EP0502105A4 - Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens - Google Patents

Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens

Info

Publication number
EP0502105A4
EP0502105A4 EP19910900526 EP91900526A EP0502105A4 EP 0502105 A4 EP0502105 A4 EP 0502105A4 EP 19910900526 EP19910900526 EP 19910900526 EP 91900526 A EP91900526 A EP 91900526A EP 0502105 A4 EP0502105 A4 EP 0502105A4
Authority
EP
European Patent Office
Prior art keywords
immunogens
particles used
antiviral agents
retroviral particles
replicating recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910900526
Other languages
English (en)
Other versions
EP0502105A1 (en
Inventor
Omar K. Haffar
Shiu-Lok Hu
Allen W. Senear
Bruce M. Travis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of EP0502105A1 publication Critical patent/EP0502105A1/en
Publication of EP0502105A4 publication Critical patent/EP0502105A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910900526 1989-11-20 1990-11-20 Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens Withdrawn EP0502105A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43920589A 1989-11-20 1989-11-20
US439205 1999-11-12

Publications (2)

Publication Number Publication Date
EP0502105A1 EP0502105A1 (en) 1992-09-09
EP0502105A4 true EP0502105A4 (en) 1993-02-24

Family

ID=23743729

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910900526 Withdrawn EP0502105A4 (en) 1989-11-20 1990-11-20 Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens

Country Status (14)

