EP0370866B1 - Verfahren zur Elektrosynthese von Aldehyden - Google Patents
Verfahren zur Elektrosynthese von Aldehyden Download PDFInfo
- Publication number
- EP0370866B1 EP0370866B1 EP89403133A EP89403133A EP0370866B1 EP 0370866 B1 EP0370866 B1 EP 0370866B1 EP 89403133 A EP89403133 A EP 89403133A EP 89403133 A EP89403133 A EP 89403133A EP 0370866 B1 EP0370866 B1 EP 0370866B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- process according
- electrolysis
- organic halide
- cathode
- aldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/25—Reduction
Definitions
- the invention relates to a process for the electrochemical synthesis of an aldehyde by electrolysis in a cell provided with electrodes of an organic halide and of an N, N-disubstituted formamide, then hydrolysis of the reaction medium.
- Aldehydes are compounds commonly used in many fields of the chemical industry, especially in perfumery, agrochemicals and pharmacy.
- aldehydes There are many methods of synthesizing aldehydes. Among these, mention may be made of those for which the aldehyde is obtained by electrolysis, in a cell provided with electrodes, an organic halide and an N, N-disubstituted formamide, then hydrolysis of the reaction medium.
- CASARDO and GALLARDO in Electrochimica Acta, Vol. 32, n ° 8, pp. 1145-1147, (1987) describe the synthesis of traces of benzaldehyde during the electrolysis of bromo or iodobenzene solutions in dimethylformamide (DMF).
- the cell has 2 separate compartments, anodic and cathodic.
- the cathode is made of mercury and the inert anode is made of graphite.
- VIEIRA and PETERS in J. Org. Chem., Vol. 51, n ° 8, pp. 1231-1239, (1986) describe the synthesis of pivalic aldehyde during the electrolysis of a solution of tert-butyl bromide in DMF. The yields are very low, less than 14%.
- the cell has 2 separate compartments, anodic and cathodic.
- the cathode is made of mercury and the inert anode is made of carbon.
- the electrolysis cell is a cell with only one compartment, i.e. for which there are no compartments separate anode and cathode. This possibility of using such a cell is an important advantage, as has already been mentioned.
- the anode is consumable, that is to say it is consumed during the electrochemical reaction of which it is the seat. This is the reason why such processes are sometimes called "soluble anode".
- the anode is made of a metal chosen from the group consisting of reducing metals and their alloys, that is to say any alloy containing at least one reducing metal.
- the anode is made of a reducing metal chosen from the group consisting of magnesium, aluminum, zinc and their alloys, that is to say any alloy containing at least one of the three metals mentioned above, namely zinc, aluminum and magnesium.
- This anode can have any shape and in particular all the classic forms of metal electrodes such as twisted wire, flat bar, cylindrical bar, renewable bed, balls, fabric, grid.
- a cylindrical bar of diameter adapted to the dimensions of the cell is used.
- the cathode is any metal such as stainless steel, gold, nickel, platinum, copper, aluminum, iron or carbon such as, for example, vitreous carbon or graphite. It is preferably formed by a grid or a cylindrical plate arranged concentrically around the anode.
- the Applicant has discovered that, unexpectedly, the efficiency is considerably improved when the cathode is covered with an electrolytic deposit of a metal M chosen from the group consisting of zinc, cadmium, lead and tin.
- the electrodeposition of the metal M on the cathode, prior to the electrosynthesis of the aldehyde, can be carried out by various methods, in particular those described in Examples 14 to 38.
- the electrodes are supplied with direct current via a stabilized power supply.
- the aldehyde corresponds to the general formula RCHO in which R represents an organic radical
- the organic halide corresponds to the general formula RX in which R has the abovementioned meaning and X represents an atom of halogen, preferably chlorine or bromine
- the N, N-disubstituted formamide corresponds to the general formula in which R1 and R2, identical or different, represent an aliphatic or aromatic chain, substituted or unsubstituted, preferably either an alkyl chain containing 1 to 8 carbon atoms, or a substituted or unsubstituted phenyl ring, or alternatively R1 and R2 form a cycle.
