EP0426403A1 - Umfüll- und Abgabevorrichtung - Google Patents

Umfüll- und Abgabevorrichtung Download PDF

Info

Publication number
EP0426403A1
EP0426403A1 EP19900311814 EP90311814A EP0426403A1 EP 0426403 A1 EP0426403 A1 EP 0426403A1 EP 19900311814 EP19900311814 EP 19900311814 EP 90311814 A EP90311814 A EP 90311814A EP 0426403 A1 EP0426403 A1 EP 0426403A1
Authority
EP
European Patent Office
Prior art keywords
spike
flow
outer end
bore
vial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900311814
Other languages
English (en)
French (fr)
Inventor
John Rohrbough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
David Bull Laboratories Pty Ltd
Original Assignee
David Bull Laboratories Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David Bull Laboratories Pty Ltd filed Critical David Bull Laboratories Pty Ltd
Publication of EP0426403A1 publication Critical patent/EP0426403A1/de
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/10—Coring prevention means, e.g. for plug or septum piecing members

Definitions

  • the present invention relates to a transfer and dispensing device, and more particularly to such a device which may include ends to penetrate seals of opposed medicament containing vials, for medicament transfer therethrough from one vial to the other.
  • U.S. Pat. 2,724,383 to Lockhart, U.S. Pat. 3,392,726 to Pochyla, and U.S. Pat. 2,362,025 to Price variously disclose devices formed of a single hollow needle having opposed pointed ends and an intermediate portion fixing the needle in the first of two telescoping necks of two opposed flexible bags or other medicament containers, the first charged with a powder and the second with a liquid, and each having a seal facing its needle end, such that on moving the necks toward each other, the needle ends penetrate the seals to flow connect the containers.
  • the second bag When so connected, the second bag is squeezed or other extraneous mechanical means are used to force the liquid from this container into the first container to admix with the powder, whereupon the latter in whose neck the needle intermediate portion is affixed, may be separated from the empty container and used as a hypodermic syringe, or be provided with a separate dispensing needle.
  • U.S. Pat. 3,306,563 to Soto shows a similar single hollow needle having opposed pointed ends and an intermediate flange coated with adhesive to form seals at the needle ends as they puncture opposed flexible bags forced against the flange to flow connect the bags, one charged with a liquid medicament and the other with a powder medicament to be admixed, the resulting filled bag apparently being separated from the empty bag and squeezed to dispense the admixture via the exposed needle end.
  • U.S. Pat. 4,405,047 to Barba discloses a similar single needle having opposed pointed ends and an intermediate flange, but in this case with two parallel bores communicating the needle ends at slightly axially offset points, the needle being used vertically so that its ends penetrate stoppers on opposed upper and lower medicament containing vials forced thereagainst to flow connect the vials, the upper vial being charged with a liquid and the lower one with a powder, whereupon the lower vial is filled with the liquid by gravity flow from the upper vial, and the filled lower vial then separated from the needle.
  • This patent further discloses a second needle, also used vertically and having two parallel bores, but having only one pointed end forming an upper inlet end containing both bores, the opposite end being fixed as a lower outlet end within a dispensing device drip chamber therebelow and containing only one of the bores, the other bore leading to an outwardly directed ball valve containing branch portion remote from the needle ends and serving as an air relief line.
  • the stopper of the above noted filled lower vial is then repenetrated by the second needle pointed end to flow connect it with the drip chamber to dispense its contents.
  • a transfer and dispensing device comprising opposed separable first and second spikes, each having an outer pointed end and an inner attachment end, a fluid flow bore extending through each spike from its inner end to its outer end, and a separate airway extending through each spike from its outer end toward its inner end and terminating in an air port remote from its outer end and spaced from its inner end, each airway containing a flow restriction formation permitting, in use, controlled flow of air therethrough while preventing flow of liquid therethrough, the first spike inner end having a connection formation communicating with its bore and the second spike inner end having a counterpart connection formation communicating with its bore, the two connection formations enabling the releasable interconnection of the inner ends of the spikes to flow connect their bores in fluid tight condition to permit a liquid to flow from the outer end of one spike to the outer end of the other spike via the flow connected bores; and a limiting means on each spike to limit, in use, the extent of penetration of their outer ends through penet
