EP0425109B1 - 3-Substituierte-2-Oxindolderivate als Interleukin-Biosynthesehemmer - Google Patents
3-Substituierte-2-Oxindolderivate als Interleukin-Biosynthesehemmer Download PDFInfo
- Publication number
- EP0425109B1 EP0425109B1 EP90310806A EP90310806A EP0425109B1 EP 0425109 B1 EP0425109 B1 EP 0425109B1 EP 90310806 A EP90310806 A EP 90310806A EP 90310806 A EP90310806 A EP 90310806A EP 0425109 B1 EP0425109 B1 EP 0425109B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- interleukin
- mammal
- pharmaceutically
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 C*(C)C(CCC(*)(CC1C(C2=O)[N+](*)[O-])C(C)(C)C)(CC1*2[N+](C)[O-])I Chemical compound C*(C)C(CCC(*)(CC1C(C2=O)[N+](*)[O-])C(C)(C)C)(CC1*2[N+](C)[O-])I 0.000 description 5
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Definitions
- This invention relates to the use of certain 3-substituted-2-oxindole derivatives and the pharmaceutically-acceptable base salts thereof to inhibit interleukin-1 biosynthesis in a mammal.
- This invention also relates to the use of such compounds for treating interleukin-1 mediated disorders and dysfunctions such as bone and connective tissue metabolism disorders and immune dysfunction in a mammal.
- the invention comprises administering an effective amount of the compounds and the salts of this invention to such a mammal.
- Certain 3-substituted-2-oxindole-1-carboxamides of the formula and the pharmaceutically-acceptable base salts thereof wherein, inter alia , X and Y are each H, F, Cl, Br or CF3; and R1 is -(CH2) n -Q-R0 where n is zero, Q is a divalent radical derived from a compound selected from the group consisting of, inter alia , furan, thiophene, thiazole, oxazole and isoxazole and R° is H or (C1-C3)alkyl are disclosed in U.S. 4,556,672 which is assigned to the assignee hereof. That patent discloses that those compounds, in addition to being useful as antiinflammatory and analgesic agents, are inhibitors of both the cyclooxygenase (CO) and lipoxygenase (LO) enzymes.
- CO cyclooxygenase
- LO lipoxygenase
- EP-A-0 393 936 which is assigned to the assignee hereof, discloses certain 3-substituted-2-oxindole compounds of the formula and the pharmaceutically-acceptable base salts thereof wherein, inter alia , X and Y are each H, F, Cl, Br or CF3; R1 is H; R2 is CONR7R8 where R7 is H and R8 is H or (C1-C6)alkyl; Q is where Q1 is W is O or S, A and B are various substituents provided A and B cannot both be H nor A be H and B be (C1-C4)alkyl; and the tautomeric form thereof as a ketone. That application discloses that those compounds are useful as inhibitors of prostaglandin H2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic antiinflammatory diseases.
- X is H, Cl or F
- Y is H or Cl
- R is benzyl or thienyl to inhibit biosynthesis of interleukin-1 (IL-1) and to treat IL-1 mediated disorders and dysfunctions.
- IL-1 interleukin-1
- Interleukin-1 has been reported to stimulate bone resorption both in vitro and in vivo .
- PGE2 is a stimulator of bone resorption and has been implicated in bone loss.
- Hayward, M. A. and Caggiano, T. J. Annual Reports in Medicinal Chemistry, 22 , Sect. IV, Chapter 17, 172-177 (1987).
- Osteoporosis is defined as a debilitory loss of bone mineral which results in higher fracture rates. See Hayward, M. A. and Caggiano, T. J., supra , and references cited therein.
- Interleukin-1 has been reported to be involved in the pathogenesis of many diseases. See Dinarello, C.A., J. Clin. Immunol., 5 , 287-297 (1985). Further still, elevated levels of IL-1 like material have been found to be associated with psoriasis. Camp, R.D., et al ., J. Immunol., 137 , 3469-3474 (1986).
- etodolac 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
- etodolac 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
- This invention relates to the use of certain 3-substituted-2-oxindole derivatives of the formula and of the pharmaceutically-acceptable base salts thereof wherein X and Y are each H, F, Cl, Br or CF3; R1 is H or (C1-C4) straight or branched-chain alkyl; and Q is where R2 is H or (C1-C3) alkyl, to inhibit the biosynthesis of IL-1, which inhibition is independent of their lipoxygenase inhibiting activity, and thus are useful in treating IL-1 mediated disorders and dysfunctions such as certain disorders of bone and connective tissue metabolism and dysfunctions of the autoimmune system in mammals.
