EP0081976A1 - Fermeture perforable pour bouteilles d'échantillon - Google Patents

Fermeture perforable pour bouteilles d'échantillon Download PDF

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Publication number
EP0081976A1
EP0081976A1 EP82306556A EP82306556A EP0081976A1 EP 0081976 A1 EP0081976 A1 EP 0081976A1 EP 82306556 A EP82306556 A EP 82306556A EP 82306556 A EP82306556 A EP 82306556A EP 0081976 A1 EP0081976 A1 EP 0081976A1
Authority
EP
European Patent Office
Prior art keywords
cap
membrane
sample container
wad
container according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82306556A
Other languages
German (de)
English (en)
Other versions
EP0081976B1 (fr
Inventor
Richard Bruce Tait
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterilin Ltd
Original Assignee
Sterilin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterilin Ltd filed Critical Sterilin Ltd
Priority to AT82306556T priority Critical patent/ATE14847T1/de
Publication of EP0081976A1 publication Critical patent/EP0081976A1/fr
Application granted granted Critical
Publication of EP0081976B1 publication Critical patent/EP0081976B1/fr
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Definitions

  • the invention relates to piercable closures for containers, particularly sterile or sterilisable containers for samples, usually blood, that may require pathological test and analysis.
  • a closure in the form of a dished cap equipped with securement means relative to a sample container, say as a push-fit or via screw-threading of its side walling, and with the dished portion of the cap having an aperture clear through but closed by an added membrane, usually of a material or materials different from the cap, more readily pierced than any practical integral thinning of the cap material.
  • a membrane that is between 0.02 mm and 0.50 mm in thickness and of a material and a specific thickness selected to afford a practical combination of piercability, robustness and resistance to moisture and water vapour penetration or transmission.
  • a relatively thick material in the above range usually, of course, has advantages, at least in robustness, compared with very thin and easily pierced membranes even where such are not subject to porosity or being left with holes therethrough, though the use of such membranes in practising this invention is not ruled out entirely.
  • One suitable membrane material is aluminium foil, which we prefer to mount upon a washer-like base apertured to register with the cap aperture when fitted, and generally to form what we call a "wad".
  • Another aspect of this invention concerns a wad for insertion as a seal into an apertured cap, the wad comprising a base member apertured to register with the cap aperture and having secured thereto an aperture-closing membrane that is readily piercable.
  • the whole wad is such as to be clamped between a container mouth edge and the cap itself about the aperture of the latter.
  • the membrane shall extend sufficiently, preferably fully, across the cap dishing. Then the membrane will either be engaged directly by all of the mouth edge of the container, or subjected to compressive clamping by the latter engaging on the base of the wad, depending on the attitude of the wad in the cap.
  • the membrane should afford a liquid-tight seal and act as a suitable barrier against bacteria and water vapour. It is also desirable that the seal should not be subject to adherence problems when, as is required for blood samples, the container must be opened for addition of blood, usually to a suitable medium already in the container (e.g. sodium citrate), and reclosed/sealed pending subsequent piercing to sample for test purposes, usually in a pipette in a pathology laboratory.
  • a suitable medium already in the container e.g. sodium citrate
  • At least wads hereof can often be interference fits to the caps. However, wherever desired or required such wads, even memberanes only, may be fixed into the cap using a suitable cement or adhesive, say of hot melt or impact types.
  • a container 10 is shown screw- fitted with a dished cap 12 via internal threading of the side wall 14 of the cap mating at 16 with exterior threading of a neck portion 18 of the container below edge 22 of its mouth.
  • Dished end 26 of the cap 12 has a centrally located aperture 28 clear through its thickness. Clamped between the interior of cap end 26, all about its aperture 28, and the container mouth edge 22 is a wad 30.
  • the wad 30 comprises an annular washer-like base 32, centrally apertured at 34 in register with the cap end aperture 28, and a membrane 36 covering that aperture 34.
  • the membrane 36 comprises aluminium foil affixed to base 32 either directly by a suitable adhesive as indicated for an expanded polythene base, or via a paper backing (not shown, but often advisable for certain wad materials, such as woodpulp board).
  • the base 32 is engaged all round by the container mouth edge 22 for desired sealing, in fact abuts substantially entirely to the periphery of the inner surface of the cap end 26.
  • the wad needs only to be pressed into place, usually as an interference fit, though it could be adheringly secured by a suitable adhesive or cement if preferred or required.
  • the membrane 36 is shown extending entirely across the base 32, including its aperture, and is subjected to edge compression through the base by action of the container mouth edge 22 to reduce risk of delamination. It is feasible to use the wad inverted so that the membrane contacts the container mouth edge, so long as a satisfactory seal results, and paper-backing of aluminium or other foil can assist both securement and sealing.
  • the complete wad is made as a unit, i.e. the base 32 and the membrane 36
  • Any suitable adhesive or cement can be used or they may simply be hot-pressed together where waxed backing paper is used for the membrane foil.
  • the base 32 of the wad 30 assists in assuring compressive obtainment of a readily broken and reattained liquid seal.
  • Adhesives based on synthetic resins are suitable, for example polyvinyl acetate. Heat sensitive adhesives are preferred for adhering membranes to wad bases. At least hot melt adhesives may even allow membranes to be dispensed with, relying instead simply on a plug of settable but readily pierced material on the cap aperture.
  • Lamination of foil to a paper backing if used is conveniently by way of synthetic latex adhesives applied hot or cold but normally using heat in the laminating process to accelerate curing.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Bridges Or Land Bridges (AREA)
  • Revetment (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
EP82306556A 1981-12-11 1982-12-08 Fermeture perforable pour bouteilles d'échantillon Expired EP0081976B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82306556T ATE14847T1 (de) 1981-12-11 1982-12-08 Durchstechbarer verschluss fuer probeflaschen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8137467 1981-12-11
GB8137467 1981-12-11