- R represents an aliphatic, arylaliphatic, aromatic, alkylaromatic or heterocyclic organic radical, substituted or unsubstituted, preferably an alkyl radical or a phenyl group, substituted or unsubstituted.
- R carries various substituents, these must be more difficult to reduce than the R-X bond.
- the formamide is DMF.
- other formamides mention may be made of N, N-dialkylformamides and N-phenyl N-methylformamide (N-methylformanilide).
- the hydrolysis of the reaction medium is for example carried out with an acidic aqueous solution.
- the formamide N, N-disubstituted in addition to its role as reagent, also plays the role of solvent. This is particularly the case when using DMF. It is then not necessary to use another solvent.
- electrolysis can be carried out in the presence of a co-solvent chosen from aprotic solvents with low electrophilicity, such as, for example, tetramethylurea (TMU) and tetrahydrofuran (THF).
- the concentration of the reactants is preferably chosen so as to ensure a very large molar excess of formamide, since the latter also preferably plays the role of solvent.
- the concentration of the organic halide in the reaction medium is generally between 0.05 and 2 mol / l.
- the reaction medium is made conductive by a slightly reducible support electrolyte.
- Mention may be made, for example, of the salts whose anion is a halide, a carboxylate, a fluoroborate, a perchlorate or a hexafluorophosphate and the cation a quaternary ammonium, aluminum, zinc, sodium, potassium, calcium, lithium, a tetraalkylphosphonium, as well as mixtures of these salts.
- tetramethylammonium fluoroborate or tetrabutylammonium bromide is used.
- the solution is oxygenated by bubbling an inert gas, nitrogen or argon for example.
- the reaction temperature is preferably between 0 and 80 ° C, for example room temperature.
- the solution is stirred, maintained under an inert atmosphere, of nitrogen or argon for example, and cooled if necessary to maintain its temperature between 0 and 80 ° C. preferably.
- the current density on the cathode is preferably chosen between 0.2 and 20 A / dm2.
- the duration of the electrolysis is preferably chosen so that the amount of current involved corresponds approximately to 2 Faraday (193 103C) per mole of organic halide.
- reaction medium After electrolysis, the reaction medium is hydrolyzed with an acidic aqueous solution, for example dilute hydrochloric acid, then extraction is carried out with an organic solvent. After drying and evaporation of the extraction solvent, the aldehyde is obtained which is identified and assayed according to conventional methods of analysis, after optional purification by passage over a column of silica for example.
- acidic aqueous solution for example dilute hydrochloric acid
- organic solvent After drying and evaporation of the extraction solvent, the aldehyde is obtained which is identified and assayed according to conventional methods of analysis, after optional purification by passage over a column of silica for example.
- a cathode covered with an electrolytic deposit of a metal M as defined above it is possible, when M represents cadmium, lead or tin, to directly introduce the metal M to be deposited on the cathode in the form of salt, cadmium bromide, lead acetate or tin chloride for example, in the organic halide and N, N-disubstituted formamide mixture.
- the metal M is deposited on the cathode.
- the yield is improved by adding the organic halide gradually into the reaction medium during electrolysis.
- a conventional electrolysis cell comprising only one compartment.
- the upper part of the cell is made of glass and is equipped with 5 tubes, including a central one, allowing the arrival and the exit of argon used as inert gas, the possible samples of solution during electrolysis, the addition of reagents, electrical passages.
- the lower part consists of a stopper fitted with a seal, screwed onto the upper glass part.
- the total volume of the cell is close to 45 cm3 and its useful volume close to 35 cc.
- the anode is a cylindrical bar with a diameter close to 1 cm, made of zinc, magnesium or aluminum according to the tests. It is introduced into the cell through the central tube and is thus located approximately in axial position relative to the cell.
- the cathode consists of a metallic cylindrical grid arranged concentrically around the anode.
