EG24516A - Peptide deformylase inhibitors - Google Patents
Peptide deformylase inhibitorsInfo
- Publication number
- EG24516A EG24516A EG2003050473A EG2003050473A EG24516A EG 24516 A EG24516 A EG 24516A EG 2003050473 A EG2003050473 A EG 2003050473A EG 2003050473 A EG2003050473 A EG 2003050473A EG 24516 A EG24516 A EG 24516A
- Authority
- EG
- Egypt
- Prior art keywords
- peptide deformylase
- deformylase inhibitors
- inhibitors
- peptide
- deformylase
- Prior art date
Links
- 239000000081 peptide deformylase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Quinoline Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27257001P | 2001-03-01 | 2001-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG24516A true EG24516A (en) | 2009-08-19 |
Family
ID=23040368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG2003050473A EG24516A (en) | 2001-03-01 | 2003-05-20 | Peptide deformylase inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7019003B2 (de) |
| EP (1) | EP1363873B1 (de) |
| JP (1) | JP4266638B2 (de) |
| KR (1) | KR20030092008A (de) |
| CN (1) | CN1505607A (de) |
| AR (1) | AR032920A1 (de) |
| AU (1) | AU2002335490B2 (de) |
| BR (1) | BR0207810A (de) |
| CA (1) | CA2439827A1 (de) |
| CZ (1) | CZ20032342A3 (de) |
| EG (1) | EG24516A (de) |
| HU (1) | HUP0303308A2 (de) |
| IL (1) | IL157643A0 (de) |
| MX (1) | MXPA03007869A (de) |
| NO (1) | NO20033828L (de) |
| NZ (1) | NZ527728A (de) |
| PE (1) | PE20020906A1 (de) |
| PL (1) | PL364563A1 (de) |
| UY (1) | UY27192A1 (de) |
| WO (1) | WO2002070541A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| JP2005532358A (ja) * | 2002-06-06 | 2005-10-27 | スミスクライン・ビーチャム・コーポレイション | ペプチドデホルミラーゼ阻害剤 |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| GB0229673D0 (en) * | 2002-12-19 | 2003-01-29 | British Biotech Pharm | Antibacterial agents |
| US7332485B2 (en) * | 2003-07-08 | 2008-02-19 | Smithkline Beecham Corp | Peptide deformylase inhibitors |
| WO2005017124A2 (en) * | 2003-08-15 | 2005-02-24 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| EP1827449A4 (de) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | Verwendung von neuen antibakteriellen verbindungen |
| WO2007016364A2 (en) * | 2005-07-29 | 2007-02-08 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
| DK1954697T3 (da) * | 2005-10-21 | 2010-06-14 | Glaxo Group Ltd | Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler |
| KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
| GB0707706D0 (en) * | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| WO2010006438A1 (en) | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| US8987272B2 (en) | 2010-04-01 | 2015-03-24 | Critical Outcome Technologies Inc. | Compounds and method for treatment of HIV |
| CA2857694A1 (en) * | 2011-12-02 | 2013-06-06 | Glaxosmithkline Intellectual Property (No.2) Limited | Peptide deformylase inhibitors |
| CN116375698B (zh) * | 2023-06-05 | 2023-08-01 | 中国林业科学研究院林产化学工业研究所 | 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| US6013792A (en) | 1993-08-05 | 2000-01-11 | Syntex (U.S.A.), Inc. | Matrix metalloprotease inhibitors |
| US6037472A (en) | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| US6028110A (en) * | 1994-05-28 | 2000-02-22 | British Biotech Pharmaceuticals Ltd. | Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors |
| GB9827805D0 (en) * | 1998-12-16 | 1999-02-10 | British Biotech Pharm | Antibacterial agents |
| EP1242581A2 (de) | 1999-12-08 | 2002-09-25 | Bayer Aktiengesellschaft | Regulation der humanen mitochondrialen deformylase |
-
2002
- 2002-02-28 UY UY27192A patent/UY27192A1/es not_active Application Discontinuation