- Such bone metabolism disorders include, osteoporosis.
- Such connective tissue metabolism disorders include periodontal disease and tissue scarring.
- examples of IL-1 mediated immune dysfunctions include allergy and psoriasis.
- the use of the compounds and their pharmaceutically-acceptable base salts comprises administering to a mammal an effective amount of such compounds.
- Administration can comprise any known method for therapeutically providing a compound to a mammal such as by oral or parenteral administration as defined hereinbelow.
- the compounds of this invention hereinabove described are acidic and form base salts. All such base salts are within the scope of this invention and can be formed as taught by that patent.
- suitable salts within the scope of this invention, include both the organic and inorganic types and include the salts formed with ammonia, organic amines, alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, alkali metal hydrides, alkali metal alkoxides, alkaline earth metal hydroxides, alkaline earth metal carbonates, alkaline earth metal hydrides and alkaline earth metal alkoxides.
- bases which form such base salts include ammonia, primary amines, such as n-propylamine, n-butylamine, aniline, cyclohexylamine, benzylamine, p-toluidine, ethanolamine and glucamine; secondary amines, such as diethylamine, diethanolamine, N-methylglucamine, N-methylaniline, morpholine, pyrrolidine and piperidine; tertiary amines, such as triethylamine, triethanolamine, N,N-dimethylaniline, N-ethylpiperidine and N-methylmorpholine; hydroxides, such as sodium hydroxide; alkoxides such as sodium ethoxide and potassium methoxide; hydrides such as calcium hydride and sodium hydride; and carbonates such as potassium carbonate and sodium carbonate.
- Preferred salts are those of sodium, potassium, ammonium, ethanolamine, diethanolamine and triethanolamine. Particularly preferred
- solvates such as the hemihydrates and monohydrates of the compounds hereinabove described.
- Interleukin-1 is known by those skilled in the art to exist in at least two forms which are referred to as the ⁇ and ⁇ forms. Dinarello, C.A. FASEB J., 2 , 108-115 (1988). As used throughout this specification and the appendant claims, the term interleukin-1 (IL-1) refers to all such forms of IL-1 including IL-1 ⁇ , IL-1 ⁇ and IL-1 ⁇ and IL-1 ⁇ collectively.
- the invention comprises administering the invention compounds and the pharmaceutically-acceptable base salts thereof to a mammal.
- Such compounds and their salts can be administered to said mammal either alone or, preferably, in combination with pharmaceutically-acceptable carriers or diluents in a pharmaceutical composition, according to standard pharmaceutical practice.
- Such administration can be oral or parenteral.
- Parenteral administration as used herein includes intravenous, intramuscular, intraperitoneal, subcutaneous, transdermal and topical including oral lavage, administration. However, it is generally preferred to administer such compounds and their salts orally.
- these compounds and their salts are most desirably administered in doses ranging from 0.5 mg/kg up to 4 mg/kg per day for oral administration and from 0.01 mg/kg up to 4 mg/kg per day for parenteral administration, although variations will still necessarily occur depending upon the weight of the subject being treated.
- the appropriate dose for inhibiting IL-1 biosynthesis in a mammal and for treatment of IL-1 mediated bone metabolism disorder, IL-1 mediated connective tissue metabolism disorder or IL-1 mediated immune dysfunction with the compounds and their salts of this invention will be readily determined by those skilled in the art of prescribing and/or administering such compounds.
- dosage levels below the lower limit of the aforesaid range may be more than adequate, while in other cases still larger doses may be employed without causing any harmful or deleterious side effects to occur, provided that such higher dose levels are first divided into several smaller doses that are to be administered throughout the day.
- tablets containing excipients such as sodium citrate, calcium carbonate and dicalcium phosphate may be employed along with various disintegrants such as starch and preferably potato or tapioca starch, alginic acid and certain complex silicates, together with binding agents such as polyvinylpyrrolidone, sucrose, gelatin and acacia. Additionally, lubricating agents such as magnesium stearate, sodium lauryl sulfate and talc are often very usual for tableting purposes.
