EP0344476A2 - Ampoule - Google Patents

Abstract

An ampoule 10 is designed with an ampoule neck 13 formed on the ampoule container 11, which ampoule neck 13 on the one hand bears a closure piece which can be removed by means of a predetermined breaking point, and on the other hand is designed as a plug-in and retention ring for the insertion of the head of an application device, for example the receiving cone 17 of a hypodermic syringe 16, in such a way that, in the connected state, the application device and the ampoule are joined firmly to form one unit. The ampoule 10 is preferably made in one piece from a thermoplastic, preferably polypropylene, and for this reason has sufficient elastic resilience at the ampoule neck 13 to be widened elastically upon insertion of the head or receiving cone 17 and to ensure the firm holding together of the application device and ampoule 10 when connected. However, in order to let air in during aspiration of the ampoule contents, the ampoule neck 13 can be designed on the inside with an axial ventilation groove. <IMAGE>

Description

Ampoule for receiving a dose of a liquid agent to be taken into an application device, preferably an injection syringe, on the ampoule vessel of which an ampoule neck with a predetermined breaking point and handle for opening the, for example, conical head of the application device is provided.

Up to now, ampoules of this type have mostly been made of glass, with the ampoule neck being sealed at its free end after the ampoule has been filled in order to seal it tightly. To open such an ampoule, the user has to prearrange the wall of the ampoule neck at a suitable point with an ampoule saw and break off the sealed portion of the ampoule neck in order to insert a pull-on cannula into the opened one, which is placed on the head of an application device, for example the cone for the injection needle of an injection syringe Insert the neck of the ampoule and transfer the contents of the ampoule to the application device, for example to be able to pull it into the injection syringe.

Glass ampoules are also already known in which a predetermined breaking point is pre-formed by scratching the wall of the ampoule neck and secured by a marking strip. In other known glass ampoules, a predetermined breaking point is formed on the ampoule neck in that an annular wall area of the ampoule neck is provided with internal stresses in the glass by means of special heat treatment. In these known glass ampoules with a predetermined breaking point on the ampoule neck, the scoring by the user is not necessary. It is only necessary to break off the part of the ampoule neck which is closed by melting, this part of the ampoule neck serving as a handle. In all known glass ampoules, the phenomenon occurs that when a part of the ampoule neck breaks off, glass particles enter the Get ampoule content. In the case of glass ampoules with a predetermined breaking point, an undesired breaking of the ampoule neck at the predetermined breaking point can also occur due to any external influences, so that the ampoule is opened unintentionally and the contents of the ampoule become unusable. Glass ampoules also have the defect that the head of the application device or the receiving cone of the injection syringe is not firmly held in the part of the ampoule neck that remains on the ampoule container. The transfer of the ampoule contents into the application device, that is to say the drawing up of the contents onto the injection syringe, therefore requires special skill and in many cases can only be done by means of the previously attached injection needle or cannula. The latter is particularly time-consuming and can impair the sterility of the injection needle.
It is therefore also known, for example from DE-AS 19 66 623, to provide syringes for single use, in which the syringe cylinder with a receiving cone for a cannula is made of a plastic ampoule and is closed at the end opposite the ampoule neck to the plunger of the syringe . The ampoule neck has a predetermined breaking point in order to break off the closed part at a defined point and to be able to use the remaining part as a receiving cone for the cannula. Such syringes for single use are expensive, since the syringe barrel and the piston guided in it must have good mutual guidance and tightness in order to squeeze out the liquid safely, but are lost after use. Moreover, the seal of the syringe used as an ampoule by means of the plunger is not sufficient for many agents, even if the ampoule designed as a single-use syringe is given additional sterile packaging.

Dose containers made of plastic are also known, for example from US Pat. No. 4,643,309, the container neck of which is conical in order to be able to insert the conical head of an injection syringe after removal of a closure cap. However, there are no facilities for admitting air, so that when the contents of the container are transferred to the injection syringe, either the seat of the head in the container neck must be loosened or the container wall must be pressed together. Both make it difficult to transfer the contents of the container and make the activity of the user unsafe during the transfer.

