EP0660710A4 - Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre. - Google Patents

Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre.

Info

Publication number
EP0660710A4
EP0660710A4 EP19930909132 EP93909132A EP0660710A4 EP 0660710 A4 EP0660710 A4 EP 0660710A4 EP 19930909132 EP19930909132 EP 19930909132 EP 93909132 A EP93909132 A EP 93909132A EP 0660710 A4 EP0660710 A4 EP 0660710A4
Authority
EP
European Patent Office
Prior art keywords
phosphonoacetyl
compositions
methods
aspartic acid
broad spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19930909132
Other languages
German (de)
English (en)
Other versions
EP0660710A1 (fr
Inventor
Herbert A Blough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/032,234 external-priority patent/US5491135A/en
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of EP0660710A4 publication Critical patent/EP0660710A4/fr
Publication of EP0660710A1 publication Critical patent/EP0660710A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP93909132A 1992-03-18 1993-03-18 Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre Withdrawn EP0660710A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85345492A 1992-03-18 1992-03-18
US853454 1992-03-18
US32234 1993-03-17
US08/032,234 US5491135A (en) 1992-03-18 1993-03-17 Compositions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals
PCT/US1993/002432 WO1993018763A1 (fr) 1992-03-18 1993-03-18 Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre

Publications (2)

Publication Number Publication Date
EP0660710A4 true EP0660710A4 (fr) 1995-03-02
EP0660710A1 EP0660710A1 (fr) 1995-07-05

Family

ID=26708159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93909132A Withdrawn EP0660710A1 (fr) 1992-03-18 1993-03-18 Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre

Country Status (10)

Country Link
EP (1) EP0660710A1 (fr)
JP (1) JPH07507770A (fr)
CN (1) CN1080853A (fr)
AU (1) AU3965993A (fr)
BR (1) BR9306123A (fr)
CA (1) CA2109435C (fr)
IL (1) IL105090A (fr)
IS (1) IS3987A (fr)
MX (1) MX9301527A (fr)
WO (1) WO1993018763A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
AU753336B2 (en) 1997-11-10 2002-10-17 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
WO1999040916A1 (fr) 1998-02-12 1999-08-19 G.D. Searle & Co. Utilisation de composes n-substitue-1,5-didesoxy-1,5-imino-d-glucitol dans le traitement des infections dues au virus de l'hepatite
WO2000047198A2 (fr) 1999-02-12 2000-08-17 G.D. Searle & Co. Utilisation de composes substitues 1,5-dideoxy-1,5-imino-d-glucitol pour traiter les infections par le virus de l'hepatite
CA2362785A1 (fr) 1999-02-12 2001-02-08 G.D. Searle & Co. Composes glucamine destines au traitement d'infections dues au virus de l'hepatite
WO2001045727A2 (fr) * 1999-12-20 2001-06-28 New Pharma Research Sweden Ab Compositions veterinaires
DE10138912A1 (de) * 2001-08-08 2003-02-27 Medinnova Ges Med Innovationen Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen
DE10343365A1 (de) * 2003-09-17 2005-04-14 Biosphings Ag Pharmazeutische Formulierungen von Xanthogenaten und Hemmstoffen der viralen Nukleinsäurereplikation
US8236768B2 (en) 2008-10-03 2012-08-07 3B Pharmaceuticals, Inc. Topical antiviral formulations
CN111317733B (zh) * 2020-03-24 2022-07-12 中国人民解放军海军军医大学 利福霉素类抗生素在制备抗黄热病毒感染药物中的应用
WO2021189444A1 (fr) * 2020-03-24 2021-09-30 中国人民解放军海军军医大学 Utilisation d'antibiotiques du type rifamycine dans la préparation de médicaments contre des infections par le virus de la fièvre jaune
CN111419839A (zh) * 2020-03-31 2020-07-17 远见生物科技（上海）有限公司 利福霉素的新用途
US20230147364A1 (en) * 2020-04-30 2023-05-11 Kyoto University Prophylactic or therapeutic agent for rna virus-related diseases
EP4313150A1 (fr) * 2021-03-26 2024-02-07 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Combinaison d'inhibiteur de la biosynthèse de la pyrimidine destinée à être utilisée dans le traitement d'infections virales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178306A (en) * 1978-08-10 1979-12-11 Parsons Jack L Preparation of N-(phosphonoacetyl)-L-aspartic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
BR9306123A (pt) 1997-08-26
JPH07507770A (ja) 1995-08-31
IL105090A0 (en) 1994-08-26
WO1993018763A1 (fr) 1993-09-30
MX9301527A (es) 1994-02-28
CN1080853A (zh) 1994-01-19
AU3965993A (en) 1993-10-21
EP0660710A1 (fr) 1995-07-05
CA2109435A1 (fr) 1993-09-19
CA2109435C (fr) 1997-03-11
IS3987A (is) 1993-09-19
IL105090A (en) 1998-08-16

