EE03287B1 - T-raku antigeeni retseptori V-piirkonna proteiinid, nende valmistamismeetodid, nende saamiseks vajalik ekspressioonivektor ning bakteriaalne rakk, neid sisaldav farmatseutiline kompositsioon, nende kasutamine medikamentide tootmisel ning diagnoosimee - Google Patents

T-raku antigeeni retseptori V-piirkonna proteiinid, nende valmistamismeetodid, nende saamiseks vajalik ekspressioonivektor ning bakteriaalne rakk, neid sisaldav farmatseutiline kompositsioon, nende kasutamine medikamentide tootmisel ning diagnoosimee

Info

Publication number
EE03287B1
EE03287B1 EE9600096A EE9600096A EE03287B1 EE 03287 B1 EE03287 B1 EE 03287B1 EE 9600096 A EE9600096 A EE 9600096A EE 9600096 A EE9600096 A EE 9600096A EE 03287 B1 EE03287 B1 EE 03287B1
Authority
EE
Estonia
Prior art keywords
preparation
methods
medicaments
manufacture
pharmaceutical composition
Prior art date
Application number
EE9600096A
Other languages
English (en)
Estonian (et)
Inventor
C. Makrides Savvas
C. Kung Patrick
Original Assignee
T Cell Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T Cell Sciences, Inc. filed Critical T Cell Sciences, Inc.
Publication of EE03287B1 publication Critical patent/EE03287B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Neurosurgery (AREA)
EE9600096A 1994-01-13 1995-01-12 T-raku antigeeni retseptori V-piirkonna proteiinid, nende valmistamismeetodid, nende saamiseks vajalik ekspressioonivektor ning bakteriaalne rakk, neid sisaldav farmatseutiline kompositsioon, nende kasutamine medikamentide tootmisel ning diagnoosimee EE03287B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/181,492 US5552300A (en) 1994-01-13 1994-01-13 T cell antigen receptor V region proteins and methods of preparation thereof
PCT/US1995/000408 WO1995019435A2 (en) 1994-01-13 1995-01-12 T cell antigen receptor v region proteins and methods of preparation thereof

Publications (1)

Publication Number Publication Date
EE03287B1 true EE03287B1 (et) 2000-08-15

Family

ID=22664497

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9600096A EE03287B1 (et) 1994-01-13 1995-01-12 T-raku antigeeni retseptori V-piirkonna proteiinid, nende valmistamismeetodid, nende saamiseks vajalik ekspressioonivektor ning bakteriaalne rakk, neid sisaldav farmatseutiline kompositsioon, nende kasutamine medikamentide tootmisel ning diagnoosimee

Country Status (21)

Country Link
US (1) US5552300A (fi)
EP (1) EP0738322A1 (fi)
JP (1) JPH10501961A (fi)
KR (1) KR100213396B1 (fi)
AU (1) AU700661B2 (fi)
BR (1) BR9506612A (fi)
CA (1) CA2181171A1 (fi)
CZ (1) CZ9602009A3 (fi)
EE (1) EE03287B1 (fi)
FI (1) FI962844A (fi)
HU (1) HUT75551A (fi)
IL (1) IL112316A0 (fi)
LV (1) LV11630B (fi)
MX (1) MX9602750A (fi)
NO (1) NO962921L (fi)
NZ (2) NZ279605A (fi)
PL (1) PL181072B1 (fi)
SG (1) SG52342A1 (fi)
SK (1) SK90696A3 (fi)
WO (1) WO1995019435A2 (fi)
ZA (1) ZA95261B (fi)

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US6113903A (en) * 1989-03-21 2000-09-05 The Immune Response Corporation Peptides and methods against diabetes
US20040229282A1 (en) * 1997-03-10 2004-11-18 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US7749498B2 (en) * 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) * 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US5986065A (en) * 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
CA2368655A1 (en) 1999-04-08 2000-10-19 Gregory M. Glenn Dry formulation for transcutaneous immunization
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US20030190705A1 (en) * 2001-10-29 2003-10-09 Sunol Molecular Corporation Method of humanizing immune system molecules
PT2363710E (pt) * 2002-08-08 2015-10-01 Baylor College Medicine Isolamento e identificação de células t
EP1644039B1 (en) * 2003-06-19 2014-10-01 Genentech, Inc. Compositions and methods for treating coagulation related disorders
WO2006003659A2 (en) * 2004-07-06 2006-01-12 Transpharma Medical Ltd. Delivery system for transdermal immunization
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
WO2007028167A2 (en) 2005-09-02 2007-03-08 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
EP2420833B1 (en) * 2006-05-05 2015-09-02 Opexa Therapeutics T-cell vaccine
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
CN102573883A (zh) 2009-06-12 2012-07-11 疫苗技术公司 用于促进细胞-介导的免疫应答的方法和组合物
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
US9790278B2 (en) 2012-05-07 2017-10-17 The Trustees Of Dartmouth College Anti-B7-H6 antibody, fusion proteins, and methods of using the same
WO2014044690A1 (en) 2012-09-18 2014-03-27 Valneva Austria Gmbh Improved vaccines