In contrast, it is an object of the invention to substantially improve ampoules which are used to hold liquid agents to be taken up in application devices, for example injection syringes, in such a way that the transfer of the ampoule content into the application device, for example the drawing up of the ampoule content onto an injection syringe, is made considerably easier and safer becomes.

This object is achieved in that the ampoule neck is made of elastically stretchable material, and is designed as an insertion and holding ring for the preferably conical head of the application device designed to attach the actual applicator (injection needle) and that a ventilation device leading into the interior of the ampoule is provided.

It is achieved by the invention that the ampoule with its ampoule neck can be securely and sufficiently firmly taken over for the ampoule contents and - apart from the air inlet - can be plugged together tightly with the respective application device. The user no longer has to hold the ampoule during the transfer of the ampoule contents into the application device, but can instead safely insert the application device into the open ampoule neck. and hold the application device, for example an injection syringe, with one hand and actuate it with the other hand to open the contents of the ampoule. The elastically stretchable design of the ampoule neck does not represent a significant increase in effort, particularly not if the entire ampoule is made in one piece from elastically stretchable material, for example plastic such as polypropylene.

In a preferred embodiment of the invention, the ampoule neck carries at its free end a closure piece which is connected in one piece to the mouth edge region of the impulse neck via an annular predetermined breaking point, the actual mouth edge of the ampoule neck being designed as a funnel-shaped introduction for the head or cone of the application device. In this case, the actual mouth edge of the neck of the ampoule can preferably be designed with a rounded curvature to form the funnel-shaped introduction. In this embodiment of the invention, the closure piece can have a substantially disc-shaped part arranged within the mouth edge region, the predetermined breaking point surrounding the closure piece being arranged so as to be recessed around the funnel-shaped insertion relative to the actual mouth edge of the ampoule neck.

In this embodiment of the invention, the head of the application device, for example the receiving cone of an injection syringe, can be inserted particularly safely and simply into the mouth edge region of the ampoule neck after the closure piece has been removed. The residues of the predetermined breaking point remaining when the closure piece is removed reach the outer surface of the head or the receiving cone and are thereby pressed against the peripheral wall of the ampoule neck, so that the detachment of plastic particles from these residues the predetermined breaking point is impossible or made harmless for the transfer of the ampoule content into the application device because particles adhering to the remnants of the predetermined breaking point are displaced radially outward from the peripheral surface of the head or receiving cone and are prevented from penetrating into the interior of the ampoule.

The provision of a ventilation device on the ampoule, which is closed during transport of the ampoule and is closed when the ampoule is in use and which can be opened simultaneously with the ampoule neck when the ampoule is in use, ensures that when the liquid ampoule contents are sucked in by the application device, for example an injection syringe, air flows into the ampoule container. This avoids the formation of a vacuum inside the ampoule container, which would resist the aspiration of the liquid ampoule contents by the application device. To form the ventilation device, the ampoule neck can have a ventilation channel on its inside, which can extend essentially axially to the ampoule neck. However, it is preferred to provide a separate ventilation opening in addition to the ampoule neck to form the ventilation device. In a preferred embodiment of the invention, this ventilation opening can be formed on a ventilation tube which extends parallel to the ampoule neck and which has a closure element which can be broken off together with the closure piece of the ampoule neck. In order to prevent the passage of air from the ventilation tube into the ampoule neck and thus into the application device with increased security, the ampoule tube can be made longer than the ampoule neck after the interior of the ampoule. The separate ventilation opening to be provided next to the ampoule neck can also be a thinned, penetrable wall area of the ampoule shoulder. It is also possible to separate and form a ventilation tube into the ampoule shoulder or another wall part of the ampoule at a distance from the ampoule neck.