Publications (2)

Publication Number Publication Date
EP0081976A1 true EP0081976A1 (fr) 1983-06-22
EP0081976B1 EP0081976B1 (fr) 1985-08-14

Family

ID=10526547

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82306556A Expired EP0081976B1 (fr) 1981-12-11 1982-12-08 Fermeture perforable pour bouteilles d'échantillon

Country Status (5)

Country Link
EP (1) EP0081976B1 (fr)
AT (1) ATE14847T1 (fr)
AU (1) AU9130382A (fr)
DE (1) DE3265463D1 (fr)
DK (1) DK545182A (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2162158A (en) * 1984-04-13 1986-01-29 Donald Paul Pilla Closure
GB2228730A (en) * 1989-03-03 1990-09-05 Instrumentation Lab Spa Container and closure
EP0398321A2 (fr) * 1989-05-17 1990-11-22 Terumo Kabushiki Kaisha Membrane de fermeture munie d'une membrane d'étanchéité
GB2234742A (en) * 1989-08-11 1991-02-13 Inibsa Lab A bottle for renal dialysis
EP0383262A3 (fr) * 1989-02-13 1991-11-13 Terumo Kabushiki Kaisha Tube de collection pour liquides
EP0577343A2 (fr) * 1992-06-26 1994-01-05 Bio-Rad Laboratories, Inc. Récipient à réactifs et support de récipients pour analyseurs cliniques automatiques
WO1995011083A2 (fr) * 1993-10-22 1995-04-27 Abbott Laboratories Tube de reaction et methode d'utilisation de celui-ci minimisant les contaminations
WO1998036261A1 (fr) * 1997-02-14 1998-08-20 Arcturus Engineering, Inc. Film absorbant a bande large pour microdissection par capture au laser
US5859699A (en) * 1997-02-07 1999-01-12 Arcturus Engineering, Inc. Laser capture microdissection analysis vessel
EP1181980A1 (fr) * 2000-08-24 2002-02-27 TTP LabTech Ltd Stockage de liquide
GB2493389A (en) * 2011-08-05 2013-02-06 Closures Ltd Cap and Method for Sealing a Drink Container

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1795263T4 (da) 2001-03-09 2017-11-13 Gen Probe Inc Fremgangsmåde til fjernelse af en fluid fra en beholder omfattende en gennembrydelig hætte

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE438801A (fr) *
CH147396A (de) * 1930-06-17 1931-06-15 Zuercher Gottlieb Abschlussvorrichtung an Versandflaschen für Flüssigkeiten.
US2099370A (en) * 1935-09-07 1937-11-16 Monnier Vital Phial
GB766778A (en) * 1954-05-25 1957-01-23 Glaxo Lab Ltd Improvements in or relating to closures for bottles, jars, vials and like containers
DE2051581A1 (de) * 1970-10-21 1972-05-04 Freienstein, Christoph, 6900 Heidelberg Deckelraster zum vereinfachten Schließen und Öffnen mehrerer Probefläschchen, Reagenzgläser etc
FR2110778A5 (fr) * 1970-10-30 1972-06-02 Alca Sa
GB1468801A (en) * 1973-03-07 1977-03-30 Accu Tech Ltd Containers
FR2349510A1 (fr) * 1976-04-26 1977-11-25 Aluminum Co Of America Fermeture de recipient et ensemble recipient-fermeture

