EP0520571A1 - Zerstäubungsdüse - Google Patents

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Publication number
EP0520571A1
EP0520571A1 EP92201841A EP92201841A EP0520571A1 EP 0520571 A1 EP0520571 A1 EP 0520571A1 EP 92201841 A EP92201841 A EP 92201841A EP 92201841 A EP92201841 A EP 92201841A EP 0520571 A1 EP0520571 A1 EP 0520571A1
Authority
EP
European Patent Office
Prior art keywords
orifice
liquid
nozzle
nozzle according
gap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92201841A
Other languages
English (en)
French (fr)
Other versions
EP0520571B1 (de
Inventor
Terence Edward Weston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weston Medical Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919114080A external-priority patent/GB9114080D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP0520571A1 publication Critical patent/EP0520571A1/de
Application granted granted Critical
Publication of EP0520571B1 publication Critical patent/EP0520571B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/0064—Lift valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/007—Outlet valves actuated by the pressure of the fluid to be sprayed being opened by deformation of a sealing element made of resiliently deformable material, e.g. flaps, skirts, duck-bill valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/0072—A valve member forming part of an outlet opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B05B11/1004—Piston pumps comprising a movable cylinder and a stationary piston
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1066—Pump inlet valves
    • B05B11/1067—Pump inlet valves actuated by pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1066—Pump inlet valves
    • B05B11/1067—Pump inlet valves actuated by pressure
    • B05B11/1069—Pump inlet valves actuated by pressure the valve being made of a resiliently deformable material or being urged in a closed position by a spring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1073—Springs
    • B05B11/1074—Springs located outside pump chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1073—Springs
    • B05B11/1077—Springs characterised by a particular shape or material

