EE200300498A - Fenüül-heterotsüklüüleetri derivaadid kui serotoniini tagasihaarde inhibiitorid - Google Patents

Fenüül-heterotsüklüüleetri derivaadid kui serotoniini tagasihaarde inhibiitorid

Info

Publication number
EE200300498A
EE200300498A EEP200300498A EEP200300498A EE200300498A EE 200300498 A EE200300498 A EE 200300498A EE P200300498 A EEP200300498 A EE P200300498A EE P200300498 A EEP200300498 A EE P200300498A EE 200300498 A EE200300498 A EE 200300498A
Authority
EE
Estonia
Prior art keywords
phenyl
serotonin reuptake
reuptake inhibitors
ether derivatives
heterocyclyl
Prior art date
Application number
EEP200300498A
Other languages
English (en)
Inventor
Diane Adam Mavis
David Andrews Mark
Edward Gymer Geoffrey
Hepworth David
Ralph Howard Harry Jr.
Stuart Middleton Donald
Stobie Alan
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of EE200300498A publication Critical patent/EE200300498A/et

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/34—Tobacco-abuse
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
EEP200300498A 2001-04-11 2002-03-27 Fenüül-heterotsüklüüleetri derivaadid kui serotoniini tagasihaarde inhibiitorid EE200300498A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0109103.2A GB0109103D0 (en) 2001-04-11 2001-04-11 Novel compounds
PCT/IB2002/001032 WO2002083643A1 (en) 2001-04-11 2002-03-27 Phenyl heterocyclyl ether derivatives as serotonin re-uptake inhibitors

Publications (1)

Publication Number Publication Date
EE200300498A true EE200300498A (et) 2004-02-16

Family

ID=9912700

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300498A EE200300498A (et) 2001-04-11 2002-03-27 Fenüül-heterotsüklüüleetri derivaadid kui serotoniini tagasihaarde inhibiitorid

Country Status (44)

Country Link
EP (1) EP1377550B9 (et)
JP (1) JP2005504728A (et)
KR (1) KR100570376B1 (et)
CN (1) CN1656072A (et)
AP (1) AP1543A (et)
AR (1) AR035818A1 (et)
AT (1) ATE281435T1 (et)
AU (1) AU2002244898B2 (et)
BG (1) BG108204A (et)
BR (1) BR0208812A (et)
CA (1) CA2443699A1 (et)
CZ (1) CZ20032677A3 (et)
DE (1) DE60201819T2 (et)
DO (1) DOP2002000371A (et)
EA (1) EA008936B1 (et)
EC (1) ECSP034802A (et)
EE (1) EE200300498A (et)
ES (1) ES2227448T3 (et)
GB (1) GB0109103D0 (et)
GE (1) GEP20053590B (et)
GT (1) GT200200071A (et)
HR (1) HRP20030824A2 (et)
HU (1) HUP0303880A2 (et)
IL (2) IL158141A0 (et)
IS (1) IS6960A (et)
MA (1) MA27010A1 (et)
MX (1) MXPA03009383A (et)
MY (1) MY136262A (et)
NO (1) NO20034525L (et)
NZ (1) NZ528481A (et)
OA (1) OA12500A (et)
PA (1) PA8543701A1 (et)
PE (1) PE20021003A1 (et)
PL (1) PL373533A1 (et)
PT (1) PT1377550E (et)
RS (1) RS79703A (et)
SI (1) SI1377550T1 (et)
SK (1) SK12452003A3 (et)
SV (1) SV2003000981A (et)
TN (1) TNSN03090A1 (et)
UA (1) UA74430C2 (et)
UY (1) UY27250A1 (et)
WO (1) WO2002083643A1 (et)
ZA (1) ZA200307507B (et)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
WO2002081728A2 (en) * 2001-04-06 2002-10-17 Smithkline Beecham Corporation Quinoline inhibitors of hyak1 and hyak3 kinases
CN1305852C (zh) * 2002-09-19 2007-03-21 伊莱利利公司 作为阿片受体拮抗剂的二芳基醚
GB0318706D0 (en) * 2003-08-08 2003-09-10 Pfizer Ltd Selective serotonin reuptake inhibitors in the treatment of disease
WO2006008635A1 (en) * 2004-07-14 2006-01-26 Pfizer Limited Process for the preparation of a 3-phenoxy-pyridine derivative
US20100063081A1 (en) 2005-06-30 2010-03-11 Stuart Edward Bradly CPCR Agonists
CN101484433A (zh) 2006-02-15 2009-07-15 艾博特公司 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
WO2008079610A2 (en) * 2006-12-21 2008-07-03 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
PL2114933T3 (pl) 2007-01-04 2012-02-29 Prosidion Ltd Piperydyny jako agoniści GPCR
DE102008053242A1 (de) 2008-10-25 2010-05-06 Saltigo Gmbh Heteroaryl-Arylether
JP2014001199A (ja) * 2012-01-25 2014-01-09 Ishihara Sangyo Kaisha Ltd 有害生物防除剤
HRP20221018T1 (hr) 2013-03-13 2023-01-06 Jazz Pharmaceuticals Ireland Limited Liječenje katapleksije
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
EP3936192A4 (en) 2019-03-06 2022-11-16 Daiichi Sankyo Company, Limited PYRROLOPYRAZOL DERIVATIVES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002252A0 (en) * 1999-02-23 2001-09-30 Pfizer Prod Inc Monoamine reuptake inhibitors for treatment of CNS disorders.
CN1242995C (zh) * 1999-05-21 2006-02-22 比奥维特罗姆股份公司 化合物,它们的用途和制备方法
AU769430B2 (en) * 1999-10-13 2004-01-29 Pfizer Products Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors

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UA74430C2 (uk) 2005-12-15
EA008936B1 (ru) 2007-10-26
HRP20030824A2 (en) 2005-08-31
ZA200307507B (en) 2004-11-19
PA8543701A1 (es) 2004-05-26
KR100570376B1 (ko) 2006-04-11
DE60201819D1 (en) 2004-12-09
KR20030088133A (ko) 2003-11-17
GEP20053590B (en) 2005-07-25
MA27010A1 (fr) 2004-12-20
NZ528481A (en) 2006-02-24
EA200300988A1 (ru) 2004-04-29
HUP0303880A2 (hu) 2004-04-28
AU2002244898B2 (en) 2007-05-24
UY27250A1 (es) 2002-12-31
ES2227448T3 (es) 2005-04-01
ECSP034802A (es) 2003-12-01
WO2002083643A1 (en) 2002-10-24
AP1543A (en) 2006-01-11
JP2005504728A (ja) 2005-02-17
DOP2002000371A (es) 2002-10-15
SV2003000981A (es) 2003-07-29
SI1377550T1 (en) 2005-02-28
TNSN03090A1 (fr) 2005-12-23
IS6960A (is) 2003-09-18
PE20021003A1 (es) 2002-11-12
PL373533A1 (en) 2005-09-05
IL158141A (en) 2007-10-31
CN1656072A (zh) 2005-08-17
ATE281435T1 (de) 2004-11-15
AP2002002468A0 (en) 2002-06-30
EP1377550B1 (en) 2004-11-03
CZ20032677A3 (cs) 2004-06-16
EP1377550B9 (en) 2005-11-23
IL158141A0 (en) 2004-03-28
CA2443699A1 (en) 2002-10-24
MY136262A (en) 2008-09-30
BG108204A (bg) 2004-12-30
GB0109103D0 (en) 2001-05-30
DE60201819T2 (de) 2005-11-03
RS79703A (en) 2006-12-15
MXPA03009383A (es) 2004-01-29
EP1377550A1 (en) 2004-01-07
PT1377550E (pt) 2005-01-31
NO20034525D0 (no) 2003-10-09
AR035818A1 (es) 2004-07-14
NO20034525L (no) 2003-12-08
GT200200071A (es) 2003-01-31
BR0208812A (pt) 2004-03-09
OA12500A (en) 2006-05-24
SK12452003A3 (sk) 2004-08-03

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