- Solid compositions of a similar type may also be employed as fillers in soft elastic and hard-filled gelatin capsules; preferred materials in this connection also include lactose or milk sugar as well as high molecular weight polyethylene glycols.
- the essential active ingredient may be combined with various sweetening or flavoring agents, coloring matter or dyes and, if so desired, emulsifying and/or suspending agents, together with diluents such as water, ethanol, propylene glycol, glycerin and various like combinations thereof.
- the preferred mode of administration of the compounds of this invention or their pharmaceutically-acceptable base salts is oral, they may be administered parenterally as well.
- solutions of these particular compounds in sesame or peanut oil or in aqueous propylene glycol may be employed, as well as sterile aqueous solutions of the corresponding water soluble base salts previously enumerated.
- aqueous solutions should be suitably buffered if necessary, and the liquid diluent rendered isotonic with sufficient saline or glucose.
- these particular aqueous solutions are especially suitable for intravenous, intramuscular and subcutaneous injection purposes.
- the sterile aqueous media employed are readily obtained by standard techniques well known to those skilled in the art.
- distilled water is ordinarily used as the liquid diluent and the final preparation is passed through a suitable bacterial filter such as a sintered glass filter or a diatomaceous-earth or unglazed porcelain filter.
- Preferred filters of this type include the Berkefeld, the Chamberland and the Asbestos Disk-Metal Seitz filter, wherein the fluid is sucked into a sterile container with the aid of a suction pump. Needless to say, the necessary steps should be taken throughout the preparation of these injectable solutions to insure that the final products are obtained in a sterile condition.
- the dosage form of the particular compound may include, by way of example, solutions, lotions, ointments, creams, gels, suppositories, rate-limiting sustained release formulations and devices therefor.
- Such dosage forms comprise the particular compound and may include ethanol, water, penetration enhancer and inert carriers such as gel-producing materials, mineral oil, emulsifying agents, benzyl alcohol and the like.
- Specific transdermal flux enhancing compositions are disclosed in European Patent Application Publication No. 217983 and in European Patent Application Publication No. 331382, both of which are assigned to the assignee of this invention.
- the dosage form of the particular compound may include solutions, lotions, ointments, creams and gels.
- C3H/HeN mice (Charles River, Wilmington, Massachusetts) are sacrificed by cervical dislocation and their abdomens sprayed with 70% ethanol to prevent bacterial contamination of the subsequent cellular preparation.
- Into the peritoneum of each mouse is injected 8 ml of RPMI1 containing 5% FCS2 , penicillin-streptomycin (100 units/ml - 100 ⁇ g/ml) and glutamine (2mM).
- the peritoneum is kneaded to help free cells.
- an incision through the skin of the abdomen is made to expose the underlying muscle layer.
- the peritoneal fluid is removed with a 20 gauge needle by inserting the needle, bevel down, through the exposed muscle layer just below the sternum.
- the peritoneal fluid from six mice is pooled in a plastic conical tube and microscopically examined for bacterial contamination. Uncontaminated fluid is centrifuged at about 600xg for six minutes and the supernatant decanted. The pelleted cells from five to six tubes are combined and resuspended in a total of 20 ml of RPMI-FCS3 . The cell number is then ascertained using a hemacytometer and cell viability determined with Trypan Blue staining also using a hemacytometer. The cells are then diluted to 3 x 106 cells/ml using RPMI-FCS. To the wells of a 35 mm well plate is added 1 ml of the above cell suspension.
- the cells are incubated for 2 hours at 37°C in a 5% CO2 atmosphere to cause adherence of the macrophages to the walls of the wells.
- the supernatant is removed by swirling the wells vigorously and decanting.
- the adherent cells i.e., macrophages
- the adherent cells are washed twice with RPMI-SF4 .
- To the wells containing adherent cells is added 1 ml of the compound under study at concentrations ranging from 0.1 to 100 ⁇ g/ml in RPMI containing 1% FCS or 1 ml of RPMI containing 1% FCS as a control.
- 100 ⁇ l of LPS5 in RPMI containing 1% FCS (1 mg/5 ml) is added to each well.
- the plates are incubated at 37°C in a 5% CO2 atmosphere for 24 hours.
- the supernatants are removed and either assayed for IL-1 immediately or otherwise refrigerated or frozen for subsequent assay.