Definitions

  • the invention relates to atomising nozzles commonly used for, but not limited to, hand held sprayers such as so-called aerosols and pump type atomisers, intended for the application of liquid household, cosmetic and pharmaceutical products.
  • Aerosol type sprayers are used throughout the world for dispensing a wide range of products, for example hair lacquer, furniture polish, cleaners, paint, insect killers and medicaments.
  • chlorofluorocarbons CFC's
  • CFC's chlorofluorocarbons
  • aerosol generators used for research and hospital applications, such as ultrasonic nebulisers and spinning disc generators, but neither is suitable for portable, convenient atomisers.
  • high pressure (125 - 500 bars) spring or gas operated pumps are in common use to inject a jet of drug through the skin (“intra-dermal injection") without the use of needles, and attachments are available to convert the jet to a spray for administering drugs to the nasal passages of large animals such as swine.
  • needle-less injectors are in common use to inject a jet of drug through the skin (“intra-dermal injection") without the use of needles, and attachments are available to convert the jet to a spray for administering drugs to the nasal passages of large animals such as swine.
  • the smallest droplet size obtainable is in the order of 40 micrometers, and the range of applications for these injectors is limited.
  • Compressed air atomisers such as air brushes and commercial paint sprayers consume large quantities of air, and to obtain droplets of 5 micrometers with water for example, a gas to liquid ratio of over 30,000:1 is required, which is impractical for convenient, portable sprayers.
  • space sprays such as flying insect killers should contain droplets ideally in the range of 20-30 micrometers diameter to ensure a long flotation time in the air, and for metered dose inhalers (MDI's) used for treating certain respiratory disorders it is essential that the aerodynamic particle size should be less than 15 micrometers, preferably less than 5 micrometers, so that the droplets are able to penetrate and deposit in the tracheobronchial and alveolar regions of the lung.
  • MDI's metered dose inhalers
  • the aerodynamic particle size should be less than 15 micrometers, preferably less than 5 micrometers, so that the droplets are able to penetrate and deposit in the tracheobronchial and alveolar regions of the lung.
  • more than 5% by weight of the droplets should have an aerodynamic size less than 6.4 micrometers, preferably more than 20 by weight of the particles have an aerodynamic size less than 6.4 micrometers.
  • Inhalers may also be designed to deliver drugs to the alveolar sacs of the lung to provide a route for adsorption into the blood stream of drugs that are poorly adsorbed from the alimentary tract.
  • the aerodynamic size of the particles is less than 10 micrometers, preferably 0.5-5 micrometers.
  • drugs used in the treatment of respiratory disorders are insoluble in vehicles such as water and are dispensed as suspensions.
  • the drugs are produced in a respirable size of 1-5 micrometers. Particles of this size tend to block the very small holes (5-10 micrometers) used by known devices to generate droplets of about 5 micrometers diameter.
  • the present invention aims to provide a design of atomising nozzle which is capable, inter alia , of being used to give a nozzle which will produce a spray of droplets of a size suitable for inhalation, without the use of liquefied gas propellants.
  • the present invention is believed to be capable of being used to give a nozzle which will produce a spray of droplets having a mean diameter anywhere in the range of from 0.5 to over 100 micrometers.
  • an atomising nozzle for producing a spray of droplets from a liquid passing through the nozzle under pressure, which nozzle comprises means defining an orifice; a closure member for the orifice, the orifice-defining means and closure member being relatively movable with respect to one another between a first position in which the closure member cooperates with the orifice to close it and a second position in which the closure member is spaced from the orifice-defining means to define a gap therebetween; and a stop for limiting relative movement between the orifice-defining means and the closure member to ensure that the width of the gap cannot exceed that which will produce a fine spray.
  • the invention is intended mainly for metered dose inhalers and manually operated pumps, it may also be applied in other applications requiring small droplets, for example in certain industrial processes.
  • the nozzle has a circular orifice which is sealingly closed by a ball urged by a spring.
  • the ball Under the action of liquid under pressure, the ball is displaced from the orifice by an amount determined by the stop, which may be fixed or adjustable, and the fluid flows through the gap thus formed and emerges as a thin circular sheet.
  • the stop which may be fixed or adjustable, and the fluid flows through the gap thus formed and emerges as a thin circular sheet.
  • the stop which may be fixed or adjustable
  • the liquid to be sprayed is caused to flow past a spherical surface and through a gap formed between that surface and a circumambient hole in a plate.
  • the plate is preferably made of a spring material and located so that it is in sealing contact with the spherical surface as a normally closed valve. Under the action of liquid under pressure, the plate is forced away from the spherical surface by an amount determined by the stop, which may be fixed or adjustable, and the fluid flows through the gap thus formed to emerge as a thin circular sheet. As the sheet of liquid expands, it becomes thinner, and the outer edge breaks into droplets, the diameter of which are determined by the size of the gap, the pressure of liquid and the physical properties of the liquid. When the pressure in the liquid is reduced below a predetermined level, the spring plate returns to its original position to seal against the spherical surface, thus preventing ingress of dirt, evaporation of the remaining product, and atmospheric contamination.
