EP0651643A4 - STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5--g(a)-REDUCTASE. - Google Patents

STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5--g(a)-REDUCTASE.

Info

Publication number
EP0651643A4
EP0651643A4 EP93915499A EP93915499A EP0651643A4 EP 0651643 A4 EP0651643 A4 EP 0651643A4 EP 93915499 A EP93915499 A EP 93915499A EP 93915499 A EP93915499 A EP 93915499A EP 0651643 A4 EP0651643 A4 EP 0651643A4
Authority
EP
European Patent Office
Prior art keywords
alkylketone
reductase inhibitors
steroids useful
steroids
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93915499A
Other languages
German (de)
English (en)
Other versions
EP0651643A1 (fr
Inventor
Dennis Alan Holt
Mark Alan Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0651643A1 publication Critical patent/EP0651643A1/fr
Publication of EP0651643A4 publication Critical patent/EP0651643A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP93915499A 1992-06-30 1993-06-30 STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5--g(a)-REDUCTASE. Withdrawn EP0651643A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9213835 1992-06-30
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds
PCT/US1993/006238 WO1994000125A1 (fr) 1992-06-30 1993-06-30 STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5-α-REDUCTASE

Publications (2)

Publication Number Publication Date
EP0651643A1 EP0651643A1 (fr) 1995-05-10
EP0651643A4 true EP0651643A4 (fr) 1995-10-04

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93915499A Withdrawn EP0651643A4 (fr) 1992-06-30 1993-06-30 STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5--g(a)-REDUCTASE.

Country Status (23)

Country Link
EP (1) EP0651643A4 (fr)
JP (1) JPH08500821A (fr)
KR (1) KR950702118A (fr)
CN (1) CN1095382A (fr)
AP (1) AP412A (fr)
AU (1) AU4545993A (fr)
BG (1) BG99313A (fr)
BR (1) BR9306748A (fr)
CA (1) CA2138956A1 (fr)
CZ (1) CZ334694A3 (fr)
FI (1) FI946189A (fr)
GB (1) GB9213835D0 (fr)
HU (1) HUT69409A (fr)
IL (1) IL106158A0 (fr)
MA (1) MA22927A1 (fr)
MX (1) MX9303970A (fr)
NO (1) NO945074L (fr)
OA (1) OA10122A (fr)
RU (1) RU94046378A (fr)
SI (1) SI9300350A (fr)
SK (1) SK159994A3 (fr)
WO (1) WO1994000125A1 (fr)
ZA (1) ZA934645B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
CA2135056A1 (fr) * 1992-05-20 1993-11-25 Donald W. Graham Nouveaux 17b-a substituant-4-aza-5a-andros-tan-3-ones olefiniques en delta-17 et delta-20 et satures, servant d'inhibiteurs de la 5a-reductase
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (ja) 2013-12-19 2015-07-16 ロレアル 組成物
WO2019154257A1 (fr) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 Régulateur de dérivé de stéroïde, son procédé de préparation et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
RU94046378A (ru) 1996-10-10
NO945074D0 (no) 1994-12-29
EP0651643A1 (fr) 1995-05-10
BR9306748A (pt) 1998-12-08
FI946189A0 (fi) 1994-12-30
CN1095382A (zh) 1994-11-23
GB9213835D0 (en) 1992-08-12
HUT69409A (en) 1995-09-28
FI946189A (fi) 1994-12-30
JPH08500821A (ja) 1996-01-30
AP9300542A0 (en) 1993-07-31
AP412A (en) 1995-09-29
SI9300350A (sl) 1993-12-31
AU4545993A (en) 1994-01-24
OA10122A (en) 1996-12-18
SK159994A3 (en) 1996-01-10
BG99313A (en) 1995-09-29
NO945074L (no) 1995-02-16
ZA934645B (en) 1994-01-25
MA22927A1 (fr) 1994-04-01
WO1994000125A1 (fr) 1994-01-06
IL106158A0 (en) 1993-10-20
CA2138956A1 (fr) 1994-01-06
CZ334694A3 (en) 1995-10-18
KR950702118A (ko) 1995-06-19
MX9303970A (es) 1994-04-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Ipc: C07J 9/00

A4 Supplementary search report drawn up and despatched

Effective date: 19950821

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Effective date: 19981231