EP0576914A3 - 14-Deoxy-14-alpha-Cardenolid-3-beta-Thioderivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen. - Google Patents

14-Deoxy-14-alpha-Cardenolid-3-beta-Thioderivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen. Download PDF

Info

Publication number
EP0576914A3
EP0576914A3 EP93109611A EP93109611A EP0576914A3 EP 0576914 A3 EP0576914 A3 EP 0576914A3 EP 93109611 A EP93109611 A EP 93109611A EP 93109611 A EP93109611 A EP 93109611A EP 0576914 A3 EP0576914 A3 EP 0576914A3
Authority
EP
European Patent Office
Prior art keywords
thioderivatives
cardenolides
deoxy
beta
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93109611A
Other languages
English (en)
French (fr)
Other versions
EP0576914A2 (de
Inventor
Mauro Gobbini
Luigi Bernardi
Mara Ferrandi
Piero Melloni
Luisa Quadri
Roberto Villa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of EP0576914A2 publication Critical patent/EP0576914A2/de
Publication of EP0576914A3 publication Critical patent/EP0576914A3/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP93109611A 1992-07-01 1993-06-16 14-Deoxy-14-alpha-Cardenolid-3-beta-Thioderivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen. Ceased EP0576914A3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4221538A DE4221538C1 (de) 1992-07-01 1992-07-01 14-Desoxy-14alpha-cardenolid-3beta-thioderivate
DE4221538 1992-07-01

Publications (2)

Publication Number Publication Date
EP0576914A2 EP0576914A2 (de) 1994-01-05
EP0576914A3 true EP0576914A3 (de) 1995-04-19

Family

ID=6462209

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93109611A Ceased EP0576914A3 (de) 1992-07-01 1993-06-16 14-Deoxy-14-alpha-Cardenolid-3-beta-Thioderivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen.

Country Status (4)

Country Link
US (1) US5489582A (de)
EP (1) EP0576914A3 (de)
JP (1) JPH0733795A (de)
DE (1) DE4221538C1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282286B1 (it) * 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268520A (en) * 1963-01-23 1966-08-23 Bayer Ag Steroid guanylhydrazones and production thereof
FR1491081A (fr) * 1965-09-01 1967-08-04 Hoechst Ag Lactones non saturées de la série des stéroïdes et leur préparation
FR1555396A (de) * 1967-03-10 1969-01-24
FR2100872A1 (de) * 1970-07-07 1972-03-24 Hoechst Ag

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1038294A (en) * 1975-04-14 1978-09-12 American Home Products Corporation Method and compositions for lowering intraocular pressure
DE2517293C2 (de) * 1975-04-18 1984-02-16 Knoll Ag, 6700 Ludwigshafen Neue Cardenolid-β-Glykoside, ihre Herstellung und Verwendung
FR2310766A1 (fr) * 1975-05-16 1976-12-10 Nativelle Sa Ets Derives de cardenolides, procede de preparation et application a titre de medicament
DE2833472A1 (de) * 1978-07-29 1980-03-06 Beiersdorf Ag Digitoxigenin-monodigitoxosid-derivate und verfahren zu ihrer herstellung
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268520A (en) * 1963-01-23 1966-08-23 Bayer Ag Steroid guanylhydrazones and production thereof
FR1491081A (fr) * 1965-09-01 1967-08-04 Hoechst Ag Lactones non saturées de la série des stéroïdes et leur préparation
FR1555396A (de) * 1967-03-10 1969-01-24
FR2100872A1 (de) * 1970-07-07 1972-03-24 Hoechst Ag

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAIDOO B K ET AL: "Cardiotonic steroids. I. Importance of 14.beta.-hydroxy group in digitoxigenin", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 63, no. 9, September 1974 (1974-09-01), WASHINGTON US, pages 1391 - 1394, XP002394977, DOI: doi:10.1002/jps.2600630912 *

Also Published As

Publication number Publication date
DE4221538C1 (de) 1994-03-31
JPH0733795A (ja) 1995-02-03
EP0576914A2 (de) 1994-01-05
US5489582A (en) 1996-02-06

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