EP1181980A1 - Stockage de liquide - Google Patents

Stockage de liquide Download PDF

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Publication number
EP1181980A1
EP1181980A1 EP00307319A EP00307319A EP1181980A1 EP 1181980 A1 EP1181980 A1 EP 1181980A1 EP 00307319 A EP00307319 A EP 00307319A EP 00307319 A EP00307319 A EP 00307319A EP 1181980 A1 EP1181980 A1 EP 1181980A1
Authority
EP
European Patent Office
Prior art keywords
container
liquid
member according
cap
hole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00307319A
Other languages
German (de)
English (en)
Inventor
Philip Blenkinsop
Michael Withers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPT Labtech Ltd
Original Assignee
TTP Labtech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TTP Labtech Ltd filed Critical TTP Labtech Ltd
Priority to EP00307319A priority Critical patent/EP1181980A1/fr
Priority to PCT/GB2001/003628 priority patent/WO2002016041A1/fr
Priority to AU2001282280A priority patent/AU2001282280A1/en
Publication of EP1181980A1 publication Critical patent/EP1181980A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • This invention relates to the storage of liquids.
  • the liquid vessel may be provided with a cap which can be pierced by a cannula or syringe.
  • the cap may be readily removable. In this latter case, the cap is removed, an aliquot taken from the vessel, and the vessel resealed either using the original cap or a fresh replacement.
  • the cost of the liquid being contained can be extremely high, and there is a growing trend to employ in many applications smaller and smaller amounts of liquid for testing or for use as a reagent.
  • a few hundred microlitres of material will be stored in the container, and only a few microlitres removed at any one time. Because of this it has become extremely important to minimise liquid wastage.
  • the present invention seeks to overcome some of these problems.
  • a liquid retaining member for insertion, in use, into the neck of a liquid sample container, the member comprising: a membrane arranged to be retained within the container in use and having a hole formed therein;
  • Figure 1 shows an example prior art container 1, which comprises a tube 1 usually formed from a polymer.
  • the container has a single open end 3 which is sealed by a cap 2.
  • the container 1 comes in one of a range of sizes, and a typical example might have a maximum volume of 1.4 ml, with a working volume of 1 ml.
  • the container 1 is inverted or agitated it is possible for the contents 5 to contact the lower face of the cap 2. Whilst the bulk of the contents 5 will drain back away from the cap 2, surface tension will tend to ensure that at least some liquid remains attached to the cap 3, especially in the interface 6 between the cap 2 and the wall of the container 1. This is shown in figure 2.
  • Figures 3 shows the results of a test with a known container of the tubular type supplied by Metrix Technologies Corporation and employing a standard elastomeric cap. As can be seen from figure 3, more than 2% of the original contents were lost over nine cycles. This corresponds to an average loss per cap removal of 3.5 microlitres. It will be appreciated that for applications where only a few microlitres are required for testing this loss would soon diminish available stock.
  • Figure 4 shows a first example of the present invention, in which components corresponding to those in figures 1 and 2 are numbered identically.
  • a container 1 again has a tubular configuration and employs a cap 2 of a configuration similar to that shown in figures 1 and 2.
  • an insert member 10 which, in use, is positioned within the container 1 beneath the cap 2.
  • the insert member 10 has a cup shape, the walls of which are designed to engage, in use, with the inner walls of the container 1 and retain the insert 10 within the container 1 such that it is resistant to shock and vibration.
  • the insert member may be formed from a polymeric material, such as polypropylene or polycarbonate.
  • It may be formed to be integral with the container 1 as part of the container manufacturing process, but is preferably configured simply to insert into a standard container. It may be that the inner wall of the container 1 has a circumferential ridge formed thereon to prevent the insert member 10 passing too far into the container 1 in use.
  • the hole 11 is of a size such that a sampling syringe or cannula can pass there through to obtain access to contents 5 in the container 1. It is, however, sufficiently small to ensure that surface tension in the liquid contents 5 being stored prevents passage of store liquid through the hole 11, as shown in figure 4.
  • Figure 5 shows a second example of the invention, in which the insert member 10 still has a central hole 11 but which is defined by cylindrical or frusto-conical side walls 13.
  • This configuration has the benefit that a greater pool of liquid contents 5 is retained in the hole 11, such that the retained liquid contents 5 may be sufficient for a sample to be obtained by a syringe or cannula 14 without needing to have a syringe or cannula 14 of a depth that is sufficient to pass through the hole 11 and down into the main body of the liquid contents 5.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Closures For Containers (AREA)
EP00307319A 2000-08-24 2000-08-24 Stockage de liquide Withdrawn EP1181980A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00307319A EP1181980A1 (fr) 2000-08-24 2000-08-24 Stockage de liquide
PCT/GB2001/003628 WO2002016041A1 (fr) 2000-08-24 2001-08-10 Stockage de liquide
AU2001282280A AU2001282280A1 (en) 2000-08-24 2001-08-10 Liquid storage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00307319A EP1181980A1 (fr) 2000-08-24 2000-08-24 Stockage de liquide

Publications (1)

Publication Number Publication Date
EP1181980A1 true EP1181980A1 (fr) 2002-02-27

Family

ID=8173223

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00307319A Withdrawn EP1181980A1 (fr) 2000-08-24 2000-08-24 Stockage de liquide

Country Status (3)

Country Link
EP (1) EP1181980A1 (fr)
AU (1) AU2001282280A1 (fr)
WO (1) WO2002016041A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper
EP0081976A1 (fr) * 1981-12-11 1983-06-22 Sterilin Limited Fermeture perforable pour bouteilles d'échantillon
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
DE19606274A1 (de) * 1995-06-02 1996-12-05 Glastechnik Graefenroda Gmbh Probenfläschchen mit Schraubverschluß und Verfahren zu seiner Herstellung
US5720925A (en) * 1994-12-06 1998-02-24 Promochem Gmbh Handelsgesellschaft Fur Chemische Produkte Flask

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper
EP0081976A1 (fr) * 1981-12-11 1983-06-22 Sterilin Limited Fermeture perforable pour bouteilles d'échantillon
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
US5720925A (en) * 1994-12-06 1998-02-24 Promochem Gmbh Handelsgesellschaft Fur Chemische Produkte Flask
DE19606274A1 (de) * 1995-06-02 1996-12-05 Glastechnik Graefenroda Gmbh Probenfläschchen mit Schraubverschluß und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
AU2001282280A1 (en) 2002-03-04
WO2002016041A1 (fr) 2002-02-28

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