EP0679064A1 - Procede et dispositif de determination percutanee non invasive de la concentration de substances presentes dans des liquides ou des tissus du corps humain - Google Patents
Procede et dispositif de determination percutanee non invasive de la concentration de substances presentes dans des liquides ou des tissus du corps humainInfo
- Publication number
- EP0679064A1 EP0679064A1 EP94929519A EP94929519A EP0679064A1 EP 0679064 A1 EP0679064 A1 EP 0679064A1 EP 94929519 A EP94929519 A EP 94929519A EP 94929519 A EP94929519 A EP 94929519A EP 0679064 A1 EP0679064 A1 EP 0679064A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- radiation
- reflectance
- spectral
- radiation source
- measuring medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000000126 substance Substances 0.000 title claims abstract description 36
- 210000001124 body fluid Anatomy 0.000 title claims description 8
- 239000010839 body fluid Substances 0.000 title claims description 8
- 230000005855 radiation Effects 0.000 claims abstract description 53
- 238000005259 measurement Methods 0.000 claims abstract description 30
- 238000001228 spectrum Methods 0.000 claims abstract description 23
- 238000010521 absorption reaction Methods 0.000 claims abstract description 12
- 210000004369 blood Anatomy 0.000 claims abstract description 11
- 239000008280 blood Substances 0.000 claims abstract description 11
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims abstract description 8
- 230000001419 dependent effect Effects 0.000 claims abstract description 6
- 230000001678 irradiating effect Effects 0.000 claims abstract description 4
- 230000003595 spectral effect Effects 0.000 claims description 40
- 238000013528 artificial neural network Methods 0.000 claims description 28
- 238000000985 reflectance spectrum Methods 0.000 claims description 18
- 238000000411 transmission spectrum Methods 0.000 claims description 15
- 239000003365 glass fiber Substances 0.000 claims description 11
- 238000011156 evaluation Methods 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 10
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 241000282412 Homo Species 0.000 claims description 5
- 238000012854 evaluation process Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 238000007619 statistical method Methods 0.000 claims description 4
- 238000007621 cluster analysis Methods 0.000 claims description 3
- 210000002200 mouth mucosa Anatomy 0.000 claims description 3
- 210000004400 mucous membrane Anatomy 0.000 claims description 3
- 238000002329 infrared spectrum Methods 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 230000036770 blood supply Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 4
- 230000001537 neural effect Effects 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 102000009027 Albumins Human genes 0.000 abstract description 2
- 108010088751 Albumins Proteins 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 239000004202 carbamide Substances 0.000 abstract description 2
- 235000012000 cholesterol Nutrition 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- 230000002503 metabolic effect Effects 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012628 principal component regression Methods 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Definitions
- the artificial neural network is specified with 401 input elements 14, 10 hidden elements 15 and one output element 16.
- the input elements 14 result from the division of the spectral range (900 - 1300) nm into spectral intervals of 1 nm bandwidth, which convert the spectrum into a sequence of 401 intensity values without gaps.
- all necessary steps of the method, including the above-mentioned connection phase of the neural network 13, are now carried out.
- the learning phase for generating the weight matrices of the neural network 13 is carried out by means of a large number of the above-mentioned.
- Spectra and the associated invasively determined substance concentrations were carried out using the error feedback method.
- the artificial neural network 13 automatically learns the ability to recognize the correct substance concentrations from the measured spectrum.
- Halogen lamp is irradiated via a glass fiber bundle 2 onto a well-perfused body surface, the oral mucosa (the upper side of the tongue should be mentioned here as an example).
- the remitted radiation is imaged via a second glass fiber bundle 3 onto the entrance slit 5 of a polychromator 4 (as a dispersing element for spectral decomposition of the radiation).
- the spectrum falling in the spectral range (900 - 1300) nm falling on the detector array 6 is divided by the choice of the mapping of the spectrum and the grid of the detector array 6 in a simple manner into uniform, seamlessly arranged spectral intervals 12 which have a range of selected for this example lnm that of the adjacent spectrum assign corresponding intensity values to the elements of the detector array 6.
- the sequence of intensity measurement values thus output by the detector array 6 to the evaluation unit 7 is evaluated in the latter via an artificial neural network 13 (corresponding to the illustration in FIG. 2).
