EP0581624B1 - Kosmetisches und/oder Nahrungsmittel enthaltend eine nicht-verseifbare Fraktion von Sesamöl und Vitamin-E - Google Patents

Kosmetisches und/oder Nahrungsmittel enthaltend eine nicht-verseifbare Fraktion von Sesamöl und Vitamin-E Download PDF

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Publication number
EP0581624B1
EP0581624B1 EP93401650A EP93401650A EP0581624B1 EP 0581624 B1 EP0581624 B1 EP 0581624B1 EP 93401650 A EP93401650 A EP 93401650A EP 93401650 A EP93401650 A EP 93401650A EP 0581624 B1 EP0581624 B1 EP 0581624B1
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Prior art keywords
approximately
sesame oil
composition
vitamin
oil
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Expired - Lifetime
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EP93401650A
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English (en)
French (fr)
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EP0581624A1 (de
Inventor
Alain Rancurel
François Laigneau
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Laboratoires Expanscience SA
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Expanchimie Sarl
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/12—Refining fats or fatty oils by distillation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the subject of the present invention is new compositions based on unsaponifiable fractions of wheat germ and sesame oils, and their uses, especially in cosmetology and as a supplement food.
  • compositions containing sesame oil mixed with tocopherol and sorbitol, used for the preservation of perishable goods are described in Japanese application JP-A-63152965.
  • compositions comprising mainly lecithin, vitamin E, wheat germ oil and a mixture of vegetable oils (including in particular sesame oil), used in the context of care of the skin linked to shaving, are described in international application WO-A-8500746.
  • Dermatological preparations containing glycerol trioleate, vegetable oils (including sesame oil or wheat germ oil), hydrogenated oil, tocopherol, lecithin and fatty acids, used mainly in the treatment of dry and irritated skin and pruritus, are described in US-A-4454159.
  • unsaponifiable applies to non-volatile substances obtained by extraction, with an organic solvent, of a solution of the substance to be examined after saponification of a vegetable or animal oil.
  • the molecular distillation method which will be further detailed in the rest of this text makes it possible to concentrate oils, in particular from plants (vegetable oils), and to obtain concentrates, also designated below by concentrates, in which the concentration of unsaponifiable matter can reach of the order of 10 to 20%, this concentration being of the order of 1 to 2% in the starting oils.
  • the anti-free radical action of the composition thus obtained was measured in operating conditions defined below, and compared to this same action measured for the concentrate of wheat germ oil, sesame oil and for the Vitamin E.
  • the inventors have thus determined that, unexpectedly, the above-mentioned composition consisting of the mixture of the two concentrates, has the characteristic of having an anti-radical activity with respect to UVA irradiation which is on the one hand higher than that presented by the wheat germ oil concentrate, and on the other hand superior to that presented by the sesame oil concentrate.
  • the anti-free radical activity of the above-mentioned composition is also higher than that measured for vitamin E whose own activity is itself higher than that of each of the two concentrates mentioned above.
  • the inventors have also observed that, just as much unexpected, the aforementioned composition consisting of the mixture of these two concentrates, is active not only preventively or immediately against effects of UVA rays, but also as part of the curative treatment of the effects UVA, while vitamin E and the two concentrates mentioned above do not have little or no curative action against these effects.
  • the present invention relates, in general, any composition comprising the unsaponifiable fraction of sesame oil in mixture with vitamin E, the proportion of sesame oil unsaponifiable in compositions of the invention being from 10% to 20% by weight.
  • the proportion of vitamin E in the composition mentioned above is between approximately 0.5% and approximately 5% by weight, and preferably between about 1% and about 3%.
  • the invention more particularly relates to any composition such as described above comprising the unsaponifiable fraction of sesame oil in mixture with one (or more) unsaponifiable fraction (s) from any oil, in particular of a vegetable oil, likely to contain vitamin E, especially soybean oil, and advantageously wheat germ oil.
