EP0629407A3 - Utilisation de protéine C humaine dans l'empêchement et le traitement des dépÔts de trombocytes. - Google Patents
Utilisation de protéine C humaine dans l'empêchement et le traitement des dépÔts de trombocytes. Download PDFInfo
- Publication number
- EP0629407A3 EP0629407A3 EP94109293A EP94109293A EP0629407A3 EP 0629407 A3 EP0629407 A3 EP 0629407A3 EP 94109293 A EP94109293 A EP 94109293A EP 94109293 A EP94109293 A EP 94109293A EP 0629407 A3 EP0629407 A3 EP 0629407A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- thrombocytes
- treatment
- prevention
- human protein
- depositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4320294A DE4320294A1 (de) | 1993-06-18 | 1993-06-18 | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
DE4320294 | 1993-06-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0629407A2 EP0629407A2 (fr) | 1994-12-21 |
EP0629407A3 true EP0629407A3 (fr) | 1995-05-24 |
EP0629407B1 EP0629407B1 (fr) | 2001-09-12 |
Family
ID=6490672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94109293A Expired - Lifetime EP0629407B1 (fr) | 1993-06-18 | 1994-06-16 | Utilisation de protéine C humaine dans l'empêchement et le traitement des dépôts de thrombocytes |
Country Status (14)
Country | Link |
---|---|
US (1) | US5614493A (fr) |
EP (1) | EP0629407B1 (fr) |
JP (1) | JP3106059B2 (fr) |
AT (2) | AT407704B (fr) |
AU (1) | AU680894B2 (fr) |
CA (1) | CA2126135C (fr) |
CZ (1) | CZ148294A3 (fr) |
DE (2) | DE4320294A1 (fr) |
DK (1) | DK0629407T3 (fr) |
ES (1) | ES2162829T3 (fr) |
FI (1) | FI942941A (fr) |
HU (1) | HU217609B (fr) |
NO (1) | NO942298L (fr) |
SK (1) | SK282358B6 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9806966D0 (en) * | 1998-03-31 | 1998-06-03 | Ppl Therapeutics Scotland Ltd | Bioloically modified device |
JP2004535461A (ja) * | 2001-07-19 | 2004-11-25 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | プロテインcの不活性化を抑制するための銅キレート剤の使用 |
EP2539448B1 (fr) * | 2010-02-26 | 2016-12-14 | The Children's Hospital of Philadelphia | Zymogène de la protéine c et ses procédés d'utilisation pour prévenir les métastases cancéreuses |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0191606A2 (fr) * | 1985-02-08 | 1986-08-20 | Eli Lilly And Company | Vecteurs et méthodes d'expression d'activité de protéine C humaine |
EP0443875A2 (fr) * | 1990-02-23 | 1991-08-28 | Eli Lilly And Company | Vecteurs et composés pour l'expression de formes zymogènes de la protéine C humaine |
EP0575054A2 (fr) * | 1992-05-21 | 1993-12-22 | Eli Lilly And Company | Dérivés de la protéine C |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT218391B (de) | 1959-01-26 | 1961-11-27 | Anton Daxboeck | Vorrichtung zur Sicherung einer Türschloßfalle, insbesondere für Kraftfahrzeuge |
AT350726B (de) * | 1976-08-30 | 1979-06-11 | Immuno Ag | Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma |
US4250139A (en) * | 1979-02-01 | 1981-02-10 | Collagen Corporation | Microwave sterilization of dry protein |
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
DE3176491D1 (en) * | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
US4440679A (en) * | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
DE3173208D1 (en) * | 1980-10-06 | 1986-01-23 | Edward Shanbrom | Method of reducing undesirable activities of biological and pharmaceutical products |
DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
US4480029A (en) * | 1981-04-27 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Biological indicators and their use |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
JPS5874617A (ja) * | 1981-10-28 | 1983-05-06 | Green Cross Corp:The | 人由来血液凝固第7因子含有水溶液の加熱処理方法 |
US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
US4481189A (en) * | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
US4379085A (en) * | 1982-05-14 | 1983-04-05 | American National Red Cross | Heat stabilization of plasma proteins |
