EP1019052A4 - Alpha 1a adrenergic receptor antagonists - Google Patents

Alpha 1a adrenergic receptor antagonists

Info

Publication number
EP1019052A4
EP1019052A4 EP98931353A EP98931353A EP1019052A4 EP 1019052 A4 EP1019052 A4 EP 1019052A4 EP 98931353 A EP98931353 A EP 98931353A EP 98931353 A EP98931353 A EP 98931353A EP 1019052 A4 EP1019052 A4 EP 1019052A4
Authority
EP
European Patent Office
Prior art keywords
alpha
receptor antagonists
adrenergic receptor
adrenergic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98931353A
Other languages
German (de)
French (fr)
Other versions
EP1019052A1 (en
Inventor
Michael A Patane
Mark G Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800231.4A external-priority patent/GB9800231D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1019052A1 publication Critical patent/EP1019052A1/en
Publication of EP1019052A4 publication Critical patent/EP1019052A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP98931353A 1997-06-18 1998-06-18 Alpha 1a adrenergic receptor antagonists Withdrawn EP1019052A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5096097P 1997-06-18 1997-06-18
US50960P 1997-06-18
GBGB9800231.4A GB9800231D0 (en) 1998-01-06 1998-01-06 Alpha 1a adrenergic receptor antagonists
GB9800231 1998-01-06
PCT/US1998/012672 WO1998057640A1 (en) 1997-06-18 1998-06-18 Alpha 1a adrenergic receptor antagonists

Publications (2)

Publication Number Publication Date
EP1019052A1 EP1019052A1 (en) 2000-07-19
EP1019052A4 true EP1019052A4 (en) 2001-05-16

Family

ID=26312903

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98931353A Withdrawn EP1019052A4 (en) 1997-06-18 1998-06-18 Alpha 1a adrenergic receptor antagonists

Country Status (5)

Country Link
EP (1) EP1019052A4 (en)
JP (1) JP2002508764A (en)
AU (1) AU8150198A (en)
CA (1) CA2294346A1 (en)
WO (1) WO1998057640A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207444B1 (en) 1997-08-05 2001-03-27 Merck & Co., Inc. Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease
WO2000006565A1 (en) 1998-07-30 2000-02-10 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6358959B1 (en) * 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
WO2000063168A1 (en) * 1999-04-16 2000-10-26 Coelacanth Chemical Corporation Synthesis of azetidine derivatives
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
TWI290549B (en) 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9857640A1 *

Also Published As

Publication number Publication date
EP1019052A1 (en) 2000-07-19
CA2294346A1 (en) 1998-12-23
AU8150198A (en) 1999-01-04
JP2002508764A (en) 2002-03-19
WO1998057640A1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
EP0998285A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
EP0822814A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
SG70110A1 (en) Ccr-3 receptor antagonists
IL134855A0 (en) Il-8 receptor antagonists
GB9927227D0 (en) CCR-3 receptor antagonists III
IL131004A0 (en) Il-8 receptor antagonists
GB2343891B (en) 4-Aroyl-piperidine CCR-3 receptor antagonists
EP0833637A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST
IL130760A0 (en) Vitronectin receptor antagonists
EP1000017A4 (en) Il-8 receptor antagonists
EP0831823A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
EP0755392A4 (en) Alpha1c adrenergic receptor antagonists
IL135028A0 (en) Vitronectin receptor antagonists
EP1019052A4 (en) Alpha 1a adrenergic receptor antagonists
EP1023068A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
IL131005A0 (en) Il-8 receptor antagonists
EP1014973A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
HK1028730A1 (en) Il-8 receptor antagonists
EP0971908A4 (en) Il-8 receptor antagonists
EP0831824A4 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
EP0853479A4 (en) ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
AU5234899A (en) Alpha 1a adrenergic receptor antagonists
GB9719392D0 (en) Alpha la adrenergic receptor antagonists
GB9605165D0 (en) Alpha 1a adrenergic receptor antagonists
GB9719706D0 (en) Alpha 1a adrenergic receptor antagonist

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000118

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/445 A, 7A 61K 31/505 B, 7C 07D 211/18 B, 7C 07D 239/34 B, 7C 07D 491/08 B, 7C 07D 487/04 B, 7C 07D 211/58 B, 7C 07D 413/14 B, 7C 07D 401/04 B, 7C 07D 413/12 B, 7C 07D 401/14 B, 7A 61P 15/10 B

A4 Supplementary search report drawn up and despatched

Effective date: 20010404

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20000703