EP0372005A4 - Expressionssysteme zur erzeugung von polypeptiden in prokaryotischen zellen. - Google Patents
Expressionssysteme zur erzeugung von polypeptiden in prokaryotischen zellen.Info
- Publication number
- EP0372005A4 EP0372005A4 EP19880910220 EP88910220A EP0372005A4 EP 0372005 A4 EP0372005 A4 EP 0372005A4 EP 19880910220 EP19880910220 EP 19880910220 EP 88910220 A EP88910220 A EP 88910220A EP 0372005 A4 EP0372005 A4 EP 0372005A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- polypeptides
- preparation
- expression systems
- prokaryotic cells
- prokaryotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11513987A | 1987-10-30 | 1987-10-30 | |
US115139 | 1987-10-30 | ||
US24076888A | 1988-09-02 | 1988-09-02 | |
US240768 | 1988-09-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0372005A1 EP0372005A1 (de) | 1990-06-13 |
EP0372005A4 true EP0372005A4 (de) | 1990-06-26 |
Family
ID=26812881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19880910220 Withdrawn EP0372005A4 (de) | 1987-10-30 | 1988-10-28 | Expressionssysteme zur erzeugung von polypeptiden in prokaryotischen zellen. |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0372005A4 (de) |
JP (1) | JP2970811B2 (de) |
WO (1) | WO1989003886A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI891308A (fi) * | 1988-03-24 | 1989-09-25 | Oncogen | Nya polypeptider med tillvaextfaktoraktivitet och dessa kodande nukleinsyrasekvenser. |
US5086164A (en) * | 1989-01-10 | 1992-02-04 | Repligen Corporation | Novel methods and compositions for treatment of angiogenic diseases |
IE901849A1 (en) * | 1989-07-19 | 1991-06-19 | Gruenenthal Gmbh | Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator |
EP0423641A3 (en) * | 1989-10-18 | 1992-01-15 | Nippon Mining Company Limited | Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha |
JPH05219963A (ja) * | 1990-07-18 | 1993-08-31 | Applied Immune Sci Inc | 温度誘導分泌発現ベクターおよびその原核細胞での使用 |
US6083686A (en) * | 1990-10-26 | 2000-07-04 | Johnson & Johnson Clinical Diagnostic Systems, Inc. | Increased production of Thermus aquaticus DNA polymerase in E. coli |
GB2253852B (en) * | 1991-02-26 | 1995-03-22 | Ici Plc | Vector for expression of heterologous polypeptide comprising inducible selection system |
EP1117805A2 (de) | 1998-10-07 | 2001-07-25 | STRYKER CORPORATION (a Michigan corporation) | Modifizierte proteine der tgf-beta superfamilie |
MXPA03008022A (es) | 2001-03-09 | 2003-12-04 | Genentech Inc | Proceso para la produccion de polipeptidos. |
US7153666B2 (en) | 2003-07-17 | 2006-12-26 | General Atomics | Methods and compositions for determination of glycated proteins |
US8187831B2 (en) * | 2003-09-19 | 2012-05-29 | General Atomics | Determination of ions using ion-sensitive enzymes |
US7022494B2 (en) | 2003-09-19 | 2006-04-04 | General Atomics | Detection of potassium ions using ion-sensitive enzymes |
US7943385B2 (en) | 2006-07-25 | 2011-05-17 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
CA2654981C (en) | 2006-07-25 | 2016-05-17 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
WO2009140343A1 (en) | 2008-05-13 | 2009-11-19 | General Atomics | Electrochemical biosensor for direct determination of percentage of glycated hemoglobin |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0173149A1 (de) * | 1984-08-21 | 1986-03-05 | Hoechst Aktiengesellschaft | Synthetische Regulationsregion |
EP0241446A2 (de) * | 1986-03-27 | 1987-10-14 | Monsanto Company | Erhöhte Produktion von Proteinen in Bakterien durch Verwendung einer neuen Ribosombindungsstelle |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4565785A (en) | 1978-06-08 | 1986-01-21 | The President And Fellows Of Harvard College | Recombinant DNA molecule |
IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
US4582800A (en) * | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
JP2595205B2 (ja) * | 1984-02-08 | 1997-04-02 | カロイン コーポレイション | 発現カセット |
US4711845A (en) * | 1984-08-31 | 1987-12-08 | Cetus Corporation | Portable temperature-sensitive control cassette |
EP0196864A3 (de) * | 1985-03-25 | 1988-03-23 | Cetus Corporation | Behandlung und Sekretion von rekombinanten Proteinen mittels alkalischer Phosphatase, dazu verwendbare DNA-Sequenzen und mittels dieser Sequenzen transformierte Zellen |
-
1988
- 1988-10-28 WO PCT/US1988/003872 patent/WO1989003886A1/en not_active Application Discontinuation
- 1988-10-28 EP EP19880910220 patent/EP0372005A4/de not_active Withdrawn
- 1988-10-28 JP JP63509398A patent/JP2970811B2/ja not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0173149A1 (de) * | 1984-08-21 | 1986-03-05 | Hoechst Aktiengesellschaft | Synthetische Regulationsregion |
EP0241446A2 (de) * | 1986-03-27 | 1987-10-14 | Monsanto Company | Erhöhte Produktion von Proteinen in Bakterien durch Verwendung einer neuen Ribosombindungsstelle |
Non-Patent Citations (4)
Title |
---|
CHEMCIAL ABSTRACTS * |
CHEMICAL ABSTRACTS * |
JOURNAL OF BIOTECHNOLOGY * |
See also references of WO8903886A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1989003886A1 (en) | 1989-05-05 |
EP0372005A1 (de) | 1990-06-13 |
JP2970811B2 (ja) | 1999-11-02 |
JPH04502851A (ja) | 1992-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19890724 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19900626 |
|
17Q | First examination report despatched |
Effective date: 19951221 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010502 |