AR007097A1 - BIARYLACETHYLENE MATRIX METALOPROTEASE INHIBITORS, A COMPOSITION THAT HAS MATRIX METALOPROTEASE INHIBITING AND THE USE OF SUCH BIARYLACETILENE IN THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents
BIARYLACETHYLENE MATRIX METALOPROTEASE INHIBITORS, A COMPOSITION THAT HAS MATRIX METALOPROTEASE INHIBITING AND THE USE OF SUCH BIARYLACETILENE IN THE MANUFACTURE OF A MEDICINAL PRODUCT.Info
- Publication number
- AR007097A1 AR007097A1 ARP970101977A ARP970101977A AR007097A1 AR 007097 A1 AR007097 A1 AR 007097A1 AR P970101977 A ARP970101977 A AR P970101977A AR P970101977 A ARP970101977 A AR P970101977A AR 007097 A1 AR007097 A1 AR 007097A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- matrix
- matrix metaloprotease
- biarylacetilene
- biarylacethylene
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Se presentan compuestos inhibitorios de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y el uso de dichos compuestos parapreparar un medicamento útil. Los compuestos tienen la fórmula (I), donde R15 es seleccionadoen tre el grupo que consiste en HOCH2, MeOCH2, (n-Pr)2NCH2,CH3CO2CH2, EtOCO2CH2, HO(CH2)2, CH3CO2(CH2)2, HO2C(CH2)2, OHC(CH2)3, HO(CH2)4, 3-HO-Ph, y PhCH2OCH2; y R16 es seleccionado entre las fórmulas (II). Estoscompuestos son útiles para inhibirlas m etaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, talescomo la osteoartritis, la artritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras decórnea, la p roteinuria, laenfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los tratarnos que producen respuestas inflamatorias, las osteopenias en las quemedia la actividad de MMP, la enfermedad de la articulacióntemporomandibular, l as enfermedades desmielinizantes del sistema nervioso; las metástasis detumores o la pérdida degenerativa de cartílago posterior a la lesión articular traumática, y la trombosis coronaria a partir de la ruptura deplacaateroesclerótica.Matrix metalloprotease inhibitory compounds, pharmaceutical compositions thereof, and the use of such compounds to prepare a useful medicament are presented. The compounds have the formula (I), where R15 is selected from the group consisting of HOCH2, MeOCH2, (n-Pr) 2NCH2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2, CH3CO2 (CH2) 2, HO2C (CH2) 2, OHC (CH2) 3, HO (CH2) 4, 3-HO-Ph, and PhCH2OCH2; and R16 is selected from formulas (II). These compounds are useful to inhibit matrix methaloproteases and therefore to combat the disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, treatments that produce inflammatory responses, osteopenias in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastases or degenerative cartilage loss after traumatic joint injury; and coronary thrombosis from atherosclerotic plate rupture.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64502896A | 1996-05-15 | 1996-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR007097A1 true AR007097A1 (en) | 1999-10-13 |
Family
ID=24587368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101977A AR007097A1 (en) | 1996-05-15 | 1997-05-12 | BIARYLACETHYLENE MATRIX METALOPROTEASE INHIBITORS, A COMPOSITION THAT HAS MATRIX METALOPROTEASE INHIBITING AND THE USE OF SUCH BIARYLACETILENE IN THE MANUFACTURE OF A MEDICINAL PRODUCT. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0912496A1 (en) |