- the neural network 13 consists of 401 input elements 14, 10 for all of
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Artificial Intelligence (AREA)
- Optics & Photonics (AREA)
- Evolutionary Computation (AREA)
- Signal Processing (AREA)
- Fuzzy Systems (AREA)
- Mathematical Physics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
L'invention a pour objet un procédé et un dispositif de détermination percutanée non invasive de la concentration de substances présentes dans les liquides ou les tissus du corps humain, ledit procédé permettant de limiter l'influence de grandeurs perturbatrices liées à chaque individu et de réduire la dominance de l'absorption de l'eau ainsi que les effets de la circulation du sang à travers les tissus. Le procédé consiste à exposer une partie appropriée de la peau à des rayons à large bande (1, 2), à enregistrer un spectre de transmission ou de réflexion (3, 4, 6), à déterminer une série de mesures d'intensité à des intervalles (12) de ce spectre définis de façon adéquate, et à analyser cette série de mesures d'intensité au moyen d'un réseau neuronal artificiel (13). Ce réseau neuronal (13) apprend, au cours d'une période d'apprentissage, de nombreuses suites de mesures d'intensité et des valeurs de concentrations obtenues simultanément de façon invasive afin de générer des matrices de poids. L'invention peut être appliquée pour la détermination non invasive de concentration de substances présentes dans le sang humain telles que hémoglobine, bilirubine, glucose, albumine, urée, cholestérol et autres produits du métabolisme.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4339067A DE4339067A1 (de) | 1993-11-16 | 1993-11-16 | Verfahren und Anordnung zur nichtinvasiven, transkutanen Bestimmung von Stoffkonzentrationen in Körperflüssigkeit oder Gewebe des Menschen |
| DE4339067 | 1993-11-16 | ||
| PCT/EP1994/003316 WO1995013739A1 (fr) | 1993-11-16 | 1994-10-07 | Procede et dispositif de determination percutanee non invasive de la concentration de substances presentes dans des liquides ou des tissus du corps humain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0679064A1 true EP0679064A1 (fr) | 1995-11-02 |
Family
ID=6502695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP94929519A Withdrawn EP0679064A1 (fr) | 1993-11-16 | 1994-10-07 | Procede et dispositif de determination percutanee non invasive de la concentration de substances presentes dans des liquides ou des tissus du corps humain |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0679064A1 (fr) |
| DE (1) | DE4339067A1 (fr) |
| WO (1) | WO1995013739A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040578A (en) * | 1996-02-02 | 2000-03-21 | Instrumentation Metrics, Inc. | Method and apparatus for multi-spectral analysis of organic blood analytes in noninvasive infrared spectroscopy |
| DE19629342C2 (de) * | 1996-07-20 | 1999-09-02 | Epsa Elektronik Und Praezision | Verfahren und Anordnung zur nicht-invasiven, transkutanen Bestimmung von Stoffkonzentrationen in Körpergeweben |
| CA2283860A1 (fr) * | 1997-03-21 | 1998-10-01 | Nellcor Puritan Bennett Inc. | Procede et appareil d'arbitrage pour obtenir les meilleures estimations de valeurs de fractions sanguines, et de rejet d'harmoniques |
| CA2358473A1 (fr) * | 1999-01-22 | 2000-07-27 | Instrumentation Metrics, Inc. | Systeme et procede de mesures non vulnerantes d'un analyte sanguin |
| US6280381B1 (en) | 1999-07-22 | 2001-08-28 | Instrumentation Metrics, Inc. | Intelligent system for noninvasive blood analyte prediction |
| DE19923658A1 (de) * | 1999-05-22 | 2000-11-23 | Infralytic Gmbh | Vorrichtung zum Messen des Organisationsgrades von Wasser in Säugetierkörpern |
| CH695000A5 (de) * | 2000-01-31 | 2005-10-31 | Swan Analytische Instr Ag | Verfahren zur Detektion von Serum und zur Erfassung seiner Qualitaet und Anordnungen hierzu. |
| JP2003535630A (ja) * | 2000-06-02 | 2003-12-02 | ヘマ メトリクス インコーポレイテッド | 血清中尿素窒素、重量オスモル濃度、プラズマ遊離ヘモグロビン、および、組織水含有量を測定するシステムおよび方法 |
| CN107192690B (zh) * | 2017-05-19 | 2019-04-23 | 重庆大学 | 近红外光谱无创血糖检测方法及其检测网络模型训练方法 |
| DE102019135877B4 (de) * | 2019-12-30 | 2021-09-30 | TRUMPF Venture GmbH | System zur Messung des Vorhandenseins und/oder der Konzentration einer in Körperflüssigkeit gelösten Analysesubstanz |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028787A (en) * | 1989-01-19 | 1991-07-02 | Futrex, Inc. | Non-invasive measurement of blood glucose |
| US5070874A (en) * | 1990-01-30 | 1991-12-10 | Biocontrol Technology, Inc. | Non-invasive determination of glucose concentration in body of patients |
| US5259382A (en) * | 1991-03-04 | 1993-11-09 | Kronberg James W | Optical transcutaneous bilirubin detector |
| US5321265A (en) * | 1992-07-15 | 1994-06-14 | Block Myron J | Non-invasive testing |
-
1993
- 1993-11-16 DE DE4339067A patent/DE4339067A1/de not_active Withdrawn
-
1994
- 1994-10-07 EP EP94929519A patent/EP0679064A1/fr not_active Withdrawn
- 1994-10-07 WO PCT/EP1994/003316 patent/WO1995013739A1/fr not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9513739A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995013739A1 (fr) | 1995-05-26 |
| DE4339067A1 (de) | 1995-05-18 |
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Legal Events
| Date | Code | Title | Description |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| 17P | Request for examination filed |
Effective date: 19950314 |
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| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT CH DE FR GB IT LI |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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| 18D | Application deemed to be withdrawn |
Effective date: 19970501 |