EP0460069B1 - Catheter d'acheminement d'impact acoustique a obturation d'extremite - Google Patents

Catheter d'acheminement d'impact acoustique a obturation d'extremite Download PDF

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Publication number
EP0460069B1
EP0460069B1 EP90904129A EP90904129A EP0460069B1 EP 0460069 B1 EP0460069 B1 EP 0460069B1 EP 90904129 A EP90904129 A EP 90904129A EP 90904129 A EP90904129 A EP 90904129A EP 0460069 B1 EP0460069 B1 EP 0460069B1
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EP
European Patent Office
Prior art keywords
end cap
guide
terminal portion
energy
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP90904129A
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German (de)
English (en)
Other versions
EP0460069A4 (en
EP0460069A1 (fr
Inventor
David I. Rosen
Harry Petschek
Stephen P. Dretler
Krishna M. Bhatta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Connecticut Innovations Inc
Original Assignee
General Hospital Corp
Connecticut Innovations Inc
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Publication date
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Publication of EP0460069A1 publication Critical patent/EP0460069A1/fr
Publication of EP0460069A4 publication Critical patent/EP0460069A4/en
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Publication of EP0460069B1 publication Critical patent/EP0460069B1/fr
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/26—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/22022—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement using electric discharge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22091—Explosive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/92—Impactors or extractors, e.g. for removing intramedullary devices
    • A61B2017/922—Devices for impaction, impact element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/92—Impactors or extractors, e.g. for removing intramedullary devices
    • A61B2017/922—Devices for impaction, impact element
    • A61B2017/927—Returning means
    • A61B2017/928—Returning means a spring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/26—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
    • A61B2018/266—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for producing a shock wave, e.g. laser lithotripsy the conversion of laser energy into mechanical shockwaves taking place in a part of the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers

