EP0574465B1 - Agencement pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques - Google Patents

Agencement pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques Download PDF

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Publication number
EP0574465B1
EP0574465B1 EP92905891A EP92905891A EP0574465B1 EP 0574465 B1 EP0574465 B1 EP 0574465B1 EP 92905891 A EP92905891 A EP 92905891A EP 92905891 A EP92905891 A EP 92905891A EP 0574465 B1 EP0574465 B1 EP 0574465B1
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EP
European Patent Office
Prior art keywords
stage
low
pass filter
measurement signals
physiological measurement
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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EP92905891A
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German (de)
English (en)
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EP0574465A1 (fr
Inventor
Lena LUNDSTRÖM
Peter Karlsson
Thomas Ohlsson
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Siemens AG
Siemens Elema AB
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Siemens AG
Siemens Elema AB
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Publication of EP0574465A1 publication Critical patent/EP0574465A1/fr
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    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03H—IMPEDANCE NETWORKS, e.g. RESONANT CIRCUITS; RESONATORS
    • H03H17/00—Networks using digital techniques
    • H03H17/02—Frequency selective networks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods

Definitions

  • the invention relates to an arrangement for filtering out baseline fluctuations from physiological measurement signals with a sampling stage for forming samples of the measurement signals, a first low-pass filter connected to it, a downstream stage for reducing the sampling rate by a predetermined factor, a subsequent non-recursive second low-pass filter, and a subsequent interpolation stage for Increase of the sampling rate by the predetermined factor and with a subtraction stage for subtracting the sampling values coming from the interpolation stage from the sampling values of the physiological measurement signal coming from the sampling stage.
  • Physiological measurement signals that are taken from patients are normally from interference signals, such as superimposed on the 50 Hz AC voltage induced by the AC network, muscular electrical potentials and artifacts in connection with the decrease in the physiological measurement signals from the patient. These disturbances, as far as they are low-frequency in comparison to the characteristic frequency of the physiological measurement signals, are expressed in the form of baseline fluctuations in the measured signal curve.
  • the baseline fluctuations are filtered out of the electrocardiogram in the form of samples in a high-pass filter, which consists of a first non-recursive low-pass filter with a Subsequent stage for reducing the sampling rate by a factor of 8, a subsequent second non-recursive low-pass filter, a subsequent interpolation stage for increasing the sampling rate by a factor of 8 and a subtraction stage in which the baseline fluctuations obtained by the low-pass filtering are subtracted from the electrocardiogram afflicted with the baseline fluctuations become.
  • a high-pass filter which consists of a first non-recursive low-pass filter with a Subsequent stage for reducing the sampling rate by a factor of 8, a subsequent second non-recursive low-pass filter, a subsequent interpolation stage for increasing the sampling rate by a factor of 8 and a subtraction stage in which the baseline fluctuations obtained by the low-pass filtering are subtracted from the electrocardiogram afflicted with the baseline fluctuations become.
  • non-recursive filters which are characterized by an impulse response with a limited number of impulses (finite impulse reponse)
  • phase shifts and thus signal distortions during filtering are avoided.
  • the computational effort, i.e. the number of arithmetic operations (multiplications) to be carried out in the case of non-recursive filters is very high, which is why in the known arrangement the sampling rate of the electrocardiogram is reduced by a factor of 8 before the electrocardiogram is fed to the second non-recursive low-pass filter.
  • the first low-pass filter is used to limit the frequency of the electrocardiogram required to reduce the sampling rate.
  • the object of the invention is to reduce the computational effort required for scanning filtering when filtering out baseline fluctuations from physiological measurement signals.
  • the first low-pass filter according to the invention is a recursive filter, the cut-off frequency of which is chosen with respect to the cut-off frequency of the second low-pass filter so that phase shifts caused by the first low-pass filter are filtered out in the second low-pass filter.
  • recursive filters are characterized by a lower computing effort related to the filter performance or filter effect.
  • the disadvantage that recursive filters cause phase shifts in the signal to be filtered does not occur in the arrangement according to the invention insofar as the frequency range in which the phase shifts are practically effective is filtered out in the second low-pass filter.
  • a reduction in signal distortions in the filtering is advantageously achieved by a delay stage for the delayed forwarding of the samples coming from the sampling stage to the subtracting stage.
  • the same delay is selected for the delay stage as occurs in the low-pass filters.
  • the arrangement according to the invention is advantageously used in the process-coupled, that is to say on-line analysis of the physiological signals.
  • Reference number 1 denotes an input of the arrangement at which a physiological measurement signal, for example an electrocardiogram taken from a patient is present.
  • a sampling stage 2 is connected to input 1 to form samples of the physiological signal.
  • the samples are transmitted on the one hand via a delay stage 3 to a first input (+) of a subtraction stage 4 and on the other hand via a first low-pass filter, a downstream stage 6 for reducing the sampling rate, a subsequent second low-pass filter 7 and a subsequent interpolation stage 8 with a second input (- ) connected to the subtraction stage 4, at the output of which the physiological measurement signal freed from the baseline fluctuations is available in the form of samples for further process-coupled (on-line) signal processing.
  • the sampled physiological measurement signal is low-pass filtered, so that at the second input (-) of the subtraction stage 4 the sample values of the baseline fluctuations appear, which are subtracted in the subtraction stage 4 from the samples of the physiological measurement signal; blocks 3 to 8 thus form a high-pass filter.
  • the low-pass filter denoted by 7 is a non-recursive filter which does not produce any phase errors during filtering.
  • the computation effort that is to say the number of arithmetic operations to be carried out and the signal delay, are relatively high in such filters.
  • the rate of samples supplied to the low pass filter 7 is reduced. This is possible due to the relatively low frequency of the baseline fluctuations.
  • the sampling rate is reduced in stage 6.
  • the low-pass filter 5 arranged upstream of stage 6 serves to limit the frequency of the sampled measurement signal required for reducing the sampling rate.
  • the first filter 5 is a recursive filter, in which the computational effort in relation to the filter performance is considerably lower.
  • the disadvantage that the recursive filter has 5 phase errors in the one to be filtered Signal does not appear, since the cut-off frequency of the filter 5 with respect to that of the filter 7 is chosen so that the phase errors in the filter 7 are filtered out.
  • the unfiltered, sampled measurement signal is delayed in parallel in delay stage 3 by the same amount in order in subtraction stage 4 to subtract the baseline fluctuations from the measurement signal free of errors due to delay differences enable.
  • a sampling rate in sampling stage 2 of 500 Hz is preferably provided; the reduction factor in stage 5 is 40.
  • the arrangement works process-linked (on-line) with a signal processor, of which only a fraction of the computing capacity is used for the filtering.