The ampoule according to the invention is preferably intended for use in conjunction with conventional injection syringes which are designed for multiple use for drawing in the liquid to be administered and with a receiving cone for applying an injection needle. In view of this preferred use, the ampoule neck is preferably designed with a greater axial length than the receiving cone of conventional injection syringes. This ensures that the receiving cone of an injection syringe pressed into the mouth of the ampoule neck is positively surrounded by the ampoule neck. It is achieved in this way that the entire amount of liquid contained in the ampoule can be sucked into the injection syringe.

In a preferred embodiment of the ampoule according to the invention, the ampoule container, together with the ampoule neck, is formed in one piece from thermoplastic material, preferably polypropylene, and is sealed at its end opposite the ampoule neck after filling. In this embodiment, the ampoule can be designed similarly to a dose container known from DE-PS 26 53 993 or 19 65 761. In this embodiment, the ampoule vessel can be particularly advantageously thicker on its part adjacent to the ampoule neck than on its part opposite the ampoule neck. As a result, the ampoule container on its part adjacent to the ampoule neck is designed to be significantly less flexible than on the part opposite the ampoule neck.This has the advantage that when the ampoule is touched on the part adjacent to the ampoule neck, undesired compression and thus inadvertent pressing out of ampoule contents avoided and the ampoule can still be firmly gripped. On the other hand, at the end remote from the ampoule neck, the container wall is sufficiently thin and flexible that it can be compressed and welded after the ampoule has been filled.

The ampoule container with a cylindrical outer shape and the open end opposite the ampoule neck can be produced in one piece with the ampoule neck and its closure piece by hand by injection molding. The cylindrical outer shape of the wall of the ampoule container has the advantage on the one hand that any further processing, in particular printing, and the feeding within the filling and welding machine is made considerably easier. On the other hand, the cylindrical outer shape has the advantage that the expansion of shape at the weld, which is unavoidable during welding, is noticeably less than that of ampoules, in which the conical shape of the ampoule container is assumed. The production of ampoules according to the invention with a cylindrical outer shape of the ampoule container by injection molding may initially appear difficult. However, for this purpose the ampoule container can be made with a slightly conically tapering interior from the open end to the ampoule neck and correspondingly with a wall thickness increasing conically from the open end to the ampoule neck. In this way, on the one hand, the demolding of the ampoule according to the invention during manufacture by injection molding is considerably facilitated and, on the other hand, a desired wall formation of the ampoule vessel is achieved with less flexibility in the part adjacent to the ampoule neck and greater flexibility in the part remote from the ampoule neck.

In the case of a one-piece design of the ampoule according to the invention made of plastic, the transition from the ampoule container to the ampoule neck can also be designed as an ampoule shoulder in which blind embossments are provided, for example for information about the volume and content of the respective ampoule. This blind embossing on the ampoule shoulder inevitably falls into the user's field of vision when touching the ampoule to open it and when attaching the ampoule to an application device, so that additional security can be given that an ampoule before opening and before applying the application device to the correct content and correct amount is checked. The empty ampoule can also be kept as a control piece.

All other details such as batch number, date of manufacture, expiry date, can be embossed on the day of the filling of the ampoules as blind embossing by the press jaws of the sealing machine in the resulting weld seam.