Definitions

  • the present invention relates to an apparatus for fracturing hard formations in the body, and more specifically, to an apparatus for transferring energy to the end cap of a flexible guide which imparts a high-velocity impulse to a target deposit thereby fracturing it.
  • Calciferous and similar deposits occur in body fluid passages of various types. Of particular interest are kidney and gall stones as well as arterial plaque.
  • Radiation in various forms has been used for destroying or removing such deposits from the internal passages of the body.
  • radiation is directed onto a light-receiving surface of a heat-generating element. The element is then placed in contact with the target deposit, melting it.
  • This approach has several drawbacks which include:
  • laser radiation is applied directly to the target deposit to ablate it or produce shock waves that induce fragmentation.
  • Direct lasertripsy has several disadvantages. Laser energy often damages healthy tissue surrounding the target deposit by direct absorption or by acting as a general heat sink for the high temperature plasma. Some deposits only weakly absorb radiation thereby requiring greater radiation exposure and damage. A sharp laser delivery fiber can cause damage if inadvertently jabbed into healthy tissue.
  • US-A-4 605 003 discloses a lithotriptor device used for crushing a stone in an organ of a living body.
  • the device includes a piston, for crushing engagement with the stone, actuated by the combustion of an explosive layer inside the piston cylinder.
  • the explosive layer is exhausted in one firing, and the device may be fired only once before being removed from the body.
  • US-A-3 785 382 discloses a device for destroying bladder and kidney stones etc. which produces hydraulic shock waves in a fluid reservoir located in a housing which remains outside the body. These shock waves are transmitted along a lithotriptor which extends into the body.
  • the present invention contemplates an apparatus as defined in either claim 1 or 10 for selectively fracturing hard deposits in fluid contained in body passages with the impact of small jack hammer like blows from a capped flexible guide inserted through the body passage to the location of a deposit to be fractured.
  • a flexible wire guide terminating with a hard mass or end cap is provided for insertion through a fluid containing body passage.
  • An energy source and delivery system in the flexible guide provide a pulse of energy in the vicinity of the cap to produce a rapid vapor expansion that causes the end cap to undergo a pulse like movement as the vapor expands against the fluid medium of the passage to impart a high-velocity impulse to the target deposit.
  • a means for fluid exchange between the interior and exterior of the apparatus is provided in the end cap region to insure the presence of fluid for increasing the direct impulse against the cap.
  • the energy source is a pulsed laser and the delivery system is an optical fiber passing through the guide to terminate adjacent to a metal end cap.
  • the laser energy causes vaporization of a small portion of the end cap to create the vapor expansion that drives the end cap forward against the inertia of the fluid.
  • the energy source is a pulsed voltage source and a pair of conductors, one of which may be the wire guide, comprising the delivery system.
  • the conductors terminate in a spark gap adjacent to the end cap.
  • a spark pulse causes fluid vaporization adjacent to the end cap, thereby driving it forward as a reaction.
  • An advantage of the invention includes the end cap's protection of surrounding healthy tissue from direct laser radiation and thermal radiation from the laser-produced plasma of the vapor expansion which forms against the inside surface of the end cap.
  • a further advantage of the invention is the elimination of inadvertent puncturing of healthy tissue by a sharply pointed laser delivery fiber.
  • the end cap is fabricated to exhibit good laser absorption providing a reliable, reproducible vapor expansion independent of the absorption characteristics of the target deposit.
  • the present invention contemplates a method and apparatus for driving a small, hard mass into fracturing, high velocity contact with hard deposits in fluid-containing body passages.
  • a first embodiment of the invention is illustrated in Fig. 1.
  • a flexible wire guide 10 which typically comprises a commercially available, helically wound French No. 3 guide (0.85 - 1.00m diameter) has an end cap 12, the cap and guide are typically of stainless steel or other material which, in response to laser radiation, will vaporize, in a rapid vapor expansion.
  • An optical fiber 14 (typically a 200 micron core) is fed through the wire guide 10 and terminates at a point 16, a short distance from the end cap 12. Laser radiation emanating from the termination 16 strikes the end cap and is absorbed by the metal of the end cap 12, causing vaporization of a small portion of the metal.
  • the helical windings of the guide 10 are opened in a terminal portion 18, for example by stretching the last few coils, to facilitate the entry of fluid from body passages, in which the guide is inserted, into the region of the termination 16.
  • the rapid vapor expansion typically of shock wave nature, generates a forward pressure impulse on the cap 12, in the nature of a miniature jack hammer.
  • the cap 12 has been inserted in a body passage, typically the urethra to a kidney stone, it is capable of fragmenting pieces of the kidney stone, such as the stone 20, to which it comes into contact.
