EP0258565A2 - Moyen pour l'identification de la position - Google Patents

Moyen pour l'identification de la position Download PDF

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Publication number
EP0258565A2
EP0258565A2 EP87109424A EP87109424A EP0258565A2 EP 0258565 A2 EP0258565 A2 EP 0258565A2 EP 87109424 A EP87109424 A EP 87109424A EP 87109424 A EP87109424 A EP 87109424A EP 0258565 A2 EP0258565 A2 EP 0258565A2
Authority
EP
European Patent Office
Prior art keywords
receptacle
sample
plate
receptacles
command
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87109424A
Other languages
German (de)
English (en)
Other versions
EP0258565A3 (fr
Inventor
Carl Owen Buyer
James Arthur Whitcomb
Paul Frank Laska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of EP0258565A2 publication Critical patent/EP0258565A2/fr
Publication of EP0258565A3 publication Critical patent/EP0258565A3/fr
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/56—Means for indicating position of a recipient or sample in an array

Definitions

  • the plate may then be manipulated to posi­tion the respective receptacles in the plate under a sampling position at which a needle is introduced into the open receptacle, the sample withdrawn, and dispensed into the testing instrument for processing. More recently with the advent of microprocessor control of several mechanisms the sampling needle has been positioned and manipulated into each of the respective receptacles to withdraw a sample for processing.
  • Microtiter plates typically are plastic plates having a plurality of receptacles located in rows and columns. Since the size of the plate is small and the size of each receptacle even smaller, it is difficult for the technician to use a pipet or other dispensing device such as syringe to introduce the various samples to be analyzed into the proper receptacles. It is very easy for the technician to improperly dispense a sample and thereby lose track of a particular patient sample. In fact most systems in use today rely heavily upon the integrity of the technician to insure that such confusion and mispositioning does not take place.
  • a dispensing tube is sensed only if the tube is contigu­ous a row or column continuously for a predetermined period of time. Additionally a means are provided that are responsive to the signal for providing a visual indication of the location of the sensed receptacle.
  • the first and second means each comprises a light emitting diode and a light detector positioned at opposite ends of each row and column, each light-­emitting diode being activated in sequence. Preferably the detectors are observed in a similar sequence. This has the advantage of reducing power required and also reducing the complexity of the system that would be required for a simultaneous sensing of all the rows and columns. Sequential sensing provides entirely sufficient speed when dealing with a human operator.
  • Finally means are included to illuminate a desired receptacle in which a sample is to be placed to aid the technician. Thus even if the sample is introduced into the wrong receptacle, the location of the sample is detected and recorded.
  • the sample entry controller 10 has circuitry shown in FIGS. 4A and 4B adapted to operate with a six column, eight row microtiter plate, by way of example.
  • the function of these workstation electronics, including the microprocessor 34, is to drive the various visible LED arrays 37 and the IR LED matrix 18 with its associated detectors 20.
  • the microprocessor controls the plate sensor 32 and inter­acts with the keyboard 12.
  • Eight of each are arranged along opposite sides of the matrix holder 16 (FIG. 1).
  • Six of each are arranged along opposite, but orthogonal sides of the matrix holder to define the matrix with forty-eight intersections corresponding to the receptacles of the microtiter plate.
  • the microprocessor select switch IR LED will be "on” by setting addresses IRAD01-3. These output lines are coupled through suitable buffers 54 which convert TTL logic used in the microprocessor to the MOS levels used for CMOS switches.
  • the outputs indicated as MIRAD0-3 control multiplexers 56 which are nothing more than analog switches to selectively connect the outputs of the detectors 20 sequentially to provide an output signal from the common terminal of the multiplexers 56. This output signal is con­nected to an amplifier 58.
  • Voltage amplifiers 60 and comparator 62 provide an output "sense" signal which is coupled back to the microprocessor. This output signal is high if there is no change in the light passing from the actuated IR LED to its corresponding detector. On the other hand the output sense signal will be low if there is a change, i.e., there is a disturbance in the infrared beam passing from the LED to its detector.
  • the samples are loaded into the respective receptacles of a microtiter plate by a pipette, syringe, or other suitable dispensing device.
  • the plate sensor detects the presence of the plate.