- the working surface of the cathode is of the order of 20 cm2.
- the cell is immersed in a thermostatic bath set to the chosen temperature.
- reaction medium is stirred, for example by means of a magnetic bar.
- This mixture is degassed by bubbling argon, then it is maintained under an argon atmosphere.
- reaction medium After constant intensity electrolysis for a corresponding period at 3 Faraday (290 103C) per mole of organic halide, the reaction medium is hydrolyzed with a 1N aqueous hydrochloric acid solution and then extracted with diethyl ether.
- the organic phase is then separated and washed with water.
- the aldehyde obtained is purified by chromatography on a silica column and then identified according to conventional methods of analysis, in particular by infrared spectrometry (IR), mass (SM) and nuclear magnetic resonance (NMR ).
- IR infrared spectrometry
- SM mass
- NMR nuclear magnetic resonance
- the organic halide concentration is 0.5 M for Examples 1, 3 to 9, 12 and 0.125 M for Example 2.
- CF3Br being a gas
- it is introduced by bubbling into the reaction medium under a pressure of 105Pa (1 bar).
- the cathode is made of nickel for examples 10 and 11, of stainless steel for examples 1 to 6, 8, 9 to 12, of lead for example 7.
- the anode is made of zinc for example 10, of aluminum for examples 1 to 4, 6 to 9 and 12.
- the volume of formamide, or mixture of formamides, is 36cm3. This volume includes the co-solvent when it is present.
- the formamide is DMF for examples 1 to 5 and 7 to 12, a 1/1 mixture by volume of DMF / N-methylformanilide for example 6.
- Examples 2 and 4 are carried out in the presence of a co-solvent.
- the co-solvent is THF and the volume ratio DMF / THF is 2/1 respectively.
- the co-solvent is TMU and the volume ratio DMF / TMU is respectively 1/1.
- the current density on the cathode is 2A / dm2 for examples 1, 2, 7 to 11, 1.5 A / dm2 for example 12, 1 A / dm2 for examples 3 and 4 and 0.5 A / dm2 for examples 5 and 6.
- the reaction temperature is 25 ° C for Examples 1 to 9 and 0 ° C for Examples 10 to 12.
- the trifluoroacetaldehyde is isolated in the form of a hydrate and the yield indicated in Table 1 is a faradaic yield calculated from the amount of electricity used.
- the experimental conditions for this example are the same as those of Example 1 but the initial concentration of benzyl chloride is 0.125 M. After electrolysis corresponding to the passage of 2 Faraday (193 103C) per mole of benzyl chloride, we add an amount of benzyl chloride equal to that present at the start. Electrolysis is then continued until the total duration thereof corresponds to 3 Faraday (290 103C) per mole of benzyl chloride used. The yield of isolated pure aldehyde is 50%.
- the cathode made of stainless steel or nickel, is covered with an electrolytic deposit of a metal M.
- MBr2 is added at a concentration of the order of 5 10 ⁇ 2M to 10 ⁇ 1M.
- the cell is equipped with a metal anode M and a current of 0.1 to 0.2 A is imposed for 0.5 to 1 hour, which makes it possible to transport M from the anode to the cathode.
- the anode M is then replaced by a magnesium bar and the electrolysis is continued at constant intensity for the time necessary for the almost complete exhaustion of the M2+ ions present in the solution.
- the organic halide is then added to this solution.
- MBr2 is added at a concentration of the order of 5 10 ⁇ 2M to 10 ⁇ 1M.
- the cell is equipped with a magnesium anode and a current of 0.1 to 0.2 A is imposed for the time necessary for the electrodeposition of the M2+ ions on the cathode.
- the organic halide is then added.
- M is cadmium, lead or tin
- DMF containing tetrabutylammonium bromide as support electrolyte at the concentration of 10 ⁇ 2M, CdBr2, Pb (CH3CO2) 2 or SnCl2 are added, at a concentration of the order of 5 10 52 to 10 ⁇ 1M, as well as organic halide.