US4511556A (en) * | 1982-06-10 | 1985-04-16 | The United States Of America As Represented By The Department Of Health And Human Services | Inactivation of a lipid virus |
JPS59134730A (ja) * | 1983-01-20 | 1984-08-02 | Green Cross Corp:The | 血液凝固第8因子の加熱処理法 |
CA1213827A (fr) * | 1983-04-29 | 1986-11-12 | Ricardo H. Landaburu | Procede de pasteurisation de la fibronectine |
US4585654A (en) * | 1983-04-29 | 1986-04-29 | Armour Pharmaceutical Co. | Process for pasteurizing fibronectin |
ATE36457T1 (de) * | 1983-05-02 | 1988-09-15 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern. |
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
JPS6054287B2 (ja) * | 1983-10-19 | 1985-11-29 | 株式会社ミドリ十字 | 血漿蛋白の加熱処理方法 |
US4490361A (en) * | 1983-12-02 | 1984-12-25 | Alpha Therapeutic Corporation | Virus inactivating heat treatment of plasma fractions |
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US4589495A (en) * | 1984-04-19 | 1986-05-20 | Weatherford U.S., Inc. | Apparatus and method for inserting flow control means into a well casing |
DE3432083A1 (de) * | 1984-08-31 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
JPH0825902B2 (ja) * | 1985-02-21 | 1996-03-13 | 株式会社ミドリ十字 | γ−グロブリンの加熱処理方法 |
US4673733A (en) * | 1985-04-11 | 1987-06-16 | Sudhish Chandra | Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents |
DE3688900T3 (de) * | 1985-06-27 | 1998-06-10 | Univ Washington | Expression von Protein C. |
DE3544663A1 (de) * | 1985-12-13 | 1987-06-19 | Schering Ag | Thrombosebehandlung mit fibrinolytika und prostacyclinen |
JPH0662436B2 (ja) * | 1986-05-19 | 1994-08-17 | 株式会社ミドリ十字 | 静注用免疫グロブリン製剤の製造方法 |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
DE3704550A1 (de) * | 1987-02-13 | 1988-08-25 | Behringwerke Ag | Verfahren zur inaktivierung huellhaltiger viren in mittels einer zelle in vitro hergestellten protein-praeparationen |
US4857320A (en) * | 1987-02-19 | 1989-08-15 | Monsanto Company | Method of enhancing the solubility of tissue plasminogen activator |
JPS63243032A (ja) * | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
DE3882411T2 (de) * | 1987-04-17 | 1993-12-16 | Teijin Ltd | Verfahren zur Trennung von aktiviertem menschlichem Protein C. |
EP0413687A1 (fr) * | 1987-05-15 | 1991-02-27 | Alan I. Rubinstein | Procede sequentiel ameliore pour le traitement de produits de facteurs de coagulation du sang humain |
IL86417A (en) * | 1987-05-22 | 1992-09-06 | Armour Pharma | Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers |
GB8721951D0 (en) * | 1987-09-18 | 1987-10-28 | Thrombosis Research Trust | Organic compounds |
US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
AT391809B (de) * | 1988-01-12 | 1990-12-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutplasmaprodukten |
JP2739050B2 (ja) * | 1988-01-28 | 1998-04-08 | ヘキスト薬品工業株式会社 | 抗血液凝固剤 |
FR2630115B1 (fr) * | 1988-04-14 | 1994-10-28 | Merieux Inst | Procede de stabilisation des solutions d'albumine humaine et solution obtenue |
DE3878227D1 (de) * | 1988-05-27 | 1993-03-18 | Centre Regional De Transfusion | Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie. |
AT397203B (de) * | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
AT390801B (de) * | 1988-07-28 | 1990-07-10 | Immuno Ag | Verfahren zur herstellung von lys-plasminogen |
GB8819607D0 (en) * | 1988-08-17 | 1988-09-21 | Wellcome Found | Novel combination |
US5156973A (en) * | 1988-11-23 | 1992-10-20 | Edward Shanbrom | Antiviral blood sampling process and apparatus |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
CA2006684C (fr) * | 1988-12-30 | 1996-12-17 | Charles T. Esmon | Anticorps monoclonaux contre la proteine c |
DE69011136T3 (de) * | 1989-01-13 | 2003-10-23 | Mitsubishi Pharma Corp | Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung. |
FR2644476A1 (fr) * | 1989-03-15 | 1990-09-21 | Sainte Agathe Nicolas De | Procede de detection et/ou d'identification de micro-organismes vivants par vibrometrie |
