MX9307203A - STEROIDAL COMPOUNDS OF ACIL-3-CARBOXI-3,5-DIENO-17Ó AND 17ß-SUBSTITUTED. - Google Patents
STEROIDAL COMPOUNDS OF ACIL-3-CARBOXI-3,5-DIENO-17Ó AND 17ß-SUBSTITUTED.Info
- Publication number
- MX9307203A MX9307203A MX9307203A MX9307203A MX9307203A MX 9307203 A MX9307203 A MX 9307203A MX 9307203 A MX9307203 A MX 9307203A MX 9307203 A MX9307203 A MX 9307203A MX 9307203 A MX9307203 A MX 9307203A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- substituted
- carboxi
- dieno
- acil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Abstract
Se describen análogos de acil-3-carboxi-3,5-dieno 17Ó y 17ß substituídos de compuestos sintéticos esteroidales, composiciones farmacéuticas que contienen estos compuestos y métodos para usar estos compuestos para inhibir 5-Ó-reductasa esteroidal. También se describen compuestos intermediarios y procedimientos usados en la preparación de estos compuestos.Described 17O and 17ß substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroidal 5-O-reductase are described. Intermediate compounds and procedures used in the preparation of these compounds are also described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929224213A GB9224213D0 (en) | 1992-11-18 | 1992-11-18 | Compounds |
GB939316954A GB9316954D0 (en) | 1993-08-14 | 1993-08-14 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9307203A true MX9307203A (en) | 1994-07-29 |
Family
ID=26302003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9307203A MX9307203A (en) | 1992-11-18 | 1993-11-17 | STEROIDAL COMPOUNDS OF ACIL-3-CARBOXI-3,5-DIENO-17Ó AND 17ß-SUBSTITUTED. |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP0673251A1 (en) |
JP (1) | JPH08503471A (en) |
CN (2) | CN1101914A (en) |
AP (1) | AP9300589A0 (en) |
AU (2) | AU5613394A (en) |
CA (1) | CA2149427A1 (en) |
IL (1) | IL107611A0 (en) |
MA (1) | MA23036A1 (en) |
MX (1) | MX9307203A (en) |
NZ (1) | NZ258723A (en) |
SI (1) | SI9300601A (en) |
WO (2) | WO1994011386A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
GB9415178D0 (en) * | 1994-07-28 | 1994-09-21 | Erba Carlo Spa | 4-azasteroids with side-chain fluoroketones |
GB9415183D0 (en) * | 1994-07-28 | 1994-09-21 | Erba Carlo Spa | 3-carboxysteroids with a fluorinated side-chain |
EP0784627A4 (en) * | 1994-10-05 | 1998-05-06 | Smithkline Beecham Corp | Process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
KR100540046B1 (en) | 1997-11-12 | 2006-01-10 | 미쓰비시 가가꾸 가부시키가이샤 | Purine Derivatives and Medicine Containing the Same as the Active Ingredient |
KR100747106B1 (en) | 1999-05-11 | 2007-08-08 | 미쯔비시 가가꾸 가부시끼가이샤 | Purine Derivative Dihydrate, Drugs Containing the Same as the Active Ingredient and Intermediate in the Production Thereof |
FR2817257B1 (en) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | CYCLOHEXYL (ALKYL) -PROPANOLAMINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
GB201102913D0 (en) | 2011-02-18 | 2011-04-06 | Univ Birmingham | Novel therapeutic |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
US5041433A (en) * | 1987-04-29 | 1991-08-20 | Smithkline Beecham Corporation | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase |
US4954446A (en) * | 1988-05-25 | 1990-09-04 | Smithkline Beecham Corporation | Aromatic steroid 5-α-reductase inhibitors |
US5032586A (en) * | 1989-08-24 | 1991-07-16 | Smithkline Beecham Corporation | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase |
US5137882A (en) * | 1990-06-11 | 1992-08-11 | Holt Dennis A | Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
CA2045866A1 (en) * | 1990-06-28 | 1991-12-29 | Gary H. Rasmusson | 17-beta-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5 alpha-reductase inhibitors |
EP0465123A3 (en) * | 1990-06-28 | 1992-05-06 | Merck & Co. Inc. | New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes |
US5196411A (en) * | 1991-08-16 | 1993-03-23 | Merck & Co., Inc. | 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors |
-
1993
- 1993-11-15 AP APAP/P/1993/000589A patent/AP9300589A0/en unknown
- 1993-11-15 IL IL10761193A patent/IL107611A0/en unknown
- 1993-11-17 MA MA23342A patent/MA23036A1/en unknown
- 1993-11-17 MX MX9307203A patent/MX9307203A/en unknown
- 1993-11-18 AU AU56133/94A patent/AU5613394A/en not_active Abandoned
- 1993-11-18 EP EP94901600A patent/EP0673251A1/en not_active Withdrawn
- 1993-11-18 WO PCT/US1993/011241 patent/WO1994011386A1/en not_active Application Discontinuation
- 1993-11-18 WO PCT/US1993/011225 patent/WO1994011004A1/en not_active Application Discontinuation
- 1993-11-18 JP JP6512499A patent/JPH08503471A/en active Pending
- 1993-11-18 EP EP94902307A patent/EP0669932A4/en not_active Withdrawn
- 1993-11-18 AU AU56717/94A patent/AU5671794A/en not_active Abandoned
- 1993-11-18 NZ NZ258723A patent/NZ258723A/en unknown
- 1993-11-18 SI SI9300601A patent/SI9300601A/en unknown
- 1993-11-18 CN CN93114775A patent/CN1101914A/en active Pending
- 1993-11-18 CA CA002149427A patent/CA2149427A1/en not_active Abandoned
- 1993-11-18 CN CN93121434A patent/CN1101916A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU5671794A (en) | 1994-06-08 |
WO1994011004A1 (en) | 1994-05-26 |
AU5613394A (en) | 1994-06-08 |
AP9300589A0 (en) | 1994-01-31 |
SI9300601A (en) | 1994-06-30 |
CN1101914A (en) | 1995-04-26 |
EP0669932A1 (en) | 1995-09-06 |
CA2149427A1 (en) | 1994-05-26 |
WO1994011386A1 (en) | 1994-05-26 |
EP0673251A1 (en) | 1995-09-27 |
EP0669932A4 (en) | 1995-10-25 |
EP0673251A4 (en) | 1995-10-25 |
NZ258723A (en) | 1996-12-20 |
MA23036A1 (en) | 1994-07-01 |
JPH08503471A (en) | 1996-04-16 |
IL107611A0 (en) | 1994-02-27 |
CN1101916A (en) | 1995-04-26 |
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