ECSP972113A - INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS - Google Patents

INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS

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Publication number
ECSP972113A
ECSP972113A ECSP972113A ECSP972113A EC SP972113 A ECSP972113 A EC SP972113A EC SP972113 A ECSP972113 A EC SP972113A EC SP972113 A ECSP972113 A EC SP972113A
Authority
EC
Ecuador
Prior art keywords
compounds
disorders
diseases
graph
pharmaceutical compositions
Prior art date
Application number
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Spanish (es)
Inventor
David R Brittelli
Brian Richard Dixon
Zandt Michael C Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972113 priority Critical patent/ECSP972113A/en
Publication of ECSP972113A publication Critical patent/ECSP972113A/en

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Abstract

Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada. (gráfico), donde r es 0-2, T es seleccionado entre (gráfico), y R40 es una estructura mono-o bi-heterocíclica. Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córneas, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la esteopenias en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso, las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria por ruptura de placa ateroesclerótica. La presente invención presenta así mismo composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula. (graph), where r is 0-2, T is selected from (graph), and R40 is a mono- or bi-heterocyclic structure. These compounds are useful for inhibiting matrix metalloproteases and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, steopenias in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system, tumor metastasis, or degenerative loss of cartilage after traumatic joint injury, and coronary thrombosis due to ruptured atherosclerotic plaque. The present invention also presents pharmaceutical compositions and methods for treating said disorders.

ECSP972113 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS ECSP972113A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972113 ECSP972113A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972113 ECSP972113A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS

Publications (1)

Publication Number Publication Date
ECSP972113A true ECSP972113A (en) 1998-04-24

Family

ID=42042944

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972113 ECSP972113A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS

Country Status (1)

Country Link
EC (1) ECSP972113A (en)

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