  • One of the visible LEDs 37 indicates a particular receptacle in which the sample is to be loaded by highlighting this desired receptacle from below through the clear plastic microtiter plate.
  • the orthogonal grid of infrared LEDs and detectors are positioned around the perimeter of the cavity 14 in a plane above the microtiter plate.
  • the microprocessor which is con­stantly cycling through all of the IR positions will detect this beam disturbance.
  • the microprocessor also determines which receptacle position has actually been loaded, i.e., whether it be the one highlighted or not. This actual position is compared to the desired position, i.e. the position of the visible LED that was lit and the user queried as to whether the loading was intended or not.
  • the microtiter plate has a bar­code reader which is read by the computer and recorded so that it may transmitted to the host computer 50 (FIG. 3) for updating and continued use of the microtiter plate.
  • the first step of this activity is a valid PI command to be received from the host computer 50.
  • the software transfers the flow to the PI routine (FIG. 5K) and monitor port 10 of the microprocessor.
  • This port is used for many purposes but bit 8 is used to read the output of an IR sensor 32 (FIG. 4A) which is set in the cavity 14 (FIG. 1) at the optimum height to measure if a microtiter plate was installed properly. If this bit is set then the plate is in. Otherwise the software increments a counter. The counter is then checked to see if it is at the maximum. The counter at maximum indicates that the user has taken too long to install a plate. This results in an error 3 being sent to the host computer.
  • the other capability that exists is the multiple feedback from the interrupt service routine.
  • the background program is running constantly, and if a plate is installed all beams should be disturbed very close together. This information can be used as a check of the plate-in sensor 32 for correct operation.
  • the workstation software then will receive a command WN (FIGS. 5L and 5M) followed by two numbers. These two numbers represent the next receptacle that the host computer would like loaded. This does not mean that the user must enter sample into this receptacle, but it is desirable.
  • the receptacle is illuminated by the software sending a visible LED (VLED) address out to the visible LED selection logic. This will backlight the desired receptacle to be loaded.
  • VLED visible LED
  • the user will then take a sample and intro­duce it via a pipet or syringe into the lighted receptacle.
  • the background routine will detect which set of orthogonal beams were disturbed, and set a flag in memory with the receptacle number. This information will then be sent back to the host computer either saying that the proper receptacle was loaded, or the number of the receptacle that actually was loaded.
  • PI (micro­titer) plate insert as described above.
  • the host system 50 will stay in that loop continuously.
  • the sample plate here a microtiter plate
  • the host system then issues a BC command which is a barcode read command to the workstation.
  • the workstation initiates the reading process and once it has gotten a valid barcode it returns that information back to the host computer 50 and the host displays that plate number. The user if desired can compare the displayed plate number with the expected plate number just for another level of security in the system.
  • the host computes 50 When the host computes 50 receives the barcode number it associates a certain database with that plate. All of the plates have a unique number. Now it checks the database to see what is the next available receptacle in the microtiter plate. In the event that it's a brand new one of course it would be receptacle number 1. It displays the target well on the CRT screen of the host computer and it also sends the WN command to the workstation.
  • the host computer can update its database to reflect the actual receptacle. Now the system prompts the operator to get the patient I.D. number. At this point the user puts in a request for the test that they would like run on that sample. The RP command illuminates all visible LEDs underneath the plate and the user knows then to pull out the plate. The host computer displays "remove plate" on the CRT, and it waits for a positive response from that back from the workstation. Sample processing begins.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP87109424A 1986-07-02 1987-06-30 Moyen pour l'identification de la position Withdrawn EP0258565A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88123786A 1986-07-02 1986-07-02
US881237 1986-07-02

Publications (2)

Publication Number Publication Date
EP0258565A2 true EP0258565A2 (fr) 1988-03-09
EP0258565A3 EP0258565A3 (fr) 1989-05-24

Family

ID=25378056

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87109424A Withdrawn EP0258565A3 (fr) 1986-07-02 1987-06-30 Moyen pour l'identification de la position

Country Status (2)