  • the present invention relates more particularly to any composition such as described above comprising the unsaponifiable fraction of germ oil from wheat mixed with the unsaponifiable fraction of sesame oil.
  • the invention more particularly relates to any composition such as described above, and characterized in that the unsaponifiable fractions of oil wheat germ and sesame oil are those contained in concentrates respective of these oils, these concentrates being advantageously prepared by molecular distillation of these oils.
  • the aforementioned molecular distillation method is carried out by spreading the oil in a thin layer on the heated surface of a conical rotor rotating at high speed. Maintaining a high vacuum of the order of 10 -3 mm Hg (or about 0.13 Pa) in the distillation chamber.
  • the distillation temperatures are advantageously between about 190 ° C and about 260 ° C, preferably between about 200 ° C and about 220 ° C, and under vacuum of the order of about 0.1 Pa to about 1.5 Pa, preferably from about 0.13 Pa to about 0.5 Pa.
  • the amounts by weight of the unsaponifiable fractions in the wheat germ oil and sesame oil concentrates are respectively from about 15% to about 25%, and from about 10% to about 20%.
  • the quantities by weight of the concentrates wheat germ oil and sesame oil vary between about 10% to about 90%, and between about 90% to about 10%, so that that the total of the quantities of these two oils makes 100%.
  • the amounts by weight of the germ oil concentrates of wheat and sesame oil are respectively around 50%.
  • compositions of the invention comprise approximately 10 to 20% by weight of unsaponifiable fractions, approximately 10% by weight of fatty acids, the remainder consisting of mono, di and triglycerides.
  • the invention also relates to any cosmetic composition
  • a composition as described above according to the invention of preferably in combination with a physiologically acceptable vehicle.
  • compositions according to the invention are advantageously formulated for topical use, in particular in the form of creams, emulsions, ointments, or in a form suitable for lip application (especially for packaging in lip sticks).
  • compositions according to the invention can also be administered by oral route, in particular in the form of capsules or tablets.
  • the invention also relates to the use of the above-mentioned compositions for the prevention and / or treatment of the skin of an individual, against the effects UVA.
  • compositions are more particularly used as treating sunscreen products, restructuring creams, nutritious, anti-wrinkle (fight against aging of the skin), and protective of day.
  • the invention also relates to any aesthetic treatment method comprising applying to the skin surface of an individual a composition according to the invention.
  • the invention also relates to the use of a composition as described above as a food composition (especially as nutritional supplement or supplement).
  • the invention also relates to any pharmaceutical composition comprising a composition as described above in combination with a physiologically acceptable vehicle.
  • compositions according to the invention are more particularly intended for the prevention or treatment of the effects of UVA on the skin, and preventing skin aging.
  • the aforementioned concentrates are advantageously obtained by molecular distillation according to the process described above. They can however be obtained by other methods, in particular by cold crystallization (see for example the article by J. JACINI: J. ASS. OFF. AN. CHEM., 1967, 50, p.85-90), or by liquid-liquid extraction (see for example the article by H. KALLEL: REV. FRANC. DES CORPS GRAS, 1975, 22, 5, p.269-270).
  • the richness in non-saponifiable matter of this distilled fraction is between 10% and 20%.
  • raw, virgin, semi-refined wheat germ oil with a feed rate from 10 to 30 kgs per hour and preferably between 15 and 25.
  • the richness in non-saponifiable matter of this distilled fraction is between 15% and 30%.
  • the actual preparation of the mixture can be carried out in a conventional mixer fitted with an anchor, the operation being carried out under an atmosphere inert by heating to a temperature close to 60 ° C.
