EP0497843A4 - (n-phthalimidoalkyl) piperidines - Google Patents

(n-phthalimidoalkyl) piperidines

Info

Publication number
EP0497843A4
EP0497843A4 EP19900916143 EP90916143A EP0497843A4 EP 0497843 A4 EP0497843 A4 EP 0497843A4 EP 19900916143 EP19900916143 EP 19900916143 EP 90916143 A EP90916143 A EP 90916143A EP 0497843 A4 EP0497843 A4 EP 0497843A4
Authority
EP
European Patent Office
Prior art keywords
phthalimidoalkyl
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900916143
Other languages
English (en)
Other versions
EP0497843A1 (en
Inventor
Engelbert Ciganek
Sang William Tam
Ann Sorrentino Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of EP0497843A1 publication Critical patent/EP0497843A1/en
Publication of EP0497843A4 publication Critical patent/EP0497843A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
EP19900916143 1989-10-27 1990-10-29 (n-phthalimidoalkyl) piperidines Withdrawn EP0497843A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42809789A 1989-10-27 1989-10-27
US428097 1989-10-27
US602024 1990-10-23

Publications (2)

Publication Number Publication Date
EP0497843A1 EP0497843A1 (en) 1992-08-12
EP0497843A4 true EP0497843A4 (en) 1992-09-23

Family

ID=23697544

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900916143 Withdrawn EP0497843A4 (en) 1989-10-27 1990-10-29 (n-phthalimidoalkyl) piperidines

Country Status (5)

Country Link
EP (1) EP0497843A4 (ko)
KR (1) KR927002347A (ko)
CA (1) CA2069318A1 (ko)
WO (1) WO1991006297A1 (ko)
ZA (1) ZA908641B (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356906A (en) * 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
US5162341A (en) * 1991-02-22 1992-11-10 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists for treatment of amphetamine abuse
US5180729A (en) * 1991-02-22 1993-01-19 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists for treatment of cocaine abuse
DK0637306T3 (da) * 1992-04-23 2001-07-30 Merrell Pharma Inc 4-Imidomethyl-1-[2'-phenyl-2'-oxoethyl]-piperidiner som serotonin-5HT2-antagonister, deres fremstilling og anvendelse til terapi
FR2713639B1 (fr) * 1993-12-09 1996-08-30 Irj Nouveaux dérivés de 2-arylalkényl-azacycloalkanes ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique.
GB9416571D0 (en) * 1994-08-16 1994-10-12 Battelle Memorial Institute Novel alkylamino derivatives as sigma 2 selective ligands
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
AU760800B2 (en) * 1997-10-24 2003-05-22 Warner-Lambert Company Method for treating disease-related or drug-induced dyskinesias
IL151533A0 (en) * 2000-02-29 2003-04-10 Mitsubishi Pharma Corp Novel cyclic amide derivatives
EP1854798A3 (en) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6656953B2 (en) * 2000-12-06 2003-12-02 Sepracor Inc. 4,4-Disubstituted piperidines, and methods of use thereof
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2012012543A1 (en) * 2010-07-20 2012-01-26 Cyrenaic Pharmaceuticals Inc. Methods of use cyclic amide derivatives to treat sigma receptor-mediated disorders
RS64819B1 (sr) * 2010-07-20 2023-12-29 Minerva Neurosciences Inc Metode upotrebe derivata cikličnih amida za lečenje šizofrenije i njenih simptoma
MY185516A (en) 2014-12-02 2021-05-19 Mitsubishi Tanabe Pharma Corp Compositions and methods for treating schizophrenia
CN111511353A (zh) 2017-06-21 2020-08-07 田边三菱制药株式会社 耐胃液的控释口服剂型
BR112021002654A2 (pt) 2018-08-21 2021-05-04 Minerva Neurosciences, Inc. uso de roluperidona para tratar sintomas e distúrbios negativos, aumentar a neuroplasticidade e promover neuroproteção
US11919860B1 (en) 2023-10-06 2024-03-05 King Faisal University 1-2(-(substituted phenyl)-2-oxoethyl)-4-(isopropoxycarbonyl)pyridin-1-ium bromides as anti-tubercular agents

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425578A (en) * 1972-10-21 1976-02-18 Wyeth John & Brother Ltd Piperidine derivatives
EP0026749A1 (en) * 1979-08-27 1981-04-08 Astra Läkemedel Aktiebolag Phthalimidine derivatives and pharmaceutical compositions containing them
EP0111397A1 (en) * 1982-11-12 1984-06-20 Bristol-Myers Company Isoindole derivatives, preparation, and uses
GB2177692A (en) * 1985-07-08 1987-01-28 Bristol Myers Co Diazinylpiperidine derivatives
EP0261688A1 (en) * 1986-09-26 1988-03-30 Sumitomo Pharmaceuticals Company, Limited Imide derivatives, and their production and use
EP0292840A2 (de) * 1987-05-25 1988-11-30 Dr. Karl Thomae GmbH Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0296560A2 (en) * 1987-06-22 1988-12-28 Eisai Co., Ltd. 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425578A (en) * 1972-10-21 1976-02-18 Wyeth John & Brother Ltd Piperidine derivatives
EP0026749A1 (en) * 1979-08-27 1981-04-08 Astra Läkemedel Aktiebolag Phthalimidine derivatives and pharmaceutical compositions containing them
EP0111397A1 (en) * 1982-11-12 1984-06-20 Bristol-Myers Company Isoindole derivatives, preparation, and uses
GB2177692A (en) * 1985-07-08 1987-01-28 Bristol Myers Co Diazinylpiperidine derivatives
EP0261688A1 (en) * 1986-09-26 1988-03-30 Sumitomo Pharmaceuticals Company, Limited Imide derivatives, and their production and use
EP0292840A2 (de) * 1987-05-25 1988-11-30 Dr. Karl Thomae GmbH Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0296560A2 (en) * 1987-06-22 1988-12-28 Eisai Co., Ltd. 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9106297A1 *

Also Published As

Publication number Publication date
EP0497843A1 (en) 1992-08-12
KR927002347A (ko) 1992-09-03
WO1991006297A1 (en) 1991-05-16
CA2069318A1 (en) 1991-04-28
ZA908641B (en) 1992-06-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19920421

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A4 Supplementary search report drawn up and despatched

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: WRIGHT, ANN SORRENTINO

Inventor name: TAM, SANG WILLIAM

Inventor name: CIGANEK, ENGELBERT

17Q First examination report despatched

Effective date: 19950220

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19960723