EP0667397A1 - Vermittler, geeignet für die elektrochemische Regenerierung von NADH, NADPH oder deren Analoga - Google Patents

Vermittler, geeignet für die elektrochemische Regenerierung von NADH, NADPH oder deren Analoga Download PDF

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Publication number
EP0667397A1
EP0667397A1 EP95100849A EP95100849A EP0667397A1 EP 0667397 A1 EP0667397 A1 EP 0667397A1 EP 95100849 A EP95100849 A EP 95100849A EP 95100849 A EP95100849 A EP 95100849A EP 0667397 A1 EP0667397 A1 EP 0667397A1
Authority
EP
European Patent Office
Prior art keywords
electrode
mediator
nadh
acridin
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95100849A
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English (en)
French (fr)
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EP0667397B1 (de
Inventor
Paul F. Corey
Matthew K. Musho
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Bayer Corp
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Bayer AG
Bayer Corp
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Publication of EP0667397A1 publication Critical patent/EP0667397A1/de
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Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/86—Inert electrodes with catalytic activity, e.g. for fuel cells
    • H01M4/90—Selection of catalytic material
    • H01M4/9008—Organic or organo-metallic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M8/00—Fuel cells; Manufacture thereof
    • H01M8/16—Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/50—Fuel cells

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Energy (AREA)
  • Sustainable Development (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Inert Electrodes (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Electrodes For Compound Or Non-Metal Manufacture (AREA)
  • Pyridine Compounds (AREA)
EP95100849A 1994-02-03 1995-01-23 Vermittler, geeignet für die elektrochemische Regenerierung von NADH, NADPH oder deren Analoga Expired - Lifetime EP0667397B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US190855 1994-02-03
US08/190,855 US5393615A (en) 1994-02-03 1994-02-03 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof

Publications (2)

Publication Number Publication Date
EP0667397A1 true EP0667397A1 (de) 1995-08-16
EP0667397B1 EP0667397B1 (de) 2001-10-04

Family

ID=22703075

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95100849A Expired - Lifetime EP0667397B1 (de) 1994-02-03 1995-01-23 Vermittler, geeignet für die elektrochemische Regenerierung von NADH, NADPH oder deren Analoga

Country Status (8)

Country Link
US (1) US5393615A (de)
EP (1) EP0667397B1 (de)
JP (1) JP3585552B2 (de)
AT (1) ATE206466T1 (de)
AU (1) AU674463B2 (de)
CA (1) CA2141494C (de)
DE (1) DE69522975T2 (de)
ES (1) ES2161787T3 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1565957A2 (de) * 2002-11-27 2005-08-24 St. Louis University Enzymimmobilisierung für die verwendung in biobrennstoffzellen und biosensoren
US8415059B2 (en) 2005-11-02 2013-04-09 St. Louis University Direct electron transfer using enzymes in bioanodes, biocathodes, and biofuel cells
US8859151B2 (en) 2003-11-05 2014-10-14 St. Louis University Immobilized enzymes in biocathodes