Country Link
EP (1) EP0258565A3 (fr)
JP (1) JPS63106565A (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649511A1 (fr) * 1989-07-06 1991-01-11 Architect Dispositif pour le traitement des plaques de microtitration
WO1998053301A2 (fr) * 1997-05-23 1998-11-26 Becton Dickinson And Company Appareil et procedes d'essai microbiologique automatise
WO1999030824A1 (fr) * 1997-12-12 1999-06-24 Combact Diagnostics Systems Ltd. Poste de chargement pour systeme robotique
USH1919H (en) * 1995-12-01 2000-11-07 E. I. Du Pont De Nemours And Company Agricultural product microscreen method and apparatus
DE19923222A1 (de) * 1999-05-20 2000-12-07 Biotul Ag I K Verfahren und Vorrichtung zum genauen Positionieren einer Pipette in einer Analyseeinrichtung
DE19956178A1 (de) * 1999-11-22 2001-05-31 Fraunhofer Ges Forschung Verfahren und Anordnung zur Dokumentierung und/oder Qualitätsicherung beim manuellen Handling von Stoffen
US6293750B1 (en) 1998-07-14 2001-09-25 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
WO2007106833A2 (fr) * 2006-03-13 2007-09-20 Sage Science, Inc. Reactif de laboratoire et ensemble echantillon, gestion et traitement
US7278328B2 (en) * 2004-09-03 2007-10-09 Protedyne Corporation Method and apparatus for handling sample holders
WO2007121324A1 (fr) * 2006-04-12 2007-10-25 Sage Science, Inc. Appareil pour guider des manipulations d'échantillons et de réactifs et réceptacles pour leur support
WO2010116216A1 (fr) * 2009-04-09 2010-10-14 Isens - Electrónica, Lda. Procédé et dispositif de stockage associé à un indicateur visuel et à un capteur d'objet
CN103257246A (zh) * 2013-05-03 2013-08-21 苏州杰诺曼博生物科技有限公司 微孔板加样指示装置
US8772049B2 (en) 2005-09-16 2014-07-08 President And Fellows Of Harvard College Screening assays and methods
US9310362B2 (en) 2003-09-25 2016-04-12 Valneva Microwell array chip and method of manufacturing same
CN106066404A (zh) * 2016-07-01 2016-11-02 中南民族大学 一种酶标微孔板上样指示控制系统及控制方法
US9494575B2 (en) 2007-08-02 2016-11-15 Toyama Prefecture Cells screening method
CN108977357A (zh) * 2017-06-01 2018-12-11 奥林巴斯株式会社 细胞培养监视系统

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04132960A (ja) * 1990-09-26 1992-05-07 Techno Medeika:Kk マイクロプレートへの滴下確認装置
JP2009012046A (ja) * 2007-07-05 2009-01-22 Jatco Ltd 鋳物の製造方法および鋳物の製造装置
JPWO2018051803A1 (ja) * 2016-09-13 2019-06-24 富士フイルム株式会社 検体管理システム
CN108303559A (zh) * 2018-01-18 2018-07-20 武汉光昱科技有限公司 一种加样示踪和记录的方法和装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR77059E (fr) * 1959-06-18 1962-01-12 Appareils pour effectuer automatiquement des opérations de chimie et des opérations analogues ou connexes
GB1444807A (en) * 1972-08-08 1976-08-04 Micromedic Systems Inc Sample-measuring devices
DD145130A1 (de) * 1979-07-27 1980-11-19 Olaf Schlimpert Vorrichtung zur automatischen erfassung der probengefaesspositionierung
EP0210148A1 (fr) * 1985-06-18 1987-01-28 Scomas AB Procédé et dispositif pour indiquer et enregistrer la position de pipettage lors d'une suite de pipettages qui est exécutée sur une plaque d'expérience munie d'une matrice avec des creux

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR77059E (fr) * 1959-06-18 1962-01-12 Appareils pour effectuer automatiquement des opérations de chimie et des opérations analogues ou connexes
GB1444807A (en) * 1972-08-08 1976-08-04 Micromedic Systems Inc Sample-measuring devices
DD145130A1 (de) * 1979-07-27 1980-11-19 Olaf Schlimpert Vorrichtung zur automatischen erfassung der probengefaesspositionierung
EP0210148A1 (fr) * 1985-06-18 1987-01-28 Scomas AB Procédé et dispositif pour indiquer et enregistrer la position de pipettage lors d'une suite de pipettages qui est exécutée sur une plaque d'expérience munie d'une matrice avec des creux

