ECSP972112A - INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS - Google Patents
INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDSInfo
- Publication number
- ECSP972112A ECSP972112A ECSP972112A ECSP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- disorders
- diseases
- pharmaceutical compositions
- matrix metalloprotease
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada: (gráfico), donde R25 es una porción feniletilo sustituída. Estos compuestos son útiles para inhibir la metaloproteasa de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis rematoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; la metátasis de tumores o la pérdida degenerativa de cartílago posterior a la lesión articular traumática, y la trombosis coronaria por ruptura de placa aterosclerótica. La presente invención se relaciona asi mismo con composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula: (graph), where R25 is a substituted phenylethyl moiety. These compounds are useful for inhibiting matrix metalloprotease and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, osteoporosis in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis due to atherosclerotic plaque rupture. The present invention likewise relates to pharmaceutical compositions and methods of treating such disorders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP972112A true ECSP972112A (en) | 1998-04-24 |
Family
ID=42042943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP972112A (en) |
-
1997
- 1997-05-12 EC ECSP972112 patent/ECSP972112A/en unknown
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