• Fig. 1 eine erfindungsgemäße gefüllte, gebrauchs­fertige Ampulle in Seitenansicht;
• Fig. 2 eine Ausführungsform der erfindungsgemäßen Ampulle vor dem Füllen in axialem Schnitt;
• Fig. 3 eine zweite Ausführungsform der erfindungs­gemäßen Ampulle vor dem Füllen in axialem Schnitt;
• Fig. 4 den Bereich 4 der Figur 3 in vergrößerter Darstellung;
• Fig. 5 den Bereich 5 der Figur 1 in Seitenansicht und vergrößerter Darstellung;
• Fig. 6 den freien Endbereich des Ampullenhalses einer erfindungsgemäßen Ampulle in axialem Teilschnitt;
• Fig. 7 ein Schnitt nach der Linie 7-7 der Figur 3;
• Fig. 8 eine axiale Draufsicht auf den Ampullenhals mit Verschlußstück;
• Fig. 9 eine erfindungsgemäße Ampulle mit zum Aufziehen des Ampulleninhalts angesetzter Injektionsspritze in perspektivischer Darstellung;
• Fig. 10 den Bereich 10 der Figur 9 in vergrößertem Teilschnitt;
• Fig. 11 ein axialer Teilschnitt einer Ampulle in bevorzugter Ausführungsform der Erfindung, wobei der übrige Teil der Ampullenwandung im wesentlichen der Ausführungsform nach Figur 3 entspricht;
• Fig. 12 einen Schnitt nach der Linie A-A der Figur 11;
• Fig. 13 eine Seitenansicht der Ampulle nach Figur 11 und 12 im Sinne des Pfeiles B in Figur 11;
• Fig. 14 eine Draufsicht auf die Ampulle nach Figur 11 bis 13 im Sinne des Pfeiles C in Figur 13 und
• Fig. 15 einen Teilschnitt durch eine abgewandelte Ausführung der Ampulle nach Figur 11 in gleicher Darstellungsweise wie Figur 11.

Embodiments of the ampoule according to the invention are explained in more detail below with reference to the drawing.
Show it:

• Figure 1 is a filled, ready-to-use ampoule according to the invention in side view.
• Figure 2 shows an embodiment of the ampoule according to the invention before filling in an axial section.
• Figure 3 shows a second embodiment of the ampoule according to the invention before filling in an axial section.
• 4 shows area 4 of FIG. 3 in an enlarged representation;
• Figure 5 shows the area 5 of Figure 1 in side view and enlarged view.
• 6 shows the free end region of the ampoule neck of an ampoule according to the invention in axial partial section;
• Figure 7 is a section along the line 7-7 of Figure 3;
• Figure 8 is an axial plan view of the ampoule neck with closure piece.
• 9 shows an ampoule according to the invention with an injection syringe attached to draw up the ampoule contents in a perspective representation;
• 10 shows the area 10 of FIG. 9 in an enlarged partial section;
• 11 shows a partial axial section of an ampoule in a preferred embodiment of the invention, the remaining part of the ampoule wall essentially corresponding to the embodiment according to FIG. 3;
• 12 shows a section along the line AA of FIG. 11;
• 13 shows a side view of the ampoule according to FIGS. 11 and 12 in the direction of arrow B in FIG. 11;
• 14 shows a plan view of the ampoule according to FIGS. 11 to 13 in the direction of arrow C in FIGS. 13 and
• 15 shows a partial section through a modified embodiment of the ampoule according to FIG. 11 in the same representation as FIG. 11.

In the examples shown in the drawing, the ampoule 10 is made in one piece from thermoplastic, namely polypropylene by injection molding. It has an ampoule container 11 which merges into an ampoule neck 13 via an ampoule shoulder 12. At the free end of the ampoule neck 13, a closure piece 14 is formed, which can be removed by twisting it off at the same time as breaking off and tearing it off. At the end remote from the ampoule neck 13, the peripheral wall of the ampoule container 11 is compressed flat after filling and welded tightly at a closure seam 15.