FR2658517B2 (fr) * | 1989-04-12 | 1992-06-19 | Fondation Nale Transfusion San | Preparation de la proteine c activee et solution de proteine c activee ainsi obtenue. |
DK0431129T3 (da) * | 1989-06-15 | 1996-06-17 | Rorer Int Overseas | Fremgangsmåder til inaktivering af virus i viruskontaminerede farmaceutiske præparater |
AT402153B (de) * | 1989-06-26 | 1997-02-25 | Immuno Ag | Protein-s-hältige pharmazeutische präparation |
HU905784D0 (en) * | 1989-09-05 | 1991-03-28 | Lilly Co Eli | Process for activating protein c |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
AT402260B (de) * | 1990-08-16 | 1997-03-25 | Immuno Ag | Protein c-hältige pharmazeutische präparation |
AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
AT395596B (de) * | 1991-06-20 | 1993-01-25 | Immuno Ag | Verfahren zur herstellung von aktiviertem protein c |
AT402263B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
JPH0564588A (ja) * | 1991-08-14 | 1993-03-19 | Teijin Ltd | 短い重鎖を有するヒトプロテインcおよび活性化ヒトプロテインc |
FR2681867B1 (fr) * | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
JP3429433B2 (ja) * | 1997-06-18 | 2003-07-22 | 松本建工株式会社 | 鉄骨造建築物に於ける冷橋防止構造 |
FR2841484B1 (fr) * | 2002-06-26 | 2004-09-10 | Boucq De Beaudignies Ghisla Le | Dispositif et procede de filtration de l'air et des gaz avec regeneration des particules captees |
-
1993
- 1993-06-18 DE DE4320294A patent/DE4320294A1/de not_active Ceased
-
1994
- 1994-06-15 AT AT0119394A patent/AT407704B/de not_active IP Right Cessation
- 1994-06-15 CZ CZ941482A patent/CZ148294A3/cs unknown
- 1994-06-16 DK DK94109293T patent/DK0629407T3/da active
- 1994-06-16 ES ES94109293T patent/ES2162829T3/es not_active Expired - Lifetime
- 1994-06-16 US US08/261,914 patent/US5614493A/en not_active Expired - Lifetime
- 1994-06-16 AT AT94109293T patent/ATE205396T1/de not_active IP Right Cessation
- 1994-06-16 DE DE69428231T patent/DE69428231T2/de not_active Expired - Lifetime
- 1994-06-16 EP EP94109293A patent/EP0629407B1/fr not_active Expired - Lifetime
- 1994-06-16 AU AU64719/94A patent/AU680894B2/en not_active Ceased
- 1994-06-17 CA CA002126135A patent/CA2126135C/fr not_active Expired - Fee Related
- 1994-06-17 NO NO942298A patent/NO942298L/no not_active Application Discontinuation
- 1994-06-17 FI FI942941A patent/FI942941A/fi unknown
- 1994-06-17 SK SK748-94A patent/SK282358B6/sk unknown
- 1994-06-17 JP JP06135468A patent/JP3106059B2/ja not_active Expired - Fee Related
- 1994-06-17 HU HU9401817A patent/HU217609B/hu not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0191606A2 (fr) * | 1985-02-08 | 1986-08-20 | Eli Lilly And Company | Vecteurs et méthodes d'expression d'activité de protéine C humaine |
EP0443875A2 (fr) * | 1990-02-23 | 1991-08-28 | Eli Lilly And Company | Vecteurs et composés pour l'expression de formes zymogènes de la protéine C humaine |
EP0575054A2 (fr) * | 1992-05-21 | 1993-12-22 | Eli Lilly And Company | Dérivés de la protéine C |
Also Published As
Publication number | Publication date |
---|---|
FI942941A0 (fi) | 1994-06-17 |
DK0629407T3 (da) | 2001-11-12 |
DE69428231D1 (de) | 2001-10-18 |
FI942941A (fi) | 1994-12-19 |
NO942298D0 (no) | 1994-06-17 |
AU680894B2 (en) | 1997-08-14 |
HU217609B (hu) | 2000-03-28 |
NO942298L (no) | 1994-12-19 |
ATA119394A (de) | 2000-10-15 |
US5614493A (en) | 1997-03-25 |
ES2162829T3 (es) | 2002-01-16 |
DE69428231T2 (de) | 2002-06-13 |
CA2126135C (fr) | 2002-02-19 |
CA2126135A1 (fr) | 1994-12-19 |
JPH0748275A (ja) | 1995-02-21 |
EP0629407B1 (fr) | 2001-09-12 |
AT407704B (de) | 2001-05-25 |
ATE205396T1 (de) | 2001-09-15 |
DE4320294A1 (de) | 1994-12-22 |
JP3106059B2 (ja) | 2000-11-06 |
SK282358B6 (sk) | 2002-01-07 |
AU6471994A (en) | 1994-12-22 |
SK74894A3 (en) | 1995-05-10 |
HUT67074A (en) | 1995-01-30 |
EP0629407A2 (fr) | 1994-12-21 |
HU9401817D0 (en) | 1994-09-28 |
CZ148294A3 (en) | 1995-01-18 |
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