- 1RPMI-1640 medium (Hazelton Research Products, Inc., Lenexa, Kansas) 2Fetal calf serum which has been screened for good responsiveness to IL-1 in the thymocyte assay (Hyclone Laboratories, Logan, Utah) and for low spontaneous proliferation in the absence of IL-1.
- 3RPMI-1640 medium containing 5% fetal calf serum.
- the supernatants are assayed quantitatively for IL-1 according to the receptor binding assay described below.
- a standard curve is generated as follows.
- EL4-6.1 murine thymoma cells [10-15 x 106 cells/ml in binding buffer (RPMI 16:0, 5% FCS, 25 mM HEPES, 0.01% NaN3, pH 7.3)] are added to varying amounts of unlabeled murine rIL-1 ⁇ [recombinant IL-1 ⁇ produced in Escherichia coli from the published sequence of amino acids 115-270 for IL-1 ⁇ , Lomedico, P.
- Filters are counted in a Searle gamma counter and non-specific binding is taken as the cpm bound in the presence of 200 ng/ml unlabeled rIL-1 ⁇ .
- a Hill calibration curve is constructed by plotting log (Y/100-Y) vs. log C where Y represents the percent of control 125I-rIL-1 ⁇ binding and C is the concentration of unlabeled rIL-1 ⁇ .
- a linear least-squares line is fitted through Y values between 20 to 80%. Then, to quantitate IL-1 levels in the supernatants obtained as described above, diluted supernatants replace rIL-1 ⁇ in the above protocol and measured percent binding values are used to determine IL-1 concentrations from a standard Hill plot. Each dilution is assayed in duplicate and generally only dilutions with Y values between 20 to 80% are used to calculate average IL-1 levels.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (11)
- Verwendung einer Verbindung der Formel
- Verwendung nach Anspruch 1, wobei die Zubereitung für eine Behandlung von durch Interleukin-1 vermittelten Knochenmetabolismusstörungen bei einem Säugetier (vorgesehen) ist.
- Verwendung nach Anspruch 2, wobei die Knochenmetabolismusstörung Osteoporose ist.
- Verwendung nach Anspruch 1, wobei die Zubereitung für eine Behandlung von durch Interleukin-1 vermittelten Bindegewebsmetabolismusstörungen bei einem Säugetier (vorgesehen) ist.
- Verwendung nach Anspruch 4, wobei die Bindegewebsmetabolismusstörung eine Periodontalerkrankung oder Gewebevernarbung ist.
- Verwendung nach Anspruch 1, wobei die Zubereitung für eine Behandlung einer durch Interleukin-1 vermittelten Immunfehlfunktion bei einem Säugetier (vorgesehen) ist.
- Verwendung nach Anspruch 6, wobei die Immunfehlfunktion eine Allergie oder Psoriasis ist.
- Verwendung einer Verbindung der Formel I oder eines pharmazeutisch akzeptablen Basesalzes derselben nach einem der Ansprüche 1 bis 8, wobei R¹ für H, Ethyl oder tert.-Butyl steht.
- Verwendung einer Verbindung der Formel I oder eines pharmazeutisch akzeptablen Basesalzes derselben nach einem der Ansprüche 1 bis 8, wobei X Cl bedeutet, Y für H steht, R¹ H, Ethyl oder tert.-Butyl entspricht und R² H oder CH₃ darstellt.