  • a body passage typically the urethra to a kidney stone
  • the presence of the body fluid creates a mass within the region of the termination 16 where the vapor expansion occurs which confines the expansion and permits a large portion of the energy of the vapor expansion to be directed against the end cap 12 producing a high-velocity, short forward impulse.
  • the source of radiation applied to the fiber 14 is a laser system 22.
  • Laser system 22 is typically a tunable dye laser.
  • the laser is operated in the mode of producing pulses of approximately 1 microsecond duration and approximately 50 millijoule energy level.
  • Other pulsed laser systems capable of promptly initiating a plasma against the cap and compatible with optical fiber transmission would also be acceptable energy sources. This would include, for example, solid state laser systems such as Alexandrite.
  • a pulsed output beam 24 from the laser 22 is applied to an optical coupling system 26 which in turn applies the pulsed radiation in beam 24 onto optical fiber 14.
  • the fiber 14 passes through a clamp 28 connected to the guide 10 and operative to hold the fiber termination 16 at a predetermined distance from the cap 12.
  • a potting compound near the termination may be used to secure the fiber termination.
  • FIG. 2 A second embodiment of the invention is illustrated in Fig. 2.
  • a wire guide 40 which may be similar to the guide 10 in Fig. 1 and typically of a size corresponding to French No. 3, terminates in an end cap 42 at a distal end 44 of the wire guide 40.
  • the wire guide is typically helically wound as described before and the termination 44 has helical wires of augmented spacing, for example, by being stretched, to permit the flow of fluid through an interior portion.
  • a wire conductor 46 is inserted through the wire guide 40, spaced and insulated from the helically wound wires of the guide 40.
  • the inner conductor 46 terminates at a point 48, adjacent to the cap 42.
  • the wire may be held in place by a positioning clamp 50, or potted in place with an adhesive as described above with respect to Fig. 1.
  • a spark generator 52 which can be a Wolfe 2137.50 or Northgate Research SDl, available in the art, has its output applied on conductors 54 and 56, the conductors are connected to the inner conductor 46 of the guide 40 and the outer helical windings of the guide 40.
  • the spark generator 52 produces an output pulse of up to several microseconds, at several KV and up to lKA current.
  • the spark generated between the termination 48 of the inner conductor 46 and the end cap 42 causes a vapor expansion of the fluid entering the tip portion 44 and/or the metal of the cap 42 creating a jack hammer like shock impulse movement of the end cap 42, permitting it to fracture calciferous deposits which it contacts.
  • a wire guide 60 typically of the type illustrated above, though not necessarily having a conducting outer shell, has a termination 62 which may be an open helical portion of the wire guide of the prior embodiments.
  • An end cap 64 is applied to the distal end of the wire guide 60.
  • a dual conductor transmission line 66 passes centrally through the wire guide 60 terminating at a point 68 adjacent to the cap 64.
  • the transmission line 66 contains first and second conductors 70 and 72 which terminate to provide a spark gap at the termination 68.
  • the gap is selected to provide, in response to energization from a spark generator 74, of the type illustrated above with respect to Fig. 2, a vaporization of the fluid within the terminal portion 62 generating an impulse motion of the cap 64.
  • a transmission line of the type provided with the above-identified supplier of the spark generator and intended for independent insertion into body passages is suitable for insertion within the guide 60.
  • Fig. 4 illustrates a further version of the embodiment of Fig. 2.
  • a spark generator 80 is provided, and a two conductor transmission line 82 conducts the output of the spark generator through a guide 84 into a stainless steel end cap 86.
  • the end cap 86 is typically cemented to the distal end 88 of the wire guide 84.
  • Apertures 90 are provided in the end cap 86 to permit body passage fluids to enter the interior of the end cap 86 to a point 92 where the conductors in the transmission cable 92 terminate in a spark gap.
  • the terminal portions of the end cap 86 wire guide 84, where it connects to the end cap 86, are typically resilient enough to permit the impulses generated by the spark from the spark gap 92 termination to drive the end cap 86 forward in jack hammer fashion to permit fracturing of hard deposits to which it is directed.
  • a wire guide 100 is inserted through a body passage 102 such as the urethra, for kidney stone fracturing, the biliary duct for gall stone fracturing and an artery for arterial plaque break-up.
  • the end tip 104 of the wire guide 100 is guided by fluoroscopy.
  • An X-ray source 106 and viewing display 108 permit the end of the wire guide 100 to be positioned adjacent to a hard deposit 110 to be fractured as illustrated.
  • Fig. 6 is an illustration of the dynamics by which an end cap 120 is jack hammered or shock driven forward into a hard deposit 122 by a spark generated by a discharge in a spark gap 126.
  • Impulse delivery systems other than laser or spark, such as chemical reaction, trigger remotely by signals supplied by a guide, may be used.