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

Un agencement connu pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques se présentant sous forme de valeurs d'échantillonnage, est composé d'un premier filtre passe-bas (5) avec un étage (6) placé en aval pour la réduction du taux d'échantillonnage, suivi d'un second filtre non-récursif (7), puis d'un étage d'interpolation (8) pour l'augmentation du taux d'échantillonnage, et d'un étage de soustraction (4) dans lequel sont soustraites des signaux de mesure dépendant des oscillations de la ligne de base les oscillations de la ligne de base obtenues par le filtrage passe-bas. Pour la réduction du nombre des opérations de calcul à effectuer lors du filetage d'échantillonnage, le premier filtre passe-bas (5) est un filtre récursif.

Claims (3)

  1. Dispositif pour filtrer des fluctuations de la ligne de base de signaux de mesure physiologiques, comportant un étage (2) d'échantillonnage pour former des valeurs d'échantillonnage des signaux de mesure, un premier filtre (5) passe-bas relié à cet étage, un étage (6) disposé à la suite pour réduire d'un facteur prédéterminé la fréquence d'échantillonnage, un second filtre (7) passe-bas non récursif disposé à la suite, un étage (8) d'interpolation relié au second filtre pour accroître, du facteur prédéterminé, la fréquence d'échantillonnage et un étage (4) soustracteur pour soustraire des valeurs d'échantillonnage, arrivant de l'étage (8) d'interpolation, des valeurs d'échantillonnage du signal de mesure physiologique, qui viennent de l'étage (2) d'échantillonnage, caractérisé par le fait que le premier filtre (5) passe-bas est un filtre récursif, dont la fréquence limite est choisie par rapport à la fréquence limite du second filtre (7) passe-bas de telle sorte que la gamme de fréquences, dans laquelle sont situés les déphasages provoqués par le premier filtre (5) passe-bas, est séparée par filtrage dans le second filtre (7) passe-bas.
  2. Dispositif suivant la revendication 1, caractérisé par un étage (3) de retardement pour la transmission retardée des valeurs d'échantillonnage, qui arrivent de l'étage (2) d'échantillonnage, à l'étage (4) soustracteur.
  3. Utilisation du dispositif selon la revendication 1 ou 2 pour l'analyse couplée au processus ou analyse on-line des signaux de mesure physiologiques.
EP92905891A 1991-03-04 1992-03-04 Agencement pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques Expired - Lifetime EP0574465B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4106858 1991-03-04
DE4106858A DE4106858A1 (de) 1991-03-04 1991-03-04 Anordnung zum herausfiltern von grundlinienschwankungen aus physiologischen messsignalen
PCT/EP1992/000474 WO1992015243A1 (fr) 1991-03-04 1992-03-04 Agencement pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques

Publications (2)

Publication Number Publication Date
EP0574465A1 EP0574465A1 (fr) 1993-12-22
EP0574465B1 true EP0574465B1 (fr) 1996-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP92905891A Expired - Lifetime EP0574465B1 (fr) 1991-03-04 1992-03-04 Agencement pour l'extraction par filtrage d'oscillations de la ligne de base dans des signaux de mesure physiologiques

Country Status (5)