- the cell is equipped with a magnesium anode and a constant intensity current is imposed.
- the cathode coated according to one of the aforementioned methods A, B or C then having served for the electrosynthesis of an aldehyde according to the invention is reused without modification in a new electrosynthesis of aldehyde with a magnesium anode, in DMF medium containing tetrabutylammonium bromide at a concentration of 10 ⁇ 2M as a support electrolyte.
- electrosynthesis is carried out at ambient temperature, by imposing a current of constant intensity such that the current density on the cathode is 1 A / dm2.
- the duration of the electrolysis is chosen so as to employ 2.1 Faraday (203 103 C) per mole of organic halide.
- reaction medium Before electrolysis, the reaction medium is degassed for bubbling of argon, then the medium is maintained under an argon atmosphere.
- the medium is hydrolyzed, then the aldehyde formed is isolated, purified, identified and assayed according to the method described for Examples 1 to 14.
- the aldehyde is recovered in the form of a hydrate.
- the following table 2 specifies for each example the nature and the concentration in DMF of the organic halide, the nature of the cathode as well as the method used for electrodepositing the metal M.
- Table 3 specifies for each example the conversion rate of the organic halide as well as the nature and the yield with respect to the starting organic halide, of the aldehyde formed. For certain examples, the yield of isolated pure aldehyde is also indicated in brackets.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Compounds Of Unknown Constitution (AREA)
- Electrodes For Compound Or Non-Metal Manufacture (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (9)
- Verfahren zur Elektrosynthese eines Aldehyds durch Elektrolyse eines organischen Halogenids und eines N,N-disubstituierten Formamids in einer mit Elektroden ausgerüsteten elektrolytischen Zelle und durch anschließende Hydrolyse in einem Reaktionsmedium, dadurch gekennzeichnet, daß die Zelle nur eine Kammer aufweist, daß man eine selbstverzehrende Anode aus einem Metall, das aus der Gruppe der reduzierenden Metalle und deren Legierungen ausgewählt ist, verwendet, daß der Aldehyd der allgemeinen Formel RCHO entspricht, in der R einen organischen Rest bedeutet, daß das organische Halogenid der allgemeinen Formel RX entspricht, in der R die vorstehend genannte Bedeutung hat und X ein Halogenatom bedeutet, daß das N,N-disubstituierte Formamid der allgemeinen Formel
- Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß die Anode aus einem reduzierenden Metall besteht, das aus der Gruppe Magnesium, Aluminium, Zink und deren Legierungen ausgewählt ist.
- Verfahren nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß X Chlor oder Brom bedeutet und daß R₁ und R₂, die gleich oder verschieden sind, eine Alkylkette mit 1 bis 8 Kohlenstoffatomen oder einen substituierten oder unsubstiutierten Phenylring bedeuten.
- Verfahren nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß R einen substituierten oder unsubstituierten organischen aliphatischen, arylaliphatischen, aromatischen, alkylaromatischen oder heterocyclischen Rest und vorzugsweise einen substituierten oder unsubstituierten Alkylrest oder Phenylrest bedeutet.
- Verfahren nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß im Reaktionsmedium zusätzlich ein organisches Lösungsmittel vorhanden ist.
- Verfahren nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß die Kathode mit einer elektrolytischen Abscheidung eines Metalls M, das aus der Gruppe Zink, Cadmium, Blei und Zinn ausgewählt ist, überzogen ist.
- Verfahren nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß zusätzlich ein Salz von Cadmium, Blei oder Zinn im Reaktionsmedium enthalten ist.
- Verfahren nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß die Konzentration des organischen Halogenids im Bereich von 0,05 bis 2 Mol/Liter liegt.