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  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Optics & Photonics (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Laser Surgery Devices (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Claims (12)

  1. Appareil pour fracturer des formations dures dans le corps, comprenant :
       un guide (10 ; 40 ; 60) adapté pour être inséré dans un passage (102) du corps contenant un fluide corporel, ledit guide présentant une partie terminale (18 ; 44 ; 62) formant un volume intérieur, ladite partie terminale étant située dans le passage du corps quand ledit guide est en position de travail ;
       un embout d'extrémité (12 ; 42 ; 64) accouplé de façon mobile à ladite partie terminale pour que l'embout d'extrémité puisse se déplacer entre une première position située au voisinage immédiat de ladite partie terminale et une seconde position espacée à ladite première position ; et
       une source d'énergie (22 ; 52 ; 74) pour produire une impulsion d'énergie, caractérisé en ce que :
       ledit guide est un guide flexible ;
       ladite partie terminale dudit guide est adaptée pour recevoir un fluide corporel provenant dudit passage du corps ; et en ce que
       l'énergie de ladite impulsion engendrée par la source d'énergie produit une vaporisation rapide dudit fluide corporel situé dans la partie terminale pour déplacer ledit embout d'extrémité de la première position à la seconde position, moyennant quoi ledit embout d'extrémité effectue une série de déplacements entre lesdites première et seconde positions.
  2. Appareil selon la revendication 1, dans lequel ladite source d'énergie (22 ; 52 ; 74) est un générateur à étincelles.
  3. Appareil selon la revendication 2, dans lequel ledit générateur à étincelles (52 ; 74) comporte un premier conducteur électrique (46 ; 70) s'étendant dans ledit guide flexible (10 ; 40 ; 60) pour appliquer des étincelles à la partie terminale (18 ; 44 ; 62).
  4. Appareil selon la revendication 3, comprenant en outre un second conducteur (72) qui s'étend dans ledit guide flexible (10 ; 40 ; 60), un intervalle d'étincelage (126) étant situé à une extrémité desdits premier et second conducteurs électriques.
  5. Appareil selon la revendication 1, dans lequel ladite source d'énergie est un laser (22) adapté pour produire une série d'impulsions d'énergie de rayonnement, chaque impulsion d'énergie de rayonnement produisant ladite vaporisation rapide dudit fluide dans ladite partie terminale (18) pour déplacer ledit embout d'extrémité (12) de ladite première position à ladite seconde position, de sorte que la série d'impulsions d'énergie de rayonnement entrai'ne une série correspondante de déplacements de l'embout d'extrémité entre lesdites première et seconde positions.
  6. Appareil selon la revendication 5, comprenant en outre une fibre optique (14) s'étendant dans le guide flexible (10) pour transmettre les impulsions d'énergie de rayonnement du laser (12) à la partie terminale (18).
  7. Appareil selon une ou plusieurs des revendications précédentes, dans lequel ledit guide flexible (10 ; 40; 60) a un diamètre extérieur de 0,85 à 1,00 mm.
  8. Appareil selon une ou plusieurs des revendications précédentes, dans lequel ladite partie terminale (18 ; 44 ; 62) comporte une extrémité élargie dudit guide flexible (10 ; 40 ; 60) pour former un accès du fluide vers l'intérieur de ladite partie terminale.
  9. Appareil selon une ou plusieurs des revendications précédentes, comprenant en outre des moyens pour renvoyer ledit embout d'extrémité (12 ; 42 ; 64) dans la première position après que ledit embout d'extrémité s'est déplacé dans ladite seconde position.
  10. Appareil pour fracturer des formations dures dans le corps, comprenant :
       un guide (84) adapté pour être inséré dans un passage (102) du corps contenant un fluide corporel, ledit guide présentant une partie terminale (88) formant un volume intérieur, ladite partie terminale étant située dans le passage du corps quand ledit guide est en position de travail ;
       un embout d'extrémité (86) accouplé de façon mobile à ladite partie terminale pour que l'embout d'extrémité puisse se déplacer entre une première position située au voisinage immédiat de ladite partie terminale et une seconde position espacée à ladite première position ; et
       une source d'énergie (80) pour produire une impulsion d'énergie, caractérisé en ce que :
       ledit guide est un guide flexible ;
       ledit embout d'extrémité comporte des ouvertures (90) pour permettre à des fluides d'entrer dans ledit embout d'extrémité du passage du corps ; et en ce que
       l'énergie de ladite impulsion engendrée par la source d'énergie produit une vaporisation rapide dudit fluide corporel situé dans ledit embout d'extrémité pour déplacer ledit embout d'extrémité de la première position à la seconde position, moyennant quoi ledit embout d'extrémité effectue une série de déplacements entre lesdites première et seconde positions.
  11. Appareil selon la revendication 10, dans lequel ladite source d'énergie (80) comporte un générateur à étincelles et dans lequel une ligne de transmission (82) à deux conducteurs conduit la sortie du générateur à étincelles dans ledit embout d'extrémité (86).
  12. Appareil selon la revendication 11, dans lequel la ligne (82) se termine en un intervalle d'étincelage disposé à l'intérieur dudit embout d'extrémité (86).
EP90904129A 1989-02-22 1990-02-22 Catheter d'acheminement d'impact acoustique a obturation d'extremite Expired - Lifetime EP0460069B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31447289A 1989-02-22 1989-02-22
US314472 1989-02-22
PCT/US1990/000904 WO1990009762A1 (fr) 1989-02-22 1990-02-22 Catheter d'acheminement d'impact acoustique a obturation d'extremite