Country Link
US (1) US5433208A (fr)
EP (1) EP0574465B1 (fr)
JP (1) JP3171256B2 (fr)
DE (2) DE4106858A1 (fr)
WO (1) WO1992015243A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662617B2 (en) * 1992-04-06 1995-09-07 Alcatel Australia Limited A tone filter
US5586556A (en) * 1995-05-11 1996-12-24 T Z Medical, Inc. Pacemaker and heart monitoring and data transmitting device and method
SE9503019D0 (sv) * 1995-09-01 1995-09-01 Siemens Elema Ab Förfarande och anordning för att korrigera för icke fysiologiska variationer i EKG-signaler
US5762068A (en) * 1995-11-27 1998-06-09 Quinton Instrument Company ECG filter and slew rate limiter for filtering an ECG signal
US5715829A (en) * 1995-11-29 1998-02-10 Hewlett-Packard Company Method and apparatus for detecting heartbeats in an ECG waveform using an activity function and on-time search
SE9601387D0 (sv) * 1996-04-12 1996-04-12 Siemens Elema Ab Anordning för övervakning av för upptagning av fysiologiska mätsignaler avsedda mätelektroder samt deras tilledningar
US6148025A (en) * 1998-04-17 2000-11-14 Lucent Technologies, Inc. System and method for compensating for baseline wander
US6249696B1 (en) 1999-01-15 2001-06-19 Medtronic Physio-Control Manufacturing Corp. Method and apparatus for increasing the low frequency dynamic range of a digital ECG measuring system
US6280391B1 (en) 1999-02-08 2001-08-28 Physio-Control Manufacturing Corporation Method and apparatus for removing baseline wander from an egg signal
EP1834578B1 (fr) * 2004-12-22 2017-03-22 Nihon Kohden Corporation Afficheur de la representation graphique d'un cardiogramme corrige et procede d'affichage correspondant
US20070078353A1 (en) * 2005-10-04 2007-04-05 Welch Allyn, Inc. Method and apparatus for removing baseline wander from an ECG signal
US8202223B2 (en) * 2008-09-19 2012-06-19 Medtronic, Inc. Method and apparatus for determining respiratory effort in a medical device
US8891713B2 (en) * 2011-04-06 2014-11-18 Siemens Medical Solutions Usa, Inc. System for adaptive sampled medical signal interpolative reconstruction for use in patient monitoring
US9126055B2 (en) 2012-04-20 2015-09-08 Cardiac Science Corporation AED faster time to shock method and device
CN105899258B (zh) * 2013-11-08 2019-07-16 皇家飞利浦有限公司 可变带宽ecg高通滤波器
EP3065632A1 (fr) * 2013-11-08 2016-09-14 Koninklijke Philips N.V. Filtre passe haut pour ecg
US9690425B2 (en) * 2014-02-24 2017-06-27 Marvel World Trade Ltd. Systems and methods for tracking baseline signals for touch detection
CN111671416B (zh) * 2020-05-29 2022-11-29 中国科学院深圳先进技术研究院 心电信号滤波方法及装置
US11740339B2 (en) 2021-04-26 2023-08-29 National Tsing Hua University Ranging system

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE210148C (fr) *
DE3007907A1 (de) * 1980-03-01 1981-09-17 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Digitaler empfaenger
US4317094A (en) * 1980-05-21 1982-02-23 Texas Instruments Incorporated Remotely controlled circuit breaker system
US4317092A (en) * 1980-06-30 1982-02-23 Hewlett-Packard Company Recursive low pass digital filter
DE3028705A1 (de) * 1980-07-29 1982-02-11 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Minimalphasiges filter zur aenderung der abtastfrequenz
US4472785A (en) * 1980-10-13 1984-09-18 Victor Company Of Japan, Ltd. Sampling frequency converter
DE3047450C2 (de) * 1980-12-17 1985-07-11 ANT Nachrichtentechnik GmbH, 7150 Backnang Filter zur Änderung der Abtastfrequenz
DD210148A1 (de) * 1982-09-15 1984-05-30 Roland Radandt Verfahren zur hochpassfilterung von signalen
US5042026A (en) * 1987-03-03 1991-08-20 Nec Corporation Circuit for cancelling whole or part of a waveform using nonrecursive and recursive filters
GB2209648B (en) * 1987-09-10 1991-10-23 Ncr Co Modem communication system having main and secondary channels
US4896152A (en) * 1989-03-02 1990-01-23 General Electric Company Telemetry system with a sending station using recursive filter for bandwidth limiting
DE3916236A1 (de) * 1989-05-18 1990-11-22 Ant Nachrichtentech Digitalfilter mit daempfungs- und phasengangentzerrung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
R. King et al., "Digital Filtering in One and Two Dimensions", Plenum Press, New York und London, 1989, Seiten 40 - 43, 48 - 49, 134 - 137, 154 - 157, 418 *

Also Published As

Publication number Publication date
US5433208A (en) 1995-07-18
DE4106858A1 (de) 1992-09-10
JP3171256B2 (ja) 2001-05-28
JPH06504696A (ja) 1994-06-02
DE59206575D1 (de) 1996-07-18
EP0574465A1 (fr) 1993-12-22
WO1992015243A1 (fr) 1992-09-17

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