  • % Hydrogenated polyisobutene 4.00 Caprylic caprylic triglycerides 3.00 Mineral oil and lanolin alcohols 2.50 Myristyle myristate 2.00 Trioleate phosphate 2.00 Oleic alcohol 2 EO 2.00 Cetyl palmitate 1.50 Copolymer peg 45 dodecyl glycol 1.50 Sesame oil and wheat germ oil concentrates 1.00 Triglycerides C18-36 1.00 Magnesium sulfate 0.30 Preservative GD 700 0.30 Perfume 0.30 Purified water Q.s.p. 100.00
  • the unsaponifiable contents are measured by the method of European Pharmacopoeia 2nd edition page V.3.4.7.
  • CSS lot 123061 sesame concentrate (around 13% unsaponifiable).
  • CGB lot 102100 wheat germ concentrate (about 20% unsaponifiable).
  • CSB lot 137111 mixture of the two (50% of the sesame oil concentrate and 50% wheat germ oil concentrate).
  • Cells are fibroblasts isolated from a young foreskin child.
  • Cell viability was quantified by a colorimetric method based on mitochondrial metabolism by cells of a tetrazolium salt (the MTT).
  • Free radicals are generated in cell culture by irradiation with ultraviolet A radiation.
  • the lamp used is a Vilber Lourmat (T40M) lamp with mercury vapor, the emission spectrum of which is maximum at 365 nm.
  • the radiation intensity is monitored by a radiometer.
  • An irradiation intensity of 2.3 Joules / cm 2 makes it possible to obtain a fibroblast toxicity close to 70% 24 hours after the irradiation.
  • the cells are exposed, after 48 hours of culture, to radiation through a Hanks solution without phenol red. After exposure, the saline solution is eliminated and the cells are brought back into contact with their culture medium for 24 hours. Cell viability is then determined by the MTT test.
  • the following diagram shows the protocol followed:
  • the anti-free radical properties of each product were sought after preventive administration, during simultaneous (immediate) administration to aggression or by administration after irradiation (curative).
  • 0.1 ml of each dilution of the product in the complete culture medium are introduced into the wells, then the seeding is carried out with 0.1 ml of cell suspension (200,000 cells / ml).
  • the contact time with the cell culture is 48 hours (D 0 - D 2 ).
  • the assets are in a Hanks solution without red phenol at the various previous concentrations. After irradiation of cells, the Hanks solution is eliminated and replaced by complete medium for 24 hours then cell survival is determined.
  • Dimethylformamide 1% has significant cytotoxicity which causes approximately 1/3 of the cells to die.
  • the percentage of dimethylformamide is 0.5% which is not cytotoxic. It's this concentration which will be used in the irradiation tests.
  • vitamin E totally protects cells against UVA up to a concentration of 10 ⁇ g / ml.
  • a filter effect linked to the solution disorder may be added to the strongest concentrations.
  • Vitamin E has practically no curative effect according to different series of experiments presented in Tables II and VI.
  • Sesame concentrate exerts a preventive effect up to the concentration of 10 ⁇ g / ml. It has no immediate effect (a slight effect is observed in higher concentrations; this is linked to a filter effect produced by the disorder middle), or curative effect.
  • Wheat germ concentrate has a preventive effect up to 5 ⁇ g / ml (lowest dose studied in this case). It has no immediate effect and curative whatever the concentration used.
  • the mixture of the 2 concentrates provides a very protective effect significant of the order of 90% with respect to UVA rays up to the concentration of 5 ⁇ g / ml.
  • the mixture is not active immediately.
  • the curative treatment reveals a significant effectiveness of approximately 90% of this mixture with the 2 highest concentrations (100 and 50 ⁇ g / ml).
  • the effectiveness is of the order of 60% up to the concentration of 5 ⁇ g / ml thus confirming the curative effect observed.
  • the combination of the 3 protocols provides 90% protection up to 5 ⁇ g / ml.
  • Table VI represents the percentage efficiency of vitamin E, pure wheat concentrate, pure sesame concentrate, and mixtures of these two last concentrates in variable proportions (33% / 66%, 50% / 50%, and 66% / 33% respectively), on culture of irradiated fibroblasts, in treatment curative.
  • the 3 concentrates are effective; they can be classified in decreasing order of activity: mixture ⁇ grain of wheat> sesame
  • the wheat germ-sesame mixture reveals an activity in treatment curative up to the concentration of 10 ⁇ g / ml. It is important to note that these effects do not appear with wheat germ or sesame concentrates administered separately or with vitamin E.
  • the mixture of the 2 concentrates shows a curative action vis-à-vis the toxicity induced by UVA which does not exist for most of the anti-free radicals conventionally used.

