EE9600183A - Kristalne (R)-(-)-2-{N-[4-(1,1-dioksido-3-okso-2,3-dihüdrobensisotiasool-2-üül) butüül ] aminometüül }kromaanhüdrokloriid, selle valmistamismeetod, kasutamine ravimite valmistamiseks ja ravimid - Google Patents
Kristalne (R)-(-)-2-{N-[4-(1,1-dioksido-3-okso-2,3-dihüdrobensisotiasool-2-üül) butüül ] aminometüül }kromaanhüdrokloriid, selle valmistamismeetod, kasutamine ravimite valmistamiseks ja ravimidInfo
- Publication number
- EE9600183A EE9600183A EE9600183A EE9600183A EE9600183A EE 9600183 A EE9600183 A EE 9600183A EE 9600183 A EE9600183 A EE 9600183A EE 9600183 A EE9600183 A EE 9600183A EE 9600183 A EE9600183 A EE 9600183A
- Authority
- EE
- Estonia
- Prior art keywords
- dihydrobenzisothiazol
- dioxido
- aminomethyl
- medicaments
- medicines
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 2
- IGKYREHZJIHPML-UNTBIKODSA-N 2-[4-[[(2r)-3,4-dihydro-2h-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydron;chloride Chemical compound Cl.O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 IGKYREHZJIHPML-UNTBIKODSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19543478A DE19543478A1 (de) | 1995-11-22 | 1995-11-22 | Kristallines Hydrochlorid von {(R)-(-)-2- N-[4-(1,1-Dioxido-3-oxo-2,3-dihydrobenzisothiazol-2-yl)-buytl]-aminomethyl}-chroman |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9600183A true EE9600183A (et) | 1997-06-16 |
Family
ID=7778081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9600183A EE9600183A (et) | 1995-11-22 | 1996-11-21 | Kristalne (R)-(-)-2-{N-[4-(1,1-dioksido-3-okso-2,3-dihüdrobensisotiasool-2-üül) butüül ] aminometüül }kromaanhüdrokloriid, selle valmistamismeetod, kasutamine ravimite valmistamiseks ja ravimid |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5830908A (es) |
| EP (1) | EP0775704B1 (es) |
| JP (1) | JPH09143180A (es) |
| KR (1) | KR970027079A (es) |
| CN (1) | CN1086703C (es) |
| AR (1) | AR004961A1 (es) |
| AT (1) | ATE201872T1 (es) |
| AU (1) | AU712922B2 (es) |
| BR (1) | BR9605646A (es) |
| CA (1) | CA2190700A1 (es) |
| CZ (1) | CZ289730B6 (es) |
| DE (2) | DE19543478A1 (es) |
| DK (1) | DK0775704T3 (es) |
| EE (1) | EE9600183A (es) |
| ES (1) | ES2159342T3 (es) |
| GR (1) | GR3036505T3 (es) |
| HU (1) | HUP9603237A3 (es) |
| IL (1) | IL119647A (es) |
| MX (1) | MX9605741A (es) |
| MY (1) | MY132473A (es) |
| NO (1) | NO307340B1 (es) |
| NZ (1) | NZ299780A (es) |
| PL (1) | PL317090A1 (es) |
| PT (1) | PT775704E (es) |
| RU (1) | RU2181723C2 (es) |
| SG (1) | SG44989A1 (es) |
| SI (1) | SI0775704T1 (es) |
| SK (1) | SK150096A3 (es) |
| TR (1) | TR199600930A2 (es) |
| TW (1) | TW449595B (es) |
| UA (1) | UA45338C2 (es) |
| ZA (1) | ZA969753B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854217A (en) * | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| BRPI0815405A2 (pt) * | 2007-08-17 | 2015-02-03 | Boehringer Ingelheim Int | Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| UA119131C2 (uk) * | 2008-08-15 | 2019-05-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Похідні пурину для застосування при лікуванні пов'язаних із fab захворювань |
| CA2736421A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CA3070513C (en) | 2010-05-05 | 2023-01-03 | Boehringer Ingelheim International Gmbh | A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4748182A (en) * | 1986-03-05 | 1988-05-31 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents |
| US5300523A (en) * | 1988-07-28 | 1994-04-05 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
-
1995
- 1995-11-22 DE DE19543478A patent/DE19543478A1/de not_active Withdrawn
-
1996
- 1996-10-30 AR ARP960104981A patent/AR004961A1/es unknown
- 1996-11-11 DE DE59607040T patent/DE59607040D1/de not_active Expired - Fee Related
- 1996-11-11 AT AT96118043T patent/ATE201872T1/de not_active IP Right Cessation
- 1996-11-11 SI SI9630292T patent/SI0775704T1/xx unknown
- 1996-11-11 PT PT96118043T patent/PT775704E/pt unknown
- 1996-11-11 EP EP96118043A patent/EP0775704B1/de not_active Expired - Lifetime
- 1996-11-11 DK DK96118043T patent/DK0775704T3/da active
- 1996-11-11 ES ES96118043T patent/ES2159342T3/es not_active Expired - Lifetime
- 1996-11-14 AU AU71772/96A patent/AU712922B2/en not_active Ceased
- 1996-11-18 JP JP8322212A patent/JPH09143180A/ja not_active Withdrawn
- 1996-11-19 CA CA002190700A patent/CA2190700A1/en not_active Abandoned
- 1996-11-19 NZ NZ299780A patent/NZ299780A/en unknown
- 1996-11-19 IL IL11964796A patent/IL119647A/xx not_active IP Right Cessation
- 1996-11-19 US US08/752,348 patent/US5830908A/en not_active Expired - Fee Related
- 1996-11-20 SG SG1996011319A patent/SG44989A1/en unknown
- 1996-11-20 TW TW085114226A patent/TW449595B/zh not_active IP Right Cessation
- 1996-11-20 PL PL96317090A patent/PL317090A1/xx unknown
- 1996-11-21 KR KR1019960056088A patent/KR970027079A/ko not_active Ceased
- 1996-11-21 EE EE9600183A patent/EE9600183A/xx unknown
- 1996-11-21 UA UA96114365A patent/UA45338C2/uk unknown
- 1996-11-21 MY MYPI96004849A patent/MY132473A/en unknown
- 1996-11-21 BR BR9605646A patent/BR9605646A/pt unknown
- 1996-11-21 MX MX9605741A patent/MX9605741A/es unknown
- 1996-11-21 SK SK1500-96A patent/SK150096A3/sk unknown
- 1996-11-21 CZ CZ19963428A patent/CZ289730B6/cs not_active IP Right Cessation
- 1996-11-21 ZA ZA969753A patent/ZA969753B/xx unknown
- 1996-11-21 NO NO964950A patent/NO307340B1/no not_active IP Right Cessation
- 1996-11-22 CN CN96114587A patent/CN1086703C/zh not_active Expired - Fee Related
- 1996-11-22 HU HU9603237A patent/HUP9603237A3/hu unknown
- 1996-11-22 TR TR96/00930A patent/TR199600930A2/xx unknown
- 1996-11-22 RU RU96122395/04A patent/RU2181723C2/ru active
-
2001
- 2001-08-31 GR GR20010401365T patent/GR3036505T3/el not_active IP Right Cessation
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