EP0649443A4 - MATERIALS DERIVED FROM OXAZOLON. - Google Patents

MATERIALS DERIVED FROM OXAZOLON.

Info

Publication number
EP0649443A4
EP0649443A4 EP93916883A EP93916883A EP0649443A4 EP 0649443 A4 EP0649443 A4 EP 0649443A4 EP 93916883 A EP93916883 A EP 93916883A EP 93916883 A EP93916883 A EP 93916883A EP 0649443 A4 EP0649443 A4 EP 0649443A4
Authority
EP
European Patent Office
Prior art keywords
oxazolone
derived materials
derived
materials
oxazolone derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93916883A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0649443A1 (en
Inventor
Joseph C Hogan Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARQULE PARTNERS, L.P.
Original Assignee
LEGOMER PARTNERS LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEGOMER PARTNERS LP filed Critical LEGOMER PARTNERS LP
Publication of EP0649443A1 publication Critical patent/EP0649443A1/en
Publication of EP0649443A4 publication Critical patent/EP0649443A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP93916883A 1992-06-30 1993-06-30 MATERIALS DERIVED FROM OXAZOLON. Ceased EP0649443A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90675692A 1992-06-30 1992-06-30
US906756 1992-06-30
US4156293A 1993-04-02 1993-04-02
US41562 1993-04-02
PCT/US1993/006240 WO1994000509A1 (en) 1992-06-30 1993-06-30 Oxazolone derived materials

Publications (2)

Publication Number Publication Date
EP0649443A1 EP0649443A1 (en) 1995-04-26
EP0649443A4 true EP0649443A4 (en) 1995-11-08

Family

ID=26718293

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93916883A Ceased EP0649443A4 (en) 1992-06-30 1993-06-30 MATERIALS DERIVED FROM OXAZOLON.

Country Status (7)

Country Link
EP (1) EP0649443A4 (pt)
JP (1) JPH08500576A (pt)
KR (1) KR950702216A (pt)
AU (1) AU678168B2 (pt)
BR (1) BR9306656A (pt)
CA (1) CA2139350A1 (pt)
WO (1) WO1994000509A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09511225A (ja) * 1993-12-28 1997-11-11 アーキュール パートナーズ，エル．ピー． オキサゾロン誘導分子のモジュール設計および合成
WO1995018627A1 (en) * 1994-01-05 1995-07-13 Arqule, Inc. Method of making polymers having specific properties
DE19714343A1 (de) * 1997-04-08 1998-10-15 Bayer Ag Chromatographische Enantiomerentrennung von Lactonen
GB9812675D0 (en) * 1998-06-11 1998-08-12 Univ Edinburgh Peptides
WO2000064845A1 (fr) * 1999-04-22 2000-11-02 Sankyo Company, Limited Cetoamides porteurs de resine et leur procede de preparation
EP2113510A1 (en) * 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin A derivatives
CN112898218B (zh) * 2020-01-14 2022-08-26 河南师范大学 一锅法合成含三氟甲基噁唑酮类化合物的方法
CN112830882A (zh) * 2020-12-31 2021-05-25 河南绿园药业有限公司 一种对羟基苯甘氨酸甲酯合成方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391191A1 (fr) * 1977-05-16 1978-12-15 Sandoz Sa Nouveaux composes polypeptidiques, lyeptidiques, leur preparation et leur application comme medicaments
EP0008097A2 (de) * 1978-08-07 1980-02-20 BASF Aktiengesellschaft Verfahren zur Herstellung von Indoleninen
EP0105665A1 (en) * 1982-09-27 1984-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional compounds and curable compositions containing same
EP0328340A2 (en) * 1988-02-09 1989-08-16 BAUSCH & LOMB INCORPORATED Hydrophilic oxygen permeable polymers
EP0433034A2 (en) * 1989-12-12 1991-06-19 Minnesota Mining And Manufacturing Company Method involving thermally sensitive alpha-amidoacetyl or beta-amidopropionyl linkages
EP0449488A1 (en) * 1990-03-28 1991-10-02 Minnesota Mining And Manufacturing Company Azlactone Michael adducts
EP0525420A1 (en) * 1991-07-01 1993-02-03 Mitsubishi Chemical Corporation Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125519A (en) * 1976-10-13 1978-11-14 Murray Goodman Polypeptides containing 3,4-dihydroxyphenylalanine
JPS60215657A (ja) * 1984-04-10 1985-10-29 Mitsui Toatsu Chem Inc Ｎ−アシルフエニルアラニン類の製造法
US4996292A (en) * 1989-06-30 1991-02-26 Fox Sidney W Self-sealing artificial skin comprising copoly-alpha-amino acid
US5039813A (en) * 1990-06-29 1991-08-13 Polaroid Corporation 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof
US5219731A (en) * 1991-11-01 1993-06-15 Wisconsin Alumni Research Foundation Method for preparing optically-active amino acid derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391191A1 (fr) * 1977-05-16 1978-12-15 Sandoz Sa Nouveaux composes polypeptidiques, lyeptidiques, leur preparation et leur application comme medicaments
EP0008097A2 (de) * 1978-08-07 1980-02-20 BASF Aktiengesellschaft Verfahren zur Herstellung von Indoleninen
EP0105665A1 (en) * 1982-09-27 1984-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional compounds and curable compositions containing same
EP0328340A2 (en) * 1988-02-09 1989-08-16 BAUSCH & LOMB INCORPORATED Hydrophilic oxygen permeable polymers
EP0433034A2 (en) * 1989-12-12 1991-06-19 Minnesota Mining And Manufacturing Company Method involving thermally sensitive alpha-amidoacetyl or beta-amidopropionyl linkages
EP0449488A1 (en) * 1990-03-28 1991-10-02 Minnesota Mining And Manufacturing Company Azlactone Michael adducts
EP0525420A1 (en) * 1991-07-01 1993-02-03 Mitsubishi Chemical Corporation Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9400509A1 *

Also Published As

Publication number Publication date
BR9306656A (pt) 1998-12-08
WO1994000509A1 (en) 1994-01-06
AU4659193A (en) 1994-01-24
CA2139350A1 (en) 1994-01-06
JPH08500576A (ja) 1996-01-23
AU678168B2 (en) 1997-05-22
KR950702216A (ko) 1995-06-19
EP0649443A1 (en) 1995-04-26

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19950130

AK Designated contracting states

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Owner name: ARQULE PARTNERS, L.P.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ARQULE, INC.

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20001012