  • the present invention provides for all combinations of surfaces and holes, but it is preferred that at least one of the components has a varying cross section so that the gap between them is opened or closed as a result of relative movement. Since the stop ensures that the gap is of substantially constant size when the components are fully apart, an even spray results from the passage of fluid throughout the length of the gap.
  • the width of the gap is preferably of the order of 5 micrometers.
  • the ratio of the length of the gap L to the width of the gap D is preferably not more than 1 and more preferably not more than 0.5.
  • the surface finish of the co-operating components in the region of the gap should be sufficiently fine so as not to adversely affect the droplet size and pattern of the spray: for example, a groove in one component would cause a stream of liquid to issue therefrom, which would probably not have the required characteristics, and could lower the pressure in the liquid sufficiently to adversely affect the quality of spray emerging from the remainder of the gap.
  • the finish should be sufficiently fine to ensure efficient sealing between the components when in the closed position.
  • the invention further provides an atomising device which comprises an atomising nozzle according to the present invention, a supply of liquid, and means for providing liquid under pressure from said supply to said nozzle.
  • the device is an inhalation device, and the liquid comprises a medicament suitable for inhalation.
  • the liquid may contain the medicament in suspension or solution, and the liquid may be an aqueous or non-aqueous liquid which is physiologically acceptable.
  • ball 1 is resiliently urged by a compression spring 6 into a position in which it is sealingly located on the circular orifice 3 of nozzle 2.
  • Stop means 5 is located on the longitudinal axis of the ball and orifice, and has a gap 8 between the face 9 of the stop means 5 and the surface of ball 1.
  • Nozzle 2 is in hydraulic communication with a dispensing means (not shown) and contains liquid 7 which is to be sprayed.
  • the size of the droplets is controlled by the dimension of the gap 10 and the velocity of the liquid, which in turn depends on the pressure generated in the dispenser.
  • a smaller gap 10 will generally produce smaller droplets, provided that the pressure in the liquid is sufficiently high to overcome the viscous drag created by the small gap, and accelerate the liquid to form a thin sheet. (If the pressure is too low, the liquid will merely ooze from the gap).
  • the ball 1 When the pressure in the liquid 7 ceases, the ball 1 is returned to sealing contact with orifice 3 by spring 6. It is preferable that the contact line between the ball 1 and orifice 3 is very thin, which may be facilitated by chamfering the nozzle as at 4, so as to leave a knife edge. This may have the additional effect of allowing a wider spray angle Z than possible with a square-edged orifice.
  • Figures 3 and 4 show a modification in which the stop means 5 is replaced by an alternative stop means 5a which has a recess 5b within which the spring 6 is housed.
  • the nozzle goes from the closed position shown in Figure 3 to the open position shown in Figure 4, the ball 1 seats itself in the open end of the recess.
  • the guidance which this provides ensures that the ball is correctly aligned with respect to the end of the conduit 2, with a uniform annular gap between the orifice 3 and the ball.
  • the spray produced is thus substantially uniform both in distribution around the gap and in droplet size.
  • Figure 5 shows a spherical surface 20 which is located at the outer edge of the discharge conduit 21 containing the liquid to be sprayed 22.
  • a spring plate 24 having a circular orifice 25 is held against the spherical surface 20 so that the circular orifice 25 makes sealing contact with the spherical surface 25, and the outer edge of the spring plate 24 is in sealing contact with the abutment face 26 of conduit 21, thus preventing the passage of liquid 22.
  • a plate 27 having a circular hole 29 is assembled on to the outer face of spring plate 24 so that the hole 29 is co-axial with orifice 25.
  • a step or recess 30 in plate 27 provides a gap 28 between the spring plate 24 and plate 27, the assembly of the two plates being held in sealing contact with the abutment 26 by retaining member 33, which may be a crimped-on ring as shown.
  • the liquid 22 is pressurised by the dispensing means (not shown), and forces plate 24 away from the spherical surface 20, against the inherent bias provided by the fact that the plate 24 is a spring plate, to create the gap 32 between the circular orifice 25 and spherical surface 20.
  • the size of the gap 32 is determined by the size of the gap 28 and by the diameter of the hole 29 in the plate 27, which, between them, determine the extent to which the spring plate 24 can flex.
  • the liquid issues from the gap 32 as a thin circular sheet, the outer edge of which breaks into droplets as previously described.
  • the edge of the circular orifice 25 in spring plate 24 may have a chamfer 40 as shown in Figure 7, which may permit a wider spray angle than possible with a square-edged orifice.
  • the spring plate 24 may have corrugations co-axial with the orifice 25 as shown in Figure 8, which will facilitate the flexing of the spring plate. When the pressure is removed from the liquid 22, the spring plate 24 returns to sealing contact with the spherical surface 20.
  • Figures 5 and 6 the spherical surface 20 is shown diagrammatically as being at the end of a rod, and means (not shown) would be required to support the rod with respect to the fluid discharge conduit 21.
  • Figures 9 and 10 show a modified embodiment in which there is a spherical surface 20a formed on a disc 50 which is secured to, or integral with, the inner wall of the conduit 21.
  • the disc 50 is provided with at least one port 51 through which liquid can pass from the interior of the conduit 21 to the region immediately below the plate 24.