The ampoule neck 13 is elastically stretchable due to the production of the entire ampoule 10 from polypropylene and as an insertion and retaining ring for the head of one Application device, for example the receiving cone 17, an injection syringe 16, wherein this conical head or receiving cone 17 is used to attach the actual applicator, for example a conventional injection needle. As FIGS. 2, 3, 4, 6 and 8 show, the closure piece 14 has a disk-shaped part 18 and an actuating part 19. The disc-shaped part 18 of the closure piece 14 is arranged in the interior of the mouth edge region 20 of the container neck 13 and is connected in one piece to the mouth edge region 20 of the ampoule neck 13 via an annular predetermined breaking point 21 surrounding the periphery of the disc-shaped part 18. In this way, the container neck 13 is sealed at its free end by the disk-shaped part 18 of the closure piece 14 and the predetermined breaking point 21. The predetermined breaking point 21 is destroyed by unscrewing, breaking off and tearing off the closure piece 13. After removal of the closure piece 14, the mouth of the ampoule neck 13 is exposed. The head of an application device, for example the receiving cone 17 of an injection syringe, 16 can now be inserted into the open end of the ampoule neck 13. In order to facilitate the safe, rapid insertion of this head or receiving cone 17, the rim area 20 of the ampoule neck is essentially funnel-shaped towards the inside. The different embodiments shown in the drawing show variations in the design of this funnel-shaped introduction. In the example in FIG. 2, the actual mouth edge 22 of the ampoule neck 13 is curved with an approximately semicircular cross section. In the example in FIGS. 3 and 4, the actual mouth edge 23 of the ampoule neck 13 is designed with an outer rounding and an inner conical bevel, while in the example in FIG that instead of the conical funnel inlet provided in the example of FIGS. 3 and 4, there is a reinforced funnel inlet that is stronger than the example of FIG. As FIGS. 2 to 6 show, the predetermined breaking point 21 is recessed in the mouth edge region 20 of the ampoule neck 13, so that the head of the application device or the receiving cone 17 of an injection syringe 16 has already been inserted into the ordinary mouth rim 22, 23, 25 of the ampoule neck 13 before it reaches the remnants of the predetermined breaking point 21.

As FIGS. 2, 3, 4, 6 and 7 show, an axially extending ventilation channel 26 is formed in the interior of the ampoule neck 13, which has an arcuate profile with a depth 27 of for example 0.4 mm and a width 28 of 1.0 mm can. The inner diameter 29 of the container neck 13 can be approximately 4 mm and the outer diameter 30 approximately 6 mm.

As shown in FIGS. 3 to 6 and 8, the actuating part 19 of the closure piece 14 can be approximately plate-shaped or tab-shaped in order to ensure secure gripping for twisting, breaking off and tearing off the closure piece 14. For further improvement, axially extending grip ribs 31 can be formed on the actuating part 19.

As FIGS. 2 and 3 show, in the illustrated examples of the ampoule 10, the ampoule container 11 is initially open at its end opposite the ampoule neck 13 in order to fill it from this end. The peripheral wall of the ampoule container 11 has a greater thickness in the vicinity of the ampoule neck 13 and the ampoule shoulder 12 than at its open end.

In the example in FIG. 2, the peripheral wall of the ampoule housing 11 has a slightly conical shape after the open one End widening shape and a portion 32 of greater thickness 33 adjacent to the ampoule shoulder 12, for example of approximately 0.5 mm. A part 34 of the peripheral wall with a thickness 35 of approximately 0.35 mm is formed in the vicinity of the open end.

In the example of FIG. 3, the outer wall of the ampoule container 11 is cylindrical on the outside and has a decreasing wall thickness from the ampoule shoulder 12 to the open end, namely a thickness 36 adjacent to the ampoule shoulder 12, for example 0.55 mm and a thickness 37 of, for example, 0.35 mm at the open end. As a result, the interior formed in the ampoule container 11 before the closure tapers conically from the open end to the ampoule shoulder 12.

As FIGS. 9 and 10 show, the ampoule neck 13 is elastically widened from the free end when the conical head of an application device, for example the receiving cone 17 of an injection syringe 16, is inserted, so that the ampoule neck 13 with its inner surface firmly on the outer surface of the conical head or the receiving cone 17 sets. The application device, for example the injection syringe 16 and the attached ampoule 10, then form a firmly held unit, in which the opening of the ampoule contents onto the application device is made considerably easier. Only the ventilation channel 26 leaves an axially extending channel between the receiving cone 17 and the inner surface of the ampoule neck 13 in order to admit air during the aspiration of the liquid ampoule contents.