Similar Documents

Publication Publication Date Title
EP0660710A4 (fr) Compositions d'acide n-(phosphonoacetyle)-l-aspartique (pala) et procedes d'utilisation de ces dernieres en tant que compositions antivirales a large spectre.
IL112495A0 (en) Phenylacetic acid derivatives, their preparation and compositions containing them
ZA931934B (en) Compostitions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals
ZA9510138B (en) Cosmetic compositions containing betullnic acid
ZA935532B (en) Crystalline amifostine compositions and methods for the preparation and use of same
AU7694787A (en) Compositions for the prolonged action of anti-plaque agents
NZ212436A (en) D,l-glutamic and d,l-aspartic acid derivatives and pharmaceutical compositions
GB2216119B (en) Preparation of organometallic amide compositions
PT78341B (en) Process for the preparation of new 3-(3,4-di-hydroxyphenyl)-alanine phosphorilates derivatives and compositions for tanning containing then
AU2392392A (en) Novel benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use
PH24326A (en) Substituted 3,4-dihydro-2h-benzopyrans,pharmaceutical compositions containing same and method of use thereof
PH23447A (en) B-actam compounds,pharmaceutical compositions containing the same and method of use thereof
HUT41206A (en) Fungicide compositions containing alpha-oximino-alpha-carbamoyl-acetonitril derivatives as active agents and process for producing the active agents
DE3463038D1 (en) Titanium chelates and compositions containing these chelates
HUT41764A (en) Herbicide compositions containing 5-amino-4-cyano-1-pyridyl-pyrazole derivatives as active agents and process for producing the active agents
HUT44011A (en) Herbicide compositions containing n-substituted-3,4,5,6-tetrahydro-phtalimide derivatives as active components and process for producing the active components
PL317467A1 (en) Novel taxoides, method of obtaining them and pharmaceutic compositions containing them
HUT44129A (en) Herbicide compositions containing 1-aryl-pyrazol derivatives as active components and process for producing 1-aryl-pyrazol derivatives
PH21556A (en) Phenyl nonatetraenoic acid derivatives, pharmaceutical compositions containing the same and method of use thereof
NZ210716A (en) Pyridyloxytrifluoromethanesulphonanilide derivatives and compositions for protecting keratin from insects
AU583390B2 (en) Co-vulcanizable compositions of fluoroelastomers
AU3454984A (en) 1,z-dithiolanes and pharmaceutical compositions
UA42797C2 (uk) Похідні хінолон- і нафтиридонкарбонової кислоти та похідні ізоіндолу для їх одержання
ZA939155B (en) Substituted N-hydroxycinnamamides processes for their preparation compositions containing them and their use
HU9700437D0 (en) Substituted thiophenyl-alkenyl-carboxylic-acid-guanidid-derivatives, their production, their use as active component of pharmaceutical compositions, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
A4 Supplementary search report drawn up and despatched
AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19941017

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19980526

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19981205