  • the transfer and dispensing device may provide gravity flow transfer of a liquid medicament from a charging vial thereabove penetrated by the upper spike, to a solid or liquid medicament in a receiving vial therebelow penetrated by the lower spike, for admixture in the receiving vial without retransfer to the charging vial, under controlled flow of air facilitating the transfer while preventing liquid leakage from the device, yet permitting the lower spike and receiving vial to be detached from the upper spike and connected directly and without modification to a device for dispensing the admixture.
  • the device may be used to administer quickly and safely a preset dosage of two medicaments separated from each other until used, and readily combined at the time of use, under improved conditions of sterility, the device may be provided in compact storable sterile form.
  • the device may be fabricated from conventional materials and components in simple and inexpensive manner.
  • the transfer and dispensing device may further include associated first and second vials, each forming a medicament containing chamber having an opening closed by a penetrable seal, the medicament of the second vial being a liquid and that of the first vial being a liquid or a solid, the vials being arranged such that upon penetrating the first vial seal by the first spike outer end and penetrating the second vial seal by the second spike outer end, gravity flow transfer of the liquid from the second vial through the bores of the opposed interconnected spikes to the first vial will take place when the second spike is disposed generally above the first spike.
  • connection formations include a luer lock formation on the first spike and a counterpart luer lock formation on the second spike mating with the first spike luer lock formation.
  • first spike When detached from the second spike, the first spike may be directly connected without modification to a dispensing device having a corresponding counterpart luer lock formation mating with the first spike luer lock formation.
  • each flow restriction formation may comprise a check valve and/or a hydrophobic air filter.
  • the first and/or second spike is tubular and defines a generally axial bore therethrough
  • the or each airway includes an outer end portion located laterally of the axial bore and extending from the spike outer end and a branch portion extending outwardly from the spike at a point remote from the spike outer end and toward the spike inner end at an inclined angle to the axis of the bore
  • the or each flow restriction formation comprises a check valve in the form of a ball valve in the corresponding branch portion.
  • each airway includes an outer end portion located laterally of the axial bore and extending from the spike outer end and a branch portion extending outwardly from the spike at a point remote from the spike outer end and toward the spike inner end at an inclined angle to the axis of the bore, and each flow restriction formation comprises a check valve in the form of a ball valve in the corresponding branch portion.
  • the lower spike ball valve will permit air outflow through its port while preventing liquid outflow therethrough
  • the upper spike ball valve will permit air inflow through its port while preventing liquid outflow therethrough.
  • the fluid bore is located laterally of the spike axis and includes a scoop-type outer end opening
  • the airway includes an outer end portion located laterally of the spike axis and extending centrally from the spike at a point remote from the spike outer end; the diameter of the airway being such that fluid flow through the airway is prevented.
  • the device according to this aspect of the present invention may have a reduced tendency for liquid or vacuum blockage of the airway in use.
  • the diameter of the airway is in the range of approximately 0.5mm to approximately 1.5mm.
  • the flow restriction formation in the airway comprises a hydrophobic air filter and optionally a cap therefor.
  • a hinged cap air filter is preferred.
  • the first and second vial seals may be penetrated. The hinged caps may then be opened to permit air to vent the respective vials and permit fluid flow with gravity.
  • Limiting means may be provided on the spikes to limit the extent of penetration of their outer ends through corresponding penetrable seals closing respective vials to be connected to the opposed spike outer ends. Also, a removable closure may be provided for the inner end of one spike to seal its bore thereat upon detachment from the inner end of the other spike.
  • a kit of parts including first and second vials, each forming a medicament containing chamber having an opening closed by a penetrable seal; and a transfer and dispensing device comprising each having an outer pointed end and an inner attachment end, a fluid flow bore extending through each spike from its inner end to its outer end, and a separate airway extending through each spike from its outer end toward its inner end and terminating in an air port remote from its outer end and spaced from its inner end, each airway containing a flow restriction formation permitting, in use, controlled flow of air therethrough while preventing flow of liquid therethrough, the first spike inner end having a connection formation communicating with its bore and the second spike inner end having a counterpart connection formation communicating with its bore, the two connection formations enabling the releasable interconnection of the inner ends of the spikes to flow connect their bores in fluid tight condition to permit a liquid to flow from the outer end of one spike to the outer end of the other spike via the flow connected bores; and a transfer and dispensing device comprising each having an