Country Link
EP (1) EP0502105A4 (enrdf_load_html_response)
JP (1) JPH05503629A (enrdf_load_html_response)
KR (1) KR920703639A (enrdf_load_html_response)
AU (1) AU636944B2 (enrdf_load_html_response)
CA (1) CA2068713A1 (enrdf_load_html_response)
ES (1) ES2052478T1 (enrdf_load_html_response)
FI (1) FI922277A0 (enrdf_load_html_response)
GR (1) GR930300005T1 (enrdf_load_html_response)
HU (1) HUT60506A (enrdf_load_html_response)
NO (1) NO921969L (enrdf_load_html_response)
OA (1) OA09698A (enrdf_load_html_response)
TW (1) TW216446B (enrdf_load_html_response)
WO (1) WO1991007425A1 (enrdf_load_html_response)
ZA (1) ZA909302B (enrdf_load_html_response)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69034052T2 (de) * 1989-06-01 2003-09-25 Applied Biotechnology, Inc. Rekombinante vectoren , die für selbstzusammengesetzte, defekte, sich nichtselbstvermehrende viruspartikel kodieren
US5861282A (en) * 1989-10-16 1999-01-19 Whitehead Institute For Biomedical Research Non-infectious HIV particles and uses therefor
WO1991019803A1 (en) * 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
DE4124817A1 (de) * 1991-07-26 1993-01-28 Basf Ag Waessrige polymerisatdispersionen
AU672372B2 (en) * 1991-11-08 1996-10-03 Pharmacia & Upjohn Company Feline leukemia virus vaccines
CA2118026A1 (en) * 1992-04-14 1993-10-28 Guy T. Layton Induction of ctl responses
US7001759B1 (en) 1993-01-26 2006-02-21 The Trustees Of The University Of Pennsylvania Compositions and methods for delivery of genetic material
ATE302854T1 (de) 1993-01-26 2005-09-15 Univ Pennsylvania Zusammensetzungen und verfahren zur verabreichung von genetischem material
DK1473369T3 (da) 1993-01-26 2009-03-09 Univ Pennsylvania Præparater og fremgangsmåde til administration af genetisk materiale
GB9304239D0 (en) * 1993-03-01 1993-04-21 British Bio Technology Viral particles
US5858838A (en) 1998-02-23 1999-01-12 Taiwan Semiconductor Manufacturing Company, Ltd. Method for increasing DRAM capacitance via use of a roughened surface bottom capacitor plate
US6291157B1 (en) 1998-02-23 2001-09-18 Connaught Laboratories Limited Antigenically-marked non-infectious retrovirus-like particles
US5955342A (en) * 1994-08-15 1999-09-21 Connaught Laboratories Limited Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region
US6080408A (en) 1994-08-22 2000-06-27 Connaught Laboratories Limited Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles
CN1185811A (zh) * 1995-03-31 1998-06-24 H·沃尔夫 依赖于逆转录病毒样颗粒的抗原呈递系统
US6013506A (en) * 1995-06-05 2000-01-11 Wardley; Richard C. Feline leukemia virus vaccines
US6121021A (en) * 1997-12-16 2000-09-19 Connaught Laboratories Limited Constitutive expression of non-infectious HIV-like particles
JP2003523721A (ja) 1998-12-31 2003-08-12 カイロン コーポレイション 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
ATE384795T1 (de) 1998-12-31 2008-02-15 Novartis Vaccines & Diagnostic Modifizierte hiv env polypeptide
EP1980617A1 (en) 1998-12-31 2008-10-15 Novartis Vaccines and Diagnostics, Inc. Improved expression of HIV polypeptides and production of virus-like particles
CA2401974C (en) 2000-03-02 2013-07-02 Emory University Dna expression vectors and methods of use
US8623379B2 (en) 2000-03-02 2014-01-07 Emory University Compositions and methods for generating an immune response
CN100446812C (zh) * 2001-03-08 2008-12-31 美国国有健康与人类服务部 表达修饰的hiv包膜、gag和pol基因的mva
CA2452015C (en) 2001-07-05 2012-07-03 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
KR101814857B1 (ko) 2011-04-06 2018-01-04 바이오백심 리미티드 인간에서의 hiv 질환의 예방 및/또는 치료를 위한 제약 조성물
ES2937963T3 (es) 2015-07-21 2023-04-03 Modernatx Inc Vacunas de enfermedad infecciosa
WO2018170270A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Varicella zoster virus (vzv) vaccine
US11752206B2 (en) 2017-03-15 2023-09-12 Modernatx, Inc. Herpes simplex virus vaccine
WO2020190750A1 (en) * 2019-03-15 2020-09-24 Modernatx, Inc. Hiv rna vaccines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241239A2 (en) * 1986-04-07 1987-10-14 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce A cell line producing aids viral antigens without producing infectious virus particles
EP0381146A1 (en) * 1989-02-02 1990-08-08 Banyu Pharmaceutical Co., Ltd. Antigenic noninfectious HIV-producing cloned T cell
EP0386882A1 (en) * 1989-02-06 1990-09-12 Dana Farber Cancer Institute Packaging defective HIV provirus, cell lines, and uses thereof
WO1991005860A1 (en) * 1989-10-16 1991-05-02 Whitehead Institute For Biomedical Research Non-infectious hiv-1 particles and uses therefor
WO1991005864A1 (en) * 1989-10-13 1991-05-02 Connaught Laboratories Limited Production of genetically-engineered vaccines for aids and other retroviral diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241239A2 (en) * 1986-04-07 1987-10-14 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce A cell line producing aids viral antigens without producing infectious virus particles
EP0381146A1 (en) * 1989-02-02 1990-08-08 Banyu Pharmaceutical Co., Ltd. Antigenic noninfectious HIV-producing cloned T cell
EP0386882A1 (en) * 1989-02-06 1990-09-12 Dana Farber Cancer Institute Packaging defective HIV provirus, cell lines, and uses thereof
WO1991005864A1 (en) * 1989-10-13 1991-05-02 Connaught Laboratories Limited Production of genetically-engineered vaccines for aids and other retroviral diseases
WO1991005860A1 (en) * 1989-10-16 1991-05-02 Whitehead Institute For Biomedical Research Non-infectious hiv-1 particles and uses therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AIDS RES. HUM. RETROVIRUSES vol. 6, no. 1, 1990, page 63 V. KARAKOSTAS 'Assembly of retrovitus particles lacking env protein in cells infected with recombinant vaccinia virus expressing the HIV1' *
J. VIROL. vol. 63, no. 6, 1989, pages 2550 - 2556 C. PENG ET AL. 'Role of hiv type 1 specific protease' *
J. VIROL. vol. 64, no. 6, 1990, pages 2653 - 2659 O. HAFFAR ET AL. 'HIV-like nonreplicating gag-env particles assemble in a recombinant vaccinia virus expression system' *
PROC. NATL. ACAD. SCI. USA vol. 86, no. 22, 1989, pages 8964 - 8967 V. KARAKOSTAS 'HIV-like particles produced by a vaccinia virus expression vector' *
See also references of WO9107425A1 *
VIROLOGY vol. 160, no. 2, 1987, pages 323 - 329 H. GENDELMAN ET AL. 'Molecular characterisation of a polymerase mutant human HIV' *

