EP0252940A4 - Antisense-rna zur behandlung von retroviralen krankheiten. - Google Patents

Antisense-rna zur behandlung von retroviralen krankheiten.

Info

Publication number
EP0252940A4
EP0252940A4 EP19870900464 EP87900464A EP0252940A4 EP 0252940 A4 EP0252940 A4 EP 0252940A4 EP 19870900464 EP19870900464 EP 19870900464 EP 87900464 A EP87900464 A EP 87900464A EP 0252940 A4 EP0252940 A4 EP 0252940A4
Authority
EP
European Patent Office
Prior art keywords
treatment
disease states
sense rna
retroviral disease
retroviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870900464
Other languages
English (en)
French (fr)
Other versions
EP0252940A1 (de
Inventor
Paul E Neiman
Richard Yue-Leung To
Shane C Booth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fred Hutchinson Cancer Center
Original Assignee
Fred Hutchinson Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred Hutchinson Cancer Research Center filed Critical Fred Hutchinson Cancer Research Center
Publication of EP0252940A1 publication Critical patent/EP0252940A1/de
Publication of EP0252940A4 publication Critical patent/EP0252940A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19870900464 1985-12-05 1986-11-26 Antisense-rna zur behandlung von retroviralen krankheiten. Withdrawn EP0252940A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80597685A 1985-12-05 1985-12-05
US805976 1985-12-05

Publications (2)

Publication Number Publication Date
EP0252940A1 EP0252940A1 (de) 1988-01-20
EP0252940A4 true EP0252940A4 (de) 1989-07-27

Family

ID=25193005

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870900464 Withdrawn EP0252940A4 (de) 1985-12-05 1986-11-26 Antisense-rna zur behandlung von retroviralen krankheiten.

Country Status (3)

Country Link
EP (1) EP0252940A4 (de)
JP (1) JPS63501923A (de)
WO (1) WO1987003451A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751181A (en) * 1984-12-31 1988-06-14 Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
DE3650756T2 (de) * 1985-03-21 2001-10-04 Cornell Res Foundation Inc Vom parasit abgeleiteter widerstand
EP0240332B1 (de) * 1986-04-02 1995-07-12 Pioneer Hi-Bred International, Inc. Pflanzen, resistent gegen den Anti-sens RNS aufweisenden Virus
US5194428A (en) * 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5637573A (en) * 1986-05-23 1997-06-10 Agrawal; Sudhir Influenza virus replication inhibiting oligonucleotide analogues and their pharmaceutical compositions
CA1327171C (en) * 1987-06-26 1994-02-22 Lisa J. Hock Recombinant human cytomegalovirus containing foreign gene and use thereof
US5110802A (en) * 1987-07-14 1992-05-05 City Of Hope Oligonucleotide phosphonates and method of inhibiting a human immunodeficiency virus in vitro utilizing said oligonucleotide phosphonates
CA1340843C (en) * 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
FR2622207B1 (fr) * 1987-10-21 1990-03-09 Agronomique Inst Nat Rech Vecteurs d'integration et d'expression d'un gene heterologue, cellules infectees avec ces vecteurs et procede de production d'une proteine ou de modification genetique d'animaux
ATE208813T1 (de) * 1988-02-16 2001-11-15 Greatbatch Gen Aid Ltd Modifizierte zellen mit resistenz gegen retroviralinfektionen
US5580761A (en) * 1988-02-16 1996-12-03 Greatbatch Gen-Aid Ltd. Method of conferring resistance to immunodeficiency viral infection
EP0402402B1 (de) * 1988-02-26 1995-12-27 Worcester Foundation For Biomedical Research, Inc. Hemmung von htlv-iii durch exogene oligonukleotide
GB8827592D0 (en) * 1988-11-25 1988-12-29 Taniguchi T Improvements in & relating to regulation of expression
GB8901778D0 (en) * 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US5087617A (en) * 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US6034233A (en) * 1990-05-04 2000-03-07 Isis Pharmaceuticals Inc. 2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome
NZ241310A (en) * 1991-01-17 1995-03-28 Gen Hospital Corp Trans-splicing ribozymes
NZ241311A (en) * 1991-01-17 1995-03-28 Gen Hospital Corp Rna sequence having trans-splicing activity, plant strains
DK1314431T3 (da) 1993-04-30 2008-11-10 Wellstat Biologics Corp Oprensede sammensætninger af Newcastle disease virus
US6010904A (en) * 1995-06-07 2000-01-04 The General Hospital Corporation Cell ablation using trans-splicing ribozymes
US6776986B1 (en) 1996-06-06 2004-08-17 Novartis Ag Inhibition of HIV-1 replication by antisense RNA expression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983001451A1 (en) * 1981-10-23 1983-04-28 Molecular Biosystems Inc Oligonucleotide therapeutic agent and methods of making same
WO1986005516A1 (en) * 1985-03-21 1986-09-25 Duke University Parasite-derived resistance
WO1987007300A2 (en) * 1986-05-23 1987-12-03 Worcester Foundation For Experimental Biology Inhibition of htlv-iii by exogenous oligonucleotides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5813909B2 (ja) * 1979-12-20 1983-03-16 株式会社トスカ 係止片群
JPS6024009B2 (ja) * 1980-09-11 1985-06-11 株式会社トスカ 取付部片集合体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983001451A1 (en) * 1981-10-23 1983-04-28 Molecular Biosystems Inc Oligonucleotide therapeutic agent and methods of making same
WO1986005516A1 (en) * 1985-03-21 1986-09-25 Duke University Parasite-derived resistance
WO1987007300A2 (en) * 1986-05-23 1987-12-03 Worcester Foundation For Experimental Biology Inhibition of htlv-iii by exogenous oligonucleotides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8703451A1 *

Also Published As

Publication number Publication date
JPS63501923A (ja) 1988-08-04
WO1987003451A1 (en) 1987-06-18
EP0252940A1 (de) 1988-01-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19871119

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19890727

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19910601

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TO, RICHARD, YUE-LEUNG

Inventor name: NEIMAN, PAUL, E.

Inventor name: BOOTH, SHANE, C.