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE438801A (fr) *
CH147396A (de) * 1930-06-17 1931-06-15 Zuercher Gottlieb Abschlussvorrichtung an Versandflaschen für Flüssigkeiten.
US2099370A (en) * 1935-09-07 1937-11-16 Monnier Vital Phial
GB766778A (en) * 1954-05-25 1957-01-23 Glaxo Lab Ltd Improvements in or relating to closures for bottles, jars, vials and like containers
DE2051581A1 (de) * 1970-10-21 1972-05-04 Freienstein, Christoph, 6900 Heidelberg Deckelraster zum vereinfachten Schließen und Öffnen mehrerer Probefläschchen, Reagenzgläser etc
FR2110778A5 (fr) * 1970-10-30 1972-06-02 Alca Sa
GB1468801A (en) * 1973-03-07 1977-03-30 Accu Tech Ltd Containers
FR2349510A1 (fr) * 1976-04-26 1977-11-25 Aluminum Co Of America Fermeture de recipient et ensemble recipient-fermeture

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2162158A (en) * 1984-04-13 1986-01-29 Donald Paul Pilla Closure
EP0383262A3 (fr) * 1989-02-13 1991-11-13 Terumo Kabushiki Kaisha Tube de collection pour liquides
GB2228730A (en) * 1989-03-03 1990-09-05 Instrumentation Lab Spa Container and closure
GB2228730B (en) * 1989-03-03 1993-03-24 Instrumentation Lab Spa Sample cuvette with a welded stopper
EP0398321A2 (fr) * 1989-05-17 1990-11-22 Terumo Kabushiki Kaisha Membrane de fermeture munie d'une membrane d'étanchéité
EP0398321A3 (fr) * 1989-05-17 1991-08-21 Terumo Kabushiki Kaisha Membrane de fermeture munie d'une membrane d'étanchéité
US5122126A (en) * 1989-05-17 1992-06-16 Terumo Kabushiki Kaisha Nozzle member provided with sealing membrane
GB2234742A (en) * 1989-08-11 1991-02-13 Inibsa Lab A bottle for renal dialysis
EP0577343A2 (fr) * 1992-06-26 1994-01-05 Bio-Rad Laboratories, Inc. Récipient à réactifs et support de récipients pour analyseurs cliniques automatiques
EP0577343A3 (en) * 1992-06-26 1994-06-08 Bio Rad Laboratories Reagent receptacle and support rack for automated clinical analyzers
WO1995011083A2 (fr) * 1993-10-22 1995-04-27 Abbott Laboratories Tube de reaction et methode d'utilisation de celui-ci minimisant les contaminations
WO1995011083A3 (fr) * 1993-10-22 1995-08-31 Abbott Lab Tube de reaction et methode d'utilisation de celui-ci minimisant les contaminations
EP1245286A2 (fr) * 1993-10-22 2002-10-02 Abbott Laboratories Tube de réaction et méthode d'utilisation de celui-ci minimisant les contaminations
EP1245286A3 (fr) * 1993-10-22 2004-01-02 Abbott Laboratories Tube de réaction et méthode d'utilisation de celui-ci minimisant les contaminations
US5859699A (en) * 1997-02-07 1999-01-12 Arcturus Engineering, Inc. Laser capture microdissection analysis vessel
WO1998036261A1 (fr) * 1997-02-14 1998-08-20 Arcturus Engineering, Inc. Film absorbant a bande large pour microdissection par capture au laser
EP1181980A1 (fr) * 2000-08-24 2002-02-27 TTP LabTech Ltd Stockage de liquide
WO2002016041A1 (fr) * 2000-08-24 2002-02-28 Ttp Labtech Ltd. Stockage de liquide
GB2493389A (en) * 2011-08-05 2013-02-06 Closures Ltd Cap and Method for Sealing a Drink Container

Also Published As

Publication number Publication date
DE3265463D1 (en) 1985-09-19
EP0081976B1 (fr) 1985-08-14
DK545182A (da) 1983-06-12
AU9130382A (en) 1983-06-16
ATE14847T1 (de) 1985-08-15

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