- 2002-02-28 AR ARP020100730A patent/AR032920A1/es not_active Application Discontinuation
- 2002-03-01 CZ CZ20032342A patent/CZ20032342A3/cs unknown
- 2002-03-01 HU HU0303308A patent/HUP0303308A2/hu unknown
- 2002-03-01 IL IL15764302A patent/IL157643A0/xx unknown
- 2002-03-01 AU AU2002335490A patent/AU2002335490B2/en not_active Ceased
- 2002-03-01 BR BRPI0207810-4A patent/BR0207810A/pt not_active IP Right Cessation
- 2002-03-01 US US10/469,433 patent/US7019003B2/en not_active Expired - Fee Related
- 2002-03-01 JP JP2002569860A patent/JP4266638B2/ja not_active Expired - Fee Related
- 2002-03-01 CA CA002439827A patent/CA2439827A1/en not_active Abandoned
- 2002-03-01 PL PL02364563A patent/PL364563A1/xx not_active Application Discontinuation
- 2002-03-01 EP EP02748375.9A patent/EP1363873B1/de not_active Expired - Lifetime
- 2002-03-01 NZ NZ527728A patent/NZ527728A/en not_active IP Right Cessation
- 2002-03-01 PE PE2002000170A patent/PE20020906A1/es not_active Application Discontinuation
- 2002-03-01 MX MXPA03007869A patent/MXPA03007869A/es not_active Application Discontinuation
- 2002-03-01 KR KR10-2003-7011370A patent/KR20030092008A/ko not_active Ceased
- 2002-03-01 WO PCT/US2002/006275 patent/WO2002070541A2/en not_active Ceased
- 2002-03-01 CN CNA028092570A patent/CN1505607A/zh active Pending
-
2003
- 2003-05-20 EG EG2003050473A patent/EG24516A/xx active
- 2003-08-28 NO NO20033828A patent/NO20033828L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4266638B2 (ja) | 2009-05-20 |
| AR032920A1 (es) | 2003-12-03 |
| PL364563A1 (en) | 2004-12-13 |
| NO20033828L (no) | 2003-10-06 |
| UY27192A1 (es) | 2002-09-30 |
| WO2002070541A2 (en) | 2002-09-12 |
| PE20020906A1 (es) | 2002-12-08 |
| KR20030092008A (ko) | 2003-12-03 |
| US7019003B2 (en) | 2006-03-28 |
| EP1363873A2 (de) | 2003-11-26 |
| JP2004537507A (ja) | 2004-12-16 |
| BR0207810A (pt) | 2008-04-15 |
| MXPA03007869A (es) | 2003-12-04 |
| CN1505607A (zh) | 2004-06-16 |
| NO20033828D0 (no) | 2003-08-28 |
| CZ20032342A3 (cs) | 2004-04-14 |
| AU2002335490B2 (en) | 2005-10-20 |
| EP1363873A4 (de) | 2006-01-04 |
| WO2002070541A3 (en) | 2002-12-19 |
| EP1363873B1 (de) | 2016-04-20 |
| US20040087585A1 (en) | 2004-05-06 |
| HUP0303308A2 (hu) | 2004-01-28 |
| CA2439827A1 (en) | 2002-09-12 |
| NZ527728A (en) | 2004-09-24 |
| IL157643A0 (en) | 2004-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB0125445D0 (en) | Protease Inhibitors | |
| AU2002367773A8 (en) | Fab i inhibitors | |
| IL157657A0 (en) | Metalloproteinase inhibitors | |
| IL157570A0 (en) | Metalloproteinase inhibitors | |
| IL157650A0 (en) | Metalloproteinase inhibitors | |
| EG24516A (en) | Peptide deformylase inhibitors | |
| AU2002230385A1 (en) | Peptide deformylase inhibitors | |
| ZA200408315B (en) | Peptide deformylase inhibitors | |
| IL152638A0 (en) | Peptide deformylase inhibitors | |
| AU2003296960A8 (en) | Peptide deformylase inhibitors | |
| EP1383729A4 (de) | Peptiddeformylaseinhibitoren | |
| IL151884A0 (en) | Peptide deformylase inhibitors | |
| EP1401453A4 (de) | Proteasehemmer | |
| AU2002255634A1 (en) | Peptide deformylase inhibitors | |
| EP1515956A4 (de) | Peptiddeformylaseinhibitoren | |
| AU2003212418A8 (en) | Peptide deformylase | |
| AU2002252585A1 (en) | Peptide deformylase inhibitors | |
| HK1060114A (en) | Peptide deformylase inhibitors | |
| AU2002335615A1 (en) | Peptide deformylase inhibitors | |
| HK1054864A (en) | Peptide deformylase inhibitors | |
| ZA200208909B (en) | Peptide deformylase inhibitors. | |
| ZA200208906B (en) | Peptide deformylase inhibitors. | |
| GB0101134D0 (en) | Inhibitors | |
| GB0101135D0 (en) | Inhibitors | |
| GB0128453D0 (en) | Inhibitors |