Publications (3)

Publication Number Publication Date
EP0460069A1 EP0460069A1 (fr) 1991-12-11
EP0460069A4 EP0460069A4 (en) 1991-12-27
EP0460069B1 true EP0460069B1 (fr) 1996-01-17

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EP90904129A Expired - Lifetime EP0460069B1 (fr) 1989-02-22 1990-02-22 Catheter d'acheminement d'impact acoustique a obturation d'extremite

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EP (1) EP0460069B1 (fr)
JP (1) JPH0614936B2 (fr)
AT (1) ATE133050T1 (fr)
AU (1) AU637786B2 (fr)
DE (1) DE69024949T2 (fr)
DK (1) DK0460069T3 (fr)
ES (1) ES2081367T3 (fr)
IL (1) IL93494A (fr)
WO (1) WO1990009762A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7072891A (en) * 1990-01-09 1991-08-05 Candela Laser Corporation Method and apparatus for fragmentation of hard substances
US5496306A (en) * 1990-09-21 1996-03-05 Light Age, Inc. Pulse stretched solid-state laser lithotripter
DE4036570A1 (de) * 1990-11-16 1992-05-21 Osypka Peter Katheter zur verminderung oder beseitigung von verengungen in gefaessen
CA2120516A1 (fr) * 1991-10-03 1993-04-15 Ralph De La Torre Dispositif et methode de vasodilatation
US6406486B1 (en) 1991-10-03 2002-06-18 The General Hospital Corporation Apparatus and method for vasodilation
IL104028A (en) * 1991-12-16 1996-06-18 Psi Medical Products Inc A device for stabbing a creature in the passage of the body
DE4313768C2 (de) * 1993-04-27 2002-07-11 Walz Elektronik Gmbh Vorrichtung zur Steinzertrümmerung
DE9312684U1 (de) * 1993-08-25 1993-11-04 Richard Wolf Gmbh, 75438 Knittlingen Sonde zum intrakorporalen Fragmentieren von Steinen
WO1995024866A1 (fr) * 1994-03-15 1995-09-21 Dodick Jack M Cible pour instrument chirurgical a laser
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DE69024949T2 (de) 1996-09-05
WO1990009762A1 (fr) 1990-09-07
JPH04503175A (ja) 1992-06-11
IL93494A0 (en) 1990-11-29
IL93494A (en) 1995-05-26
ATE133050T1 (de) 1996-02-15
AU5190990A (en) 1990-09-26
DE69024949D1 (de) 1996-02-29
EP0460069A4 (en) 1991-12-27
DK0460069T3 (da) 1996-03-18
JPH0614936B2 (ja) 1994-03-02
EP0460069A1 (fr) 1991-12-11
ES2081367T3 (es) 1996-03-01
AU637786B2 (en) 1993-06-10

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