YU18697A - Biaryl acetilenes as inhibitors of matrix metalloproteases - Google Patents
Biaryl acetilenes as inhibitors of matrix metalloproteasesInfo
- Publication number
- YU18697A YU18697A YU18697A YU18697A YU18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- disease
- conditions
- treating
- pharmaceutical compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Dati su matrična metaloproteazna inhibirajuća jedinjenja, farmaceutski preparati koji ih sadrže i postupak za tretiranje obolenja uz korišćenja takvih jedinjenja. Jedinjenja pronalaska imaju opštu formulu gde R5 se bira iz grupe koja obuhvata: HOCH2, (n-Pr)2CH2; CH3CO2CH2; EtOCO2CH2; HO(CH3)2; CH3CO2(CH2)2; HO2C(CH2)2; OHC(CH2)3, HO(CH2)4, 3-HO-Ph i PhCH2OCH2; i R16 se bira izmedju Ova jedinjenja su primenjiva u inhibiranju matričnih metaloproteaza i stoga suzbijaju stanja u kojima učestvuju MMP-e takvih kao što su osteoartritis, reumatoidni artritis, septični artritis, periodontalno obolenje, kornealna ulceracija, proteinurija, aneurismalno aortno obolenje, distrofobna epidermoliza, buloza, stanja koja dovode do inflamatornih odgovora, osteopeniaza uzrokovana pomoću MMP aktivnosti, tempero mandibularno zglobno obolenja, demelatina-ciono obolenja nervnog sistema, tumorne metastaze ili degenerativni gubitak hrskavice koje prati traumatsku povredu zgloba i koronarna tromboza usled arteroskleroznog raskidanja pločica. Predmetni pronalazak takodje obezbedjuje farmaceutske preparate i postupke za tretiranje takvih stanja.Matrix metalloprotease inhibiting compounds, pharmaceutical compositions containing them and a method for treating a disease using such compounds are provided. The compounds of the invention have the general formula wherein R 5 is selected from the group consisting of: HOCH 2, (n-Pr) 2 CH 2; CH3CO2CH2; EtOCO2CH2; HO (CH3) 2; CH3CO2 (CH2) 2; HO2C (CH2) 2; OHC (CH2) 3, HO (CH2) 4, 3-HO-Ph and PhCH2OCH2; and R16 is selected from These compounds are useful in inhibiting matrix metalloproteases and therefore suppress conditions involving MMPs such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic oropharyngeal disease bullosa, conditions leading to inflammatory responses, osteopenia caused by MMP activity, tempero-mandibular joint disease, demelatina-tion diseases of the nervous system, tumor metastases or degenerative cartilage loss that accompanies traumatic joint injury and coronary thrombosis due to atherosclerosis. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64502896A | 1996-05-15 | 1996-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU18697A true YU18697A (en) | 1999-11-22 |
Family
ID=24587368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU18697A YU18697A (en) | 1996-05-15 | 1997-05-12 | Biaryl acetilenes as inhibitors of matrix metalloproteases |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0912496A1 (en) |
JP (1) | JP3090957B2 (en) |
CN (1) | CN1139570C (en) |
AR (1) | AR007097A1 (en) |
AU (1) | AU710759B2 (en) |
BR (1) | BR9709077A (en) |
CA (1) | CA2253796C (en) |
CO (1) | CO5080759A1 (en) |
HN (1) | HN1997000088A (en) |
HR (1) | HRP970245B1 (en) |
ID (1) | ID16910A (en) |
PA (1) | PA8429301A1 (en) |
SV (1) | SV1997000035A (en) |
TN (1) | TNSN97084A1 (en) |
TW (1) | TW381079B (en) |
WO (1) | WO1997043245A1 (en) |
YU (1) | YU18697A (en) |
ZA (1) | ZA974031B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
AR035478A1 (en) * | 1999-01-27 | 2004-06-02 | Wyeth Corp | AMIDA-HYDROXAMIC ACID, ACETYLLENE, BETA-SULPHONAMIDE AND PHOSPHINIC ACID AS INHIBITORS OF TACE, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
ES2592154T3 (en) | 2010-07-08 | 2016-11-28 | Kaken Pharmaceutical Co., Ltd. | N-Hydroxyformamide derivative and medicine containing the same |
US20170119776A1 (en) | 2014-04-03 | 2017-05-04 | Bayer Pharma Aktiengesellschaft | Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof |
CA2944614A1 (en) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases |
WO2015150363A1 (en) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
DE2112716A1 (en) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Biphenylyl-butyric acid derivs. - anti phlogistics |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 CO CO97025172A patent/CO5080759A1/en unknown
- 1997-05-09 ZA ZA9704031A patent/ZA974031B/en unknown
- 1997-05-09 TN TNTNSN97084A patent/TNSN97084A1/en unknown
- 1997-05-09 HR HR970245A patent/HRP970245B1/en not_active IP Right Cessation
- 1997-05-12 PA PA19978429301A patent/PA8429301A1/en unknown
- 1997-05-12 YU YU18697A patent/YU18697A/en unknown
- 1997-05-12 AR ARP970101977A patent/AR007097A1/en unknown
- 1997-05-12 HN HN1997000088A patent/HN1997000088A/en unknown
- 1997-05-12 CN CNB971964564A patent/CN1139570C/en not_active Expired - Fee Related
- 1997-05-12 SV SV1997000035A patent/SV1997000035A/en unknown
- 1997-05-12 TW TW086106283A patent/TW381079B/en not_active IP Right Cessation
- 1997-05-12 JP JP09540980A patent/JP3090957B2/en not_active Expired - Fee Related
- 1997-05-12 BR BR9709077A patent/BR9709077A/en not_active Application Discontinuation
- 1997-05-12 EP EP97923622A patent/EP0912496A1/en not_active Withdrawn
- 1997-05-12 WO PCT/US1997/007921 patent/WO1997043245A1/en not_active Application Discontinuation
- 1997-05-12 AU AU29386/97A patent/AU710759B2/en not_active Ceased
- 1997-05-12 CA CA002253796A patent/CA2253796C/en not_active Expired - Fee Related
- 1997-05-14 ID IDP971606A patent/ID16910A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA974031B (en) | 1998-02-19 |
TW381079B (en) | 2000-02-01 |
PA8429301A1 (en) | 2000-05-24 |
ID16910A (en) | 1997-11-20 |
BR9709077A (en) | 1999-08-03 |
AR007097A1 (en) | 1999-10-13 |
JPH11511179A (en) | 1999-09-28 |
HN1997000088A (en) | 1997-06-18 |
HRP970245B1 (en) | 2002-06-30 |
JP3090957B2 (en) | 2000-09-25 |
CN1139570C (en) | 2004-02-25 |
CO5080759A1 (en) | 2001-09-25 |
AU2938697A (en) | 1997-12-05 |
CA2253796A1 (en) | 1997-11-20 |
HRP970245A2 (en) | 1998-04-30 |
SV1997000035A (en) | 1999-01-14 |
TNSN97084A1 (en) | 2005-03-15 |
CA2253796C (en) | 2003-10-28 |
AU710759B2 (en) | 1999-09-30 |
CN1225623A (en) | 1999-08-11 |
WO1997043245A1 (en) | 1997-11-20 |
EP0912496A1 (en) | 1999-05-06 |
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