  • Figures 11 to 13 show a spray device incorporating an atomising nozzle according to the present invention. It is intended for use as an inhalation device. It comprises a reservoir 60 of liquid 61.
  • the liquid 61 may, for example, consist of an aqueous suspension of a medicament suitable for treatment of a condition such as asthma.
  • the lower end of the reservoir is defined by a piston 62 which is longitudinally slidable within the reservoir. Beneath the piston is a stopper 63 which has at least one orifice 64 therein to permit air to enter the space beneath the piston.
  • the upper end of the reservoir has a neck portion 65 to which a closure member 66 is secured.
  • a portion 67 of the closure member extends within the neck, and an O-ring seal 68 provides a seal between the neck portion 65 and the portion 67.
  • the closure member 66 has a passage 69 therethrough and a tube 70 is secured in the upper portion of this passage.
  • the lower portion of the passage defines an orifice 71, above which is a tapered portion defining a seat for a check valve ball 72. The ball is urged against the seat by a compression spring 73.
  • An outlet member 74 is mounted on the closure member 66 so as to be movable with respect thereto.
  • the outlet member 74 comprises a generally cylindrical part 75 the lower end of which engages over the closure member 66.
  • the part 75 is prevented from separating from the closure member 66 by interengaging flanges 76 and 77 thereon.
  • the outlet member 74 further comprises an outlet spout 78 through which a user can inhale through his or her mouth. In the case of an inhaler for nasal use, the spout 78 would be replaced by an appropriate nasal outlet.
  • the outlet member 74 has an inwardly extending wall 79 which serves to retain an atomising arrangement 80.
  • the hollow portion 82 has an outwardly extending flange 84 at its upper end, and a compression spring 85 is mounted between the flange and the closure member 66.
  • the interior of the hollow portion 82 communicates via a passage 86 with an atomising nozzle 90 according to the invention.
  • This is shown on a larger scale in Figure 13. As can be seen there, it corresponds substantially to what is shown in Figures 9 and 10, and comprises a spring plate 91 which cooperates with a spherical surface 92 formed on a disc 93.
  • the disc 93 is provided with at least one port 94 therethrough.
  • the user places his or her mouth over the spout 78 and squeezes the reservoir 60 and outlet member 74 together against the force of the compression spring 85 to bring the device into the position shown in Figure 12.
  • the ball 72 prevents liquid leaving the reservoir 60 through the orifice 71, and the tube 70 acts as a piston to expel part of the liquid above the ball through the nozzle 90 where it forms an atomised spray.
  • the quantity of liquid expelled in this way constitutes a metered dose, metering being effected by the stroke of the piston.
  • the user inhales this spray.
  • the spring 85 forces them apart.
  • Figure 14 shows another embodiment of spray device.
  • the figure shows the device in the discharge position.
  • a valve of similar design to that used as the atomising nozzle is used also as a non-return inlet valve.
  • Figure 14 shows an actuator 101 sealingly located on a hollow stem 104 which is integral with a hollow piston 107.
  • Piston 107 is slidingly located within the cylinder 115, the cylinder being formed as the inner part of a pump body 108.
  • the body is retained by a snap fit or other convenient method of retention in a closure 105, a gasket 106 providing a seal between the stem 104 and the closure 105.
  • Gasket 106 is free to flex with axial displacement of the piston and stem, whilst maintaining a seal.
  • a plurality of cantilever springs 109 formed integrally with piston 107, urges the piston in an outward direction by reacting against a conical surface 110 formed in the lower part of the pump body 108.
  • the piston is prevented from coming out of the pump body 108 by an abutment 116 closing on to the gasket 106 which is supported by the inside of the closure 105.
  • the lower end of the pump body 108 contains a spherical surface 111.
  • a flexible diaphragm 112 with a circular hole therein is sealingly located in the pump body 108 so that the edge of the hole is in sealing engagement with the spherical surface 111.
  • the combination of diaphragm 112 and surface 111 acts as a normally closed non-return valve 120.
  • the extreme lower part of the pump body 108 terminates in a diameter adapted to sealingly retain a dip tube 113.
  • the conduit defined by the dip tube 113 and extreme lower part of the pump body 108 is in communication with an annulus 119 formed between the spherical surface 111 and the diaphragm 112 via one or more ports 117.
  • the actuator 101 has a spherical surface 103, and a flexible diaphragm 102 with a circular hole therein, the edge of which hole is in sealing engagement with the spherical surface 103.
  • the diaphragm 102 is sealingly located by a snap fit or other convenient method within the actuator 101, and the combination of diaphragm 102 and surface 103 acts as a combined non-return valve and atomising nozzle 121.
  • the hollow stem 104 is in communication with annulus 114 via a port 118.
  • the actuator is depressed and allowed to return several times to prime the pump, the valves 120 and 121 cooperating to draw liquid from a reservoir (not shown) and to discharge the liquid from the atomising nozzle.
  • Figure 15 shows an atomising nozzle in which, unlike those described so far, a means is provided for enabling the gap through which the liquid passes to be adjusted.
  • the nozzle comprises a body 201 which has a threaded exterior to receive a threaded cap 202.
  • the cap may be adjusted to alter a gap 203 formed between a face 204 of the cap and a flexible diaphragm 205. In this way the discharge characteristics may be readily adjusted; for example a spray may be adjusted from a fine to a coarse droplet size.
  • liquid used in this specification includes solutions, suspensions and emulsions.

