ECSP972115A - SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS - Google Patents

SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS

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Publication number
ECSP972115A
ECSP972115A ECSP972115A ECSP972115A EC SP972115 A ECSP972115 A EC SP972115A EC SP972115 A ECSP972115 A EC SP972115A EC SP972115 A ECSP972115 A EC SP972115A
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EC
Ecuador
Prior art keywords
disorders
present
graph
carbons
alkyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
David R Brittelli
Jinshan Chen
Brian Richard Dixon
Zandt Michael C Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972115 priority Critical patent/ECSP972115A/en
Publication of ECSP972115A publication Critical patent/ECSP972115A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención presenta composiciones farmacéuticas y métodos para tratar ciertos trastornos, que comprenden administrar una cantidad de un compuesto o composición de la presente invención que sea eficaz para inhibir la actividad de por lo menos una metaloproteasa de matriz, que da como resultado la obtención del efecto deseado. Los compuestos de la presente invención tiene la fórmula generalizada (gráfico), donde y es 0,2 ó 3, r es 0-6, Z es (CH2)7-O(CH2)e-C6H4-(CH2)r o donde e es 0-1 y f es 1-6; R15 es -H, -CI-=Me o (gráfico), donde n es 0-4, R17 es -C2H5,-arilo o -bencilo y R16 es (gráfico), donde t es 0-1, x es 0-4 y R4 es uno de los siguientes; haluro, alquilo de 1 a 6 carbonos, OR, NR2, NO2, (R=H o alquilo de 1 a 6 carbonos). Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermolisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, las osterpenias en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso, las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria a partir de la ruptura de placa ateroesclerótica. La presente invención se relaciona asi mismo con composiciones farmacéuticas y métodos para tratar dichos trastornos.The present invention features pharmaceutical compositions and methods of treating certain disorders, which comprise administering an amount of a compound or composition of the present invention that is effective in inhibiting the activity of at least one matrix metalloprotease, resulting in obtaining the desired effect. The compounds of the present invention have the generalized formula (graph), where y is 0.2 or 3, r is 0-6, Z is (CH2) 7-O (CH2) e-C6H4- (CH2) ro where e is 0-1 and f is 1-6; R15 is -H, -CI- = Me or (graph), where n is 0-4, R17 is -C2H5, -aryl or -benzyl, and R16 is (graph), where t is 0-1, x is 0- 4 and R4 is one of the following; halide, alkyl of 1 to 6 carbons, OR, NR2, NO2, (R = H or alkyl of 1 to 6 carbons). These compounds are useful for inhibiting matrix metalloproteases and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, osterpenias in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system, tumor metastasis, or degenerative loss of cartilage after traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention likewise relates to pharmaceutical compositions and methods of treating such disorders.

ECSP972115 1997-05-12 1997-05-12 SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS ECSP972115A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972115 ECSP972115A (en) 1997-05-12 1997-05-12 SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972115 ECSP972115A (en) 1997-05-12 1997-05-12 SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS

Publications (1)

Publication Number Publication Date
ECSP972115A true ECSP972115A (en) 1998-04-24

Family

ID=42042946

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972115 ECSP972115A (en) 1997-05-12 1997-05-12 SUBSTITUTED OXYBUTYRIC ACIDS AS MATRIX METALOPROTEASE INHIBITORS

Country Status (1)

Country Link
EC (1) ECSP972115A (en)

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