As FIGS. 2 and 10 show, the ampoule neck 13 has an axial length 38 which is somewhat larger than the axial length 39 of the head of the application device or the Recording cone 17 is. As a result, the head or the receiving cone, when plugged in, ends within the ampoule neck 13, so that - as can be seen from FIG. 10 - the entire liquid content of the ampoule 10 can be aspirated into the application device or the injection syringe 16.

As shown in FIGS. 1 and 9, in the example shown 12 blind embossments 40 are provided on the ampoule shoulder, which provide information about the content and volume of the ampoule 10. These blind embossments 40 cannot be overlooked when opening the ampoule 10 and when inserting the receiving cone 17. They are also indelible and are therefore suitable for the emptied ampoule 10, possibly as evidence of administered medicine and the like. repeal.

In the preferred embodiment of the invention shown in FIGS. 11 to 14, the ventilation device is formed by a separate, but integrally molded, ventilation tube 41 on the ampoule neck 13 '. About the container neck 13 'and the ventilation tube 41, a common closure piece 14' is formed so that when the closure piece 14 'is broken, the container neck 13' and the ventilation tube 41 are opened at the same time. As Figure 11 shows, the ventilation tube 41 extends parallel to the ampoule neck 13 'and opens a distance 42 deeper in the interior of the ampoule than the ampoule neck 13, so that the partition wall 43 formed between the ampoule neck 13 and the ventilation tube 41 is still at the mouth of the ampoule neck 13 extends into the interior of the ampoule. In this way, the direct passage of air from the ventilation tube 41 into the ampoule neck 13 'and from there into the application device is prevented when the contents of the ampoule are drawn up.

In order to prevent the passage of air with even greater certainty, in a modified embodiment according to FIG. 15, the parallel ventilation tube 41 'formed on the ampoule neck 13' can also extend over a larger distance 42 'beyond the ampoule neck 13' into the interior of the ampoule.

As Figure 12 shows, the ventilation tube 41 is preferably formed with a much smaller clear cross section than the ampoule neck 13 '. For example, the passage of the ampoule neck 13 'may have approximately twice the diameter 44 as the corresponding diameter 45 of the ventilation tube 41.

Otherwise, the ampoule according to FIGS. 11 to 15 can have features corresponding to those of the ampoule according to FIGS. 1 to 10. In particular, the ampoule according to Figure 3. This applies, for example, to the closure piece 14 ', which can have a tab-like actuating part 19 with grip ribs 31 in a corresponding manner as in Figures 5 and 6.

Instead of the examples shown, provision can also be made to provide the ventilation device completely separate from the container neck 13 on the ampoule wall, preferably on the ampoule shoulder 12. For example, an easily penetrable thinned point could be formed at a distance from the ampoule neck 13. This could be, for example, at a point indicated by arrow 46 in FIG. It could also be molded into the ampoule shoulder 12 at point 46, a ventilation tube completely separate from the ampoule neck 13 and carry a breakable closure piece separate from the ampoule neck 13.

Reference symbol list

• 10 ampoules
• 11 ampoule container
• 12 ampoule shoulder
• 13, 13 ′ ampoule neck
• 14, 14 'closure piece
• 15 closure seam
• 16 hypodermic syringe
• 17 mounting cone
• 18 disc-shaped part
• 19 operating part
• 20 rim area
• 21 predetermined breaking point
• 22 rim of the mouth
• 23 rim of the mouth
• 24th
• 25 rim of the mouth
• 26 ventilation channel
• 27 depth
• 28 width
• 29 inside diameter
• 30 outer diameter
• 31 grip ribs
• 32 adjacent part of the shoulder
• 33 thickness
• 34 part of the peripheral wall
• 35 thickness
• 36 thickness
• 37 thickness
• 38 axial length
• 39 axial length
• 40 blind embossing
• 41 ventilation tubes
• 42, 42 ′ route
• 43 partition
• 44 diameter
• 45 diameter
• 46 arrow

Claims (15)