Landscapes

  • Nozzles (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Special Spraying Apparatus (AREA)
EP92201841A 1991-06-28 1992-06-23 Zerstäubungsdüse Expired - Lifetime EP0520571B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9114080 1991-06-28
GB919114080A GB9114080D0 (en) 1991-06-28 1991-06-28 Atomising valve
GB9205969 1992-03-18
GB929205969A GB9205969D0 (en) 1991-06-28 1992-03-18 Atomising pump

Publications (2)

Publication Number Publication Date
EP0520571A1 true EP0520571A1 (de) 1992-12-30
EP0520571B1 EP0520571B1 (de) 1998-09-09

Family

ID=26299156

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92201841A Expired - Lifetime EP0520571B1 (de) 1991-06-28 1992-06-23 Zerstäubungsdüse

Country Status (14)

Country Link
EP (1) EP0520571B1 (de)
JP (1) JP3162487B2 (de)
AR (1) AR247836A1 (de)
AT (1) ATE170778T1 (de)
AU (1) AU1859192A (de)
BR (1) BR9202411A (de)
CA (1) CA2072544A1 (de)
DE (1) DE69226908T2 (de)
DK (1) DK0520571T3 (de)
ES (1) ES2119794T3 (de)
FI (1) FI922965A (de)
IE (1) IE80891B1 (de)
MX (1) MX9203622A (de)
NZ (1) NZ243321A (de)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016746A1 (de) * 1994-12-01 1996-06-06 Josef Wischerath Gmbh & Co., Kg Spender
US5881954A (en) * 1993-04-30 1999-03-16 Danmist Aps Method and device for atomising fluids
US5964416A (en) * 1995-10-04 1999-10-12 Boehringer Ingelheim Gmbh Device for producing high pressure in a fluid in miniature
DE19919461A1 (de) * 1999-04-29 2000-11-02 Elias Russegger Verschließbare Düse
EP1188486A2 (de) * 2000-08-10 2002-03-20 Carow International, Inc. Pumpen-Betätigungsvorrichtung mit Kunststofffeder
WO2005107837A1 (de) * 2004-05-03 2005-11-17 Boehringer Ingelheim International Gmbh Zerstäuber zum ausbringen von flüssigkeiten für medizinische zwecke
USRE43174E1 (en) 2000-04-11 2012-02-14 Trudell Medical International Aerosol delivery apparatus
AT515995A1 (de) * 2014-07-10 2016-01-15 Tech Universität Graz Vorrichtung und Verfahren zur Zerstäubung einer Flüssigkeit
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9700689B2 (en) 2002-05-21 2017-07-11 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
WO2019086823A1 (en) * 2017-10-31 2019-05-09 Leafgreen Limited Spray configuration
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
CN115089824A (zh) * 2022-06-15 2022-09-23 宁波司麦儿医学科技有限公司 一种雾化器

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US6293279B1 (en) * 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
CN105104119A (zh) * 2015-08-19 2015-12-02 张萍 一种用于园林园艺工程的可无线通讯的智能浇灌装置
DE102016123993B4 (de) * 2016-12-09 2021-12-30 Aebi Schmidt Nederland Bv Flüssigkeitsstrahl-Verschlussdüse

