EP0831824A4 - ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS - Google Patents

ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Info

Publication number
EP0831824A4
EP0831824A4 EP96919056A EP96919056A EP0831824A4 EP 0831824 A4 EP0831824 A4 EP 0831824A4 EP 96919056 A EP96919056 A EP 96919056A EP 96919056 A EP96919056 A EP 96919056A EP 0831824 A4 EP0831824 A4 EP 0831824A4
Authority
EP
European Patent Office
Prior art keywords
alpha
receptor antagonists
adrenergic receptor
adrenergic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919056A
Other languages
German (de)
French (fr)
Other versions
EP0831824A1 (en
Inventor
Jennie Nerenberg
Mark G Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0831824A1 publication Critical patent/EP0831824A1/en
Publication of EP0831824A4 publication Critical patent/EP0831824A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
EP96919056A 1995-06-06 1996-06-04 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Withdrawn EP0831824A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US470164 1990-01-25
US47016495A 1995-06-06 1995-06-06
PCT/US1996/008672 WO1996039140A1 (en) 1995-06-06 1996-06-04 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
EP0831824A1 EP0831824A1 (en) 1998-04-01
EP0831824A4 true EP0831824A4 (en) 2001-05-02

Family

ID=23866530

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919056A Withdrawn EP0831824A4 (en) 1995-06-06 1996-06-04 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Country Status (5)

Country Link
EP (1) EP0831824A4 (en)
JP (1) JP2001516330A (en)
AU (1) AU705661B2 (en)
CA (1) CA2221842A1 (en)
WO (1) WO1996039140A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
JPWO2004092179A1 (en) * 2003-04-14 2006-07-06 日本曹達株式会社 Spiro derivatives, production methods and antioxidants
ATE509023T1 (en) 2005-07-19 2011-05-15 Merck Sharp & Dohme SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE INHIBITORS
WO2007063385A2 (en) * 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
AP2009004880A0 (en) * 2006-11-29 2009-06-30 Pfizer Prod Inc Spiroketone acetyl-COA carboxylase inhibitors
PE20081559A1 (en) 2007-01-12 2008-11-20 Merck & Co Inc SPIROCHROMANONE DERIVATIVES SUBSTITUTED AS ACETYL COA CARBOXYLASE INHIBITORS
EP2120569B1 (en) * 2007-01-12 2013-08-14 Merck Sharp & Dohme Corp. Spirochromanon derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
WO1994010989A1 (en) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Use of alpha-1c specific compounds to treat benign prostatic hyperplasia
WO1994018204A1 (en) * 1993-02-12 1994-08-18 Merck & Co., Inc. Spiro (2h-1-benzopyran-2, 4' piperidine) class iii antiarrhythmics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
WO1994010989A1 (en) * 1992-11-13 1994-05-26 Synaptic Pharmaceutical Corporation Use of alpha-1c specific compounds to treat benign prostatic hyperplasia
WO1994018204A1 (en) * 1993-02-12 1994-08-18 Merck & Co., Inc. Spiro (2h-1-benzopyran-2, 4' piperidine) class iii antiarrhythmics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9639140A1 *
YAMATO M ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF SPIRO UISOCHROMANPIPERIDINE ANALOGS FOR INHIBITION OF HISTAMINE RELEASE", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 29, no. 12, 1 December 1981 (1981-12-01), pages 3494 - 3498, XP000651856, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
WO1996039140A1 (en) 1996-12-12
EP0831824A1 (en) 1998-04-01
AU705661B2 (en) 1999-05-27
CA2221842A1 (en) 1996-12-12
JP2001516330A (en) 2001-09-25
AU6149796A (en) 1996-12-24

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