Also Published As

Publication number Publication date
AU636944B2 (en) 1993-05-13
WO1991007425A1 (en) 1991-05-30
HU9201659D0 (en) 1992-08-28
FI922277A7 (fi) 1992-05-19
HUT60506A (en) 1992-09-28
AU6905591A (en) 1991-06-13
GR930300005T1 (enrdf_load_html_response) 1993-04-28
OA09698A (en) 1993-08-30
NO921969L (no) 1992-06-26
EP0502105A1 (en) 1992-09-09
ZA909302B (en) 1991-09-25
TW216446B (enrdf_load_html_response) 1993-11-21
JPH05503629A (ja) 1993-06-17
NO921969D0 (no) 1992-05-19
ES2052478T1 (es) 1994-07-16
CA2068713A1 (en) 1991-05-21
FI922277A0 (fi) 1992-05-19
KR920703639A (ko) 1992-12-18

Similar Documents

Publication Publication Date Title
EP0502105A4 (en) Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens
EP0255486A3 (en) Titanocenes and their use
PH21379A (en) N-phenylsulfonyl-n'-pyrimidinyl and triazinyl-ureas
PH25866A (en) Sulfonylurea compounds and their herbicides
ZA875672B (en) Titanocenes and their use
PT84872A (en) Herbicides
ZA846525B (en) (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
EP0137242A3 (en) (substituted) phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
ZA898834B (en) Antiviral agents
PH23571A (en) Herbicides
ZA873073B (en) Thiazolotriazole herbicides
ZA876179B (en) Herbicides
IL82798A (en) Substituted 3-amino-2-benzoylcyclohex-2-enones and their use as herbicides
EP0406416A4 (en) Anti-hiv agent
EP0450065A4 (en) Antiviral agent
GB2184944B (en) Antiviral agents
EP0243192A3 (en) Antiviral 8-phenylxanthines
GB2230751B (en) Aerospace structures
GB2190824B (en) Pendant
GB8610532D0 (en) Herbicides
EP0440710A4 (en) New antiviral agents
PH24040A (en) Herbicides
GB8612616D0 (en) Alpha-alumina particles
GB8617948D0 (en) Phenoxybenzisoxazole herbicides
GB8617949D0 (en) Phenoxybenzisoxazole herbicides

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19920515

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TRAVIS, BRUCE, M.

Inventor name: SENEAR, ALLEN, W.

Inventor name: HU, SHIU-LOK

Inventor name: HAFFAR, OMAR, K.

ITCL It: translation for ep claims filed

Representative=s name: JACOBACCI CASETTA & PERANI S.P.A.

EL Fr: translation of claims filed
TCNL Nl: translation of patent claims filed
TCAT At: translation of patent claims filed
A4 Supplementary search report drawn up and despatched

Effective date: 19930105

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

REG Reference to a national code

Ref country code: ES

Ref legal event code: BA2A

Ref document number: 2052478

Country of ref document: ES

Kind code of ref document: T1

17Q First examination report despatched

Effective date: 19970213

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990612