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US5881954A (en) * 1993-04-30 1999-03-16 Danmist Aps Method and device for atomising fluids
WO1996016746A1 (de) * 1994-12-01 1996-06-06 Josef Wischerath Gmbh & Co., Kg Spender
US5964416A (en) * 1995-10-04 1999-10-12 Boehringer Ingelheim Gmbh Device for producing high pressure in a fluid in miniature
US6402055B1 (en) 1995-10-04 2002-06-11 Boehringer Ingelheim Gmbh Device for producing high pressure in a fluid in miniature
US6497373B2 (en) 1995-10-04 2002-12-24 Boehringer International Gmbh Device for producing high pressure in a fluid in miniature
US6918547B2 (en) 1995-10-04 2005-07-19 Joachim Jaeger Device for producing high pressure in a fluid in miniature
US7104470B2 (en) 1995-10-04 2006-09-12 Boehringer Ingelheim International Gmbh Device for producing high pressure in a fluid in miniature
DE19919461A1 (de) * 1999-04-29 2000-11-02 Elias Russegger Verschließbare Düse
USRE43174E1 (en) 2000-04-11 2012-02-14 Trudell Medical International Aerosol delivery apparatus
USRE46050E1 (en) 2000-04-11 2016-07-05 Trudell Medical International Aerosol delivery apparatus
USRE45068E1 (en) 2000-04-11 2014-08-12 Trudell Medical International Aerosol delivery apparatus
EP1188486A3 (de) * 2000-08-10 2002-05-15 Carow International, Inc. Pumpen-Betätigungsvorrichtung mit Kunststofffeder
EP1188486A2 (de) * 2000-08-10 2002-03-20 Carow International, Inc. Pumpen-Betätigungsvorrichtung mit Kunststofffeder
US10881816B2 (en) 2002-05-21 2021-01-05 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US9814849B2 (en) 2002-05-21 2017-11-14 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US9700689B2 (en) 2002-05-21 2017-07-11 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US7819342B2 (en) 2004-05-03 2010-10-26 Boehringer Ingelheim International Gmbh Atomizer for dispensing liquids for medical purposes
EA009854B1 (ru) * 2004-05-03 2008-04-28 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель жидкостей медицинского назначения
WO2005107837A1 (de) * 2004-05-03 2005-11-17 Boehringer Ingelheim International Gmbh Zerstäuber zum ausbringen von flüssigkeiten für medizinische zwecke
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
AT515995A1 (de) * 2014-07-10 2016-01-15 Tech Universität Graz Vorrichtung und Verfahren zur Zerstäubung einer Flüssigkeit
AT515995B1 (de) * 2014-07-10 2018-08-15 Univ Graz Tech Vorrichtung und Verfahren zur Zerstäubung einer Flüssigkeit
WO2019086823A1 (en) * 2017-10-31 2019-05-09 Leafgreen Limited Spray configuration
CN115089824A (zh) * 2022-06-15 2022-09-23 宁波司麦儿医学科技有限公司 一种雾化器
CN115089824B (zh) * 2022-06-15 2024-02-02 宁波司麦儿医学科技有限公司 一种雾化器

Also Published As

Publication number Publication date
EP0520571B1 (de) 1998-09-09
AU1859192A (en) 1993-01-07
JPH06178954A (ja) 1994-06-28
FI922965A0 (fi) 1992-06-26
BR9202411A (pt) 1993-01-26
ES2119794T3 (es) 1998-10-16
IE922089A1 (en) 1992-12-30
DE69226908D1 (de) 1998-10-15
IE80891B1 (en) 1999-05-19
CA2072544A1 (en) 1992-12-29
DK0520571T3 (da) 1999-06-07
NZ243321A (en) 1994-11-25
AR247836A1 (es) 1995-04-28
JP3162487B2 (ja) 2001-04-25
ATE170778T1 (de) 1998-09-15
FI922965A (fi) 1992-12-29
MX9203622A (es) 1993-11-01
DE69226908T2 (de) 1999-01-28

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