EP0618927A1 - Cytokine mit einem ungepaarten cystein-rest und konjugaten davon - Google Patents

Cytokine mit einem ungepaarten cystein-rest und konjugaten davon

Info

Publication number
EP0618927A1
EP0618927A1 EP93901259A EP93901259A EP0618927A1 EP 0618927 A1 EP0618927 A1 EP 0618927A1 EP 93901259 A EP93901259 A EP 93901259A EP 93901259 A EP93901259 A EP 93901259A EP 0618927 A1 EP0618927 A1 EP 0618927A1
Authority
EP
European Patent Office
Prior art keywords
cytokine
cysteine residue
cytokines
conjugated
unpaired cysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901259A
Other languages
English (en)
French (fr)
Other versions
EP0618927A4 (de
Inventor
Tse Wen Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Publication of EP0618927A1 publication Critical patent/EP0618927A1/de
Publication of EP0618927A4 publication Critical patent/EP0618927A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP93901259A 1991-12-10 1992-12-10 Cytokine mit einem ungepaarten cystein-rest und konjugaten davon. Withdrawn EP0618927A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80545291A 1991-12-10 1991-12-10
US805452 1991-12-10
PCT/US1992/010889 WO1993012142A1 (en) 1991-12-10 1992-12-10 Cytokines with an unpaired cysteine residue and conjugates thereof

Publications (2)

Publication Number Publication Date
EP0618927A1 true EP0618927A1 (de) 1994-10-12
EP0618927A4 EP0618927A4 (de) 1995-05-24

Family

ID=25191607

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901259A Withdrawn EP0618927A4 (de) 1991-12-10 1992-12-10 Cytokine mit einem ungepaarten cystein-rest und konjugaten davon.

Country Status (5)

Country Link
EP (1) EP0618927A4 (de)
JP (1) JP2704214B2 (de)
AU (1) AU666914B2 (de)
CA (1) CA2124672A1 (de)
WO (1) WO1993012142A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165458A (en) * 1997-12-26 2000-12-26 Pharmaderm Laboratories Ltd. Composition and method for dermal and transdermal administration of a cytokine
EP1183357A2 (de) * 1999-05-20 2002-03-06 Scios Inc. Vaskuläre endothelzellen wachstumsfaktordimere
AU5023300A (en) 1999-05-20 2000-12-12 Scios Inc. Vascular endothelial growth factor variants
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
GB0123262D0 (en) * 2001-09-27 2001-11-21 Adprotech Ltd Polymeric compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0105777A1 (de) * 1982-09-22 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Lipopeptiden, deren Herstellung und Anwendung als Emulgiermittel
EP0236987A2 (de) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Chemisch modifizierte Proteine und deren Herstellung
EP0354992A2 (de) * 1988-07-08 1990-02-21 Yeda Research And Development Company Limited VIP-Konjugate und deren aktive Fragmente mit hydrophoben Anteilen und topische Zuberetungen zur Verwendung in der Behandlung männlicher Impotenz
WO1990012874A2 (en) * 1989-04-21 1990-11-01 Genetics Institute, Inc. Cysteine added variants of polypeptides and chemical modifications thereof
EP0441765A1 (de) * 1990-02-09 1991-08-14 Washington University Neue Enzymsubstrate auf der Basis von Fettsäureanalogen
WO1991012229A1 (en) * 1990-02-12 1991-08-22 National Research Council Of Canada Process for preparing acyl derivatives of acylatable compounds
EP0458064A2 (de) * 1990-05-04 1991-11-27 American Cyanamid Company Stabilisierung von Somatotropin und anderen Proteinen durch Modifizierung von Cysteinsresten

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0105777A1 (de) * 1982-09-22 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Lipopeptiden, deren Herstellung und Anwendung als Emulgiermittel
EP0236987A2 (de) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Chemisch modifizierte Proteine und deren Herstellung
EP0354992A2 (de) * 1988-07-08 1990-02-21 Yeda Research And Development Company Limited VIP-Konjugate und deren aktive Fragmente mit hydrophoben Anteilen und topische Zuberetungen zur Verwendung in der Behandlung männlicher Impotenz
WO1990012874A2 (en) * 1989-04-21 1990-11-01 Genetics Institute, Inc. Cysteine added variants of polypeptides and chemical modifications thereof
EP0441765A1 (de) * 1990-02-09 1991-08-14 Washington University Neue Enzymsubstrate auf der Basis von Fettsäureanalogen
WO1991012229A1 (en) * 1990-02-12 1991-08-22 National Research Council Of Canada Process for preparing acyl derivatives of acylatable compounds
EP0458064A2 (de) * 1990-05-04 1991-11-27 American Cyanamid Company Stabilisierung von Somatotropin und anderen Proteinen durch Modifizierung von Cysteinsresten

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol.26, 1987, WASHINGTON D.C.,USA pages 1029 - 1036 WILCOX ET AL 'THE MAJORITY OF CELLULAR FATTY ACID ACYLATED PROTEINS ARE LOCALIZED TO THE CYTOPLASMIC SURFACE OF THE PLASMA MEMBRANE' *
See also references of WO9312142A1 *

Also Published As

Publication number Publication date
CA2124672A1 (en) 1993-06-24
WO1993012142A1 (en) 1993-06-24
AU666914B2 (en) 1996-02-29
EP0618927A4 (de) 1995-05-24
JP2704214B2 (ja) 1998-01-26
JPH07502508A (ja) 1995-03-16
AU3323593A (en) 1993-07-19

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