EP0353238A1 - Nouveaux produits intermediaires et procede - Google Patents

Nouveaux produits intermediaires et procede

Info

Publication number
EP0353238A1
EP0353238A1 EP19880903211 EP88903211A EP0353238A1 EP 0353238 A1 EP0353238 A1 EP 0353238A1 EP 19880903211 EP19880903211 EP 19880903211 EP 88903211 A EP88903211 A EP 88903211A EP 0353238 A1 EP0353238 A1 EP 0353238A1
Authority
EP
European Patent Office
Prior art keywords
methyl
ester
nitrophenyl
dimethyl
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19880903211
Other languages
German (de)
English (en)
Inventor
Wolf-Rüdiger Ulrich
Hermann Amschler
Dieter Flockerzi
Kurt Klemm
Bernhard Kohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of EP0353238A1 publication Critical patent/EP0353238A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Definitions

  • Y represents a halogen atom
  • n represents the number 1, 2 or 3
  • R3 is benzyl
  • reaction temperature in the reaction of ZW with compound IV depends on the other reaction conditions, with temperature generally between 20 ° C. and the boiling point of the solvent used being preferred.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Des composés énantiomériquement purs ou sous forme racémique ont la formule (ZW) dans laquelle les substituants ont les notations données dans la description. Sont également décrits un procédé pour fabriquer ce composé ainsi qu'un procédé pour les faire réagir.
EP19880903211 1987-03-27 1988-03-24 Nouveaux produits intermediaires et procede Pending EP0353238A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH119387 1987-03-27
CH1193/87 1987-03-27

Publications (1)

Publication Number Publication Date
EP0353238A1 true EP0353238A1 (fr) 1990-02-07

Family

ID=4204681

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19880903211 Pending EP0353238A1 (fr) 1987-03-27 1988-03-24 Nouveaux produits intermediaires et procede
EP88104690A Withdrawn EP0287828A1 (fr) 1987-03-27 1988-03-24 Produits intermédiaires et leur préparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP88104690A Withdrawn EP0287828A1 (fr) 1987-03-27 1988-03-24 Produits intermédiaires et leur préparation

Country Status (4)

Country Link
EP (2) EP0353238A1 (fr)
AU (1) AU1570588A (fr)
DE (1) DE3809912A1 (fr)
WO (1) WO1988007524A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804630D0 (en) * 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
JPH02149563A (ja) * 1988-11-30 1990-06-08 Nisshin Flour Milling Co Ltd ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法
DE4041814A1 (de) * 1990-12-24 1992-07-02 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von dihydrophyridincarbonsaeuren
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
JPH07501551A (ja) * 1991-12-02 1995-02-16 セプラコア，インコーポレーテッド 光学的に純粋なｓ（−）フェロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
DE4430094A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel
CA2466806A1 (fr) 2001-10-24 2003-05-01 Sepracor Inc. Procede de resolution de racemate d'amlodipine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8807524A1 *

Also Published As

Publication number Publication date
DE3809912A1 (de) 1988-10-27
AU1570588A (en) 1988-11-02
WO1988007524A1 (fr) 1988-10-06
EP0287828A1 (fr) 1988-10-26

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19890912

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Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT 88104690.8/0287828 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) VOM 23.05.90.