EP0569656A1 - Vorrichtung zum Schliessen zweiteiliger Kapseln - Google Patents

Vorrichtung zum Schliessen zweiteiliger Kapseln Download PDF

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Publication number
EP0569656A1
EP0569656A1 EP92830210A EP92830210A EP0569656A1 EP 0569656 A1 EP0569656 A1 EP 0569656A1 EP 92830210 A EP92830210 A EP 92830210A EP 92830210 A EP92830210 A EP 92830210A EP 0569656 A1 EP0569656 A1 EP 0569656A1
Authority
EP
European Patent Office
Prior art keywords
capsule
liquid
parts
capsules
rod
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92830210A
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English (en)
French (fr)
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EP0569656B1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senesi Roberto
Original Assignee
Senesi Roberto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesi Roberto filed Critical Senesi Roberto
Priority to AT92830210T priority Critical patent/ATE126692T1/de
Priority to EP92830210A priority patent/EP0569656B1/de
Priority to DE69204278T priority patent/DE69204278D1/de
Publication of EP0569656A1 publication Critical patent/EP0569656A1/de
Application granted granted Critical
Publication of EP0569656B1 publication Critical patent/EP0569656B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof

Definitions

  • the invention relates to a device for closing two-part capsules, for example capsules for medicinal use, comprising a support means for an upper part of the capsule and means of application on said upper part of the capsule. a liquid intended to cause the reciprocal junction between the upper part of the capsule and the lower part thereof.
  • the invention also relates to a method for closing two-part capsules, for example capsules for medicinal use, comprising the distribution phases on one of the two capsule parts of a liquid intended to cause the reciprocal junction of the two parts of the capsule. the capsule and then union of the two parts of the capsule to cause the joining by gluing.
  • capsules made of gelatin or, according to the most recent technique, starch are frequently used as containers for powdered medicaments. These capsules have a first part or body, inside which is introduced the powder to be packaged, and an upper cap which must be slipped on the body and welded thereto.
  • liquids of various kinds depending on the type of substance used for producing the capsule.
  • capsules made of starch it is sufficient to apply on the inner edge of the upper part of the capsule a small amount of water or another solvent, which causes a softening of the starch. Then by putting the upper part of the capsule on the body thereof and drying, we obtain an effective and reliable closure of the capsule itself.
  • the object of the present invention is to provide a device of the type mentioned in the preamble of the main claim, which allows to obtain a correct application of the liquid on the upper part of the capsule in a simpler and more reliable way than for your traditional type devices.
  • the device according to the invention is based on a new principle of application of the liquid, which uses application means comprising an absorbent member which removes the fluid in a container by capillary action and distributes it on the upper part of the container. capsule, in correspondence of the joining edge of said upper part with the body of the capsule. Therefore, the device according to the invention does not include liquid compression means or suction means thereof. Moreover, it is not necessary to make mechanical devices of small dimensions with spray nozzles and suction ports, as is necessary in devices of known type. The entire liquid collection process and application thereof is carried out passively by exploiting the physical characteristics of an absorbent means, which may be constituted for example by a buff synthetic skin, cotton fiber or similar material .
  • the device comprises a rod corresponding to the upper end of which is disposed a member of absorbent material which receives the liquid by capillarity from a tank placed underneath.
  • a rod corresponding to the upper end of which is disposed a member of absorbent material which receives the liquid by capillarity from a tank placed underneath.
  • a disco member of absorbent material in correspondence of said upper end of the rod may be disposed a disco member of absorbent material, the diameter of which corresponds to the diameter of the edge of the upper inner portion of the capsule, so that the latter can be threaded on the disco element to and be wetted uniformly therethrough along the entire circumference of the coupling edge with the body of the capsule.
  • the disco member of an absorbent material may be in contact with a web-like linear member extending along the stem from said upper end to a reservoir below, for sampling the liquid. contained in said tank.
  • the longitudinal member may be made in the form of a strip housed in longitudinal seats formed in a central axis of housing, surrounded by an outer cylindrical closure member.
  • the upper part of the capsule must be taken by a feeding device via a suitable support means which makes it possible to successively present said capsule part to the means for applying the liquid and then to the body of the capsule beforehand. filled with powder or other substance to be packaged.
  • the support means may comprise, according to the invention, a cavity or a housing provided with an annular seal, in which the upper part of the capsule can be inserted with a slight interference under the effect of a simple movement of lowering the support means on the capsule portion predisposed on the supply device.
  • the annular seal maintains the upper portion of the capsule for as long as is necessary for applying the liquid to the edge thereof and until the top of the capsule adheres to the body of the capsule.
  • an extractor or by creating an overpressure in the cavity of the support means it causes the dislocation of the upper capsule portion out of this cavity; said upper portion remains adhered to the capsule body suitably supported in a restraint seat.
  • a carrier member equipped with one or more of said support means and adapted to be positioned in a first position in correspondence with a device for feeding the upper parts of the capsule and a second position. in correspondence of the corresponding means for applying the liquid. From this position, after wetting the edge of all the capsule parts supported by the various support means of the carrier member, the latter is moved by translation in a third position in correspondence of corresponding means for supporting the body or lower part of the capsule. Lowering the equipped carrier means for supporting the upper parts of the capsule causes the simultaneous closure of all the capsule bodies placed below.