- Verfahren nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß man das organische Halogenid im Verlauf der Elektrolyse fortschreitend zusetzt.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT89403133T ATE94590T1 (de) | 1988-11-23 | 1989-11-15 | Verfahren zur elektrosynthese von aldehyden. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8815235 | 1988-11-23 | ||
FR8815235A FR2639364B1 (fr) | 1988-11-23 | 1988-11-23 | Procede d'electrosynthese d'aldehydes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0370866A1 EP0370866A1 (de) | 1990-05-30 |
EP0370866B1 true EP0370866B1 (de) | 1993-09-15 |
Family
ID=9372136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP89403133A Expired - Lifetime EP0370866B1 (de) | 1988-11-23 | 1989-11-15 | Verfahren zur Elektrosynthese von Aldehyden |
Country Status (7)
Country | Link |
---|---|
US (1) | US4988416A (de) |
EP (1) | EP0370866B1 (de) |
JP (1) | JP2812748B2 (de) |
AT (1) | ATE94590T1 (de) |
DE (1) | DE68909184T2 (de) |
ES (1) | ES2045513T3 (de) |
FR (1) | FR2639364B1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9207546D0 (en) * | 1992-04-07 | 1992-05-20 | Atomic Energy Authority Uk | Hydrolysis |
DE4428905A1 (de) | 1994-08-16 | 1996-02-29 | Hoechst Ag | Verfahren zur Elektrosynthese von Aldehyden |
US5756851A (en) * | 1996-10-21 | 1998-05-26 | Albemarle Corporation | Production of nabumetone or precursors thereof |
JP2004530044A (ja) * | 2001-04-12 | 2004-09-30 | アストラゼネカ アクチボラグ | 微細工学的反応装置 |
WO2007131969A2 (en) * | 2006-05-15 | 2007-11-22 | Akzo Nobel N.V. | An electrochemical process to prepare a halogenated carbonyl group-containing compound |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4547271A (en) * | 1984-09-12 | 1985-10-15 | Canada Packers Inc. | Process for the electrochemical reduction of 7-ketolithocholic acid to ursodeoxycholic acid |
US4601797A (en) * | 1984-12-19 | 1986-07-22 | Monsanto Company | Electrochemical carboxylation of p-isobutylacetophenone and other aryl ketones |
US4582577A (en) * | 1984-12-19 | 1986-04-15 | Monsanto Company | Electrochemical carboxylation of p-isobutylacetophenone |
FR2579626B1 (fr) * | 1985-03-29 | 1987-05-15 | Poudres & Explosifs Ste Nale | Procede d'electrosynthese de cetones et d'aldehydes |
FR2579627B1 (fr) * | 1985-03-29 | 1987-05-15 | Poudres & Explosifs Ste Nale | Procede d'electrosynthese d'alcools |
FR2586710B1 (fr) * | 1985-09-05 | 1990-03-30 | Poudres & Explosifs Ste Nale | Cellule d'electrolyse organique a electrode consommable |
-
1988
- 1988-11-23 FR FR8815235A patent/FR2639364B1/fr not_active Expired - Lifetime
-
1989
- 1989-11-15 ES ES89403133T patent/ES2045513T3/es not_active Expired - Lifetime
- 1989-11-15 AT AT89403133T patent/ATE94590T1/de active
- 1989-11-15 DE DE89403133T patent/DE68909184T2/de not_active Expired - Fee Related
- 1989-11-15 EP EP89403133A patent/EP0370866B1/de not_active Expired - Lifetime
- 1989-11-17 US US07/437,820 patent/US4988416A/en not_active Expired - Fee Related
- 1989-11-24 JP JP1303444A patent/JP2812748B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2045513T3 (es) | 1994-01-16 |
JP2812748B2 (ja) | 1998-10-22 |
FR2639364A1 (fr) | 1990-05-25 |
EP0370866A1 (de) | 1990-05-30 |
DE68909184D1 (de) | 1993-10-21 |
FR2639364B1 (fr) | 1990-12-28 |
DE68909184T2 (de) | 1994-04-07 |
US4988416A (en) | 1991-01-29 |
ATE94590T1 (de) | 1993-10-15 |
JPH02185989A (ja) | 1990-07-20 |
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