  • the kit further includes a dispensing device including a bore and a connection formation communicating with its bore and adapted to mate with the counterpart connection formation of the second spike.
  • a dispensing device including a bore and a connection formation communicating with its bore and adapted to mate with the counterpart connection formation of the second spike.
  • a vial transfer and dispensing device 1 including a pair of opposed separate unilateral spikes 2,3, respectively having an outer pointed end 4,5 and an inner attachment end 6,7, and a fluid flow bore 8,9 extending through the spike from an outer end opening 10,11 to an inner end opening 12,13 thereof.
  • Spikes 2,3 also respectively have a separate airway 14,15 extending through the spike from an outer end opening 16,17 toward inner end 6,7 and terminating in an air port 18,19 remote from outer end 4,5 and spaced from inner end 6,7.
  • Each airway 14,15 contains a flow restriction formation permitting controlled flow of air therethrough while preventing flow of liquid therethrough, such as a check valve in the form of a ball valve 20,21 having a ball 22,23, e.g. of stainless steel, and/or a hydrophobic air filter 24,25 (shown in phantom in Figure 1), each of which operates in known manner to permit air to bypass ball 22,23 or flow through filter 24,25, i.e. in either direction, while preventing liquid outflow through port 18,19.
  • a check valve in the form of a ball valve 20,21 having a ball 22,23, e.g. of stainless steel
  • a hydrophobic air filter 24,25 shown in phantom in Figure 1
  • each hydrophobic air filter 24,25 may be provided with a hinged cap 24a, 25a.
  • the hinged caps further assist in preventing flow of liquid through the airways 14,15.
  • spikes 2,3 are tubular and define generally axial bores 8,9 therethrough, while airways 14,15 respectively include an outer end portion 14a, 15a located laterally of axial bore 8,9 and extending from spike outer end 4,5, and a branch portion 14b,15b extending outwardly from spike 2,3 at a point remote from spike outer end 4,5 and toward spike inner end 6,7 at an inclined, e.g. 45 degree, angle to the axis of bore 8,9.
  • airways 14,15 respectively include an outer end portion 14a, 15a located laterally of axial bore 8,9 and extending from spike outer end 4,5, and a branch portion 14b,15b extending outwardly from spike 2,3 at a point remote from spike outer end 4,5 and toward spike inner end 6,7 at an inclined, e.g. 45 degree, angle to the axis of bore 8,9.
  • Inner end 6 of spike 2 has a connection formation such as an external luer lock tab 26 and tapered female inlet 28 communicating with bore 8, and inner end 7 of spike 3 has a counterpart connection formation such as an internal luer lock tab 27 and tapered male outlet 29 communicating with bore 9 and mating with external luer lock tab 26 and tapered female inlet 28 to interconnect releasably inner ends 6,7 of spikes 2,3 and flow connect their bores 8,9 in fluid tight condition, to permit a liquid to flow from outer end opening 11 of spike 3 to outer end opening 10 of spike 2 via the flow connected bores 8,9.
  • These luer lock formations permit easy and rapid connection and relase of spikes 2,3, and may be of standard size.
  • Lateral flanges 30,31 are provided on the intermediate shank portions of spikes 2,3 adjacent branch portions 14b,15b, to define pointed outer ends 4,5 outwardly thereof as relatively short ends, and to form finger grips to aid in manipulating spikes 2,3 to connect and disconnect inner ends 6,7, e.g. by twisting clockwise to connect their luer lock formations and counterclockwise to disconnect such formations, as well as limiting means to limit the extent of penetration of such short outer ends 4,5 through the penetrable seals closing the vials to be connected to spikes 2,3 ( Figure 2). Outer ends 4,5 need only be sufficiently long to penetrate the vial seals to communicate openings 10,11 and 16,17 with the vial chambers.
  • a removable closure cap 32 is attached by cord or strap 33 to branch portion 14b of lower spike 2 for mounting on inner end 6, e.g. to enclose external luer lock tab 26, for sealing bore 8 thereat upon detaching spike 2 from inner end 7 of spike 3.
  • a vertical twist tab 34 may be provided on the side of spike 3 extending in a radial plane passing through the axis of bore 9.
  • vials 40,41 which may be of the standard known type, respectively forming a medicament containing chamber having an opening 42,43 closed by a penetrable seal 44,45, such as a rubber plug or stopper, may be used with device 1.
  • Upper vial 41 is charged with a preset dosage of a liquid, e.g. sterile water, as medicament 47
  • lower vial 40 is charged with a preset dosage of either another liquid or a solid, such as a particulate powder or tablet, etc., as medicament 46 compatible with, e.g. dissolvable in, medicament 47 of upper vial 41.
  • valves 20,21 and/or filters 24,25 by their very nature, will prevent outflow of liquid from device 1, otherwise sealed by the connection of inner ends 6,7 and the respective interconnections of spike outer ends 4,5 in penetrating engagement with seals 44,45 of vials 40,41.