JP (1) | JP3090957B2 (en) |
CN (1) | CN1139570C (en) |
AR (1) | AR007097A1 (en) |
AU (1) | AU710759B2 (en) |
BR (1) | BR9709077A (en) |
CA (1) | CA2253796C (en) |
CO (1) | CO5080759A1 (en) |
HN (1) | HN1997000088A (en) |
HR (1) | HRP970245B1 (en) |
ID (1) | ID16910A (en) |
PA (1) | PA8429301A1 (en) |
SV (1) | SV1997000035A (en) |
TN (1) | TNSN97084A1 (en) |
TW (1) | TW381079B (en) |
WO (1) | WO1997043245A1 (en) |
YU (1) | YU18697A (en) |
ZA (1) | ZA974031B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
AR035478A1 (en) * | 1999-01-27 | 2004-06-02 | Wyeth Corp | AMIDA-HYDROXAMIC ACID, ACETYLLENE, BETA-SULPHONAMIDE AND PHOSPHINIC ACID AS INHIBITORS OF TACE, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
CA2804918C (en) | 2010-07-08 | 2018-03-06 | Kaken Pharmaceutical Co., Ltd. | N-hydroxyformamide derivative and medicament containing same |
CN106458938A (en) | 2014-04-03 | 2017-02-22 | 拜耳制药股份公司 | Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof |
CA2944614A1 (en) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases |
EP3126339A1 (en) | 2014-04-03 | 2017-02-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
DE2112716A1 (en) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Biphenylyl-butyric acid derivs. - anti phlogistics |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 CO CO97025172A patent/CO5080759A1/en unknown
- 1997-05-09 ZA ZA9704031A patent/ZA974031B/en unknown
- 1997-05-09 TN TNTNSN97084A patent/TNSN97084A1/en unknown
- 1997-05-09 HR HR970245A patent/HRP970245B1/en not_active IP Right Cessation
- 1997-05-12 CA CA002253796A patent/CA2253796C/en not_active Expired - Fee Related
- 1997-05-12 HN HN1997000088A patent/HN1997000088A/en unknown
- 1997-05-12 EP EP97923622A patent/EP0912496A1/en not_active Withdrawn
- 1997-05-12 CN CNB971964564A patent/CN1139570C/en not_active Expired - Fee Related
- 1997-05-12 YU YU18697A patent/YU18697A/en unknown
- 1997-05-12 PA PA19978429301A patent/PA8429301A1/en unknown
- 1997-05-12 TW TW086106283A patent/TW381079B/en not_active IP Right Cessation
- 1997-05-12 JP JP09540980A patent/JP3090957B2/en not_active Expired - Fee Related
- 1997-05-12 WO PCT/US1997/007921 patent/WO1997043245A1/en not_active Application Discontinuation
- 1997-05-12 AR ARP970101977A patent/AR007097A1/en unknown
- 1997-05-12 BR BR9709077A patent/BR9709077A/en not_active Application Discontinuation
- 1997-05-12 SV SV1997000035A patent/SV1997000035A/en unknown
- 1997-05-12 AU AU29386/97A patent/AU710759B2/en not_active Ceased
- 1997-05-14 ID IDP971606A patent/ID16910A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2253796A1 (en) | 1997-11-20 |
CN1139570C (en) | 2004-02-25 |
CN1225623A (en) | 1999-08-11 |
HRP970245B1 (en) | 2002-06-30 |
ID16910A (en) | 1997-11-20 |
CO5080759A1 (en) | 2001-09-25 |
WO1997043245A1 (en) | 1997-11-20 |
HRP970245A2 (en) | 1998-04-30 |
SV1997000035A (en) | 1999-01-14 |
BR9709077A (en) | 1999-08-03 |
EP0912496A1 (en) | 1999-05-06 |
HN1997000088A (en) | 1997-06-18 |
JPH11511179A (en) | 1999-09-28 |
AU710759B2 (en) | 1999-09-30 |
PA8429301A1 (en) | 2000-05-24 |
AU2938697A (en) | 1997-12-05 |
ZA974031B (en) | 1998-02-19 |
YU18697A (en) | 1999-11-22 |
TW381079B (en) | 2000-02-01 |
CA2253796C (en) | 2003-10-28 |
TNSN97084A1 (en) | 2005-03-15 |
JP3090957B2 (en) | 2000-09-25 |
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