1) ampoule for receiving a dose of a liquid agent to be taken into an application device, preferably an injection syringe, on the ampoule vessel of which an ampoule neck with a predetermined breaking point and handle for opening, which is suitable for inserting the conical head of the application device, is provided,
characterized in that
the neck of the ampoule (13, 13 ') is designed as an elastic, stretchable push-in and retaining ring for securely attaching the application device head and a ventilation device (26, 41, 41') leading into the interior of the ampoule (10) is provided. 2) Ampoule according to claim 1, characterized in that the ampoule neck (13, 13 ') carries at its free end a closure piece (14, 14') which is integral with the mouth edge region (20) of the ampoule neck via an annular predetermined breaking point (21) (13, 13 ') is connected, the actual mouth edge (22, 23) of the ampoule neck (13, 13') being designed as a funnel-shaped introduction for the head of the application device (injection syringe 16). 3) ampoule according to claim 2, characterized in that the actual mouth edge (23) of the ampoule neck (13) is formed to form the funnel-shaped introduction with a rounded curvature. 4) Ampoule according to claim 2 or 3, characterized in that the closure piece (14) is substantially disc-shaped and is arranged within the mouth edge region (20), wherein the predetermined breaking point (21) surrounding the closure piece (14) deepens around the funnel-shaped insertion is arranged opposite the ordinary mouth edge (22, 23, 25) of the ampoule neck. 5) Ampoule according to one of claims 1 to 4, characterized in that the ampoule neck (13) has on its inside a ventilation channel (26) which preferably extends substantially axially to the ampoule neck (13). 6) ampoule according to one of claims 1 to 4, characterized in that a separate ventilation opening is provided in addition to the ampoule neck (13, 13 '). 7) Ampoule according to claim 6, characterized in that the ventilation opening is formed on a ventilation tube (41, 41 ') extending parallel to the ampoule neck (13'), which has a closure element which can be broken off together with the closure piece (14) of the ampoule neck. 8) Ampoule according to claim 7, characterized in that the ventilation tube (41 ') relative to the ampoule neck (13') is extended after the ampoule interior. 9) ampoule according to claim 1 preferably for use in connection with conventional injection syringes which are designed for multiple use for sucking in the liquid to be applied and with a receiving cone for attaching an injection needle as the head of the application device, characterized in that the ampoule neck (13, 13 ' ) with a greater axial length (38) than the receiving cone (17) of conventional injection syringes (16). 10) ampoule according to one of claims 1 to 9, characterized in that the ampoule container (11) together with the ampoule neck (13, 13 ') and possibly the ventilation tube (41, 41') consists in one piece of thermoplastic material, preferably polypropylene and at its end opposite the ampoule neck (13, 13 ') is sealed after filling. 11) Ampoule according to claim 10, characterized in that the ampoule container (11) on its part (32) adjacent to the ampoule neck has a thicker wall than on its part opposite the ampoule neck (34). 12) Ampoule according to claim 10 or 11, characterized in that the ampoule container (11) at its end opposite the ampoule neck is compressed flat after filling in the manner of a tube and is tightly welded in a transverse seam (15). 13) ampoule according to one of claims 10 to 12, characterized in that the ampoule container (11) with a cylindrical outer shape and the ampoule neck (13, 13 ') opposite open end in one piece with the ampoule neck (13, 13 ') and possibly the ventilation tube (41, 41') and the closure piece (14, 14 ') with handle (19) is made by injection molding. 14) ampoule according to claim 13, characterized in that the ampoule container (11) is made with a conically tapering interior from the open end to the ampoule neck and correspondingly with increasing wall thickness from the open end to the ampoule neck. 15) ampoule according to one of claims 10 to 14, characterized gekennzeichent, d-aß as a transition from the ampoule container (11) to the ampoule neck (13, 13 ') an ampoule shoulder (12) is formed, in which blind embossments (40) are attached, for example for information on the volume and content of the respective ampoule (10).

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