  • spike 3 may be easily and rapidly detached from spike 2 by mere twisting action, e.g. aided by flanges 30,31 and tab 34, to disconnect their luer lock connections 26,28 and 27,29 at inner ends 6,7, for removing spike 3 and its vial 41 and exposing inner end 6 of spike 2 still connected to vial 40.
  • Inner end 6 of spike 2 can then be sealed by closure cap 32, and spike 2 and its connected vial 40 manually shaken to assure complete admixing of medicaments 46 and 47.
  • Spike 2 and vial 40 may then be used directly and without modification with a standard dispensing device, such as a conventional empty disposable syringe, having a bore and a counterpart, e.g. standard, connection formation, like luer lock tab 27 and tapered male outlet 29, communicating with its bore and mating with luer lock tab 26 and tapered female outlet 28 of spike 2, to interconnect releasably the syringe and spike 2 and flow connect their bores in fluid tight condition.
  • the admixed medicaments 46,47 in vial 40 can be dispensed via bore 4 of spike 2 into the syringel e.g. by simply inverting vial 40 and aspirating any desired volume thereof into the syringe.
  • FIG. 3 an alternative embodiment of a vial transfer and dispensing device 1 is shown where like parts are identified with like numerals.
  • Opposed spikes 2′ and 3′ have a separate relatively narrow airway 14′,15′ extending through each spike from an outer end opening 16′,17′ adjacent the pointed end toward inner end 6′,7′ and terminating in an air port 18′,19′ remote from outer end 4′,5′ and spaced from an inner end 6′,7′.
  • Each airway 14′,15′ contains a flow restriction formation permitting controlled flow of air therethrough, such as a hydrophobic air filter 24′,25′ which permits air to flow through filter 24′,25′, while preventing liquid outflow through port 18′,19′.
  • Each hydrophobic air filter 24′.25′ is provided with a hinged cap 48,49 which may be opened to permit air to vent the respective vials and permit fluid flow with gravity.
  • Each spike 2′,3′ is tubular and defines a fluid bore 8′,9′ therethrough located laterally of the spike axis and includes a scoop-type outer end opening 10′,11′ which is rearwardly spaced from the spike pointed end on a concave face 26′,27′.
  • Airway 14′,15′ includes an outer end portion 14a′,15a′ located laterally of the spike axis and a radial portion 14b′,15b′ extending outwardly from spike 2′,3′ at a 90 o angle.
  • Lateral flanges 30′,31′ are provided on the intermediate shank portions of spikes 2′,3′ to define pointed outer ends 4′,5′ outwardly thereof as relatively short ends, and to form finger grips to aid in manipulating spikes 2′,3′ to connect and disconnect inner ends 6′,7′, e.g. by twisting clockwise to connect their luer lock formations and counterclockwise to disconnect such formations, as well as limiting means to limit the extent of penetration of such short outer ends 4′,5′ through the penetrable seals closing the vials to be connected to spikes 2′,3′ ( Figure 2). Outer ends 4′,5′ need only be sufficiently long to penetrate the vial seals to communicate openings 10′,11′ and 16′,17′ with the vial chambers.
  • the hydrophobic air filter 24′ will permit air outflow through port 18′ while preventing liquid outflow therethrough and hydrophobic air filter 25′ will permit air inflow through port 19′ which preventing liquid outflow therethrough.
  • All portions of the spikes may be made from any suitable rigid plastic such as polycarbonate, e.g. by injection molding technique, especially with all portions of each spike being integrally interconnected, e.g. by sonic welding technique, to form a one-piece member.
  • any suitable rigid plastic such as polycarbonate
  • all portions of each spike being integrally interconnected, e.g. by sonic welding technique, to form a one-piece member.
  • no portion of the spikes need be made from metal, which is significant in the case of plastic short pointed outer ends 4,5 in that while they will be sufficiently pointed to achieve rapid penetration of standard rubber or like material stoppers on the vials, they will not be so sharp as to present a danger of puncturing the skin of the user.
  • valves 20,21 may contain balls 22,23 of stainless steel or other suitable commercially available material.
  • Hydrophobic air filters are conventional elements which may be made of appropriate hydrophobic plastic and simply mounted, e.g. as discs, against recessed shoulders inwardly of the ports in accordance with known techniques.
  • the device according to the present invention may be used as a manually operated liquid-liquid (wet-wet) or liquid-solid (wet-dry powder) mixing and transfer system. It is especially useful for combining the medicaments by one-way transfer from the upper vial to the lower vial without retransfer to the upper vial, instead attaining mixing only in the lower vial, after detaching the upper spike and its vial and closing the lower vial and lower spike.
  • the spikes and vials may be compactly prepackaged as disposable, one-time use, sterile items, e.g. as an emergency kit, with the spikes connected as a preassembled unit having removable protective caps (not shown) on their outer ends, with similar caps being provided on the vial stoppers.
EP19900311814 1989-11-01 1990-10-29 Umfüll- und Abgabevorrichtung Withdrawn EP0426403A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43058089A 1989-11-01 1989-11-01
US430580 1989-11-01

