ECSP972113A - INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS - Google Patents
INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDSInfo
- Publication number
- ECSP972113A ECSP972113A ECSP972113A ECSP972113A EC SP972113 A ECSP972113 A EC SP972113A EC SP972113 A ECSP972113 A EC SP972113A EC SP972113 A ECSP972113 A EC SP972113A
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Abstract
Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada. (gráfico), donde r es 0-2, T es seleccionado entre (gráfico), y R40 es una estructura mono-o bi-heterocíclica. Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córneas, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la esteopenias en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso, las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria por ruptura de placa ateroesclerótica. La presente invención presenta así mismo composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula. (graph), where r is 0-2, T is selected from (graph), and R40 is a mono- or bi-heterocyclic structure. These compounds are useful for inhibiting matrix metalloproteases and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, steopenias in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system, tumor metastasis, or degenerative loss of cartilage after traumatic joint injury, and coronary thrombosis due to ruptured atherosclerotic plaque. The present invention also presents pharmaceutical compositions and methods for treating said disorders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972113 ECSP972113A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972113 ECSP972113A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP972113A true ECSP972113A (en) | 1998-04-24 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP972113 ECSP972113A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED BIARILOXOBUTIRIC ACIDS |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP972113A (en) |
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1997
- 1997-05-12 EC ECSP972113 patent/ECSP972113A/en unknown
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