  • reference numeral 1 indicates a feeding device on which there are several closure capsules or upper portion S of capsule, coming from a suitable container. Each of these S parts is taken by a corresponding support means indicated generically by 3 and shown in greater detail in FIG. 2.
  • a carrier member 5 for example in the form of a bar extending perpendicularly to the plane of the drawing, on which is applied a series of support means 3. With a lowering movement along the arrow f3 (FIG 2), each support means 3 is threaded onto an upper portion S of capsule placed below.
  • the support means 3 of the capsule portion S comprises a cylindrical member 7 forming a cavity 9 with a groove 11 in which is housed a seal 13 annular and circular section.
  • the support means 3 When the support means 3 is threaded onto the capsule portion S, it enters the cavity 9 and is held with slight interference by the seal 13 in the position shown in FIG. 3.
  • the upper capsule portion S has an edge of lower thickness, intended to be threaded onto a corresponding upper edge of a capsule body shown in particular in FIG. 7 and indicated by C.
  • a suitable liquid on the edge B of the upper part S of the capsule is provided to stably join the upper part S and the lower part C of the capsule.
  • the liquid used may be water, or a solution of water and alcohol or a similar liquid, which causes a softening or a partial dissolution of the starch in the d-zone. 'application.
  • the edge B of the capsule portion S has thus been moistened and thus partially dissolved or softened, it can be threaded onto the upper edge of the capsule body C so that the successive drying of the starch causes the junction of the two parts C and S and sealingly encloses the contents P of the capsule.
  • the means 15 comprise a rod consisting of a central axis 17 and an outer cylindrical member 19.
  • the axis 17 has two diametrically opposed flats 21 which form, with a cylindrical chamber 23 defined by the organ cylindrical 19, two longitudinal seats for a strip of absorbent material indicated by 25.
  • the strip 25 is U-shaped inside the two diametrically opposed seats 21, while in an intermediate section of said strip is provided a hole, so that the strip 25 can be slipped onto the end 29 of the 17 having a reduced diameter, in order to be maintained in a predetermined position relative to the axis 17.
  • a threaded hole in which s' engages a screw 31 for locking on the axis 17 an end member 33.
  • the screw 31 squeezes the end member 33 on the rod 17 so as to keep the disc member in close contact with the band 25 for the purposes indicated below.
  • the length of the end 29 and the thickness of the web-forming material 25 and the disco element 35 can be suitably calibrated to clamp with the desired force absorbent material and thus obtain the distribution of the correct amount of liquid
  • the application means 15 is supported by a cross member 37 which can carry a plurality of said application means 15 arranged in a row or in several rows, and in any case according to a provision corresponding to the arrangement of the support means 3 which are presented above the means 15 and lowered thereon to bring the upper parts S of the capsule in contact with the different disco elements 33 arranged in correspondence of the ends of the different means of application 15 carried by your cross member 37.
  • a container (not shown) in which is contained the liquid L to be uniformly applied to the edge B of the capsule parts S.
  • the strip 25 has a length such that its ends 25E are always immersed in the liquid L, which is taken by capillarity and goes up along the two branches of the strip 25 to impregnate the disco element of 35. Therefore, when an upper portion S of capsule is threaded onto the disco member 35 (which suitably exceeds the external profit of the rod formed by the members 17, 19 and 33), on the annular edge B of said portion S is distributed uniformly an amount of liquid L sufficient to cause the softening or partial dissolution of the material constituting the capsule.
  • the carrier member 5 with the support means 3 may be raised and moved by translation to arrive in correspondence of a member 40 which has a plurality of seats 42 in which are housed the body C of the capsules which must be closed by means of the upper parts S appropriately wetted along their edges B
  • the support means 37 are then lifted to thread the capsule portions S onto the capsule bodies C and thereby to close the capsules themselves.
  • FIG. 7 is shown the closing phase of the capsules.
  • the carrier member 5 can be lifted along the arrow f5 from the position of FIG. 7 to disengage the part S of the seat 9.
  • the dislocation of the upper part S of the capsule out of the seat 9 can be facilitated by means of an extractor or an overpressure created in said seat 9, by acting through the orifice placed above it (Fig. 2).
  • the different capsules are hermetically closed and ready to be packaged. They are extracted from the member 40 by means of a suitable extractor or other.
  • the device according to the invention can be used not only for the closure of starch capsules which require the application of liquid solvents (such as water or mixtures of water and alcohol or the like), but also in all your other cases in which, for the closing of the capsule, is necessary the application of a liquid whose properties The physical properties are such that they allow the sampling in a reservoir by capillarity.
  • the rod 17 with the tip 33, the absorbent strip 25 and the disco element 35 could be vertically movable inside the cylindrical member 19.
  • the disco element 35 could be cyclically compressed between the upper edge of the cylindrical member 19 fixed and the tip 33 movable, each liquid application operation on the upper part S of the capsule.
  • the pressing of the disco element causes the dispensing of a larger amount of liquid.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Seal Device For Vehicle (AREA)
  • Credit Cards Or The Like (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
EP92830210A 1992-05-07 1992-05-07 Vorrichtung zum Schliessen zweiteiliger Kapseln Expired - Lifetime EP0569656B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT92830210T ATE126692T1 (de) 1992-05-07 1992-05-07 Vorrichtung zum schliessen zweiteiliger kapseln.
EP92830210A EP0569656B1 (de) 1992-05-07 1992-05-07 Vorrichtung zum Schliessen zweiteiliger Kapseln
DE69204278T DE69204278D1 (de) 1992-05-07 1992-05-07 Vorrichtung zum Schliessen zweiteiliger Kapseln.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92830210A EP0569656B1 (de) 1992-05-07 1992-05-07 Vorrichtung zum Schliessen zweiteiliger Kapseln