Publications (1)

Publication Number Publication Date
EP0426403A1 true EP0426403A1 (de) 1991-05-08

Family

ID=23708167

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900311814 Withdrawn EP0426403A1 (de) 1989-11-01 1990-10-29 Umfüll- und Abgabevorrichtung

Country Status (10)

Country Link
EP (1) EP0426403A1 (de)
JP (1) JPH03186271A (de)
KR (1) KR910009231A (de)
AU (1) AU637130B2 (de)
CA (1) CA2023887A1 (de)
FI (1) FI905390A0 (de)
IE (1) IE903141A1 (de)
NO (1) NO904733L (de)
NZ (1) NZ234984A (de)
ZA (1) ZA906801B (de)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521460A1 (de) * 1991-07-04 1993-01-07 Axel von Brand Transfer- und Entnahmespike
DE4414697A1 (de) * 1994-04-27 1995-11-02 Caremed Gmbh Vertrieb Med Lab Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
WO2003030810A1 (en) * 2001-10-08 2003-04-17 Novo Nordisk A/S Cartridge with an excentric puncturing area
DE202018003413U1 (de) 2018-05-02 2018-08-09 Wolfgang Eikel Container mit einer Flüssigkeit
WO2019015773A1 (en) * 2017-07-20 2019-01-24 Janssen Biotech, Inc. MEDICATION MIXING DEVICE
CN109528489A (zh) * 2019-01-29 2019-03-29 江苏省人民医院 一种药液勾兑输送装置
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
WO2021154909A1 (en) * 2020-01-30 2021-08-05 Yukon Medical, Llc Transfer device with user-controlled venting
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
IT202100027071A1 (it) * 2021-10-21 2023-04-21 Bormioli Pharma Spa Dispensatore di una sostanza fluida
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040162540A1 (en) * 2003-02-13 2004-08-19 Becton, Dickinson And Company Transfer device
JP5095382B2 (ja) * 2007-12-26 2012-12-12 テルモ株式会社 接続具
JP5725342B2 (ja) * 2011-04-26 2015-05-27 ニプロ株式会社 薬液調製用器具
JP7447734B2 (ja) * 2020-08-25 2024-03-12 ニプロ株式会社 トランスファーニードル
KR102544380B1 (ko) * 2022-01-29 2023-06-16 (주)동방지퍼 지퍼용 슬라이더와 손잡이의 결착방법 및 이로 인해 제조된 지퍼

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
FR2273723A1 (fr) * 1974-06-10 1976-01-02 Abbott Lab Unite de transfert de substance avec une piece de transfert a deux canaux
US4405047A (en) * 1981-07-22 1983-09-20 Sterling Drug, Inc. Unit package for poultry vaccination
DE3627231A1 (de) * 1986-08-11 1988-02-18 Codan Medizinische Geraete Ueberleitungsgeraet zum mischen von in unterschiedlichen behaeltern befindlichen medikamenten

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
FR2273723A1 (fr) * 1974-06-10 1976-01-02 Abbott Lab Unite de transfert de substance avec une piece de transfert a deux canaux
US4405047A (en) * 1981-07-22 1983-09-20 Sterling Drug, Inc. Unit package for poultry vaccination
DE3627231A1 (de) * 1986-08-11 1988-02-18 Codan Medizinische Geraete Ueberleitungsgeraet zum mischen von in unterschiedlichen behaeltern befindlichen medikamenten

