ECSP972114A - BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE - Google Patents
BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASEInfo
- Publication number
- ECSP972114A ECSP972114A ECSP972114A ECSP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A
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Abstract
Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada (gráfico), donde R15 es seleccionado entre el grupo que consiste en HOCH2, MEOCH2, (N-Pr)2Nch2, CH3CO2CH2, EtOCO2CH2, HO(CH2)2CH3CO2 (CH2)2, HO; C(CH2)2, OHC(CH2)3, HO(CH2)4, Ph, y 3 -HO-Ph, y Ph y PhCH2OCH2:y (gráfico), Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria a partir de la ruptura de placa ateroesclerótica. La presente invención presenta asi mismo composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula (graph), where R15 is selected from the group consisting of HOCH2, MEOCH2, (N-Pr) 2Nch2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2CH3CO2 (CH2) 2, HO ; C (CH2) 2, OHC (CH2) 3, HO (CH2) 4, Ph, and 3 -HO-Ph, and Ph and PhCH2OCH2: and (graph), These compounds are useful for inhibiting matrix metalloproteases and, for Therefore, to combat the disorders to which MMPs contribute, such as rheumatoid osteoarthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that they produce inflammatory responses, osteoporosis in which they mediate MMP activity, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastases or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention also presents pharmaceutical compositions and methods for treating said disorders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP972114A true ECSP972114A (en) | 1998-04-24 |
Family
ID=42042945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP972114A (en) |
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1997
- 1997-05-12 EC ECSP972114 patent/ECSP972114A/en unknown
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