Publications (2)

Publication Number Publication Date
EP0569656A1 true EP0569656A1 (de) 1993-11-18
EP0569656B1 EP0569656B1 (de) 1995-08-23

Family

ID=8212099

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92830210A Expired - Lifetime EP0569656B1 (de) 1992-05-07 1992-05-07 Vorrichtung zum Schliessen zweiteiliger Kapseln

Country Status (3)

Country Link
EP (1) EP0569656B1 (de)
AT (1) ATE126692T1 (de)
DE (1) DE69204278D1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034269A1 (en) * 1994-06-16 1995-12-21 Warner-Lambert Company Process and apparatus for producing closed sealed capsules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2187703A (en) * 1986-03-12 1987-09-16 Warner Lambert Co Process for filling and sealing a vessel
DE3814097A1 (de) * 1987-04-27 1988-11-17 Mg 2 Spa Maschine zur befeuchtung eines an einem unterteil zu befestigenden deckels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2187703A (en) * 1986-03-12 1987-09-16 Warner Lambert Co Process for filling and sealing a vessel
DE3814097A1 (de) * 1987-04-27 1988-11-17 Mg 2 Spa Maschine zur befeuchtung eines an einem unterteil zu befestigenden deckels

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034269A1 (en) * 1994-06-16 1995-12-21 Warner-Lambert Company Process and apparatus for producing closed sealed capsules
US5617710A (en) * 1994-06-16 1997-04-08 Warner-Lambert Company Process and apparatus for producing closed sealed capsules
CN1104876C (zh) * 1994-06-16 2003-04-09 沃尼尔·朗伯公司 制造密封胶囊的方法和设备

Also Published As

Publication number Publication date
DE69204278D1 (de) 1995-09-28
EP0569656B1 (de) 1995-08-23
ATE126692T1 (de) 1995-09-15

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