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649511A1 (fr) * 1989-07-06 1991-01-11 Architect Dispositif pour le traitement des plaques de microtitration
USH1919H (en) * 1995-12-01 2000-11-07 E. I. Du Pont De Nemours And Company Agricultural product microscreen method and apparatus
US6150158A (en) * 1995-12-01 2000-11-21 E. I. Du Pont De Nemours And Company Agricultural product microscreen method and apparatus
WO1998053301A2 (fr) * 1997-05-23 1998-11-26 Becton Dickinson And Company Appareil et procedes d'essai microbiologique automatise
WO1998053301A3 (fr) * 1997-05-23 1999-07-01 Becton Dickinson Co Appareil et procedes d'essai microbiologique automatise
US6096272A (en) * 1997-05-23 2000-08-01 Becton Dickinson & Company Automated microbiological testing apparatus and methods therefor
US7115384B2 (en) 1997-05-23 2006-10-03 Becton Dickinson And Company Automated microbiological testing apparatus and method therefor
US6372485B1 (en) 1997-05-23 2002-04-16 Becton Dickinson And Company Automated microbiological testing apparatus and method therefor
WO1999030824A1 (fr) * 1997-12-12 1999-06-24 Combact Diagnostics Systems Ltd. Poste de chargement pour systeme robotique
US6332636B1 (en) 1998-07-14 2001-12-25 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
US6293750B1 (en) 1998-07-14 2001-09-25 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
US6374982B1 (en) 1998-07-14 2002-04-23 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
DE19923222C2 (de) * 1999-05-20 2001-11-22 Jandratek Gmbh Verfahren zum genauen Positionieren mindestens einer Pipette in einer Analyseeinrichtung
DE19923222A1 (de) * 1999-05-20 2000-12-07 Biotul Ag I K Verfahren und Vorrichtung zum genauen Positionieren einer Pipette in einer Analyseeinrichtung
DE19956178C2 (de) * 1999-11-22 2001-11-15 Fraunhofer Ges Forschung Verfahren und Anordnung zur Dokumentierung und/oder Qualitätsicherung beim manuellen Handling von Stoffen
DE19956178A1 (de) * 1999-11-22 2001-05-31 Fraunhofer Ges Forschung Verfahren und Anordnung zur Dokumentierung und/oder Qualitätsicherung beim manuellen Handling von Stoffen
US9310362B2 (en) 2003-09-25 2016-04-12 Valneva Microwell array chip and method of manufacturing same
US7278328B2 (en) * 2004-09-03 2007-10-09 Protedyne Corporation Method and apparatus for handling sample holders
US8835188B2 (en) 2005-09-16 2014-09-16 Presidents And Fellows Of Harvard College Screening assays and methods
US8865479B2 (en) 2005-09-16 2014-10-21 President And Fellows Of Harvard College Screening assays and methods
US11154833B2 (en) 2005-09-16 2021-10-26 President And Fellows Of Harvard College Screening assays and methods
US10137426B2 (en) 2005-09-16 2018-11-27 President And Fellows Of Harvard College Screening assays and methods
US8772049B2 (en) 2005-09-16 2014-07-08 President And Fellows Of Harvard College Screening assays and methods
US8835187B2 (en) 2005-09-16 2014-09-16 Presidents And Fellows Of Harvard College Screening assays and methods
US9463431B2 (en) 2005-09-16 2016-10-11 President And Fellows Of Harvard College Screening assays and methods
WO2007106833A3 (fr) * 2006-03-13 2007-11-15 Sage Science Inc Reactif de laboratoire et ensemble echantillon, gestion et traitement
WO2007106833A2 (fr) * 2006-03-13 2007-09-20 Sage Science, Inc. Reactif de laboratoire et ensemble echantillon, gestion et traitement
WO2007121324A1 (fr) * 2006-04-12 2007-10-25 Sage Science, Inc. Appareil pour guider des manipulations d'échantillons et de réactifs et réceptacles pour leur support
US9494575B2 (en) 2007-08-02 2016-11-15 Toyama Prefecture Cells screening method
US9977017B2 (en) 2007-08-02 2018-05-22 Toyama Prefecture Apparatus for screening cells
WO2010116216A1 (fr) * 2009-04-09 2010-10-14 Isens - Electrónica, Lda. Procédé et dispositif de stockage associé à un indicateur visuel et à un capteur d'objet
CN103257246A (zh) * 2013-05-03 2013-08-21 苏州杰诺曼博生物科技有限公司 微孔板加样指示装置
CN106066404A (zh) * 2016-07-01 2016-11-02 中南民族大学 一种酶标微孔板上样指示控制系统及控制方法
CN108977357A (zh) * 2017-06-01 2018-12-11 奥林巴斯株式会社 细胞培养监视系统

Also Published As

Publication number Publication date
EP0258565A3 (fr) 1989-05-24
JPS63106565A (ja) 1988-05-11

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