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* Cited by examiner, † Cited by third party
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GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US5498542A (en) * 1994-09-29 1996-03-12 Bayer Corporation Electrode mediators for regeneration of NADH and NADPH
US5520786A (en) * 1995-06-06 1996-05-28 Bayer Corporation Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof
US5866353A (en) * 1996-12-09 1999-02-02 Bayer Corporation Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration
US6500571B2 (en) * 1998-08-19 2002-12-31 Powerzyme, Inc. Enzymatic fuel cell
GB0120698D0 (en) * 2001-08-24 2001-10-17 Isis Innovations Ltd Fuel cell
US7163616B2 (en) * 2001-09-14 2007-01-16 Bayer Corporation Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes
WO2003040690A2 (en) * 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
US20050186652A1 (en) * 2002-02-22 2005-08-25 Wong Luet L. Electrochemical detection
GB0204232D0 (en) * 2002-02-22 2002-04-10 Isis Innovation Assay
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
CN1981404A (zh) * 2004-03-15 2007-06-13 圣路易斯大学 微流体生物燃料电池
EP2371927B1 (de) 2004-09-16 2020-03-11 Life Technologies Corporation Floureszierende Farbstoffverbindungen, Konjugate und Verwendungen damit
KR20080086977A (ko) * 2005-11-02 2008-09-29 세인트 루이스 유니버시티 소수성 개질된 다당류에 고정화된 효소
WO2008082694A2 (en) * 2006-07-14 2008-07-10 Akermin, Inc. Organelles in bioanodes, biocathodes, and biofuel cells
WO2008036516A1 (en) 2006-09-22 2008-03-27 Bayer Healthcare Llc Biosensor system having enhanced stability and hematocrit performance
ES2825036T3 (es) 2006-10-24 2021-05-14 Ascensia Diabetes Care Holdings Ag Amperometría de decaimiento transitorio
EP2080243A2 (de) * 2006-11-06 2009-07-22 Akermin, Inc. Bioanoden- und biokathodenstapelbaugruppen
ES2636676T3 (es) 2007-09-24 2017-10-06 Ascensia Diabetes Care Holdings Ag Método de ensayo de múltiples electrodos
EP2056383A1 (de) * 2007-11-02 2009-05-06 Tsing Hua University Membranelektrodenanordnung und Verfahren zu ihrer Herstellung
CA2708156C (en) 2007-12-10 2018-01-23 Bayer Healthcare Llc Reagents and methods for detecting analytes
RU2524660C2 (ru) 2007-12-10 2014-07-27 БАЙЕР ХЕЛТКЭА ЭлЭлСи Способ получения медиатора 3-фенилимино-3н-фенотиазина или 3-фенилимино-3н-феноксазина
EP2235526B1 (de) 2007-12-10 2018-02-14 Ascensia Diabetes Care Holdings AG Poröse partikelreagenzzusammensetzungen, vorrichtungen und verfahren für biosensoren
BRPI0913667A2 (pt) * 2008-02-20 2016-08-02 Nagarjuna Fertilizers And Chemicals Ltd microorganismos geneticamente transformados com aumento simultâneo de potencial de redução e atividades de enzima redutiva para fermentação de biomassa
US8008037B2 (en) * 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
EP3435077A1 (de) 2008-07-10 2019-01-30 Ascensia Diabetes Care Holdings AG Systeme und verfahren mit amperometrischem und voltametrische arbeitszyklen
DK2373805T3 (en) 2008-12-08 2015-12-07 Bayer Healthcare Llc Reagent LOW TOTAL SALT AND SYSTEMS FOR biosensors
US8283347B2 (en) * 2009-06-01 2012-10-09 Bayer Healthcare Llc Redox molecules and methods of making the same
KR101685234B1 (ko) 2009-11-10 2016-12-09 바이엘 헬스케어 엘엘씨 바이오센서용 언더필 인식 시스템
WO2011075575A1 (en) 2009-12-17 2011-06-23 Bayer Healthcare Llc Transdermal systems, devices, and methods to optically analyze an analyte
WO2011084607A1 (en) 2009-12-17 2011-07-14 Bayer Healthcare Llc Transdermal systems, devices, and methods for biological analysis
US9233788B2 (en) 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
US8742063B2 (en) 2010-05-28 2014-06-03 Bayer Healthcare Llc Polymer bonded redox molecules and methods of making the same
EP2913408A1 (de) 2010-12-29 2015-09-02 Life Technologies Corporation Ddao-verbindungen als fluoreszenzreferenzsandards
TWI565943B (zh) 2011-07-22 2017-01-11 拜耳保健公司 具有增進測量性能之生物感測器乾燥劑系統
CA2891285C (en) 2013-01-28 2021-05-04 F. Hoffmann-La Roche Ag Novel glucose oxidases derived from aspergillus niger
KR102372113B1 (ko) * 2016-10-05 2022-03-07 에프. 호프만-라 로슈 아게 다중 분석물 진단 테스트 엘리먼트들을 위한 검출 시약들 및 전극 배열들, 그리고 그것을 사용하는 방법들
RU2706117C1 (ru) * 2019-09-03 2019-11-14 Федеральное государственное бюджетное образовательное учреждение высшего образования «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва» Применение материала на основе безметального электрокатализатора для получения молекулярного водорода из воды в присутствии органических солей

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490464A (en) * 1981-04-08 1984-12-25 Gorton Lo G Electrode for the electrochemical regeneration of coenzyme, a method of making said electrode, and the use thereof
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5264092A (en) 1991-10-02 1993-11-23 Moltech Corporation Redox polymer modified electrode for the electrochemical regeneration of coenzyme

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490464A (en) * 1981-04-08 1984-12-25 Gorton Lo G Electrode for the electrochemical regeneration of coenzyme, a method of making said electrode, and the use thereof
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5264092A (en) 1991-10-02 1993-11-23 Moltech Corporation Redox polymer modified electrode for the electrochemical regeneration of coenzyme

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DOLABDJIAN ET AL.: "Enzyme Engineering", vol. 4, 1978, PLENUM PRESS, pages: 399 - 400
HILL ET AL., NEW PHYTOLOGY, vol. 77, 1976, pages 1 - 9
IN J. ELECTROANAL. CHEM., vol. 287, 1990, pages 61 - 80
J. ELECTROANAL CHEM., vol. 292, 1990, pages 115 - 138
M. PERSSON ET AL., BIOTECHNOLOGY, vol. 9, 1991, pages 280 - 284

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1565957A2 (de) * 2002-11-27 2005-08-24 St. Louis University Enzymimmobilisierung für die verwendung in biobrennstoffzellen und biosensoren
US7638228B2 (en) 2002-11-27 2009-12-29 Saint Louis University Enzyme immobilization for use in biofuel cells and sensors
EP2343765A1 (de) * 2002-11-27 2011-07-13 St. Louis University Bioanoden für die Anwendung in Biobrennstoffzellen
EP2343766A1 (de) * 2002-11-27 2011-07-13 St. Louis University Immobilisierte Enzyme und deren Verwendung in Bio-Brennstoffzellen und Sensoren
US8048660B2 (en) 2002-11-27 2011-11-01 Saint Louis University Immobilized enzymes and uses thereof
US8859151B2 (en) 2003-11-05 2014-10-14 St. Louis University Immobilized enzymes in biocathodes
US8415059B2 (en) 2005-11-02 2013-04-09 St. Louis University Direct electron transfer using enzymes in bioanodes, biocathodes, and biofuel cells

Also Published As

Publication number Publication date
AU8028094A (en) 1995-08-10
JP3585552B2 (ja) 2004-11-04
US5393615A (en) 1995-02-28
EP0667397B1 (de) 2001-10-04
CA2141494C (en) 2003-01-14
DE69522975D1 (de) 2001-11-08
ATE206466T1 (de) 2001-10-15
JPH07310194A (ja) 1995-11-28
DE69522975T2 (de) 2002-04-04
ES2161787T3 (es) 2001-12-16
CA2141494A1 (en) 1995-08-04
AU674463B2 (en) 1996-12-19

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