen
WO1993023038A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. 17-AMINO SUBSTITUTED 4-AZASTEROID 5α-REDUCTASE INHIBITORS
WO1994008040A1 (en) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Dna encoding human alpha 1 adrenergic receptors and uses thereof
WO1994010989A1 (en) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Use of alpha-1c specific compounds to treat benign prostatic hyperplasia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016213A1 (en) * 1991-03-20 1992-10-01 Merck & Co., Inc. Pharmaceutical combination for the treatment of prostatic hyperplasia, containing a 5 alpha-reductase inhibitor and an antiandrogen
WO1993023038A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. 17-AMINO SUBSTITUTED 4-AZASTEROID 5α-REDUCTASE INHIBITORS
WO1994008040A1 (en) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Dna encoding human alpha 1 adrenergic receptors and uses thereof
WO1994010989A1 (en) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Use of alpha-1c specific compounds to treat benign prostatic hyperplasia

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRUNO J.F. ET AL.: "Molecular cloning and sequencing of a cDNA encoding a human alpha1A adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 179, no. 3, 30 September 1991 (1991-09-30), pages 1485 - 1490, XP002059308 *
HARISAWA A.: "Cloning, functional expression and tissue distribution of human cDNA for the alpha1C-adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 195, no. 2, 15 September 1993 (1993-09-15), pages 902 - 909, XP002059309 *
LEPOR H ET AL: "THE ALPHA-ADRENOCEPTOR SUBTYPE MEDIATING THE TENSION OF HUMAN PROSTATIC SMOOTH MUSCLE", THE PROSTATE, vol. 22, no. 4, 16 June 1993 (1993-06-16), pages 301 - 307, XP002047748 *
MELLIN T N ET AL: "AZASTEROIDS AS INHIBITORS OF TESTOSTERONE 5ALPHA-REDUCTASE IN MAMMALIAN SKIN", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 44, no. 2, February 1993 (1993-02-01), pages 121 - 131, XP002028037 *
SCHWINN D A & LOMASNEY J W: "Pharmacological characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 227, no. 4, 1 December 1992 (1992-12-01), pages 433 - 436, XP002075428 *
See also references of WO9421660A1 *

Also Published As

Publication number Publication date
EP0689547A1 (en) 1996-01-03
JPH08508163A (en) 1996-09-03
AU6445394A (en) 1994-10-11
WO1994021660A1 (en) 1994-09-29
AU685789B2 (en) 1998-01-29
CA2158345A1 (en) 1994-09-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19951016

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Effective date: 19980910

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Effective date: 20010907