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
US4873190A (en) * 1984-06-13 1989-10-10 Massachusetts Institute Of Technology Heterodimeric T lymphocyte receptor
WO1985003947A1 (en) * 1984-03-01 1985-09-12 The Board Of Trustees Of The Leland Stanford Jr. U T-cell receptor-specific for antigen polypeptides and related polynucleotides
US4845026A (en) * 1985-12-03 1989-07-04 T Cell Sciences, Inc. Assay systems for detecting cell-free T cell antigen receptor related molecules and the clinical utilities of the assays
US5340921A (en) * 1986-07-03 1994-08-23 T Cell Sciences, Inc. Γ, δT cell receptor and methods and detection
US5260223A (en) * 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
US5024940A (en) * 1987-02-19 1991-06-18 T Cell Sciences, Inc. Nucleic acids encoding the delta chain of the T cell antigen receptor
US5185250A (en) * 1986-07-03 1993-02-09 T Cell Sciences, Inc. Human γ, δT cell antigen receptor polypeptides and nucleic acids
ES2093606T3 (es) * 1987-06-23 1997-01-01 Univ Leland Stanford Junior Gen del receptor de celulas t localizado en el locus alfa y estructuras artificiales de adn.
US5223426A (en) * 1988-12-15 1993-06-29 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor
CA2046909A1 (en) * 1989-03-21 1990-09-22 Mark D. Howell Vaccination and methods against diseases resulting from pathogenic responses by specific t cell populations
WO1990014068A2 (en) * 1989-05-02 1990-11-29 Irun Robert Cohen Anti-ergotypic t cells for the treatment or prevention of autoimmune diseases and methods of use thereof
CA2072356A1 (en) * 1989-12-29 1991-06-30 James L. Urban Diagnosis and treatment of diseases
US5216132A (en) * 1990-01-12 1993-06-01 Protein Design Labs, Inc. Soluble t-cell antigen receptor chimeric antigens
DK0527199T4 (da) * 1990-05-01 2000-12-04 Univ Leland Stanford Junior Præparater til anvendelse ved en fremgangsmåde tilbehandling af et menneske, der lider afdissemineret sclerose
DE69124518T2 (de) * 1990-08-09 1997-05-15 National Jewish Center For Immunology And Respiratory Medicine, Denver, Col. Herstellung monoklonaler Antikörper gegen menschliches Vbeta T-Zellrezeptorelement unter Verwendung rekombinanter DNA-Vektoren
IE920447A1 (en) * 1991-02-12 1992-08-12 Roussel Uclaf NUCLEOTIDE SEQUENCES CODING FOR ß-CHAIN VARIABLE REGIONS OF¹HUMAN T-LYMPHOCYTE RECEPTORS, CORRESPONDING PEPTIDE SEGMENTS¹AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
JPH07502977A (ja) * 1991-05-31 1995-03-30 ゾーマ・コーポレーション 免疫関連疾患用治療薬としてのｔ細胞レセプターペプチド
JPH06511241A (ja) * 1991-09-23 1994-12-15 ジェネンテク，インコーポレイテッド 自己免疫疾患の診断および治療
US5333487A (en) * 1991-11-15 1994-08-02 Hughes Aircraft Company Spark-excited fluorescence sensor
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor

Also Published As

Publication number Publication date
NZ332715A (en) 2000-06-23
EP0738322A1 (en) 1996-10-23
PL319374A1 (en) 1997-08-04
IL112316A0 (en) 1995-03-30
NO962921L (no) 1996-09-02
PL181072B1 (pl) 2001-05-31
SG52342A1 (en) 1999-06-22
CZ9602009A3 (en) 1997-12-17
HUT75551A (en) 1997-05-28
KR100213396B1 (ko) 1999-08-02
WO1995019435A2 (en) 1995-07-20
JPH10501961A (ja) 1998-02-24
SK90696A3 (en) 1997-07-09
BR9506612A (pt) 1997-09-16
MX9602750A (es) 1997-05-31
US5552300A (en) 1996-09-03
NZ279605A (en) 1999-01-28
AU1678495A (en) 1995-08-01
FI962844A (fi) 1996-08-29
AU700661B2 (en) 1999-01-14
ZA95261B (en) 1995-11-14
FI962844A0 (fi) 1996-07-12
HU9601908D0 (en) 1996-09-30
LV11630B (en) 1997-08-20
CA2181171A1 (en) 1995-07-20
WO1995019435A3 (en) 1995-08-24
LV11630A (lv) 1996-12-20
KR970700772A (ko) 1997-02-12
NO962921D0 (no) 1996-07-11

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