EP0226837A3 - Pyri(mi)dyl-oxy-und -thio-benzoesäure-Derivate - Google Patents

Pyri(mi)dyl-oxy-und -thio-benzoesäure-Derivate Download PDF

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Publication number
EP0226837A3
EP0226837A3 EP86116247A EP86116247A EP0226837A3 EP 0226837 A3 EP0226837 A3 EP 0226837A3 EP 86116247 A EP86116247 A EP 86116247A EP 86116247 A EP86116247 A EP 86116247A EP 0226837 A3 EP0226837 A3 EP 0226837A3
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Prior art keywords
optionally substituted
alkyl
alkenyl
sulfur
radical
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EP86116247A
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English (en)
French (fr)
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EP0226837A2 (de
Inventor
Klaus Dr. Sasse
Reiner Dr. Fischer
Hermann Dr. Hagemann
Hans-Joachim Dr. Santel
Robert R. Dr. Schmidt
Klaus Dr. Lürssen
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Bayer AG
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Bayer AG
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Publication of EP0226837A2 publication Critical patent/EP0226837A2/de
Publication of EP0226837A3 publication Critical patent/EP0226837A3/de
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/761,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/781,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/86Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/20N-Aryl derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
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    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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    • C07ORGANIC CHEMISTRY
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pyri(mi)dyl-oxy- bzw. -thio-benzoesäure-Derivate der Formel (I), in welcher
R¹, R² und R³ unabhängig voneinander jeweils für Wasserstoff, Halogen, Alkyl, für gegebenenfalls substituiertes Alkoxy, Halogenalkyl, Alkenyl oder für gegebenenfalls substituiertes Amino steht oder
R¹ und R² oder R² und R³ gemeinsam für einen ankon­ densierten 3- bis 6-gliedrigen carbocyclischen Ring stehen,
mit der Maßgabe, daß mindestens einer der Reste R¹, R² oder R³ für Alkyl oder für einen Teil des 3- bis 6-gliedrigen ankondensierten carbocyc­ lischen Ringes steht,
Z für eine (-CH=)-Gruppe oder ein Stickstoffatom steht,
X für Sauerstoff oder Schwefel steht,
Y für Halogen, Nitro, Cyano, Amino, Alkylcar­ bonylamino, Alkoxycarbonylamino, Phenoxy­ carbonylalkylamino, Alkyl, Alkoxy oder Halogenalkyl steht, wobei Y gleich oder ver­ schieden sein kann,
n für eine ganze Zahl von 0 bis 4 steht,
A für Sauerstoff, Schwefel, einen Rest R⁵-N= oder einen Rest R⁶O-N= steht,
wobei
R⁵ für Wasserstoff, Alkyl, Hydroxyalkyl, Alkenyl, für jeweils gegebenenfalls substituiertes Cycloalkyl, Aryl oder Aralkyl steht,
R⁶ für Wasserstoff, jeweils gegebenenfalls substi­ tuiertes Alkyl oder einfach oder mehrfach unge­ sättigtes Alkenyl steht,
B für Sauerstoff, Schwefel, für einen Rest - -R⁷ oder - -OR⁸ steht,

wobei
R⁷ für Wasserstoff, für gegebenenfalls substituiertes Alkyl oder für Alkenyl steht,
R⁸ für Wasserstoff, jeweils gegebenenfalls substi­ tuiertes Alkyl oder einfach oder mehrfach unge­ sättigtes Alkenyl steht und
R⁴ für gegebenenfalls substituiertes gesättigtes oder ungesättigtes Alkyl , gegebenenfalls substi­ tuiertes Cycloalkyl, Aryl oder eine 5-bis 7- gliedrigen Heterocyclus steht, oder
gemeinsam mit R⁵ und B oder mit R⁶ und B oder mit R⁷ und B oder mit R⁸ und B oder mit A und B einen 5- oder 6-gliedrigen Ring bilden kann,
mehrere Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und/oder Wachstumsregulatoren.
EP86116247A 1985-12-05 1986-11-24 Pyri(mi)dyl-oxy-und -thio-benzoesäure-Derivate Withdrawn EP0226837A3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3543037 1985-12-05
DE3543037 1985-12-05
DE19863602016 DE3602016A1 (de) 1985-12-05 1986-01-24 Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate
DE3602016 1986-01-24

Publications (2)

Publication Number Publication Date
EP0226837A2 EP0226837A2 (de) 1987-07-01
EP0226837A3 true EP0226837A3 (de) 1989-07-26

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ID=25838550

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86116247A Withdrawn EP0226837A3 (de) 1985-12-05 1986-11-24 Pyri(mi)dyl-oxy-und -thio-benzoesäure-Derivate

Country Status (9)

Country Link
US (1) US4871387A (de)
EP (1) EP0226837A3 (de)
KR (1) KR870005995A (de)
AU (1) AU592839B2 (de)
BR (1) BR8605956A (de)
DE (1) DE3602016A1 (de)
DK (1) DK583986A (de)
HU (1) HUT45372A (de)
IL (1) IL80843A0 (de)

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DE3611193A1 (de) * 1986-04-04 1987-10-15 Bayer Ag N-substituierte benzamide
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AU3772800A (en) * 1999-03-24 2000-10-09 Sepracor, Inc. Diaryl thioethers, compositions and uses thereof
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EP2027087A2 (de) 2006-05-18 2009-02-25 MannKind Corporation Intrazelluläre kinase-inhibitoren
MX2010002258A (es) 2007-08-27 2010-04-22 Helicon Therapeutics Inc Compuestos terapeuticos de isoxazol.
PT2303270T (pt) 2008-05-05 2017-08-25 Sanofi Sa Derivados fundidos do ácido ciclopentanocarboxílico substituídos por acilamino e sua utilização como produtos farmacêuticos
EP2236505A1 (de) 2009-04-03 2010-10-06 Bayer CropScience AG Acylierte Aminopyridine und - pyridazine als Insektizide
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
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Title
CHEMICAL ABSTRACTS. Band 84, Nr. 19, 10 Mai 1976, Seite 482, Spalte 1, Zusammenfassung Nr. 135477r, Columbus, Ohio, US; R. MAEDA et al.: "Pyridyloxyphenylalkanoic or pyridyloxybenzoicacid derivatives"; & JP-A-50 111 076 (SHIONOGI & CO LTD) 01-09-1975, in Zusammenhang mit CHEMICAL SUBSTANCE INDEX, Band 84, Januar-Juni 1976, Seite 861, CS, Spalte 3, Seite 882 CS, Spalte 1 *
CHEMICAL ABSTRACTS. Band 93, Nr. 15, 13 Oktober 1980, Seite 722, Spalte 1, Zusammenfassung Nr. 150268c, Columbus, Ohio, US; T. KIJIMA et al.: "2-Phenoxypyrimidine derivatives"; & JP-A-54 117 486 (SANKYO CO LTD) 12-09-1979 *

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AU592839B2 (en) 1990-01-25
AU6587786A (en) 1987-06-11
BR8605956A (pt) 1987-09-15
KR870005995A (ko) 1987-07-08
DE3602016A1 (de) 1987-06-11
HUT45372A (en) 1988-07-28
EP0226837A2 (de) 1987-07-01
DK583986A (da) 1987-06-06
IL80843A0 (en) 1987-03-31
DK583986D0 (da) 1986-12-04
US4871387A (en) 1989-10-03

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