EP0660710A4 - Compositions of n-(phosphonoacetyl)-l-aspartic acid and methods of their use as broad spectrum antivirals. - Google Patents

Compositions of n-(phosphonoacetyl)-l-aspartic acid and methods of their use as broad spectrum antivirals.

Info

Publication number
EP0660710A4
EP0660710A4 EP19930909132 EP93909132A EP0660710A4 EP 0660710 A4 EP0660710 A4 EP 0660710A4 EP 19930909132 EP19930909132 EP 19930909132 EP 93909132 A EP93909132 A EP 93909132A EP 0660710 A4 EP0660710 A4 EP 0660710A4
Authority
EP
European Patent Office
Prior art keywords
phosphonoacetyl
compositions
methods
aspartic acid
broad spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19930909132
Other languages
German (de)
French (fr)
Other versions
EP0660710A1 (en
Inventor
Herbert A Blough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/032,234 external-priority patent/US5491135A/en
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of EP0660710A4 publication Critical patent/EP0660710A4/en
Publication of EP0660710A1 publication Critical patent/EP0660710A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP93909132A 1992-03-18 1993-03-18 Compositions of n-(phosphonoacetyl)-l-aspartic acid and methods of their use as broad spectrum antivirals Withdrawn EP0660710A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85345492A 1992-03-18 1992-03-18
US853454 1992-03-18
US08/032,234 US5491135A (en) 1992-03-18 1993-03-17 Compositions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals
PCT/US1993/002432 WO1993018763A1 (en) 1992-03-18 1993-03-18 Compositions of n-(phosphonoacetyl)-l-aspartic acid and methods of their use as broad spectrum antivirals
US32234 1998-02-27

Publications (2)

Publication Number Publication Date
EP0660710A4 true EP0660710A4 (en) 1995-03-02
EP0660710A1 EP0660710A1 (en) 1995-07-05

Family

ID=26708159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93909132A Withdrawn EP0660710A1 (en) 1992-03-18 1993-03-18 Compositions of n-(phosphonoacetyl)-l-aspartic acid and methods of their use as broad spectrum antivirals

Country Status (10)

Country Link
EP (1) EP0660710A1 (en)
JP (1) JPH07507770A (en)
CN (1) CN1080853A (en)
AU (1) AU3965993A (en)
BR (1) BR9306123A (en)
CA (1) CA2109435C (en)
IL (1) IL105090A (en)
IS (1) IS3987A (en)
MX (1) MX9301527A (en)
WO (1) WO1993018763A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
MY122499A (en) 1997-11-10 2006-04-29 Searle & Co Use of alkylated iminosugars to treat multidrug resistance
BR9907882A (en) 1998-02-12 2000-10-17 Searle & Co Use of unsubstituted 1,5-dideoxy-1,5-imino-d-glucitol compounds for the treatment of hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
EP1239923A2 (en) * 1999-12-20 2002-09-18 New Pharma Research Sweden AB Stabilized veterinary compositions comprising more than one antiviral agent
DE10138912A1 (en) * 2001-08-08 2003-02-27 Medinnova Ges Med Innovationen Use of active substances for the prophylaxis and / or therapy of viral diseases as well as test system for finding such active substances
DE10343365A1 (en) * 2003-09-17 2005-04-14 Biosphings Ag Pharmaceutical Formulations of Xanthogenates and Inhibitors of Viral Nucleic Acid Replication
US8236768B2 (en) 2008-10-03 2012-08-07 3B Pharmaceuticals, Inc. Topical antiviral formulations
WO2021189444A1 (en) * 2020-03-24 2021-09-30 中国人民解放军海军军医大学 Use of rifamycin antibiotics in preparation of drugs against yellow fever virus infections
CN111317733B (en) * 2020-03-24 2022-07-12 中国人民解放军海军军医大学 Application of rifamycin antibiotics in preparation of drugs for resisting yellow fever virus infection
CN111419839A (en) * 2020-03-31 2020-07-17 远见生物科技（上海）有限公司 New application of rifamycin
JPWO2021221111A1 (en) * 2020-04-30 2021-11-04
WO2022200615A1 (en) * 2021-03-26 2022-09-29 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Pyrimidine biosynthesis inhibitor combination for use in treating viral infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178306A (en) * 1978-08-10 1979-12-11 Parsons Jack L Preparation of N-(phosphonoacetyl)-L-aspartic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
BR9306123A (en) 1997-08-26
MX9301527A (en) 1994-02-28
CA2109435C (en) 1997-03-11
EP0660710A1 (en) 1995-07-05
JPH07507770A (en) 1995-08-31
AU3965993A (en) 1993-10-21
WO1993018763A1 (en) 1993-09-30
IL105090A0 (en) 1994-08-26
CN1080853A (en) 1994-01-19
IL105090A (en) 1998-08-16
CA2109435A1 (en) 1993-09-19
IS3987A (en) 1993-09-19

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