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Claims (17)

  1. Zusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E, wobei der Anteil dieser nicht-verseifbaren Fraktion von Sesamöl zwischen 10 und 20 Gewichtsprozent liegt.
  2. Zusammensetzung nach Anspruch 1, dadurch gekennzeichnet, daß der Anteil an Vitamin E von etwa 0,5 bis etwa 5 Gewichtsprozent und vorteilhafterweise von etwa 1 bis etwa 3 Gewichtsprozent beträgt.
  3. Zusammensetzung nach Anspruch 1 oder 2, die die nicht-verseifbare Fraktion von Sesamöl in Mischung mit einer (oder mehreren) nicht-verseifbaren Fraktion(en) umfaßt, welche aus dem Gesamtöl stammt/stammen, insbesondere aus einem pflanzlichen Öl, das Vitamin E enthalten kann, insbesondere aus Sojaöl und vorteilhafterweise aus Weizenkeimöl.
  4. Zusammensetzung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß sie die nicht-verseifbare Fraktion von Weizenkeimöl in Mischung mit der nicht-verseifbaren Fraktion von Sesamöl umfaßt.
  5. Zusammensetzung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß sie eine Mischung eines Weizenkeimöl-Konzentrats und eines Sesamöl-Konzentrats umfaßt, wobei diese Konzentrate jeweils die nicht-verseifbaren Fraktionen von Weizenkeimöl und Sesamöl enthalten und durch Molekulardestillation dieser Öle erhältlich sind, die insbesondere bei einer Temperatur zwischen etwa 190 °C und etwa 260 °C, vorteilhafterweise zwischen etwa 200 °C und etwa 220 °C bei einem Vakuum in der Größenordnung von etwa 0,1 Pa bis etwa 1,5 Pa, vorteilhafterweise etwa 0,13 Pa bis etwa 0,5 Pa durchgeführt wird.
  6. Zusammensetzung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die Menge der nicht-verseifbaren Fraktionen in den Konzentraten des Weizenkeimöls und des Sesamöls jeweils etwa 15 bis etwa 25 Gewichtsprozent und etwa 10 bis etwa 20 Gewichtsprozent betragen.
  7. Zusammensetzung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß die Mengen der Konzentrate des Weizenkeimöls und des Sesamöls jeweils zwischen etwa 10 und etwa 90 Gewichtsprozent und zwischen etwa 90 und etwa 10 Gewichtsprozent variieren, so daß die Gesamtmenge dieser zwei Öle 100 Gewichtsprozent betragen.
  8. Zusammensetzung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß die Mengen der Konzentrate des Weizenkeimöls und des Sesamöls jeweils etwa 50 Gewichtsprozent betragen.
  9. Verwendung einer Zusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8 für die Herstellung von kosmetischen Zusammensetzungen.
  10. Kosmetische Zusammensetzung, welche die Gesamtzusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8, vorzugsweise zusammen mit einem physiologisch annehmbaren Medium enthält.
  11. Kosmetische Zusammensetzung nach Anspruch 10, dadurch gekennzeichnet, daß sie für die topische Anwendung formuliert ist, insbesondere in Form von Cremes, Emulsionen, Pomaden oder auch in einer zur Anwendung auf die Lippen geeigneten Form, wobei die Zusammensetzung insbesondere als Sonnenschutzprodukt zum Schutz vor den Wirkungen von UVA-Strahlung auf der Haut sowie als Behandlungsprodukt nach Besonnung, Wiederaufbau-Creme, Nährcreme, Anti-Faltencreme und Tagesschutzcreme verwendbar ist.
  12. Verfahren zur Schönheitsbehandlung, dadurch gekennzeichnet, daß es die Anwendung einer Zusammensetzung nach Anspruch 10 oder 11 auf die Hautoberfläche eines Individuums umfaßt.
  13. Verwendung einer Zusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8 für die Herstellung von pharmazeutischen Zusammensetzungen zur vorbeugenden oder behandelnden Anwendung gegen die Wirkungen von UVA-Strahlung auf der Haut.
  14. Verwendung einer Zusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8 für die Herstellung von pharmazeutischen Zusammensetzungen zur Vorbeugung gegen Hautalterung.
  15. Pharmazeutische Zusammensetzung, dadurch gekennzeichnet, daß sie die Gesamtzusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8, vorzugsweise zusammen mit einem physiologisch annehmbaren Medium enthält.
  16. Verwendung einer Zusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8 zur Herstellung von Nahrungsmittelzusammensetzungen oder Nährstoffergänzungsmitteln.
  17. Nährstoffergänzungsmittel, dadurch gekennzeichnet, daß es die Gesamtzusammensetzung umfassend die nicht-verseifbare Fraktion von Sesamöl in Mischung mit Vitamin E gemäß einem der Ansprüche 1 bis 8 umfaßt.
EP93401650A 1992-06-25 1993-06-25 Kosmetisches und/oder Nahrungsmittel enthaltend eine nicht-verseifbare Fraktion von Sesamöl und Vitamin-E Expired - Lifetime EP0581624B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9207830A FR2692783B1 (fr) 1992-06-25 1992-06-25 Compositions à base de fractions insaponifiables d'huiles de germe de blé et de sésame, et leurs utilisations notamment en cosmétologie et en qualité de complément alimentaire.
FR9207830 1992-06-25

