ECSP972112A - INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS - Google Patents

INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS

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Publication number
ECSP972112A
ECSP972112A ECSP972112A ECSP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A
Authority
EC
Ecuador
Prior art keywords
compounds
disorders
diseases
pharmaceutical compositions
matrix metalloprotease
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Donald John Wolanin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972112 priority Critical patent/ECSP972112A/en
Publication of ECSP972112A publication Critical patent/ECSP972112A/en

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Abstract

Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada: (gráfico), donde R25 es una porción feniletilo sustituída. Estos compuestos son útiles para inhibir la metaloproteasa de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis rematoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; la metátasis de tumores o la pérdida degenerativa de cartílago posterior a la lesión articular traumática, y la trombosis coronaria por ruptura de placa aterosclerótica. La presente invención se relaciona asi mismo con composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula: (graph), where R25 is a substituted phenylethyl moiety. These compounds are useful for inhibiting matrix metalloprotease and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, osteoporosis in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis due to atherosclerotic plaque rupture. The present invention likewise relates to pharmaceutical compositions and methods of treating such disorders.

ECSP972112 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS ECSP972112A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972112 ECSP972112A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972112 ECSP972112A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS

Publications (1)

Publication Number Publication Date
ECSP972112A true ECSP972112A (en) 1998-04-24

Family

ID=42042943

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972112 ECSP972112A (en) 1997-05-12 1997-05-12 INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS

Country Status (1)

Country Link
EC (1) ECSP972112A (en)

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