ECSP972114A - BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE - Google Patents

BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE

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Publication number
ECSP972114A
ECSP972114A ECSP972114A ECSP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A
Authority
EC
Ecuador
Prior art keywords
compounds
disorders
diseases
graph
pharmaceutical compositions
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Jinshan Chen
Brian Richard Dixon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972114 priority Critical patent/ECSP972114A/en
Publication of ECSP972114A publication Critical patent/ECSP972114A/en

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Abstract

Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada (gráfico), donde R15 es seleccionado entre el grupo que consiste en HOCH2, MEOCH2, (N-Pr)2Nch2, CH3CO2CH2, EtOCO2CH2, HO(CH2)2CH3CO2 (CH2)2, HO; C(CH2)2, OHC(CH2)3, HO(CH2)4, Ph, y 3 -HO-Ph, y Ph y PhCH2OCH2:y (gráfico), Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria a partir de la ruptura de placa ateroesclerótica. La presente invención presenta asi mismo composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula (graph), where R15 is selected from the group consisting of HOCH2, MEOCH2, (N-Pr) 2Nch2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2CH3CO2 (CH2) 2, HO ; C (CH2) 2, OHC (CH2) 3, HO (CH2) 4, Ph, and 3 -HO-Ph, and Ph and PhCH2OCH2: and (graph), These compounds are useful for inhibiting matrix metalloproteases and, for Therefore, to combat the disorders to which MMPs contribute, such as rheumatoid osteoarthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that they produce inflammatory responses, osteoporosis in which they mediate MMP activity, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastases or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention also presents pharmaceutical compositions and methods for treating said disorders.

ECSP972114 1997-05-12 1997-05-12 BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE ECSP972114A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972114 ECSP972114A (en) 1997-05-12 1997-05-12 BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972114 ECSP972114A (en) 1997-05-12 1997-05-12 BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE

Publications (1)

Publication Number Publication Date
ECSP972114A true ECSP972114A (en) 1998-04-24

Family

ID=42042945

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972114 ECSP972114A (en) 1997-05-12 1997-05-12 BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE

Country Status (1)

Country Link
EC (1) ECSP972114A (en)

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