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EP0581624A1 EP0581624A1 (de) 1994-02-02
EP0581624B1 true EP0581624B1 (de) 1999-01-07

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EP (1) EP0581624B1 (de)
AT (1) ATE175343T1 (de)
DE (1) DE69322912T2 (de)
DK (1) DK0581624T3 (de)
ES (1) ES2128400T3 (de)
FR (1) FR2692783B1 (de)

Cited By (5)

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US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof

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DE4426148A1 (de) * 1994-07-22 1996-01-25 Henkel Kgaa Kosmetische und/oder pharmazeutische Zubereitungen
FR2724663B1 (fr) * 1994-09-20 1997-01-24 Fabre Pierre Dermo Cosmetique Huile d'argan enrichie, procede de preparation et composition cosmetique la comprenant
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ES2100821B1 (es) * 1995-12-11 1998-02-16 Cabrelles Sanz Jose Composicion de un producto tonico armonizador del cuerpo humano aplicable sobre la piel.
FR2744633A1 (fr) * 1996-02-14 1997-08-14 Saccoccio Guy Antoine Louis Jo Onction reparatrice pour la peau
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FR2798591B1 (fr) 1999-09-22 2001-10-26 Pharmascience Lab Utilisation d'un produit d'huile vegetale pour augmenter la synthese des lipides cutanes en cosmetique, pharmacie ou dermatologie et en tant qu'additif alimentaire
FR2806260B1 (fr) * 2000-03-20 2005-04-08 Pharmascience Lab Utilisation d'une huile vegetale concentree en sa fraction insaponifiable en tant qu'ingredient alimentaire, procede de preparation de cette huile, composition ou complement alimentaire la contenant
EP1711194B1 (de) * 2003-10-24 2009-11-25 Cognis France, S.A.S. Pflanzenextrakt und seine pharmazeutische und kosmetische verwendung

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FR2041594A5 (de) * 1969-04-30 1971-01-29 Expanscience
FR2102888A5 (en) * 1970-08-24 1972-04-07 Sarb Unsaponifiable fraction from vegetable oil - without saponifying whole batch of oil
US4454159A (en) * 1981-12-28 1984-06-12 Albert Musher Dermatological treatment preparations
US4525344A (en) * 1983-08-15 1985-06-25 Tutsky Ronald J Skin care and shaving composition
JPH0787763B2 (ja) * 1986-08-07 1995-09-27 日清製油株式会社 食品用品質保持剤
FR2648347B1 (fr) * 1989-06-15 1994-04-29 Sederma Sa Preparations cosmetiques possedant des proprietes adoucissantes
FR2653974B1 (fr) * 1989-11-03 1992-12-31 Expanchimie Sarl Additif alimentaire constitue d'extraits de soja et/ou d'avocat.
FR2656219B1 (fr) * 1989-12-21 1993-04-09 Maya Khla Composition parfumee et son procede de preparation.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products

Also Published As

Publication number Publication date
FR2692783A1 (fr) 1993-12-31
ATE175343T1 (de) 1999-01-15
EP0581624A1 (de) 1994-02-02
ES2128400T3 (es) 1999-05-16
FR2692783B1 (fr) 1995-05-05
DE69322912D1 (de) 1999-02-18
DK0581624T3 (da) 1999-08-30
DE69322912T2 (de) 1999-08-26

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