EP0673251A4 - - Google Patents

Info

Publication number
EP0673251A4
EP0673251A4 EP94901600A EP94901600A EP0673251A4 EP 0673251 A4 EP0673251 A4 EP 0673251A4 EP 94901600 A EP94901600 A EP 94901600A EP 94901600 A EP94901600 A EP 94901600A EP 0673251 A4 EP0673251 A4 EP 0673251A4
Authority
EP
European Patent Office
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94901600A
Other versions
EP0673251A1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929224213A external-priority patent/GB9224213D0/en
Priority claimed from GB939316954A external-priority patent/GB9316954D0/en
Application filed filed Critical
Publication of EP0673251A1 publication Critical patent/EP0673251A1/en
Publication of EP0673251A4 publication Critical patent/EP0673251A4/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
EP94901600A 1992-11-18 1993-11-18 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors Withdrawn EP0673251A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9224213 1992-11-18
GB929224213A GB9224213D0 (en) 1992-11-18 1992-11-18 Compounds
GB9316954 1993-08-14
GB939316954A GB9316954D0 (en) 1993-08-14 1993-08-14 Compounds
PCT/US1993/011225 WO1994011004A1 (en) 1992-11-18 1993-11-18 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors

Publications (2)

Publication Number Publication Date
EP0673251A1 EP0673251A1 (en) 1995-09-27
EP0673251A4 true EP0673251A4 (en) 1995-10-25

Family

ID=26302003

Family Applications (2)

Application Number Title Priority Date Filing Date
EP94902307A Withdrawn EP0669932A4 (en) 1992-11-18 1993-11-18 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase.
EP94901600A Withdrawn EP0673251A1 (en) 1992-11-18 1993-11-18 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP94902307A Withdrawn EP0669932A4 (en) 1992-11-18 1993-11-18 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase.

Country Status (12)

Country Link
EP (2) EP0669932A4 (en)
JP (1) JPH08503471A (en)
CN (2) CN1101914A (en)
AP (1) AP9300589A0 (en)
AU (2) AU5613394A (en)
CA (1) CA2149427A1 (en)
IL (1) IL107611A0 (en)
MA (1) MA23036A1 (en)
MX (1) MX9307203A (en)
NZ (1) NZ258723A (en)
SI (1) SI9300601A (en)
WO (2) WO1994011386A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
GB9415183D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 3-carboxysteroids with a fluorinated side-chain
EP0784627A4 (en) * 1994-10-05 1998-05-06 Smithkline Beecham Corp Process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
CN1130363C (en) 1997-11-12 2003-12-10 三菱化学株式会社 Purine derivatives and medicine containing the same as the active ingredient
CA2373015A1 (en) 1999-05-11 2000-11-16 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
FR2817257B1 (en) 2000-11-30 2009-03-20 Sanofi Synthelabo CYCLOHEXYL (ALKYL) -PROPANOLAMINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0465123A2 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes
EP0465142A1 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. 17Beta-acyl-3-carboxy-androsta-3, 5-dienes as testosterone 5alpha-reductase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041433A (en) * 1987-04-29 1991-08-20 Smithkline Beecham Corporation 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5137882A (en) * 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
US5196411A (en) * 1991-08-16 1993-03-23 Merck & Co., Inc. 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0465123A2 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes
EP0465142A1 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. 17Beta-acyl-3-carboxy-androsta-3, 5-dienes as testosterone 5alpha-reductase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9411004A1 *

Also Published As

Publication number Publication date
EP0673251A1 (en) 1995-09-27
JPH08503471A (en) 1996-04-16
WO1994011004A1 (en) 1994-05-26
IL107611A0 (en) 1994-02-27
NZ258723A (en) 1996-12-20
SI9300601A (en) 1994-06-30
AU5671794A (en) 1994-06-08
EP0669932A1 (en) 1995-09-06
AU5613394A (en) 1994-06-08
AP9300589A0 (en) 1994-01-31
CN1101916A (en) 1995-04-26
EP0669932A4 (en) 1995-10-25
CN1101914A (en) 1995-04-26
CA2149427A1 (en) 1994-05-26
WO1994011386A1 (en) 1994-05-26
MA23036A1 (en) 1994-07-01
MX9307203A (en) 1994-07-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19950516

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A4 Supplementary search report drawn up and despatched

Effective date: 19950908

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RHK1 Main classification (correction)

Ipc: C07J 9/00

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990601