- Verwendung einer Verbindung der Formel I oder eines pharmazeutisch akzeptablen Basesalzes derselben nach einem der Ansprüche 1 bis 10, wobei sich die pharmazeutische Zubereitung zur oralen oder parenteralen Verabreichung eignet.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42144589A | 1989-10-13 | 1989-10-13 | |
US421445 | 1989-10-13 | ||
US52905090A | 1990-05-25 | 1990-05-25 | |
US529050 | 1990-05-25 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0425109A2 EP0425109A2 (de) | 1991-05-02 |
EP0425109A3 EP0425109A3 (en) | 1992-01-15 |
EP0425109B1 true EP0425109B1 (de) | 1994-08-03 |
Family
ID=27025248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP90310806A Expired - Lifetime EP0425109B1 (de) | 1989-10-13 | 1990-10-03 | 3-Substituierte-2-Oxindolderivate als Interleukin-Biosynthesehemmer |
Country Status (14)
Country | Link |
---|---|
US (1) | US5192790A (de) |
EP (1) | EP0425109B1 (de) |
JP (1) | JPH0684300B2 (de) |
KR (1) | KR910007526A (de) |
AT (1) | ATE109349T1 (de) |
AU (1) | AU624739B2 (de) |
CA (1) | CA2027394C (de) |
DE (1) | DE69011272T2 (de) |
DK (1) | DK0425109T3 (de) |
HU (2) | HUT59004A (de) |
IE (1) | IE63140B1 (de) |
IL (1) | IL95880A (de) |
MY (1) | MY106834A (de) |
PT (1) | PT95566B (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6266485B1 (en) | 1998-02-19 | 2001-07-24 | Emerson Electric Co. | One-piece plastic tank and temperature control system for a hot water dispenser |
JP2002525362A (ja) * | 1998-09-30 | 2002-08-13 | エスヴァイン、アンゲリカ | 代謝性骨障害の治療および予防のためのロダニンカルボン酸誘導体 |
US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
IN162090B (de) * | 1984-03-19 | 1988-03-26 | Pfizer | |
IN161509B (de) * | 1984-05-04 | 1987-12-19 | Pfizer | |
US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
US4678802A (en) * | 1985-07-09 | 1987-07-07 | Pfizer Inc. | 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents |
GB8517958D0 (en) * | 1985-07-16 | 1985-08-21 | Cellena Cell Eng Ag | Compositions containing melatonin/homologues |
JPH01501705A (ja) * | 1986-01-30 | 1989-06-15 | ユニバ−シテイ・オブ・ユタ | 骨損失の治療 |
US4677132A (en) * | 1986-03-12 | 1987-06-30 | American Home Products Corporation | Inhibition of bone resorption by etodolac |
US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
-
1990
- 1990-10-02 IL IL9588090A patent/IL95880A/en not_active IP Right Cessation
- 1990-10-03 DK DK90310806.6T patent/DK0425109T3/da active
- 1990-10-03 DE DE69011272T patent/DE69011272T2/de not_active Expired - Fee Related
- 1990-10-03 EP EP90310806A patent/EP0425109B1/de not_active Expired - Lifetime
- 1990-10-03 AT AT90310806T patent/ATE109349T1/de not_active IP Right Cessation
- 1990-10-11 JP JP2273150A patent/JPH0684300B2/ja not_active Expired - Lifetime
- 1990-10-11 PT PT95566A patent/PT95566B/pt not_active IP Right Cessation
- 1990-10-11 CA CA002027394A patent/CA2027394C/en not_active Expired - Fee Related
- 1990-10-11 MY MYPI90001771A patent/MY106834A/en unknown
- 1990-10-12 AU AU64582/90A patent/AU624739B2/en not_active Ceased
- 1990-10-12 HU HU906436A patent/HUT59004A/hu unknown
- 1990-10-12 IE IE364890A patent/IE63140B1/en not_active IP Right Cessation
- 1990-10-12 KR KR1019900016153A patent/KR910007526A/ko not_active Application Discontinuation
-
1991
- 1991-12-17 US US07/808,491 patent/US5192790A/en not_active Expired - Fee Related
-
1995
- 1995-05-11 HU HU95P/P00128P patent/HU210902A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
AU624739B2 (en) | 1992-06-18 |
HUT59004A (en) | 1992-04-28 |
JPH0684300B2 (ja) | 1994-10-26 |
AU6458290A (en) | 1991-04-18 |
JPH03133929A (ja) | 1991-06-07 |
MY106834A (en) | 1995-07-31 |
CA2027394C (en) | 1995-01-03 |
KR910007526A (ko) | 1991-05-30 |
EP0425109A2 (de) | 1991-05-02 |
HU210902A9 (en) | 1995-09-28 |
CA2027394A1 (en) | 1991-04-14 |
IL95880A (en) | 1995-12-31 |
ATE109349T1 (de) | 1994-08-15 |
DE69011272T2 (de) | 1994-11-24 |
DK0425109T3 (da) | 1994-11-21 |
EP0425109A3 (en) | 1992-01-15 |
HU906436D0 (en) | 1991-04-29 |
DE69011272D1 (de) | 1994-09-08 |
US5192790A (en) | 1993-03-09 |
PT95566A (pt) | 1991-08-14 |
IE903648A1 (en) | 1991-04-24 |
IE63140B1 (en) | 1995-03-22 |
PT95566B (pt) | 1997-11-28 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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