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521460A1 (de) * 1991-07-04 1993-01-07 Axel von Brand Transfer- und Entnahmespike
DE4414697A1 (de) * 1994-04-27 1995-11-02 Caremed Gmbh Vertrieb Med Lab Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
EP0679380A1 (de) * 1994-04-27 1995-11-02 Care Med Gmbh, Vertrieb Med.-Lab. Produkte Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
DE4414697C2 (de) * 1994-04-27 1998-06-18 Caremed Vertriebsgesellschaft Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
WO2003030810A1 (en) * 2001-10-08 2003-04-17 Novo Nordisk A/S Cartridge with an excentric puncturing area
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US11786443B2 (en) 2016-12-06 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
WO2019015773A1 (en) * 2017-07-20 2019-01-24 Janssen Biotech, Inc. MEDICATION MIXING DEVICE
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
WO2019210893A1 (de) 2018-05-02 2019-11-07 Lars Lange Container mit einer ersten zu mischenden flüssigkeit
DE202018003413U1 (de) 2018-05-02 2018-08-09 Wolfgang Eikel Container mit einer Flüssigkeit
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
CN109528489A (zh) * 2019-01-29 2019-03-29 江苏省人民医院 一种药液勾兑输送装置
CN109528489B (zh) * 2019-01-29 2024-02-27 江苏省人民医院 一种药液勾兑输送装置
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11484470B2 (en) 2019-04-30 2022-11-01 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
US11786442B2 (en) 2019-04-30 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
WO2021154909A1 (en) * 2020-01-30 2021-08-05 Yukon Medical, Llc Transfer device with user-controlled venting
EP4096615A4 (de) * 2020-01-30 2024-02-28 Yukon Medical Llc Transfervorrichtung mit benutzergesteuerter entlüftung
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
IT202100027071A1 (it) * 2021-10-21 2023-04-21 Bormioli Pharma Spa Dispensatore di una sostanza fluida
WO2023067516A1 (en) * 2021-10-21 2023-04-27 Bormioli Pharma S.p.A. A dispenser of a fluid substance

Also Published As

Publication number Publication date
NZ234984A (en) 1993-02-25
AU6106390A (en) 1991-05-09
JPH03186271A (ja) 1991-08-14
NO904733L (no) 1991-05-02
KR910009231A (ko) 1991-06-28
ZA906801B (en) 1991-07-31
IE903141A1 (en) 1991-05-08
FI905390A0 (fi) 1990-10-31
CA2023887A1 (en) 1991-05-02
AU637130B2 (en) 1993-05-20
NO904733D0 (no) 1990-10-31

Similar Documents

Publication Publication Date Title
EP0426403A1 (de) Umfüll- und Abgabevorrichtung
US4583971A (en) Closed drug delivery system
US5897526A (en) Closed system medication administering system
AU614792B2 (en) Dual compartmented container
US4392851A (en) In-line transfer unit
EP0079326B1 (de) Abnahmevorrichtung für Flüssigkeiten
US5533994A (en) Storage and transfer bottle designed for storing two components of a medicamental substance
US5409141A (en) Two component mixing and delivery system
EP0465632B1 (de) Integrale rekonstitutionsvorrichtung
CN1802143B (zh) 重新组配装置
EP1145702B1 (de) Adapter zur Mischung und zum Spritzen von Präparaten
US4146153A (en) Sterile dispensing device
US4392850A (en) In-line transfer unit
US5006118A (en) Liquid transfer assemblies
US5401253A (en) Intravenous infusion of pharmaceuticals
AU726273B2 (en) Improved mixing and delivery system
US5257986A (en) Container for the separate sterile storage of at least two substances and for mixing said substances
US4695272A (en) Drug release device
JPS59500602A (ja) 混合装置
US4475914A (en) Medicament container and transfer device
JP2004520111A (ja) 医療使用の液体または粉末を包装し且つ移すためのアンプル
EP3924020A1 (de) Transfervorrichtung zur verwendung mit infusionsflüssigkeitsbehältern
US4872872A (en) Medicament container/dispenser assembly
US4715851A (en) Means for handling two solutions which are to be mixed together
JP3345860B2 (ja) 輸液用容器

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17P Request for examination filed

Effective date: 19911107

17Q First examination report despatched

Effective date: 19930608

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19931019